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Elsevier

Academic Press

  • Body-on-a-Chip

    Essentials and Applications
    • 1st Edition
    • Anthony Atala + 1 more
    • English
    Body-on-a-Chip: Essentials and Applications provides the reader high-quality information, in a single resource, that is necessary to explore the use of BOC systems from design and development to testing and personalized medicine, to medical research and diagnostics. BOC systems can recapitulate native tissue/ organ architecture, diffusion kinetics of drugs physiological flow conditions etc., similar to what would happen in the body, they are particularly powerful in predicting human efficacy prior to clinical testing of a drug, determining potential toxicity, or in clinical studies to test underlying mechanisms or action or adverse effects. With recent advancements in high-throughput analysis systems and artificial intelligence, it has also become possible to screen several drugs at a time.

  • Building Blocks of Neuroimmunometabolism

    From Molecular Pathways to Therapeutic Strategies
    • 1st Edition
    • Sachchida Nand Rai + 2 more
    • English
    Building Blocks of Neuroimmunometabolis... From Molecular Pathways to Therapeutic Strategies offers an authoritative exploration of the intricate relationship between the immune system and neurodegenerative diseases. This essential resource addresses the critical gap in understanding how immune responses and metabolic processes jointly influence the onset and progression of conditions such as Alzheimer’s, Parkinson’s, and multiple sclerosis. The book provides an examination of key molecular pathways and cellular interactions, emphasizing the role of immunometabolism in disease mechanisms. Beginning with an introduction to the concept of immunometabolism, it explores the connections between the immune and nervous systems, setting the stage for understanding neurodegenerative diseases.In addition, the book discusses pivotal topics such as the role of microglia and macrophages in neuroinflammation, the metabolic regulation of T cells, and the impact of oxidative stress and mitochondrial dysfunction. The gut-brain axis is examined for its influence on brain health, alongside innovative therapeutic strategies targeting immunometabolic pathways and lifestyle interventions.

  • Advances in Organometallic Chemistry

    • 1st Edition
    • Volume 85
    • English
    Advances in Organometallic Chemistry provides a comprehensive overview of recent developments and emerging trends in the field of organometallic chemistry. Covering a wide range of topics, the book explores the synthesis, structure, reactivity, and applications of organometallic compounds across various chemical disciplines. Chapters are authored by leading experts and highlight both fundamental research and innovative applications, including catalysis, materials science, bioorganometallic chemistry, and sustainable processes. This volume serves as an essential reference for researchers, graduate students, and professionals seeking up-to-date information on the dynamic and interdisciplinary field of organometallic chemistry.

  • miRNA in Human Disease

    From Biomarkers to Therapeutics
    • 1st Edition
    • Parul Gupta + 6 more
    • English
    miRNA in Human Disease: From Biomarkers to Therapeutics explores the critical role of microRNAs (miRNAs) in the development and progression of various diseases, emphasizing their significance as biomarkers and therapeutic targets. Sections provide a comprehensive overview of the biogenesis, function, and regulation of miRNAs, offering insights into how these small noncoding RNA molecules influence gene expression and contribute to disease development and progression. The book covers traditional and advanced methods for miRNA extraction, the role of miRNAs in infectious diseases, cancer, neurological disorders, cardiovascular disease, hemoglobinopathies, pregnancy complications, and metabolic disorders.Sections also discuss the latest research on miRNA-based therapies, including the design and delivery of miRNA mimics and inhibitors and their potential applications in personalized medicine. With a strong focus on practical implementation, the book includes detailed case studies and real-world examples that demonstrate the clinical relevance of miRNA research. It addresses the challenges and future directions in the field, providing a roadmap for researchers, clinicians, and industry professionals to harness the potential of miRNAs for disease diagnosis, treatment, and prevention.

  • Computational and Experimental Approaches in Protein Engineering and Design

    • 1st Edition
    • Aditya Kumar Padhi + 1 more
    • English
    Computational and Experimental Approaches in Protein Engineering and Design offers a one-stop resource for students, researchers, and practitioners. Cutting-edge techniques in AI and machine learning applications are expertly covered in the book, empowering readers with the tools they need to tackle modern challenges in biotechnology and therapeutics. Step-by-step protocols provide readers with actionable guidance to transition smoothly from computational modelling to laboratory implementation. The inclusion of real-world case studies makes the theoretical concepts relatable and actionable and immediately applicable to solving complex problems, such as producing protein-based vaccines for immunotherapy.The book’s focus on synthetic biology positions it at the forefront of innovation, appealing to a broad audience, from those involved in tissue engineering to those exploring next-generation therapeutics. With its forward-looking approach, emphasizing machine-learning-dri... protein design and nanobody engineering, this book is an indispensable resource for researchers preparing to navigate the future of biotechnology.

  • International Review Research in Developmental Disabilities

    • 1st Edition
    • Volume 70
    • English
    International Review Research in Developmental Disabilities series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Wearable Smart Sensing Devices for Sustainable Healthcare

    Techniques, Fabrication, Data Collection and Analysis
    • 1st Edition
    • Arpana Parihar + 2 more
    • English
    Wearable Smart Sensing Devices for Sustainable Healthcare: Techniques, Fabrication, Data Collection and Analysis presents a complete overview of the techniques for developing integrated wearable sensors, the systems that power them, and the fabrication issues involved in making them. The book bridges the gap between theory and practice, offering scientific knowledge and practical insights. Written by renowned researchers and industry experts, this book provides valuable understanding and insights into the design, data processing, analysis, and fabrication of wearable sensors that is ideal for academic engineering and scientific researchers, industry engineers, and scientists interested in developing wearable sensor devices.

  • Innovations and Human Factors Challenges in Healthcare Product Design

    • 1st Edition
    • Kamalpreet Sandhu + 3 more
    • English
    Innovations and Human Factors Challenges in Healthcare Product Design covers best practices and advanced design methods to capture, document, and validate various challenges at the early stage of the design process, also delving into how to mitigate design strategies to address those challenges without compromising the cost, effort, safety, and quality of the device. The book provides a comprehensive collection of technical notes, research designs, design methods and processes, case studies, comprehensive literature on the industrial impact of design methods and processes, and applications of digital technologies for design, analysis, manufacturing, testing, and deployment. Readers will find multidisciplinary coverage of the application of technology and science for product design in healthcare sectors.

  • Adverse Childhood Experiences

    Using Evidence to Advance Research, Practice, Policy, and Prevention
    • 2nd Edition
    • Gordon J. G. Asmundson + 1 more
    • English
    The second edition of “Adverse Childhood Experiences: Using Evidence to Advance Research, Practice, Policy, and Prevention” delves deeper into the foundational ACEs Study, providing a thorough review alongside comprehensive definitions and assessment methodologies. From mental and physical health outcomes to the neurodevelopmental mechanisms linking ACEs to psychopathology, sexual violence, and sexual health outcomes, this edition presents a nuanced understanding of the complex interplay between adverse experiences and lifelong consequences. Newly incorporated content addresses contemporary issues, redefining ACEs, exploring the appropriateness of routine screening, and contemplating ACEs from a global perspective. Professionals working with children and families, including physicians, nurses, social workers, psychologists, lawyers, judges, public health leaders, policy makers, and government delegates, will find this evidence-based resource invaluable. "Adverse Childhood Experiences" not only equips practitioners with the latest research findings but also presents strategies for preventing ACEs, fostering trauma-informed care, resilience, and emphasizing the crucial role of safe, stable, and nurturing environments for children. This second edition cements its status as an indispensable guide, addressing the evolving landscape of ACEs with precision and relevance.

  • The Journey from Cocoa to Chocolate

    Preserving Flavor and Bioactive Compounds
    • 1st Edition
    • Ravi Pandiselvam + 1 more
    • English
    The Journey from Cocoa to Chocolate: Preserving Flavor and Bioactive Compounds provides an end-to-end review of different pre-processing and processing methods and their effects on the nutritional, physiochemical, sensorial properties, and health benefits of cocoa. Readers will explore the journey from cocoa beans to chocolate, including recent advances in processing techniques and the utilization of cocoa by-products for improved sustainability and waste reduction. The book emphasizes cocoa's beneficial components, also including retention processing techniques that do not sacrifice sensorial properties. Readers from academia, research, food science, and the chocolate industry will benefit from this new resource.Cocoa beans contain huge sources of phytochemicals that act as both flavor agents and bioactive compounds. Care must be taken in the processing of cocoa into chocolate in order to maintain cocoa's natural health benefits while enhancing flavor to create the sweet treat we know and love.

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