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Elsevier

Books in Chemistry

Chemistry topic areas include: physical and theoretical, computational, organic, organometallic and inorganic, pharmaceutical and medicinal, analytical and bioanalytical, nuclear, general, nanochemistry, geochemistry, materials and polymer, as well as environmental, green and sustainable chemistry.

  • Mossbauer Spectroscopy

    Principles and Applications
    • 1st Edition
    • A. G. Maddock
    • English
    Mossbauer spectroscopy has proved itself a versatile technique, finding applications in diverse areas of science and industry. Starting from physics and chemistry it spread into biochemistry, mineralogy, biochemistry, corrosion science, geochemistry and archaeology, with applications in industrial and scientific research. The author aims to help advanced university students, professionals and research workers who ask the question "what's in it for us?". After a concise account of experimental techniques, he emphasizes those applications in which there are few, if any, alternative ways of obtaining the same information about electron fields and the nuclei. He explains areas of industrial interest, including the important applications related to tin and iron on which there is much activity in research and development, and interprets the extension of Mossbauer techniques to main group, transitional and other suitable elements. Attention is paid to factors which may lead to misinterpretation of spectra and another chapter covers the complexities of interpreting emission spectra.

  • Environmental Immunochemical Analysis Detection of Pesticides and Other Chemicals

    A User's Guide
    • 1st Edition
    • Shirley J. Gee + 2 more
    • English
    This book is a tutorial designed to instruct the reader in use and application of immunochemical methods of analysis for environmental contaminants. A brief introduction describes basic principles and the advantages and disadvantages of the technology, and gives a listing of references which supply more detail. Preparation of the laboratory for use of this technology and the general scientific considerations prior to using the technology are discussed. Detailed step-wise procedures are given for analysis of selected analytes, triazine herbicides, carbaryl, paraquat, and p-nitrophenols, etc. In addition to the specific immunoassay methods, a series of support techniques necessary to perform immunochemical methods are described. This book provides specific instruction for certain analytes, but also serves to familiarize the novice reader with many generic concepts needed to successfully utilize immunochemistry technology including: applications, sampling, sample preparation, extraction, cleanup, quality assurance, methods development and optimization, data handling and troubleshooting. It is not necessary for the reader to actually perform the immunoassays given in this user's guide to obtain familiarity with these concepts. The guide is written so that the information presented can be applied to other immunoassays not given here. Thus, the strength of the guide is its universal applicability to immunoassay methods.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 67
    • English
    Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area--one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties.

  • Advances in Molecular Similarity

    • 1st Edition
    • Volume 1
    • R. Carbo-Dorca + 1 more
    • English
    The aim of this text is to provide reviews and monographs on topics involving molecular similarity, ranging from the fundamental physical properties underlying molecular behaviour to applications in industrially important fields such as pharmaceutical drug design and molecular engineering. The editors hope that this series will encourage new ideas and approaches, help to systematize the rapidly accumulating new chemical information, and make chemistry better understood and better applied.

  • Advances in Dendritic Macromolecules

    • 1st Edition
    • Volume 3
    • G.R. Newkome
    • English
    The series Advances in Dendritic Macromolecules aims to cover the synthesis and supramolecular chemistry of dendritic or cascade super-molecules as well as their less perfect hyperbranched cousins.In Volume 3, Chapter 1 describes the synthesis and characterization of dendrimers and hyperbranched polyesters, both based on 2,2-bis(hydroxymethy... acid, as the AB2-monomer. Chapter 2, discusses the advantages and drawbacks of dendritic molecular architectures necessary to create polymeric organic magnetic materials. In Chapter 3, Balzani and colleagues delineate their contributions to the field of polynuclear transition metal complexes in the design and construction of dendritic nanostructures; these luminesence and redox-active complexes suggest their role as photochemical molecular devices operating by photoinduced energy and electron transfer processes. Chapter 4, reviews the overall progress on redox-active dendrimers, especially as redox catalysts, organic conductors, modified electrodes, and models for electron transfer proteins. Chapter 5, summarizes the pioneering research in organometallic dendritic macromolecules and then delineates the redox properties of a series of silicon-based ferrocenyl-containin... dendrimers.

  • Alkaloids: Chemical and Biological Perspectives

    • 1st Edition
    • Volume 11
    • S.W. Pelletier
    • English
    Volume 11 of this series presents five timely reviews on current research on alkaloids. Chapter 1 by Paul L. Schiff, Jr. is a monumental survey of research that has been carried out over the past decade on the Thalictrum alkaloids. Forty-six new alkaloids are described from fifteen species of the genus Thalictrum, as well as 116 alkaloids of known structure from thirty-six species and subspecies of the genus. The chapter includes discussions of isolation and structure elucidation, analysis, biosynthesis, cell culture, and pharmacology. Also featured are inclusive compilations of botanical sources, alkaloids by alkaloid types, and calculated molecular weights of the Thalictrum alkaloids.Chapter 2 by Giovanni Appendino provides a fascinating treatment of Taxine, a collective name referring to a mixture of diterpenoid alkaloids from the yew tree (genus: Taxus). Taxine is responsible for the toxic properties of the yew tree that has been documented in historical and fictional literature, from Julius Caesar to Shakespeare, and from Agatha Christie to T.S. Eliot. The chapter treats the history, isolation techniques, structure elucidation, chemistry, and pharmacology of Taxine.Chapter 3 by Mary D. Menachery surveys the alkaloids of South American Menispermaceae (moonseed family). Many different structural types are included in this family. The alkaloid-bearing plants are woody-vines, shrubs, or small trees. Several of these species possess potent curare activity. The chemistry as well as pharmacology of these alkaloids is summarized.Chapter 4 by Russell J. Molyneux, Robert J. Nash, and Naoki Asano treats the chemistry and biological activity of the calystegines and related nortropane alkaloids. These polyhydroxylated bicyclic alkaloids represent another class of compounds that inhibit glycosidases, producing profound effects in biological systems by disrupting the essential cellular function of glycoprotein processing.Chapter 5, a related chapter by Robert J. Nash, Naoki Asano, and Alison A. Watson, reviews polyhydroxylated alkaloids that inhibit glycosidases. Topics covered include distribution, ecological significance and toxicity, isolation, synthesis, and biosynthesis.

  • Annual Reports on NMR Spectroscopy

    • 1st Edition
    • Volume 33
    • English
    In comparison with other methods currently available for investigating the structure and dynamics of molecular NMR is egregious. The widespread applicability of the series of NMR techniques now commonly available is exemplified in the topics appearing in Annual Reports on NMR Spectroscopy Volume 33.

  • Robustness of Analytical Chemical Methods and Pharmaceutical Technological Products

    • 1st Edition
    • Volume 19
    • M.M.W.B. Hendriks + 2 more
    • English
    In analytical chemistry and pharmaceutical technology attention is increasingly focussed on improving the quality of methods and products. This book aims at fostering the awareness of the potential of existing mathematical and statistical methods to improve this quality. It provides procedures and ideas on how to make a product or a method less sensitive to small variations in influencing factors. Major issues covered are robustness and stability improvement and ruggedness testing. General strategies and a theoretical introduction to these methods are described, and thorough overviews of methods used in both application areas and descriptions of practical applications are given.Features of this book:• Gives a good overview of mathematical and statistical methods used in two application areas, i.e. pharmaceutical technology and analytical chemistry• Illustrates the different approaches available to attain robustness• Gives ideas on how to use methods in practical situations.The book is intended for those who develop and optimize, and are responsible for the overall quality of, analytical methods and pharmaceutical technological products and procedures.

  • NMR Spectroscopy and its Application to Biomedical Research

    • 1st Edition
    • S.K. Sarkar
    • English
    NMR has become the most diverse spectroscopic tool available to date in biomedical research. It is now routinely used to study biomolecular structure and dynamics particularly as a result of recent developments of a cascade of highly sophisticated multidimensional NMR pulse sequences, and of advances in genetic engineering to produce biomolecules, uniformly or selectively enriched with 13C, 15N and 2H.Features of this book:• Provides an up-to-date treatment of NMR techniques and their application to problems of biomedical interest• Most refined multidimensional pulse sequences including the basic aspects are covered by leading NMR spectroscopists.The book will be useful to NMR spectroscopists, biochemists, and to molecular biologists interested in the use of NMR techniques for solving biological problems.

  • Annual Reports in Medicinal Chemistry

    • 1st Edition
    • Volume 31
    • James A. Bristol
    • English
    Advances in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

  • Molecular Electrostatic Potentials

    Concepts and Applications
    • 1st Edition
    • Volume 3
    • J.S. Murray + 1 more
    • English
    Over the past 25 years, the molecular electrostatic potential has become firmly established as an effective guide to molecular interactions. With the recent advances in computational technology, it is currently being applied to a variety of important chemical and biological systems. Its range of applicability has expanded from primarily a focus on sites for electrophilic and nucleophilic attack to now include solvent effects, studies of zeolite, molecular cluster and crystal behavior, and the correlation and prediction of a wide range of macroscopic properties. Moreover, the increasing prominence of density functional theory has raised the molecular electrostatic potential to a new stature on a more fundamental conceptual level. It is rigorously defined in terms of the electron density, and has very interesting topological characteristics since it explicitly reflects opposing contributions from the nuclei and the electrons.This volume opens with a survey chapter by one of the original pioneers of the use of the electrostatic potential in studies of chemical reactivity, Jacopo Tomasi. Though the flow of the succeeding chapters is not stringently defined, the overall trend is that the emphasis changes gradually from methodology to applications. Chapters discussing more theoretical topics are placed near the end. Readers will find the wide variety of topics provided by an international group of authors both convincing and useful.

  • Vibrational Intensities

    • 1st Edition
    • Volume 22
    • B.S. Galabov + 1 more
    • English
    The current volume is a single topic volume on the vibrational intensities in the infrared and Raman spectra. Vibrational intensities in infrared and Raman spectra are important physical quantities that are directly related to the distribution and fluctuations of electric charges in the molecule. These spectral parameters can be experimentally determined with good accuracy for many molecules. Additionally, infrared and Raman intensities are presently estimated theoretically by advanced analytical derivative ab initio molecular orbital methods. These fundamental molecular quantities are being used in structural, and other studies, on a limited basis.Features of this book- Presents in a systematic way, the theoretical approaches that are used in analyzing and predicting vibrational intensities- The formalisms developed are illustrated with detailed numerical examples- Most of the theoretical models described were obtained and then applied to chosen molecules- A consistent notation is used in presenting the different theoretical approaches, thus eliminating another barrier in understanding some methods, especially those developed by the Russian spectroscopic school.

  • Principles of Asymmetric Synthesis

    • 1st Edition
    • Volume 14
    • R.E. Gawley + 1 more
    • English
    The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present a detailed analysis of the factors that govern stereoselectivity in organic reactions. It is important to note that the references were each individually checked by the authors to verify relevance to the topics under discussion. The study of stereoselectivity has evolved from issues of diastereoselectivity... through auxiliary-based methods for the synthesis of enantiomerically pure compounds (diastereoselectivit... followed by separation and auxiliary cleavage), to asymmetric catalysis. In the latter instance, enantiomers (not diastereomers) are the products, and highly selective reactions and modern purification techniques allow preparation - in a single step - of chiral substances in 99% ee for many reaction types. After an explanation of the basic physical-organic principles of stereoselectivity, the authors provide a detailed, annotated glossary of stereochemical terms. A chapter on "Analytical Methods" provides a critical overview of the most common methods for analysis of stereoisomers. The authors then follow the 'tried-and-true' format of grouping the material by reaction type. Thus, there are four chapters on carbon-carbon bond forming reactions (enolate alkylations, organometal additions to carbonyls, aldol and Michael reactions, and cycloadditions and rearrangements), one chapter on reductions and hydroborations (carbon-hydrogen bond forming reactions), and one on oxidations (carbon-oxygen and carbon-nitrogen bond forming reactions). Leading references are provided to natural product synthesis that have been accomplished using a given reaction as a key step. In addition to tables of examples that show high selectivity, a transition state analysis is presented to explain - to the current level of understanding - the stereoselectivity of each reaction. In one case (Cram's rule) the evolution of the current theory is detailed from its first tentative (1952) postulate to the current Felkin-Anh-Heathcock formalism. For other reactions, only the currently accepted rationale is presented. Examination of these rationales also exposes the weaknesses of current theories, in that they cannot always explain the experimental observations. These shortcomings provide a challenge for future mechanistic investigations.

  • The Language of Shape

    The Role of Curvature in Condensed Matter: Physics, Chemistry and Biology
    • 1st Edition
    • S. Hyde + 6 more
    • English
    This book develops the thesis that structure and function in a variety of condensed systems - from the atomic assemblies in inorganic frameworks and organic molecules, through molecular self-assemblies to proteins - can be unified when curvature and surface geometry are taken together with molecular shape and forces. An astonishing variety of synthetic and biological assemblies can be accurately modelled and understood in terms of hyperbolic surfaces, whose richness and beauty are only now being revealed by applied mathematicians, physicists, chemists and crystallographers. These surfaces, often close to periodic minimal surfaces, weave and twist through space, carving out interconnected labyrinths whose range of topologies and symmetries challenge the imaginative powers.The book offers an overview of these structures and structural transformations, convincingly demonstrating their ubiquity in covalent frameworks from zeolites used for cracking oil and pollution control to enzymes and structural proteins, thermotropic and lyotropic bicontinuous mesophases formed by surfactants, detergents and lipids, synthetic block copolymer and protein networks, as well as biological cell assemblies, from muscles to membranes in prokaryotic and eukaryotic cells. The relation between structure and function is analysed in terms of the previously neglected hidden variables of curvature and topology. Thus, the catalytic activity of zeolites and enzymes, the superior material properties of interpenetrating networks in microstructured polymer composites, the transport requirements in cells, the transmission of nerve signals and the folding of DNA can be more easily understood in the light of this.The text is liberally sprinkled with figures and colour plates, making it accessible to both the beginning graduate student and researchers in condensed matter physics and chemistry, mineralogists, crystallographers and biologists.

  • Fundamentals of Inorganic Membrane Science and Technology

    • 1st Edition
    • Volume 4
    • A.J. Burggraaf + 1 more
    • English
    Inorganic membrane science and technology is a new field of membrane separation technology which until recently was dominated by the earlier field of polymer membranes. Currently the subject is undergoing rapid development and innovation.The present book describes the fundamental principles of both synthesis of inorganic membranes and membrane supports and also the associated phenomena of transport and separation in a semi-quantitative form.Features of this book:- Examples are given which illustrate the state-of-the-art in the synthesis of membranes with controlled properties- Future possibilities and limitations are discussed- The reader is provided with references to more extended treatments in the literature- Potential areas for future innovation are indicated.By combining aspects of both the science and technology of inorganic membranes this book serves as a useful source of information for scientists and engineers working in this field. It also provides some observations of important investigators who have contributed to the development of this subject.

  • Recent Developments and Applications of Modern Density Functional Theory

    • 1st Edition
    • Volume 4
    • Jorge M. Seminario
    • English
    The present status of Density Functional Theory (DFT), which has evolved as the main technique for the study of matter at the atomistic level, is described in this volume. Knowing the behavior of atoms and molecules provides a sure avenue for the design of new materials with specific features and properties in many areas of science and technology. A technique based on purely first principles allowing large savings in time and money greatly benefits the specialist or designer of new materials.The range of areas where DFT is applied has expanded and continues to do so. Any area where a molecular system is the center of attention can be studied using DFT.The scope of the 22 chapters in this book amply testifies to this.

  • Hypervalent Iodine in Organic Synthesis

    • 1st Edition
    • A. Varvoglis
    • English
    This book describes the fascinating chemistry of the many kinds of organic compounds of hypervalent iodine. Each chapter deals with a particular iodine compound or families of compounds which have been used as reagents in a plethora of useful transformations. These include assorted oxidation, such as with the precious Dess-Martin reagent as well as with a wide range of further reactions. Prominent features of hypervalent iodine reagents derived from iodobenzene are: ready availability, operational simplicity, mild reaction conditions, and high efficiency. They are environmentally safe and can be recycled. New species may be easily prepared by introducing substituents in the benzene ring or changing the ligand attached to iodine. Their combination with other reagents broadens considerably their synthetic potential. Today, no synthetic chemist can afford to ignore the valuable hypervalentiodine reagents.

  • Handbook of Thermodynamic Diagrams

    Inorganic Compounds and Elements
    • 1st Edition
    • Volume 4
    • Carl L. Yaws
    • English
    Thermodynamic property data are important in many engineering applications in the chemical processing and petroleum refining industries. The "Handbook of Thermodynamic Diagrams" series presents volume and enthalpy diagrams (graphs) for the major organic chemicals and hydrocarbons, as well as the major inorganic compounds and elements. The graphs, arranged by carbon number and chemical formula, cover a wide range of pressures and temperatures to enable engineers to determine quickly values at various points. This volume covers inorganic compounds and elements.

  • Advances in Inorganic Chemistry

    • 1st Edition
    • Volume 44
    • English
    Advances in Inorganic Chemistry presents timely and informative summaries of the current progress in a variety of subject areas within inorganic chemistry, ranging from bioinorganic to solid state. This acclaimed serial features reviews written by experts in the area and is an indispensable reference to advanced researchers. Each volume of Advances in Inorganic Chemistry contains an index, and each chapter is fully referenced.

  • Polymer Synthesis

    Volume 3
    • 2nd Edition
    • Stanley R. Sandler + 1 more
    • English
    This volume, which completes the Second Edition of this widely respected three-volume set, continues the tradition of providing detailed and concise laboratory instructions for the preparation of organic and inorganic polymers. Updates are provided on the preparation of various types of polymers including olefin-sulfur dioxide copolymers, polythioesters, sulfide polymers, polyisocyanates, polyoxyalkylhydroxy compounds, polyvinyl carbazole, polyvinyl acetate, polyallyl esters, and polyvinyl flouride. The procedures were chosen on the basis of safety and to be representative of preparation methods for a general class of polymers. Fundamental and practical information on polymer synthesis is combined with extensive references and reviews of the patent literature.

  • Advanced Thermodynamics for Engineers

    • 1st Edition
    • D. Winterbone + 1 more
    • English
    Although the basic theories of thermodynamics are adequately covered by a number of existing texts, there is little literature that addresses more advanced topics. In this comprehensive work the author redresses this balance, drawing on his twenty-five years of experience of teaching thermodynamics at undergraduate and postgraduate level, to produce a definitive text to cover thoroughly, advanced syllabuses.The book introduces the basic concepts which apply over the whole range of new technologies, considering: a new approach to cycles, enabling their irreversibility to be taken into account; a detailed study of combustion to show how the chemical energy in a fuel is converted into thermal energy and emissions; an analysis of fuel cells to give an understanding of the direct conversion of chemical energy to electrical power; a detailed study of property relationships to enable more sophisticated analyses to be made of both high and low temperature plant and irreversible thermodynamics, whose principles might hold a key to new ways of efficiently covering energy to power (e.g. solar energy, fuel cells). Worked examples are included in most of the chapters, followed by exercises with solutions. By developing thermodynamics from an explicitly equilibrium perspective, showing how all systems attempt to reach a state of equilibrium, and the effects of these systems when they cannot, the result is an unparalleled insight into the more advanced considerations when converting any form of energy into power, that will prove invaluable to students and professional engineers of all disciplines.

  • Modern Aspects of Diffusion-Controlled Reactions

    Cooperative Phenomena in Bimolecular Processes
    • 1st Edition
    • Volume 34
    • E. Kotomin + 1 more
    • English
    This monograph deals with the effects of reactant spatial correlations arising in the course of basic bimolecular reactions describing defect recombination, energy transfer and exciton annihilation in condensed matter. These effects lead to the kinetics considered abnormal from the standard chemical kinetics point of view. Numerous bimolecular reaction regimes and conditions are analysed in detail. Special attention is paid to the development and numerous applications of a novel, many-point density (MPD) formalism, which is based on Kirkwood's superposition approximation used for decoupling three-particle correlation functions.The book demonstrates that incorporation of the reaction-induced spatial correlations of similar reactants (e.g., vacancy-vacancy) leads to the development of an essentially non-Poisson spectrum of reactant density fluctuations. This can completely change the kinetics at longer times since it no longer obeys the law of mass action. The language of the correlation lengths and critical exponents similar to physics of critical phenomena is used instead. A relation between MPD theory and synergistics is discussed. The validity of the theorem giving a critical complexity for the two-step reactions exhibiting self-organization phenomena is questioned. Theoretical results are illustrated by numerous experimental data.

  • NMR of Polymers

    • 1st Edition
    • Frank A. Bovey + 1 more
    • English
    NMR has made important contributions to our understanding of structure–property relationships in polymers. This book provides an up-to-date and comprehensive overview of the fundamentals of NMR, with applications of multidimensional NMR and the new solution and solid-state methods in polymer science. NMR of Polymers is written by leading authorities for graduate students and professionals in academia and industry.

  • Advances in Organometallic Chemistry

    • 1st Edition
    • Volume 40
    • English
    This widely acclaimed serial contains authoritative reviews that address all aspects of organometallic chemistry, a field which has expanded enormously since the publication of Volume 1 in 1964. Almost all branches of chemistry and material science now interface with organometallic chemistry - the study of compounds containing carbon-metal bonds. Organometallic compounds range from species which are so reactive that they only have a transient existence at ambient temperatures to species which are thermally very stable. Organometallics are used extensively in the synthesis of useful compounds on both large and small scales. Industrial processes involving plastics, polymers, electronic materials, and pharmaceuticals all depend on advancesments in organometallic chemistry. In basic research, Organometallics have contributed inter alia to metal cluster chemistry, surface chemistry, the stablilization of highly reactive species by metal coordination, chiral synthesis, the formulation of multiple bonds between carbon and the other elements and between the elements themselves. Advances in Organometallic Chemistry is an essential reference work for the academic and industrial chemist and will provide up-to-date material at the cutting edge of chemistry research.

  • Advances in Quantum Chemistry

    • 1st Edition
    • Volume 27
    • Per-Olov Lowdin
    • English
    Advances in Quantum Chemistry publishes surveys of current developments in the rapidly developing field of quantum chemistry--a field that falls between the historically established areas of mathematics, physics,chemistry, and biology. With invited reviews written by leading international researchers, each presenting new results, this quality serial provides a single vehicle for following progress in this interdisciplinary area.

  • Handbook of Infrared and Raman Spectra of Inorganic Compounds and Organic Salts

    Text and Explanations
    • 1st Edition
    • Richard A. Nyquist + 2 more
    • English

  • Handbook of Infrared and Raman Spectra of Inorganic Compounds and Organic Salts

    Raman Spectra
    • 1st Edition
    • Richard A. Nyquist + 2 more
    • English

  • Handbook of Infrared and Raman Spectra of Inorganic Compounds and Organic Salts

    Infrared Spectra
    • 1st Edition
    • Richard A. Nyquist + 2 more
    • English

  • Analytical Profiles of Drug Substances and Excipients

    • 1st Edition
    • Volume 24
    • English
    Although the official compendia define a drug substance as to identity, purity, strength, and quality, they normally do not provide other physical or chemical data, nor do they list methods of synthesis or pathways of physical or biological degradation and metabolism. Such information is scattered throughout the scientific literature and the files of pharmaceutical laboratories. Edited by the Associate Director of Analytical Research and Development for the AmericanAssociation of Pharmaceutical Scientists, Analytical Profiles of Drug Substances and Excipients brings this information together into one source. The scope of the series has recently been expanded to include profiles of excipient materials.

  • Handbook of Infrared and Raman Spectra of Inorganic Compounds and Organic Salts, Four-Volume Set

    • 1st Edition
    • Richard A. Nyquist + 3 more
    • English
    This four-volume handbook presents unique data of infrared and Raman spectra that are extremely useful for the analysis of inorganic compounds and organic salts. The spectra charts as presented in the volumes may be used to facilitate spectra-structure identification of most compounds, while cross-indexing of data allows for easy comparison of infrared and Raman spectra of the same compound. This comprehensive four-volume set, based on the authors' extensive lifetime research, is an essential reference for industrial and academic researchers and their libraries. Analytical chemists, molecular spectroscopists, materials scientists (especially polymer scientists), chemical engineers, environmentalists, geologists, andothers involved in analyzing a wide range of inorganic compounds and organic salts will want to keep the Handbook within easy reach. This set is a"must"for pharmaceutical and chemical companies, as well as for industrial and academic libraries.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 66
    • English
    Established in 1960, Advances in Hetrocyclic Chemistry is the definitive serial in the area-one of great importance to organic chemists, polymer chemists, and many biological scientists.

  • Progress in Heterocyclic Chemistry

    A Critical Review of the 1995 Literature Preceded by Two Chapters on Current Heterocyclic Topics
    • 1st Edition
    • Volume 8
    • H. Suschitzky
    • English
    Progress in Heterocyclic Chemistry (PHC) is an annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC). The volumes in the series contain both highlights of the previous year's literature on heterocyclic chemistry and articles on new developing topics of interest to heterocyclic chemists. The highlight chapters in Volume 8 are all written by leading researchers in their field and these chapters constitute a systematic survey of the important original material reported in the literature on heterocyclic chemistry in 1995. The volume also contains an article on Geminal Diazides of Heterocycles and an article on Radical Methodologies for the synthesis of heterocyclic compounds.As with previous volumes in the series, Volume 8 will enable academic and industrial chemists, and advanced students to keep abreast of developments in heterocyclic chemistry in an effortless way.

  • Synthetic and Natural Phenols

    • 1st Edition
    • Volume 52
    • J.H.P. Tyman
    • English
    The chemistry of phenols tends to be ignored in organic chemical textbooks and to be lost amongst the many classes of functional derivatives. This volume is not intended to provide a textbook approach but rather to give an account of developments in phenol chemistry in the last two decades.Features of this book:• Numerous phenolic systems have been covered in detail, e.g. phenolic propanoids.• The emphasis throughout has been on synthesis, on what can be achieved by the use of phenolic intermediates and in the construction of phenolic end products.• Many chapters enable the reader to refer to the original literature wherever possible.• Various chapters provide a fund of tutorial material and problems for undergraduate studies and further, which will encourage perusal of the literature. Some 2000 references to applied and academic papers are given.Phenols are ubiquitous substances and now it is more widely accepted that there are pros and cons connected with their usage. The pros for compounds are well-known and are illustrated by perennial panaceas such as aspirin, paracetamol, codeine, etc. The cons are less obvious because they are also materials deeply entrenched in our standard of living and in most cases inherent hazards have only recently come to light. The book will be of interest to postgraduate students in academic and industrial work.

  • Gas Chromatography and Mass Spectrometry

    A Practical Guide
    • 1st Edition
    • Fulton G. Kitson + 2 more
    • English
    This guide provides, under one cover, a wealth of practical information designed to facilitate the effectiveness of the GC/MS user. Separation conditions for numerous compound types are provided along with derivatized and underivatized compounds. A section on how to interpret mass spectral data, an extensive correlation of ion masses and neutral losses with possible structures, and examples of mass spectra are provided to further aid structure determination. Also included are basic information on instrumentation, ionization methods, quantitation, tips on the operation of mass spectrometers, the best derivatization procedures for a variety of compound types, troubleshooting techniques, and a variety of other information found to be useful to the practicing user of GC/MS instrumentation. This guide would be immediately valuable to the novice as well as the experienced GC/MS user who may not have the breadth of experience covered in this book.

  • Annual Reports in Organic Synthesis 1996

    • 1st Edition
    • English
    This handy reference tool is an organized annual review of synthetically useful information. It abstracts synthetic reactions from the major chemistry journals of the past year and includes reactions and methods thatare new and reasonably general. The reactions are presented in a convenient pictorial format designed for rapid visual retrieval of information. A comprehensive table of contents and a senior author index are included.The Journal of the American Chemical Society has aptly described this publication as an"aid to the harassed organic chemist who cannot keep up with the never-diminishing stream of new primary literature"and hails it"an outstandingly good buy."

  • Pharmaceutical and Biomedical Applications of Capillary Electrophoresis

    • 1st Edition
    • Volume 2
    • S.M. Lunte + 1 more
    • English
    The book describes the theory and applications of Capillary Electrophoresis (CE) in the field of pharmaceutical and biomedical analysis. It is targeted towards users who are intimately involved in analytical problems, especially those which involve small samples. This book presents the technique of capillary electrophoresis from the point of view of the serious hands-on use in the field of pharmaceutical and biomedical analysis. An overview of general theory is presented to acquaint the novice with the fundamental principles. A more theoretical approach is taken in the presentation of electrokinetic chromatography. The next chapter discusses advances in column technologies, the preceding chapters having provided a foundation as to how separations occur. In the next three chapters, recognized experts in their fields present fundamentals and state-of-the-art techniques in the areas of optical, electrochemical and mass spectrometric detection. The major focus of the remaining chapters is on applications. This includes the analysis of pharmaceuticals, amino acids and peptides, macromolecules, nucleosides, nucleotides and oligonucleotides. The use of CE for analysis of small ions and separation of biological particles is also discussed. The issue of sample preparation for analysis by CE is addressed, especially as it relates to clinical analysis.

  • Surfactants in Analytical Chemistry

    Applications of Organized Amphiphilic Media
    • 1st Edition
    • Volume 31
    • E. Pramauro + 1 more
    • English
    Provided here is a collective source of data covering the actual uses of amphiphilic organized media in analytical chemistry and an explanation of the mechanisms by which these systems exert their different functions in each analytical scheme.The volume has been organized into two parts. The first part, consisting of three chapters, describes the structural features and properties of amphiphilic aggregates and the analysis of the interactions between analytes and these assemblies. Attention is focussed on the distribution and location of solutes within the different regions of the microheterogeneous media, and on the observed effects on chemical equilibria, kinetics and molecular properties of substrates. The second part, comprising five chapters, centers on the applications of amphiphilic systems in specific analytical techniques, such as spectroscopy, chromatography, electroanalysis, etc. The role of surfactant aggregates is examined in the light of existing theories and models, and performances are compared with those obtained with traditional methods. The potential interest of some recently developed surfactant-based separations, such as extractions with reversed micelles or micellar-enhanced ultrafiltration, in biotechnology and pollution control is also underlined. Finally, the need for new functionalized surfactants, designed specifically for the novel analytical applications is considered, e.g. the preparation of chelating micelles obtained from suitable amphiphilic ligands and their performances as extracting systems for metal ions are described.Researcher... working on the applications of surfactants in environmental chemistry and biotechnology and organic and physical chemists concerned with reactivity and synthesis in organized media will find this a valuable text.

  • Neural Networks in QSAR and Drug Design

    • 1st Edition
    • James Devillers
    • English
    Comprehensive and impeccably edited, Neural Networks in QSAR and Drug Design is the first book to present an all-inclusive coverage of the topic. The book provides a practice-oriented introduction to the different neural network paradigms, allowing the reader to easily understand and reproduce the results demonstrated. Numerous examples are detailed, demonstrating a variety of applications to QSAR and drug design.The contributors include some of the most distinguished names in the field, and the book provides an exhaustive bibliography, guiding readers to all the literature related to a particular type of application or neural network paradigm. The extensive index acts as a guide to the book, and makes retrieving information from chapters an easy task. A further research aid is a list of software with indications of availablility and price, as well as the editors scale rating the ease of use and interest/price ratio of each software package. The presentation of new, powerful tools for modeling molecular properties and the inclusion of many important neural network paradigms, coupled with extensive reference aids, makes Neural Networks in QSAR and Drug Design an essential reference source for those on the frontiers of this field.

  • Applications of Synchrotron Radiation to Materials Analysis

    • 1st Edition
    • Volume 7
    • H. Saisho + 1 more
    • English
    Synchroton radiation (SR) is utilized in most scientific fields. This book will therefore be useful not only for researchers engaged in analytical chemistry, and those studying the basic fields such as physics, chemistry, biology, as well as earth science, medicine, and life science but also for those engaged in research for elucidating structure of material and its function in the application fields including applied physics, semiconductor engineering, and metal engineering. The book has a highly interdisciplinary character. The outstanding characteristics of SR have also contributed to the rapid development of new fields and applications in analytical chemistry.Features of this book:• Explains the basics of SR• Facilities and instrumentation are covered to facilitate the planning of experiments using SR.• Aspects for the future development of SR are included together with an introduction to the latest techniques which are expected to find increasing use in the coming years.This book should stimulate students specializing in analytical chemistry and materials science to have an interest in SR. In addition, it will provide scientists who are beginning analytical chemistry research using SR with instructive and illustrative descriptions. The book can also be used as an explanatory text for advanced research on the application of SR.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 65
    • English
    Praise for the Series:"The typesetting, arrangement of references, and drafting of structural formulas adhere to the high standards of this series and provide a model for good publishing...The content is, as to be expected, excellent."--Journal of the American Chemical SocietyEstablished in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area - one of great importance to organic chemists, polymer chemists, and many biological scientists.

  • High Resolution Separation and Analysis of Biological Macromolecules, Part B: Applications

    • 1st Edition
    • Volume 271
    • John N. Abelson + 1 more
    • English
    The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 260 volumes have been published (all of them still in print) and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences.

  • Comprehensive Supramolecular Chemistry

    • 1st Edition
    • Jerry L. Atwood + 1 more
    • English
    Comprehensive Supramolecular Chemistry covers for the first time in eleven detailed volumes the exciting inter- and multidisciplinary area of modern supramolecular chemistry. This subject, which has now reached an astonishing diversity and complexity, has developed at a remarkably rapid pace following the initial discoveries of crown ethers and cryptands in the late sixties.The numerous references, including many recent citations, constitute an unrivalled in-depth source for direct entry to the widespread primary literature on any aspect of this most highly topical area. The many carefully selected illustrations and instructive schematic representations make the chapters easily readable.

  • Raman Microscopy

    Developments and Applications
    • 1st Edition
    • George Turrell + 1 more
    • English
    One of the first books devoted entirely to the subject of Raman microscopy, Raman Microscopy addresses issues of great interest to engineers working in Raman-microscope development and researchers concerned with areas ofapplication for this science. The book is written by several world recognized experts, who summarize the Raman effect before discussing the hardware and software involved in todays instruments. This format provides an excellent introduction to this up-and-coming discipline. All important applications, including those in materials science and earth science are covered in depth.

  • High Resolution Separation and Analysis of Biological Macromolecules, Part A: Fundamentals

    • 1st Edition
    • Volume 270
    • John N. Abelson + 1 more
    • English
    The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 260 volumes have been published (all of them still in print) and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences.

  • Organic Synthesis: Theory and Applications

    • 1st Edition
    • Volume 3
    • T. Hudlicky
    • English
    Part of a series which covers areas of organic synthesis ranging from the latest developments in enantioselective methodologies, to reviews of updated chemical methods. The volumes are written by experts, who describe their own area of expertise, as well as those of their peers.

  • Chemistry and Pharmacology

    • 1st Edition
    • Volume 48
    • English
    Internationally acclaimed for more than forty years, this Series, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of the rapidly expanding field of the chemotaxonomy, structureelucidation... synthesis, biosynthesis, and biology of all classes of alkaloids from higher and lower plants, marine organisms, or various terrestrial animals. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids. Over the years, this Series has become the standard in natural product chemistry to which all other book series aspire. The Alkaloids: Chemistry and Pharmacology endures as an essential reference for all natural product chemists and biologists who have an interest in alkaloids, their diversity, and their unique biological profile.

  • The Aqueous Phase Behavior of Surfactants

    • 1st Edition
    • Robert G. Laughlin
    • English
    Surfactants play an important role in many human endeavors, ranging from consumer products (cosmetics, foods, and powdered soaps) to many aspects of biology and pharmaceuticals. This book presents researchers with the basic principles governing phase behavior of surfactants, the relationship between phase behavior and molecular structure, and the various ways in which this information can be applied. Coverage includes qualitative concepts and relationships between phase science and thermodynamics, as well as how this information can be used to describe surfactant systems.

  • Signal Treatment and Signal Analysis in NMR

    • 1st Edition
    • Volume 18
    • D.N. Rutledge
    • English
    Signal analysis and signal treatment are integral parts of all types of Nuclear Magnetic Resonance. In the last ten years, much has been achieved in the development of dimensional spectra. At the same time new NMR techniques such as NMR Imaging and multidimensional spectroscopy have appeared, requiring entirely new methods of signal analysis. Up until now, most NMR texts and reference books limited their presentation of signal processing to a short introduction to the principles of the Fourier Transform, signal convolution, apodisation and noise reduction. To understand the mathematics of the newer signal processing techniques, it was necessary to go back to the primary references in NMR, chemometrics and mathematics journals.The objective of this book is to fill this void by presenting, in a single volume, both the theory and applications of most of these new techniques to Time-Domain, Frequency-Domain and Space-Domain NMR signals. Details are provided on many of the algorithms used and a companion CD-ROM is also included which contains some of the computer programs, either as source code or in executable form. Although it is aimed primarily at NMR users in the medical, industrial and academic fields, it should also interest chemometricians and programmers working with other techniques.

  • Interfacial Tensiometry

    • 1st Edition
    • Volume 3
    • A.I. Rusanov + 1 more
    • English
    This is the first monograph devoted to interfacial tensiometry and is therefore the definitive source of information on measuring surface tension. More than 40 methods for measuring surface tension both at the liquid-fluid and solid-fluid boundaries are described including methods using computational techniques, tele- and video-apparatus, and laser techniques. A central place in the book has been given to methods based on the investigation of properties of liquid and gaseous menisci both in the presence or absence of a gravitational field and a rotational one. Their description is preceded by a chapter on the theory of menisci including the derivation of various forms of the Laplace formula. The application of the methods for studying the equilibrium and dynamic surface tension has been considered. Dynamic methods used for very small surface life-times are described and a separate chapter is devoted to the theory of surface tension which will ensure a better understanding of the material. A systematic analysis of the material embracing all kinds of interfaces including solid surfaces, the history of each method, its theoretical foundation, characterization of measuring procedures and setups, a large number of numeric tables and plots and representative illustrations make the book encyclopedic in character.

  • Development and Validation of Analytical Methods

    • 1st Edition
    • Volume 3
    • Christopher M. Riley + 1 more
    • English
    The need to validate an analytical or bioanalytical method is encountered by analysts in the pharmaceutical industry on an almost daily basis, because adequately validated methods are a necessity for approvable regulatory filings. What constitutes a validated method, however, is subject to analyst interpretation because there is no universally accepted industry practice for assay validation. This book is intended to serve as a guide to the analyst in terms of the issues and parameters that must be considered in the development and validation of analytical methods. In addition to the critical issues surrounding method validation, this book also deals with other related factors such as method development, data acquisition, automation, cleaning validation and regulatory considerations. The book is divided into three parts. Part One, comprising two chapters, looks at some of the basic concepts of method validation. Chapter 1 discusses the general concept of validation and its role in the process of transferring methods from laboratory to laboratory. Chapter 2 looks at some of the critical parameters included in a validation program and the various statistical treatments given to these parameters.Part Two (Chapters 3, 4 and 5) of the book focuses on the regulatory perspective of analytical validation. Chapter 3 discusses in some detail how validation is treated by various regulatory agencies around the world, including the United States, Canada, the European Community, Australia and Japan. This chapter also discusses the International Conference on Harmonization (ICH) treatment of assay validation. Chapters 4 and 5 cover the issues and various perspectives of the recent United States vs. Barr Laboratories Inc. case involving the retesting of samples. Part Three (Chapters 6 - 12) covers the development and validation of various analytical components of the pharmaceutical product development process. This part of the book contains specific chapters dedicated to bulk drug substances and finished products, dissolution studies, robotics and automated workstations, biotechnology products, biological samples, analytical methods for cleaning procedures and computer systems and computer-aided validation. Each chapter goes into some detail describing the critical development and related validation considerations for each topic.This book is not intended to be a practical description of the analytical validation process, but more of a guide to the critical parameters and considerations that must be attended to in a pharmaceutical development program. Despite the existence of numerous guidelines including the recent attempts by the ICH to be implemented in 1998, the practical part of assay validation will always remain, to a certain extent, a matter of the personal preference of the analyst or company. Nevertheless, this book brings together the perspectives of several experts having extensive experience in different capacities in the pharmaceutical industry in an attempt to bring some consistency to analytical method development and validation.

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