Apoptosis in Health and Disease - Part B
- 1st Edition, Volume 126 - June 2, 2021
- Imprint: Academic Press
- Editor: Rossen Donev
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 8 5 3 1 7 - 0
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 5 3 1 8 - 7
Apoptosis in Health and Disease - Part B, Volume 126 in the Advances in Protein Chemistry and Structural Biology focuses on apoptotic responses in numerous conditions - from bact… Read more
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Request a sales quoteApoptosis in Health and Disease - Part B, Volume 126 in the Advances in Protein Chemistry and Structural Biology focuses on apoptotic responses in numerous conditions - from bacterial and parasite infections, to pathological states such as oxidative stress, pulmonary hypertension, and different cancer types, etc. In addition, the book provides therapeutic strategies for targeting apoptosis. These new advanced understandings are playing a major influence in drug discovery and the introduction of new therapies that target the cell death process.
Apoptosis, or programmed cell death, is the mechanism by which cells die either physiologically or pathologically. Vast research in apoptosis has advanced our understanding of basic physiological and pathological processes occurring in cells, organs and organisms, and its role in a number of diseases.
- Integrates experimental and computational methods for studying apoptosis in health and different diseases
- Includes strategies for identification of suitable therapeutic targets
- Discusses the design of treatments targeting key points in the apoptotic cascade
Protein chemists, molecular cell biologists, immunologists, structural biologists, computational biochemists, medical doctors, pharmacologists and other researchers working in the field of transport proteins and drug design. Articles published here would also be of a considerable benefit to medical, biology and pharmacology students specializing in this field
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Chapter One: Structural insights of macromolecules involved in bacteria-induced apoptosis in the pathogenesis of human diseases
- Abstract
- 1: Introduction
- 2: Pathogenesis and apoptosis
- 3: Role of bacterial component signaling through cellular receptors
- 4: Effector molecules of apoptosis
- 5: Role of bacterial toxins in pore-forming mechanism
- 6: Bacterial type-III protein secretion pathway
- 7: Bacterial infection-induced apoptosis
- 8: Apoptosis regulation during bacterial infections
- 9: The YhaK protein
- 10: Bacterial kinase family proteins involved in apoptosis
- 11: The effector kinase domain
- 12: Structural insights of protein-protein interactions
- 13: Mechanism of inhibition
- 14: Concluding remarks
- Acknowledgments
- Chapter Two: Apoptosis: A friend or foe in mesenchymal stem cell-based immunosuppression
- Abstract
- 1: Introduction
- 2: Factors affecting immunosuppressive properties of MSC
- 3: MSC-dependent immunosuppression is relied on phagocytosis of apoptotic MSC
- 4: An important role of IDO/kynurenine pathway for immunoregulatory properties of apoptotic MSC
- 5: Molecular and cellular mechanisms responsible for beneficial effects of apoptotic MSC in the attenuation of sepsis
- 6: An interplay between autophagy and apoptosis in MSC-based immunomodulation
- 7: Conclusions
- Chapter Three: Differential roles of farnesoid X receptor (FXR) in modulating apoptosis in cancer cells
- Abstract
- 1: Introduction
- 2: FXR and diseases
- 3: FXR is differentially expressed in different cancers
- 4: Role of activators in the inhibition/induction of apoptosis
- 5: Role of inhibitors in the inhibition/induction of apoptosis
- 6: Conclusions
- Chapter Four: Alternative approaches to overcome chemoresistance to apoptosis in cancer
- Abstract
- 1: Apoptosis
- 2: Non-apoptotic, alternate cell death mechanisms
- 3: Conclusion
- Acknowledgments
- Conflict of interests
- Chapter Five: Recent developments in CCR5 regulation for HIV cure
- Abstract
- 1: Introduction
- 2: Conclusion
- Acknowledgments
- Chapter Six: RNA-seeded membraneless bodies: Role of tandemly repeated RNA
- Abstract
- 1: Introduction
- 2: Mechanisms of MLO assembly
- 3: Tandemly repeated RNA: A novel player in MLO game?
- 4: MLO built on TR DNA in disease
- 5: Conclusion
- Competing interests
- Author contributions
- Acknowledgments
- Funding
- Chapter Seven: Cell death mechanisms and their roles in pregnancy related disorders
- Abstract
- 1: Introduction
- 2: Overview of apoptosis
- 3: Apoptosis in normal pregnancy
- 4: Apoptosis in different pregnancy complications
- 5: Factors influencing apoptosis
- 6: Overview of autophagy
- 7: Interplay between apoptosis and autophagy
- 8: Autophagy in different pregnancy complications
- 9: Conclusion
- Acknowledgments
- Chapter Eight: The concept of protein folding/unfolding and its impacts on human health
- Abstract
- 1: Introduction
- 2: Establishing forces in folded proteins
- 3: Models of protein folding
- 4: In vivo folding
- 5: Amyloid structures
- 6: Molten globule and its structure
- 7: Computational approaches of protein folding
- 8: Folding of multi-domain and multi-subunit proteins
- 9: Misfolding and disease
- 10: Concluding remarks
- Acknowledgments
- Chapter Nine: Apoptosis in health and diseases of the eye and brain
- Abstract
- 1: Introduction: An overview of apoptosis
- 2: Apoptosis in the health of the eye and the brain
- 3: Apoptosis in diseases of the eye
- 4: Apoptosis and diseases of the brain
- 5: Conclusion
- Chapter Ten: Apoptotic signals at the endoplasmic reticulum-mitochondria interface
- Abstract
- 1: Introduction
- 2: Apoptosis: A programmed form of cell death
- 3: MAMs and players
- 4: MAMs and functions
- 5: The role of MAMs in apoptosis
- 6: Conclusions
- Acknowledgments
- Edition: 1
- Volume: 126
- Published: June 2, 2021
- No. of pages (Hardback): 356
- No. of pages (eBook): 356
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780323853170
- eBook ISBN: 9780323853187
RD
Rossen Donev
Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.
Affiliations and expertise
Head of Research, MicroPharm Limited, UKRead Apoptosis in Health and Disease - Part B on ScienceDirect