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    • Brucella Melitensis

      • 1st Edition
      • February 25, 2021
      • Jangampalli Adi Pradeepkiran + 1 more
      • English
      • Paperback
        9 7 8 0 3 2 3 8 5 6 8 1 2
      • eBook
        9 7 8 0 3 2 3 8 9 9 9 7 0
      Brucella Miletensis: Identification and Characterization of Potential Drug Targets presents a systematic approach to identifying and characterizing drug targets using bioinformatics. The book shows the potential of bioinformatic tools in the identification of virulence targets in pathogenic bacteria and viruses, in general, and in B. militensis 16M in particular. Chapters identify putative genes as potential drug targets, employ a subtractive genomic approach, consider the virulent genes of this bacteria that negatively affects humans, list twelve potential virulence genes as drug targets, and consider the screening of potential drugs against the bacteria’s virulence genes through molecular modeling, computational screening, drug discovery and molecular docking studies. In addition, the book demonstrates in silico approaches that offer insights into the identification of drug targets in B.melitensis 16M. The title employs a step-by-step approach to understanding drug targets by identifying and characterizing vaccine targets for Brucella melitensis, in silico screening, and the identification of novel drug targets from the total Brucella melitensis proteome. Other sections cover computational modeling and evaluation of the best potential drug targets through comparative modeling, molecular docking, and dynamics simulations of novel drug targets and in silico validation and ADMET analysis for best lead molecules.

    • Encyclopedia of Virology

      • 4th Edition
      • February 24, 2021
      • Dennis H. Bamford + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 8 1 4 5 1 5 9
      • eBook
        9 7 8 0 1 2 8 1 4 5 1 6 6
      Encyclopedia of Virology, Fourth Edition, Five Volume Set builds on the solid foundation laid by the previous editions, expanding its reach with new and timely topics. In five volumes, the work provides comprehensive coverage of the whole virosphere, making this a unique resource. Content explores viruses present in the environment and the pathogenic viruses of humans, animals, plants and microorganisms. Key areas and concepts concerning virus classification, structure, epidemiology, pathogenesis, diagnosis, treatment and prevention are discussed, guiding the reader through chapters that are presented at an accessible level, and include further readings for those needing more specific information. More than ever now, with the Covid19 pandemic, we are seeing the huge impact viruses have on our life and society. This encyclopedia is a must-have resource for scientists and practitioners, and a great source of information for the wider public.

    • Intelligent Data-Analytics for Condition Monitoring

      • 1st Edition
      • February 24, 2021
      • Hasmat Malik + 2 more
      • English
      • Paperback
        9 7 8 0 3 2 3 8 5 5 1 0 5
      • eBook
        9 7 8 0 3 2 3 8 5 5 1 1 2
      Intelligent Data-Analytics for Condition Monitoring: Smart Grid Applications looks at intelligent and meaningful uses of data required for an optimized, efficient engineering processes. In addition, the book provides application perspectives of various deep learning models for the condition monitoring of electrical equipment. With chapters discussing the fundamentals of machine learning and data analytics, the book is divided into two parts, including i) The application of intelligent data analytics in Solar PV fault diagnostics, transformer health monitoring and faults diagnostics, and induction motor faults and ii) Forecasting issues using data analytics which looks at global solar radiation forecasting, wind data forecasting, and more. This reference is useful for all engineers and researchers who need preliminary knowledge on data analytics fundamentals and the working methodologies and architecture of smart grid systems.

    • Advances in Heterocyclic Chemistry

      • 1st Edition
      • Volume 133
      • February 23, 2021
      • English
      • Hardback
        9 7 8 0 1 2 8 2 0 9 8 5 1
      • eBook
        9 7 8 0 1 2 8 2 0 9 8 6 8
      Advances in Heterocyclic Chemistry, Volume 133 is the latest release in this definitive series of great importance to organic chemists, polymer chemists, and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature also is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive review contains comprehensive chapters on Organosilicon azoles: Structure, silylotropy and NMR spectroscopy, Recent advances in the Nenitzescu indole synthesis (1990–2019), One-pot reactions of three-membered rings giving N,O,S-heterocycles, Organometallic complexes of functionalized chelating azines: Part 2, and more.

    • Protein Kinases in Drug Discovery

      • 1st Edition
      • Volume 124
      • February 22, 2021
      • Rossen Donev
      • English
      • Hardback
        9 7 8 0 3 2 3 8 5 3 1 3 2
      • eBook
        9 7 8 0 3 2 3 8 5 3 1 4 9
      Protein Kinases in Drug Discovery, Volume 124 discusses the latest information on protein kinases and how they modify other proteins by chemically adding phosphate groups to them. New chapters in this release include Transport Proteins and AMPs: Implications in Human Disease, Protein kinase CK2 inhibition as a pharmacological strategy, Emerging role of Protein kinase in diabetes mellitus: From Mechanism to therapy, Dual Roles of ATP-binding site in Protein Kinases: Orthosteric inhibition and Allosteric Regulation, Pseudokinases in drug discovery and development: progress, challenges and future prospects, Comparison of knowledge-based vs. combinatorial peptide library approaches for the identification of protein kinase substrates, and more.

    • Recent Advances in iPSC-Derived Cell Types

      • 1st Edition
      • February 21, 2021
      • Alexander Birbrair
      • English
      • Paperback
        9 7 8 0 1 2 8 2 2 2 3 0 0
      • eBook
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      The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology.Recent Advances in iPSC-derived Cell Types, Volume 4 addresses how different cell types can be derived from induced pluripotent stem cells.Somatic cells can be reprogrammed into Induced pluripotent stem cells by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. The volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to form different cell types which can be used in cell therapy as well as to model several diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different pathologies. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cellular populations, tissues and organs using state-of-art techniques. This volume will cover what we know so far about the use of iPSCs to derive different cell types, such as: erythroid cells, mucosal-associated invariant T cells, megakaryocytes, cerebral cortical neurons, inner ear cell types, airway epithelial cells, male germ cells, trophoblasts, cardiomyocytes, βpancreatic cells, and more. The volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and organ transplantation; and is contributed by world-renowned authors in the field.

    • Quantum Information Processing, Quantum Computing, and Quantum Error Correction

      • 2nd Edition
      • February 20, 2021
      • Ivan B. Djordjevic
      • English
      • Paperback
        9 7 8 0 1 2 8 2 1 9 8 2 9
      • eBook
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      The Second Edition of Quantum Information Processing, Quantum Computing, and Quantum Error Correction: An Engineering Approach presents a self-contained introduction to all aspects of the area, teaching the essentials such as state vectors, operators, density operators, measurements, and dynamics of a quantum system. In additional to the fundamental principles of quantum computation, basic quantum gates, basic quantum algorithms, and quantum information processing, this edition has been brought fully up to date, outlining the latest research trends. These include: Key topics include: Quantum error correction codes (QECCs), including stabilizer codes, Calderbank-Shor-Stea... (CSS) codes, quantum low-density parity-check (LDPC) codes, entanglement-assiste... QECCs, topological codes, and surface codes Quantum information theory, and quantum key distribution (QKD) Fault-tolerant information processing and fault-tolerant quantum error correction, together with a chapter on quantum machine learning. Both quantum circuits- and measurement-based quantum computational models are described The next part of the book is spent investigating physical realizations of quantum computers, encoders and decoders; including photonic quantum realization, cavity quantum electrodynamics, and ion traps In-depth analysis of the design and realization of a quantum information processing and quantum error correction circuits This fully up-to-date new edition will be of use to engineers, computer scientists, optical engineers, physicists and mathematicians.

    • Applications of Nanobiotechnology for Neglected Tropical Diseases

      • 1st Edition
      • February 20, 2021
      • Fabio Rocha Formiga + 2 more
      • English
      • Paperback
        9 7 8 0 1 2 8 2 1 1 0 0 7
      • eBook
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      Applications of Nanobiotechnology for Neglected Tropical Diseases describes recent advances in nanobiotechnology that can be applied to reducing the global disease burden of neglected tropical diseases (NTDs). The book explores the application of nanotechnology on the development of safe, effective, and reliable tools to prevent, diagnose, and treat NTDs. Furthermore, Applications of Nanobiotechnology for Neglected Tropical Diseases includes multidisciplinary content, combining knowledge from biochemistry, medicinal chemistry, material sciences, pharmacology, and pharmaceutics. The book is divided into three main parts, each outlining one major type of approach: (1) nano-based approaches for prevention, (2) nano-diagnostics and detection, and (3) nanotherapeutics. Each part contains chapters that delve into the different applications of the type of approach being presented in that part. A discussion of other approaches against NTD follows these three parts. This book is remarkable in its ability to encompass and thoroughly explain the latest techniques in nanobiotechnology, from basic research to patient-oriented investigation.

    • Phytomedicine

      • 1st Edition
      • February 20, 2021
      • Rouf Ahmad Bhat + 2 more
      • English
      • Paperback
        9 7 8 0 1 2 8 2 4 1 0 9 7
      • eBook
        9 7 8 0 1 2 8 2 4 1 1 0 3
      Phytomedicine: A Treasure of Pharmacologically Active Products from Plants aims to present updated knowledge of plant-based medicines in terms of their research and development, production, and utilization, from the viewpoint of sustainability and by using the latest technologies. The book explores different phytometabolites on a mass scale, coupled with the efficacy, performance and applicability on target organisms to treat curable and fatal diseases. Readers will find a coherent package of phytotherapeutic information regarding inclusive assortment of research based, scientific amplitude of metabolites from the plant world encompassing various action plans. Information is presented sequentially regarding phytochemistry, biological activity and the serviceable aspects of bioactive compounds. The book also addresses various advancements and achievements of novel drugs from plants using molecular and enzymatic activities, and various technological tools in an ecofriendly fashion.

    • Basic Statistics with R

      • 1st Edition
      • February 20, 2021
      • Stephen C. Loftus
      • English
      • Paperback
        9 7 8 0 1 2 8 2 0 7 8 8 8
      • eBook
        9 7 8 0 1 2 8 2 0 9 2 6 4
      Basic Statistics with R: Reaching Decisions with Data provides an understanding of the processes at work in using data for results. Sections cover data collection and discuss exploratory analyses, including visual graphs, numerical summaries, and relationships between variables - basic probability, and statistical inference - including hypothesis testing and confidence intervals. All topics are taught using real-data drawn from various fields, including economics, biology, political science and sports. Using this wide variety of motivating examples allows students to directly connect and make statistics essential to their field of interest, rather than seeing it as a separate and ancillary knowledge area. In addition to introducing students to statistical topics using real data, the book provides a gentle introduction to coding, having the students use the statistical language and software R. Students learn to load data, calculate summary statistics, create graphs and do statistical inference using R with either Windows or Macintosh machines.

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