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Elsevier

Academic Press

  • Liquid Biopsy in Urogenital Cancers and its Clinical Utility

    • 1st Edition
    • Seyed Mohammad Kazem Aghamir
    • English
    Liquid Biopsy in Urogenital Cancers and Their Clinical Utility presents updated information on liquid biopsy techniques and their utility for diagnosing urological cancers. As a promising and recent diagnostic method, these techniques can be used for identifying tumors at initial stage, thus greatly improving treatment outcomes and survivorship. Chapters provide an overview of liquid biopsy as a new tool for diagnosis, monitoring and personalized medicine in urogenital cancers and explain its applicability in different cancer types, including bladder, prostate, kidney and testis tumors, female genital tract and pediatric urogenital tumors. This is a valuable resource for cancer researchers, oncologists, graduate students, urologists and biomedical researchers who need to understand more about liquid biopsy and its use for urogenital cancers.

  • Lipids in Plants and Algae: From Fundamental Science to Industrial Applications

    • 1st Edition
    • Volume 101
    • English
    Lipids in Plants and Algae: From Fundamental Science to Industrial Applications, Volume 101 provides in-depth reviews on the most important aspects of the field. Topics in this volume encompass the most recent data about the physical properties of membrane lipids, lipid biosynthesis and metabolism (including glycerolipids, fatty acids, sterols, N-acylethanolamines, prostaglandins, phytoprostane), lipid storage, acyl flux, the dynamic and transport of glycerolipids, and the conversion of fatty acids into hydrocarbons. Lipid metabolism and lipidomics in plants and algae are one of the most challenging areas in biology, not only for fundamental research but also for the sustainable production of valuable molecules for green chemistry, including biofuel and health.

  • Handbook on Opium

    History and Basis of Opioids in Therapeutics
    • 1st Edition
    • Vasanth Kumar
    • English
    Handbook of Opium: History and Basis of Opioids in Therapeutics traces the history of poppy from its prehistory, its use in Greek and Egyptian medicine through the European Renaissance, and the opioid epidemic of the present day. The book explores the discovery of morphine and its alkaloids, reviews its biosynthetic process, and covers the evolution of synthetic opioids. Further, it reviews the biological effects of opium and the molecular basis of its actions, including future perspectives in clinical applications with therapeutic targets. The book is interspersed with numerous notes on the events and great minds in history and medicine who advocated, analyzed and advanced opium through history. The book is a comprehensive review on opium, covering a breadth of topics, including its history, botany, chemistry, trade, physiology, clinical use and molecular biology, with numerous references, tables, vignettes and illustrations included for additional understanding.

  • Advances in Agronomy

    • 1st Edition
    • Volume 172
    • Donald L. Sparks
    • English
    Advances in Agronomy, Volume 172, the latest release in this leading reference on the topic, contains a variety of updates and highlights new advances in the field, with each chapter written by an international board of authors.

  • RAS: Past, Present, and Future

    • 1st Edition
    • Volume 153
    • English
    Advances in Cancer Research, volume 153 provides a timely review of the biology, biochemistry, and current approaches to therapeutically target the RAS oncoprotein, the most frequently mutated oncogene family in human cancers. 2021 saw the approval of the first direct RAS inhibitor (sotorasib) for use in treating non-small cell lung cancers harboring KRAS(G12C) mutations. The successful approval and use of this drug highlights that the once “undruggable” RAS is indeed pharmacologically tractable. This volume provides an overview of efforts to develop additional approaches to therapeutically target oncogenic RAS. In addition, the reader will find excellent reviews on the history and research efforts to understand the biochemistry and oncogenic activity of RAS in human cancers.

  • Nuclear Decommissioning Case Studies

    The People Side
    • 1st Edition
    • Volume 3
    • Michele Laraia
    • English
    Nuclear Decommissioning Case Studies, Volume Three: The People Side presents a selection of global case studies on different aspects of Nuclear Decommissioning. This volume focuses on the people side of nuclear decommissioning, including stakeholder impacts, public relations and workforce factors. It presents a selection of case studies on stakeholders, socioeconomics and human factors, providing readers with a guide and information to deal with common, often contentious challenges. The events covered in this publication range from change management, stakeholder motivation, involvement and leadership adequacies. Decommissioning experts, including regulators, operators, waste managers, researchers and academics will find this book to be suitable supplementary material to Michele Laraia’s reference works on the theory and applications of nuclear decommissioning. Alongside the case studies books in this series, readers will obtain an understanding of stakeholder, socioeconomic and people-related case studies, what happened, and what we can learn from them.

  • Selenoprotein Structure and Function

    • 1st Edition
    • Volume 662
    • English
    Selenoprotein Structure and Function, Volume 662 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this new release include Identification of Selenoprotein O substrates using a biotinylated ATP analog, Selenium-encoded isotopic signature targeted profiling, Designing tRNASec variants for efficient selenocysteine incorporation using Sec-specific reporters, Preparation of selenoprotein S by chemical ligation, Examining xCT-mediated selenium uptake and selenoprotein production capacity in cells, SecMS analysis of selenoprotein with selenocysteine insertion sequence and beyond, Selenocysteine substitutions in thiyl radical enzymes, and much more. Additional chapters cover Recombinant selenoprotein expression in E. coli based upon the redefinition of a UAG codon in an RF1-depleted host strain, Metabolic labeling with radioactive selenium in zebrafish, Low pH isoTOP-ABPP to identify selenocysteines, Expression of selenoproteins via genetic code expansion in mammalian cells, Alpha-methyl selenocysteine as a tool for the study of selenoproteins, Selective selenol fluorescent probes: design, synthesis, structural determinants, and biological applications, and much more.

  • Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications - Part B

    • 1st Edition
    • Volume 187
    • English
    Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications - Part B, Volume 187 represents the collation of chapters written by eminent scientists worldwide. Chapters in this new release include Design and fabrication of microfluidics devices for molecular biology applications, Micro/Nanofluidics devices for drug delivery, From organ-on-chip to body-on-chip: the next generation of microfluidics platforms for in vitro drug toxicity testing, Micro/Nanofluidics for high throughput drug screening, Design, fabrication and assembly of lab-on-a-chip and its uses, Advances in microfluidic 3D cell culture for pre-clinical drug development, Tissue and organ culture on lab-on-a chip for biomedical applications, and much more.

  • Multiple Biological Activities of Unconventional Seed Oils

    • 1st Edition
    • Abdalbasit Adam Mariod
    • English
    Multiple Biological Activities of Unconventional Seed Oils brings detailed knowledge concerning the biological properties of oils (antioxidant, antimicrobial, antidiabetic, antitumor, anti-inflammatory, etc.), the content of individual substances with health-promoting properties, methods for biological properties assay, the influence of raw material quality and technological processes on the quality of oils, and possible raw materials and oil contaminants with adverse health effects. The book's chapters also highlight the unique properties of new oils, along with their biological activities. Less than a decade ago, the vegetable oils on grocery store shelves were derived from conventional oil seeds e.g., cotton, groundnut, sesame, corn sunflower and soybean. However, as consumers began to understand how fat intake affects overall health, researchers, plant growers and food manufacturers started to produce oils from unconventional sources. This book highlights what we've learned in the process.

  • Meeting the Challenges of Data Quality Management

    • 1st Edition
    • Laura Sebastian-Coleman
    • English
    Meeting the Challenges of Data Quality Management outlines the foundational concepts of data quality management and its challenges. The book enables data management professionals to help their organizations get more value from data by addressing the five challenges of data quality management: the meaning challenge (recognizing how data represents reality), the process/quality challenge (creating high-quality data by design), the people challenge (building data literacy), the technical challenge (enabling organizational data to be accessed and used, as well as protected), and the accountability challenge (ensuring organizational leadership treats data as an asset). Organizations that fail to meet these challenges get less value from their data than organizations that address them directly. The book describes core data quality management capabilities and introduces new and experienced DQ practitioners to practical techniques for getting value from activities such as data profiling, DQ monitoring and DQ reporting. It extends these ideas to the management of data quality within big data environments. This book will appeal to data quality and data management professionals, especially those involved with data governance, across a wide range of industries, as well as academic and government organizations. Readership extends to people higher up the organizational ladder (chief data officers, data strategists, analytics leaders) and in different parts of the organization (finance professionals, operations managers, IT leaders) who want to leverage their data and their organizational capabilities (people, processes, technology) to drive value and gain competitive advantage. This will be a key reference for graduate students in computer science programs which normally have a limited focus on the data itself and where data quality management is an often-overlooked aspect of data management courses.

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