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Elsevier

Books in Life sciences

  • Advances in Poultry Welfare

    • 1st Edition
    • English
    Advances in Poultry Welfare provides a targeted overview of contemporary developments in poultry welfare. The reviews in the volume address topical issues related to poultry welfare research and assessment, with a focus on identifying practical strategies for improvement as well as information gaps that remain to be filled. Part One provides an introduction to poultry production systems and gives a broad overview of current poultry welfare issues. Part Two moves on to review several aspects of poultry management, focusing on hatchery practices, early rearing, and slaughter. Part Three deals with welfare assessment on the farm, while Part Four explores continuing challenges, such as feather pecking and skeletal problems. This is followed in Part Five by a discussion of emerging issues, with chapters covering alternative parasite control methods, backyard poultry production, mass depopulation, and genetic approaches to reducing the impact of environmental stressors on welfare. This book is an essential part of the wider ranging series Advances in Farm Animal Welfare, with coverage of cattle, sheep, pigs, and poultry. With its expert editor and international team of contributors, Advances in Poultry Welfare is a key reference tool for welfare research scientists and students, veterinarians involved in welfare assessment, and indeed anyone with a professional interest in the welfare of poultry.

  • Imaging of Brain Concussion, An Issue of Neuroimaging Clinics of North America

    • 1st Edition
    • Volume 28-1
    • Roy Riascos + 1 more
    • English
    This issue of Neuroimaging Clinics of North America focuses on Imaging of Brain Concussion, and is edited by Drs. Roy Riascos and Eliana E. Bonfante-Mejia. Articles will include: Traumatic Brain Injury: definition, neurosurgery, trauma-orthopedics, neuroimaging, and psychology-psychiatr... Multimodality advanced imaging for brain concussions; Perfusion weighted images in brain concussion; PET and SPECT in brain concussion; Imaging of chronic concussion; Imaging of concussion in young athletes; Imaging on concussion in blast injury; Conventional CT and MR in brain concussion; Structural imaging: structural MRI in concussion; Susceptibility weighted imaging and MR spectroscopy in concussion; Functional imaging fMRI – BOLD and resting state techniques in mTBI; Diffusion Weighted and Diffusion Tensor Imaging in mTBI; and more!

  • Advances in Agricultural Animal Welfare

    Science and Practice
    • 1st Edition
    • Joy Mench
    • English
    Advances in Agricultural Animal Welfare fully explores developments in the key areas of agricultural animal welfare assessment and improvement. Analyzing current topical issues, as well as reviewing the historical welfare issues, the volume is a comprehensive review of the field. Divided into five sections, the book opens in Part One by reviewing advances in animal welfare science, examining cognitive psychology, genetics and genomics. Part Two then looks at transdisciplinary research in animal welfare, with coverage of bioethics, welfare and sustainability from both environmental and food safety perspectives. Part Three explores the process of translating science into policy and practice, followed by discussion on the global achievability of welfare standards in Part Four. Finally, Part Five highlights some emerging issues in agricultural animal welfare. This book is an essential part of the wider ranging series Advances in Farm Animal Welfare, with coverage of cattle, sheep, pigs, poultry and aquaculture. With its expert editor and international team of contributors, Advances in Agricultural Animal Welfare is a key reference tool for welfare research scientists and students, practicing vets involved in welfare assessment, and indeed anyone with a professional interest in the welfare of agricultural animals.

  • Personalized Predictive Modeling in Type 1 Diabetes

    • 1st Edition
    • Eleni I. Georga + 2 more
    • English
    Personalized Predictive Modeling in Diabetes features state-of-the-art methodologies and algorithmic approaches which have been applied to predictive modeling of glucose concentration, ranging from simple autoregressive models of the CGM time series to multivariate nonlinear regression techniques of machine learning. Developments in the field have been analyzed with respect to: (i) feature set (univariate or multivariate), (ii) regression technique (linear or non-linear), (iii) learning mechanism (batch or sequential), (iv) development and testing procedure and (v) scaling properties. In addition, simulation models of meal-derived glucose absorption and insulin dynamics and kinetics are covered, as an integral part of glucose predictive models. This book will help engineers and clinicians to: select a regression technique which can capture both linear and non-linear dynamics in glucose metabolism in diabetes, and which exhibits good generalization performance under stationary and non-stationary conditions; ensure the scalability of the optimization algorithm (learning mechanism) with respect to the size of the dataset, provided that multiple days of patient monitoring are needed to obtain a reliable predictive model; select a features set which efficiently represents both spatial and temporal dependencies between the input variables and the glucose concentration; select simulation models of subcutaneous insulin absorption and meal absorption; identify an appropriate validation procedure, and identify realistic performance measures.

  • Textbook of Nephro-Endocrinology

    • 2nd Edition
    • Ajay K. Singh + 1 more
    • English
    Textbook of Nephro-Endocrinology... Second Edition, continues to be the definitive translational reference in the field of nephro-endocrinology... investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers researchers and clinicians expert analyses of nephro-endocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoporosis, and hypoparathyroidism. Changes to this edition include new chapters focused on hypercalcemia/hypoca... and the interaction of dialysis, chronic renal disease, and endocrine diseases. All chapters have been updated to include more preclinical data and more tables and schema that help translate this data into clinical recommendations. The section on hormones and renal insufficiency discusses insulin/diabetes, growth hormone, sex steroids, thyroid hormone, acid–base disturbances, and pregnancy.

  • Advances in Cattle Welfare

    • 1st Edition
    • Cassandra Tucker
    • English
    Advances in Cattle Welfare provides a targeted overview of contemporary issues in dairy and beef cattle welfare. The volume addresses welfare-related topics in both research and on-farm applications. Opening with an introduction to cattle production systems, the book covers the three major areas of cattle welfare; on-farm welfare assessment, behavioral priorities of cattle and novel perspectives on specific aspects of management. Chapters examine the key issues within each area, including such topics as the goals and measures included in welfare assessments, the importance to cattle of access to pasture and engaging in social behavior, human-animal interactions, painful procedures, and disease and metabolic challenge. This book is an essential part of the wider ranging series Advances in Farm Animal Welfare, with coverage of cattle, sheep and pigs. With its expert editor and international team of contributors, Advances in Cattle Welfare is a key reference tool for welfare research scientists and students, veterinarians involved in welfare assessment, and indeed anyone with a professional interest in the welfare of cattle.

  • Dyneins

    Dynein Mechanics, Dysfunction, and Disease
    • 2nd Edition
    • Stephen M. King
    • English
    Dyneins: Structure, Biology and Disease, Second Edition, offers a broad view of dyneins mechanics, dysfunction, and disease, providing an overview of dyneins from structure and function, to dysfunction and disease. Since the first edition, enormous strides have been taken in understanding dynein structure, its organization in the axoneme, single molecule motor mechanics, and the consequences of defects for human biology, disease, and development. To account for these enormous strides, the second edition is extensively revised. Additionally, the coverage has expanded from 24 to 42 chapters, and is now housed in two volumes. Much of the expanded coverage occurs in Volume 2 which focuses on dynein dysfunction and disease, such as the role of dynein and cancer. Volume 1 covers the history and evolution of dyneins, dyneins in ciliary biology, and cytoplasmic dynein biology, while Volume 2 covers the structure and mechanics of dynein motors and dynein dysfunction and disease.

  • Cheetahs: Biology and Conservation

    Biodiversity of the World: Conservation from Genes to Landscapes
    • 1st Edition
    • English
    Cheetahs: Biology and Conservation reports on the science and conservation of the cheetah. This volume demonstrates the interdisciplinary nature of research and conservation efforts to study and protect the cheetah. The book begins with chapters on the evolution, genetics, physiology, ecology and behavior of the species, as well as distribution reports from range countries. These introductory chapters lead into discussions of the challenges facing cheetah survival, including habitat loss, declining prey base, human-wildlife conflict, illegal trade, and newly-emerging threats, notably climate change. This book also focuses on conservation strategies and solutions, including environmental education and alternative livelihoods. Chapters on the role of captive cheetahs to conservation and the long-term research of the species are included, as are a brief discussion of the methods and analyses used to study the cheetah. The book concludes with the conservation status and future outlook of the species. Cheetahs: Biology and Conservation is a valuable resource for the regional and global communities of cheetah conservationists, researchers, and academics. Although cheetah focussed the book provides information relevant to the study of broader topics such as wildlife conservation, captive breeding, habitat management, conservation biology and animal behaviour. Cover photograph by Angela Scott

  • Examining Ecology

    Exercises in Environmental Biology and Conservation
    • 1st Edition
    • Paul A. Rees
    • English
    Examining Ecology: Exercises in Environmental Biology and Conservation explains foundational ecological principles using a hands-on approach that features analyzing data, drawing graphs, and undertaking practical exercises that simulate field work. The book provides students and lecturers with real life examples to demonstrate basic principles. The book helps students, instructors, and those new to the field learn about the principles of ecology and conservation by completing a series of problems. Prior knowledge of the subject is not assumed; the work requires users to be able to perform simple calculations and draw graphs. Most of the exercises in the book have been used widely by the author’s own students over a number of years, and many are based on real data from published research. Exercises are succinct with a broad number of options, which is a unique feature among similar books on this topic. The book is primarily intended as a resource for students, academics, and instructors studying, teaching, and working in zoology, ecology, biology, wildlife conservation and management, ecophysiology, behavioural ecology, population biology and ecology, environmental biology, or environmental science. Students will be able to progress through the book attempting each exercise in a logical sequence, beginning with basic principles and working up to more complex exercises. Alternatively they may wish to focus on specific chapters on specialist areas, e.g., population dynamics. Many of the exercises introduce students to mathematical methods (calculations, use of formulae, drawing of graphs, calculating simple statistics). Other exercises simulate fieldwork projects, allowing users to ‘collect’ and analyze data which would take considerable time and effort to collect in the field.

  • Encyclopedia of Cardiovascular Research and Medicine

    • 1st Edition
    • Volume 4
    • Douglas B. Sawyer + 1 more
    • English
    Encyclopedia of Cardiovascular Research and Medicine, Four Volume Set offers researchers over 200 articles covering every aspect of cardiovascular research and medicine, including fully annotated figures, abundant color illustrations and links to supplementary datasets and references. With contributions from top experts in the field, this book is the most reputable and easily searchable resource of cardiovascular-focus... basic and translational content for students, researchers, clinicians and teaching faculty across the biomedical and medical sciences. The panel of authors chosen from an international board of leading scholars renders the text trustworthy, contemporary and representative of the global scientific expertise in these domains. The book's thematic structuring of sections and in-depth breakdown of topics encourages user-friendly, easily searchable chapters. Cross-references to related articles and links to further reading and references will further guide readers to a full understanding of the topics under discussion. Readers will find an unparalleled, one-stop resource exploring all major aspects of cardiovascular research and medicine.

  • Multiple Sclerosis, An Issue of Neurologic Clinics

    • 1st Edition
    • Volume 36-1
    • Darin T. Okuda
    • English
    This issue of Neurologic Clinics, edited by Dr. Darin T. Okuda, focuses on Multiple Sclerosis. Topics include, but are not limited to, Myelin and Axonal Repair Strategies in Multiple Sclerosis; Common Clinical and Imaging Conditions Misdiagnosed as Multiple Sclerosis; Topographical Model for Multiple Sclerosis: A Novel Approach to Understanding Clinical Phenotypes and Disease Activity; Incidental Anomalies Characteristic of CNS Demyelination: Radiologically Isolated Syndrome; Pediatric Multiple Sclerosis: From Recognition to Practical Clinical Management; Progressive Forms of Multiple Sclerosis: Distinct Entity or Time Dependent Phenomena; Advanced Symptom Management Strategies in Multiple Sclerosis, Ethnic Considerations and Multiple Sclerosis Disease Variability; The Dynamics of the Gut Microbiome in Multiple Sclerosis in Relation to Disease; Spinal Cord Imaging in Relation to Clinical Status in Multiple Sclerosis, and more.

  • Hazard Analysis and Risk Based Preventive Controls

    Building a (Better) Food Safety Plan
    • 1st Edition
    • Patricia A. Wester
    • English
    Hazard Analysis and Risk Based Preventive Controls: Building a (Better) Food Safety Plan is directed to those food safety professionals charged with ensuring or assisting with FSMA’s preventative controls (PC) implementation and compliance in their routine job duties. The target audience includes those currently involved in the development, management, and execution of HACCP and/or other advanced food safety management systems, as well as those interested in advancing their knowledge base to gain a more thorough comprehension of HARPC requirements. FSMA topics covered include: identifying the food safety team and PCQI; creating the HARPC implementation strategy; starting the food safety plan; conducting a thorough hazard analysis; identifying adequate preventive control measures; determining appropriate PC management components; recognizing applicable verification and validation activities; supply chain management program; recall plans. Other operational topics include: document control systems; internal audit programs; third party audit management; regulatory visit preparation; and maintaining compliance.

  • Manual of Chronic Total Occlusion Interventions

    A Step-by-Step Approach
    • 2nd Edition
    • Emmanouil Brilakis
    • English
    Manual of Coronary Chronic Total Occlusion Interventions: A Step-by-Step Approach, Second Edition, is an easy to read reference for coronary chronic total occlusion interventions (CTO). Written by recognized national and international experts in the field, this reference compiles the steps necessary to preform, what pitfalls to watch out for, and troubleshooting tactics necessary for coronary chronic total occlusion interventions (CTO). This second edition is updated with new developments in the field. The 2nd edition covers techniques like the Carlino technique, "scratch and go", "BASE", double-blind stick and swap, and subintimal crush, along with tips about how to use the latest complex PCI equipment. It also covers recently published trials, CTO scores and hybrid series. Written to bring a practical and easy to read approach, this book is perfect for interventional cardiologists, interventional and general cardiology fellows, cardiology researchers, physicians, cardiac catheterization laboratory personnel, technical staff,industry professionals and everyone else interested in understanding the cutting edge and rapidly evolving field of coronary CTO interventions.　　

  • Starch in Food

    Structure, Function and Applications
    • 2nd Edition
    • Malin Sjöö + 1 more
    • English
    Starch in Food: Structure, Function and Applications, Second Edition, reviews starch structure, functionality and the growing range of starch ingredients used to improve the nutritional and sensory quality of food. The new edition is fully updated and brings new chapters on starch and health, isolation, processing and functional properties of starch. Part One illustrates how plant starch can be analyzed and modified, with chapters on plant starch synthesis, starch bioengineering and starch-acting enzymes. Part Two examines the sources of starch, from wheat and potato, to rice, corn and tropical supplies. Part Three looks at starch as an ingredient and how it is used in the food industry, with chapters on modified starches and the stability of frozen foods, starch-lipid interactions and starch-based microencapsulation. Part Four covers starch as a functional food, investigating the impact of starch on physical and mental performance, detecting nutritional starch fractions and analyzing starch digestion. The book is a standard reference for those working in the food industry, especially to starch scientists, food researchers, post-docs, practitioners in the starch area and students.

  • Encyclopedia of Marine Mammals

    • 3rd Edition
    • Bernd Würsig + 2 more
    • English
    The Encyclopedia of Marine Mammals, Third Edition covers the ecology, behavior, conservation, evolution, form and function of whales, dolphins, seals, sea lions, manatees, dugongs, otters and polar bears. This edition provides new content on anthropogenic concerns, latest information on emerging threats such as ocean noise, and impacts of climate change. With authors and editors who are world experts, this new edition is a critical resource for all who are interested in marine mammals, especially upper level undergraduate and graduate students, researchers, and managers, and is a top reference for those in related fields, from oceanographers to environmental scientists.

  • Inhaled Pharmaceutical Product Development Perspectives

    Challenges and Opportunities
    • 1st Edition
    • Anthony J. Hickey
    • English
    Inhaled Pharmaceutical Product Development Perspectives: Challenges and Opportunities describes methods and procedures for consideration when developing inhaled pharmaceuticals, while commenting on product development strategies and their suitability to support regulatory submission. It bridges the gap between the aspirations of scientists invested in new technology development and the requirements that must be met for any new product. The book brings together emerging analytical and inhalation technologies, providing perspectives that illuminate formulation and device design, development, regulatory compliance, and practice. Focusing on underlying scientific and technical principles known to be acceptable from the current regulatory perspective, this monograph will remain useful as a high-level guide to inhaled product development for the foreseeable future.

  • Hepatitis C in Developing Countries

    Current and Future Challenges
    • 1st Edition
    • Sanaa M. Kamal
    • English
    Hepatitis C in Developing Countries: Current and Future Challenges explores the current state of HCV in several countries, including Africa, Asia and South America. It maintains a dedicated focus on the epidemiology, clinical patterns, virologic diversity, coinfections, natural history and progression, complications, and response to standard of care (SOC) pegylated interferon and ribavirin therapy of HCV with recommendations specific to middle and low income countries. Readers will find detailed information on the burden of HCV infection from a global health and economic perspective, along with data from multicenter trials on DAAs that have enrolled patients infected with HCV non-genotype 1.

  • Neurofeedback

    Tools, Methods and Applications
    • 1st Edition
    • Pascale Vincent
    • English
    The artificial intelligence of robots capable of learning from their errors and modifying their behavior accordingly is modeled on the activity of neurons in the brain.Emotional stress, traffic accidents, bereavement; these are all factors that can disrupt this neural activity, sometimes to the point of generating suffering that can be difficult to relieve. Neurofeedback, derived from neuroscience, is a computerized technique for training and re-balancing the brain’s electrical activity using neuroplasticity, which allows the brain to self-correct and regain a stable equilibrium, thus promoting recovery from traumas and a return to well-being. Neurofeedback: Tools, Methods and Applications deals with neurofeedback, explaining the functioning of the tool, its action on the equilibration of neural activity, and the differences between classical and dynamic systems. The results of the author's research and observations, the applications of these two tools, and the effects produced on the patients are explored, along with testimonies that describe and explain concepts in detail.Different neurofeedback tools are presented in this book, together with their function and explicit specificities adapted to the needs of each user. Their applications to psychological and cognitive disorders make neurofeedback an efficient and promising neurotherapy technique.

  • Dyneins

    The Biology of Dynein Motors
    • 2nd Edition
    • Stephen M. King
    • English
    Dyneins: The Biology of Dynein Motors, Second Edition, offers a broad view of dyneins from structure, composition and organization, to biology of dynein function in both cytoplasm and cilia. As the second book in a pair on this topic, these works provide an overview of dyneins, from structure and function, to dysfunction and disease. Since the first edition, enormous strides have been taken in understanding dynein structure, its organization in the axoneme, single molecule motor mechanics and the consequences of defects for human biology, disease and development. This second edition is extensively revised, with coverage expanded from 24 to 42 chapters. Much of the expanded coverage occurs in Volume Two on dynein dysfunction and disease, such as the role of dynein and cancer, while Volume One covers the history and evolution of dyneins, dyneins in ciliary biology and cytoplasmic dynein biology.

  • The Cardiovascular System

    Development, Plasticity and Physiological Responses
    • 1st Edition
    • Volume 36B
    • A. Kurt Gamperl + 3 more
    • English
    The Cardiovascular System: Phenotypic and Physiological Responses, Volume 37, part of a two-volume set, provides comprehensive coverage of the current state of knowledge in this very active and growing field of research, also highlighting the tremendous diversity in cardiovascular morphology and function among the various fish taxa and the anatomical and physiological plasticity shown by this system when faced with various abiotic and biotic challenges. Specific chapters in this updated book include Research Technologies/Methodo... for Studying Fish Cardiovascular Function, Cardiovascular Development in Embryonic and Larval Fishes, Cardiovascular Responses to Limiting Oxygen Levels, and Temperature and the Cardiovascular System. The book's chapters integrate molecular and cellular data with the growing body of knowledge on heart and in vivo cardiovascular function, and as a result, provide insights into some of the most interesting, and important, questions that still need to be answered in this field.

  • Fruit Juices

    Extraction, Composition, Quality and Analysis
    • 1st Edition
    • Gaurav Rajauria + 1 more
    • English
    Fruits Juices is the first and only comprehensive resource to look at the full scope of fruit juices from a scientific perspective. The book focuses not only on the traditional ways to extract and preserve juices, but also the latest novel processes that can be exploited industrially, how concentrations of key components alter the product, and methods for analysis for both safety and consumer acceptability. Written by a team of global experts, this book provides important insights for professionals in industrial and academic research as well as in production facilities.

  • Temporal Sampling and Representation Updating

    • 1st Edition
    • Volume 236
    • English
    Temporal Sampling and Representation Updating, Volume 236, addresses the gap between laboratory studies using static or predictable stimuli and the more complex change that is a characteristic of the real world. Topics in this new volume include a section on Unfolding the time course of emotion perception, Temporal sampling and representation updating for action in interception and grasping tasks, The influence of Cognitive Control and Attention on Temporal Sampling: Lessons from the Attentional Blink, Synchronizing tracking eye movements with the motion of a visual target, and Sampling feature distributions with visual search in heterogeneous displays.

  • Platform Technologies in Drug Discovery and Validation

    • 1st Edition
    • Volume 50
    • English
    Platform Technologies in Drug Discovery and Validation, Volume 50, the latest release in the Annual Reports in Medicinal Chemistry series, provides timely and critical reviews of important topics in medicinal chemistry, with an emphasis on emerging topics in the biological sciences. Topics covered in this new volume include DELT, Oligos: ASO, siRNA, CRISPR, Micro-fluidic chemistry, High throughput screening, Kinase-centric computational drug development, Virtual Screening, Phenotypic screening, PROTACS, Chemical Biology, Fragment-based lead generation, Antibody-Drug Conjugates, Antibody-recruiting small molecules, Deuteration, and Peptides.

  • The Human Microbiome

    • 1st Edition
    • Volume 44
    • English
    Methods in Microbiology, Volume 44 presents the latest volume in the most prestigious series devoted to techniques and methodology in the field, with updated chapters that cover Metabolomics and the vaginal microbial ecosystem and health, Esophageal microbiome, Bioinformatics methods, Evolution of biomolecules, genomes and communities, and Gut microbial metabolism or the acquisition of the gut microbiome. Established for over 30 years, this comprehensive series provides ready-to-use recipes, the latest emerging techniques, and novel approaches on tried, tested and established methods.

  • Fungal Phylogenetics and Phylogenomics

    • 1st Edition
    • Volume 100
    • English
    Fungal Phylogenetics and Phylogenomics, Volume 100, the latest release in the Advances in Genetics series, presents users with new chapters that delve into such topics as the Advances of fungal phylogenomics and the impact on fungal systematics, Data crunching for fungal phylogenomics: insights into data collection and phylogenetic inference based on genome data for fungi, Genomic and epigenomic traits of emerging fungal pathogens, Advances in fungal gene cluster diversity and evolution, Phylogenomics of Fusarium oxysporum species complex, Phylogenomic analyses of pathogenic yeasts, and the Phylogenetics and phylogenomics of rust fungi. The series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, critically analyzing future directions.

  • Risk Management of Complex Inorganic Materials

    A Practical Guide
    • 1st Edition
    • Violaine Verougstraete
    • English
    Risk Management of Complex Inorganic Materials: A Practical Guide facilitates the risk assessment and management of complex inorganic materials around the world by providing accessible and specific guidance on their assessment. Inorganic complex materials, such as ores and concentrates, metal containing- glasses, ceramic and inorganic pigments, alloys, and UVCBs produced during the manufacturing of metals present specificities not addressed by most guidance documents. This book explains the main characteristics of inorganic complex materials affecting their hazard and risk assessment and management, including their source and main uses, also covering hazard and exposure assessment, risk characterization and risk management. It is an essential reference for regulators involved in risk assessment and risk management, industry experts charged of compliance with chemical management program requirements, consultants preparing chemicals management files for companies and regulators, and academics involved in research on complex inorganic materials.

  • HIV/AIDS

    Oxidative Stress and Dietary Antioxidants
    • 1st Edition
    • Victor R. Preedy + 1 more
    • English
    HIV/AIDS: Oxidative Stress and Dietary Antioxidants provides comprehensive coverage of oxidative stress in HIV/AIDS, focusing on both the pathological process around molecular and cellular metabolism and the complications that can arise due to nutritional imbalance. It provides a pathway for researchers and clinicians to gain an in-depth understanding of the role of oxidative stress, bridging the transdisciplinary divide between virologists, immunologists, physicians, clinical workers, food scientists and nutritionists to advance medical sciences and enable preventative treatment strategies. Very often oxidative stress is a feature of HIV/AIDs or of the treatment of HIV/AIDs. While immunologists, physicians and clinical workers understand the processes in HIV/AIDs, they may be less conversant in the science of nutrition and dietetics. Similarly, nutritionists and dietitians may be less conversant with the detailed clinical background and science of HIV/AIDs.

  • Sustainable Management of Arthropod Pests of Tomato

    • 1st Edition
    • Waqas Wakil + 2 more
    • English
    Sustainable Management of Arthropod Pests of Tomato provides insight into the proper and appropriate application of pesticides and the integration of alternative pest management methods. The basis of good crop management decisions is a better understanding of the crop ecosystem, including the pests, their natural enemies, and the crop itself. This book provides a global overview of the biology and management of key arthropod pests of tomatoes, including arthropod-vectored diseases. It includes information that places tomatoes in terms of global food production and food security, with each pest chapter including the predators and parasitoids that have specifically been found to have the greatest impact on reducing that particular pest. In-depth coverage of the development of resistance in tomato plants and the biotic and abiotic elicitors of resistance and detailed information about the sustainable management of tomato pests is also presented.

  • Cerebrospinal Fluid in Neurologic Disorders

    • 1st Edition
    • Volume 146
    • English
    Cerebrospinal Fluid in Neurologic Disorders, Volume 146 provides a brief overview on the current use of CSF in clinical routine, the physiology of CSF, and its usefulness and potential as a biomarker. The second part addresses the main purpose of the volume, describing CSF from a research perspective in context with the most important diagnostic entities in neurology. The book's authors provide insight into the current understanding of CSF changes in these various conditions and what it tells us about the nature of neurological diseases. Furthermore, methodological aspects are discussed, as are shortcomings that need to be addressed. Finally, the book provides an outlook for potential directions that can be explored to improve the various aspects of CSF research with the ultimate goal of being incorporated in clinical practice.

  • The Lateralized Brain

    The Neuroscience and Evolution of Hemispheric Asymmetries
    • 1st Edition
    • Sebastian Ocklenburg + 1 more
    • English
    The Lateralized Brain: The Neuroscience and Evolution of Hemispheric Asymmetries is an up-to-date teaching resource for neuroscience faculty members that teach courses concerning hemispheric asymmetries. The book provides students with all relevant information on the subject, while also giving aspiring researchers in the field an up-to-date overview of relevant, previous work. It is ideal for courses on hemispheric asymmetries, that is, the functional or structural differences between the left and the right hemispheres of the brain, and also highlights how the widespread use of modern neuroimaging techniques, such as fMRI and DTI has completely changed the way hemispheric asymmetries are currently investigated. According to the preface, the main aim of The Lateralized Brain is to provide "an up-to-date teaching resource on hemispheric asymmetries … [and] to introduce undergraduate students of all levels to the fascinating topics of hemispheric asymmetries" (p. xv)… (Sebastian Ocklenburg and Onur Güntürkün) have succeeded admirably in their stated aim and are to be congratulated on undertaking the mammoth task they set themselves. They can be proud of what they have accomplished.~ Alan A. Beaton, Department of Psychology, Swansea University, Swansea, UK, in Laterality: Asymmetries of Body, Brain and Cognition, July, 2018.

  • Principles and Practice of Clinical Research

    • 4th Edition
    • John I. Gallin + 2 more
    • English
    Principles and Practice of Clinical Research, Fourth Edition has been thoroughly revised to provide a comprehensive look at both the fundamental principles and expanding practice of clinical research. New to this edition of this highly regarded reference, authors have focused on examples that broadly reflect clinical research on a global scale while including a discussion of international regulations, studies, and implications. In addition to key topics such as bioethics, clinical outcome data, cultural diversity, protocol guidelines, and “omic” platforms, this edition contains new chapters devoted to electronic health records and information resources for clinical researchers, as well as the many opportunities associated with big data. Covering a vast number of topics and practical advice for both novice and advanced clinical investigators, this book is a highly relevant and essential resource for all those involved in conducting research.

  • New Approaches to Aortic Diseases from Valve to Abdominal Bifurcation

    • 1st Edition
    • Ion C. Tintoiu + 4 more
    • English
    New Approaches to Aortic Disease from Valve to Abdominal Bifurcation provides a complete look at aortic valve diseases from all points of view, including etiology, physiopathology, prevention, diagnosis and treatment. The book offers new insights into the aortic valve and pathology based on evidence of current diagnostic methods, treatments and post-surgery evolution. Content is split into three distinct parts for ease of reference, including an overview of aortic pathology, diagnostic evaluations methods, and treatments. Also included are guidelines and future research directions, making this a must-have volume for all cardiologists and cardiovascular surgeons who address significant issues in this topic area.

  • Bioenvironmental Issues Affecting Men's Reproductive and Sexual Health

    • 1st Edition
    • Suresh C Sikka + 1 more
    • English
    Bioenvironmental Issues Affecting Men's Reproductive and Sexual Health is structured into two parts related to men’s reproductive and sexual health with eight sections designed to enable a logical flow of such knowledge. The book is focused on the biology of key organs involved in male reproduction and the environmental influences affecting their functions with particular emphasis on clinical aspects. Individual chapters within the book range from basic to translational aspects, but all hold clinical relevance. This is an essential reference for those working and learning in the field of human reproduction, reproductive toxicology and environmental influences on reproductive and sexual health.

  • Meat Analogs

    Challenges and Perspectives
    • 1st Edition
    • Christophe Terrien
    • English
    Meat Analogs: Challenges and Perspectives provides an overview on the subject that is followed by an inventory of research perspectives to highlight the importance of issues and research relating to meat analogs. It explores the severe demographic, ecological, and economic and sociological constraints and uncertainties that exist in the allocation of food production resources. Alternative solutions, in particular meat substitutes, aka, meat analogs or mock-meats are discussed, as are dietary patterns and the control of markets.

  • Skin Tissue Models

    • 1st Edition
    • Alexandra P. Marques + 3 more
    • English
    Skin Tissue Models provides a translational link for biomedical researchers on the interdisciplinary approaches to skin regeneration. As the skin is the largest organ in the body, engineered substitutes have critical medical application to patients with disease and injury – from burn wounds and surgical scars, to vitiligo, psoriasis and even plastic surgery. This volume offers readers preliminary description of the normal structure and function of mammalian skin, exposure to clinical problems and disease, coverage of potential therapeutic molecules and testing, skin substitutes, models as study platforms of skin biology and emerging technologies. The editors have created a table of contents which frames the relevance of skin tissue models for researchers as platforms to study skin biology and therapeutic approaches for different skin diseases, for clinicians as tissue substitutes, and for cosmetic and pharmaceutical industries as alternative test substrates that can replace animal models.

  • Handbook of Neuroemergency Clinical Trials

    • 2nd Edition
    • Brett E. Skolnick + 1 more
    • English
    Handbook of Neuroemergency Clinical Trials, Second Edition, focuses on the practice of clinical trials in acute neuroscience populations, or what have been called neuroemergencies. Neuroemergencies are complex, life-threatening diseases and disorders, often with devastating consequences, including death or disability. The overall costs are staggering in terms of annual incidence and costs associated with treatment and survival, yet despite their significance as public health issues, there are few drugs and devices available for definitive treatment. The book focuses on novel therapies and the unique challenges their intended targets pose for the design and analysis of clinical trials. This volume provides neurologists, neuroscientists, and drug developers with a more complete understanding of the scientific and medical issues of relevance in designing and initiating clinical development plans for novel drugs intended for acute neuroscience populations. The editors provide the best understanding of the pitfalls associated with acute CNS drug development and the best information on how to approach and solve issues that have plagued drug development.

  • Designing Healthcare That Works

    A Sociotechnical Approach
    • 1st Edition
    • Mark Ackerman + 3 more
    • English
    Designing Healthcare That Works: A Sociotechnical Approach takes up the pragmatic, messy problems of designing and implementing sociotechnical solutions which integrate organizational and technical systems for the benefit of human health. The book helps practitioners apply principles of sociotechnical design in healthcare and consider the adoption of new theories of change. As practitioners need new processes and tools to create a more systematic alignment between technical mechanisms and social structures in healthcare, the book helps readers recognize the requirements of this alignment. The systematic understanding developed within the book’s case studies includes new ways of designing and adopting sociotechnical systems in healthcare. For example, helping practitioners examine the role of exogenous factors, like CMS Systems in the U.S. Or, more globally, helping practitioners consider systems external to the boundaries drawn around a particular healthcare IT system is one key to understand the design challenge. Written by scholars in the realm of sociotechnical systems research, the book is a valuable source for medical informatics professionals, software designers and any healthcare providers who are interested in making changes in the design of the systems.

  • zika virus disease

    From origin to outbreak
    • 1st Edition
    • Adnan I. Qureshi
    • English
    Zika Virus provides an authoritative account of one of most fascinating viruses of the 21st century, covering all the main points. It includes coverage of clinical manifestations, such as fever and fatigue, but also delves into neurological manifestations like acute demyelinating neuropathy. In addition, the book discusses new evidence that suggests that Zika fever in pregnant women can cause abnormal brain development in fetuses by mother-to-child transmission. The Zika virus infection has become one of the first where women are actively discouraged from getting pregnant. Readers will find this book to be a comprehensive resource on the topic.

  • Epigenetics of Aging and Longevity

    Translational Epigenetics vol 4
    • 1st Edition
    • Volume 4
    • Alexey Moskalev + 1 more
    • English
    Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses—including cancer and cardiovascular, metabolic, and neurodegenerative diseases—are explored in detail. This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease.

  • Fundamentals of Soil Ecology

    • 3rd Edition
    • David C. Coleman + 2 more
    • English
    Fundamentals of Soil Ecology, 3rd Edition,　offers a holistic approach to soil biology and ecosystem function, providing students and ecosystem researchers with a greater understanding of the central roles that soils play in ecosystem development and function. The text emphasizes the increasing importance of soils as the organizing center for all terrestrial ecosystems and provides an overview of theory and practice in soil ecology, both from an ecosystem and evolutionary biology point of view. This new edition is fully updated, including an expanded treatment of microbial ecology and new sections on advances in molecular techniques and climate change research. These updates make this edition an essential resource for researchers and students in soil ecology and microbiology.

  • Medical and Scientific Publishing

    Author, Editor, and Reviewer Perspectives
    • 1st Edition
    • Jasna Markovac + 2 more
    • English
    Very few doctors and scientists receive any sort of systematic training in publishing, editing, and reviewing scholarly articles, despite the central importance of that work for scientific research and for their careers. Medical and Scientific Publishing will help fill the gap and help readers to:Understand processes of scientific and medical publishingUnderstand the role of an academic in medical publishingBecome a better scientific communicatorDevelop skills to effectively serve as the editor of a medical journal Medical and Scientific Publishing is based on a successful course at the University of Michigan Medical School for third and fourth year medical students. The course teaches students not just how to write scientific and medical articles, but addresses key issues surrounding copyright, ethics, open access and much more. Students will build a strong foundation on how to do peer review and how to be authors and editors which are important skills in building a professional career.

  • In Vitro Toxicology

    • 1st Edition
    • Alok Dhawan + 1 more
    • English
    In Vitro Toxicology details the protocols and methods of in vitro testing, highlighting the usefulness of models, methods and the cost-effectiveness and reproducibility of such methodologies. The current approaches and strategies required to develop an easy, reliable, validated and high throughput system for use in alternative animal models to circumvent in vivo testing are discussed in detail. The book also includes chapters on the principles involved in the general selection and use of models that address safety concerns, regulatory acceptance and the current understandings and strategies for the identification of biomarkers in toxicity testing. Furthermore, principles involved in the general selection and use of models that address the issues of safety concerns and regulatory acceptance of these models are discussed, making the book beneficial to students, scientists, and regulators working in toxicology, as well as those in the field of chemicals and the safety assessment of novel materials.

  • Proteins in Food Processing

    • 2nd Edition
    • Rickey Y. Yada
    • English
    Proteins in Food Processing, Second Edition, reviews how proteins may be used to enhance the nutritional, textural and other qualities of food products. After two introductory chapters, the book discusses sources of proteins, examining the caseins, whey, muscle and soy proteins, and proteins from oil-producing plants, cereals and seaweed. Part Two illustrates the analysis and modification of proteins, with chapters on testing protein functionality, modeling protein behavior, extracting and purifying proteins and reducing their allergenicity. A final group of chapters delves into the functional value of proteins and how they are used as additives in foods.

  • Notes in the Category of C

    Reflections on Laboratory Animal Care and Use
    • 1st Edition
    • Steven M. Niemi
    • English
    Notes in the Category C: Reflections on Laboratory Animal Care and Use addresses how to improve laboratory animal care and use, also characterizing the current state of the industry and speculating on its long-term future. It offers analysis from a professional who has spent a lot of time in the trenches, also highlighting new approaches to produce further advances in the field. As the proper care and use of lab animals is critically important to scientists and those who depend on data generated from those animals, this comprehensive book is an ideal resource on the topic. Physicians, patients and their families, consumers, federal and non-profit research funding entities, health advocacy organizations, the FDA, EPA, regulatory approval agencies, and companies that invest billions in R&D to create new diagnostics, drugs, vaccines and medical devices will find this an informative addition for their work.

  • Neuromonitoring Techniques

    Quick Guide for Clinicians and Residents
    • 1st Edition
    • Hemanshu Prabhakar
    • English
    Neuromonitoring Techniques: Quick Guide for Clinicians and Residents provides a quick and easy guide to understanding various neuromonitoring equipment. Chapters include intracranial pressure monitoring, EEG-based monitors, evoked potentials and transcranial doppler. This book is written for trainees, clinicians and researchers in the fields of neurosurgery, neurocritical care, neuroradiology, neuroanesthesia and neurology. As specialized neuromonitoring is now routinely done in neurosurgical cases, it provides an important resource for neurologists, neurophysiologists, anesthesiologists and residents who are expected to have theoretical and practical knowledge on different systems. Each monitoring system is discussed separately, with examples, images, reference values and their interpretations.

  • Harnessing the Power of Viruses

    • 1st Edition
    • Boriana Marintcheva
    • English
    Harnessing the Power of Viruses explores the application of scientific knowledge about viruses and their lives to solve practical challenges and further advance molecular sciences, medicine and agriculture. The book contains virus-based tools and approaches in the fields of: i) DNA manipulations in vitro and in vivo; ii) Protein expression and characterization; and iii) Virus- Host interactions as a platform for therapy and biocontrol are discussed. It steers away from traditional views of viruses and technology, focusing instead on viral molecules and molecular processes that enable science to better understand life and offer means for addressing complex biological phenomena that positively influence everyday life. The book is written at an intermediate level and is accessible to novices who are willing to acquire a basic level of understanding of key principles in molecular biology, but is also ideal for advanced readers interested in expanding their biological knowledge to include practical applications of molecular tools derived from viruses.

  • Intracranial Epidural Bleeding

    History, Management, and Pathophysiology
    • 1st Edition
    • Jeremy Christopher Ganz
    • English
    Intracranial Epidural Bleeding: History, Management, and Pathophysiology examines the history of the concepts underlying the understanding of the clinical features of epidural bleeding. The pathophysiology of epidural bleeding was examined in two PhD theses in the 1980s, with the results published in top international journals. However, these concepts have not been understood by the general neurosurgical community. This book provides a comprehensive overview of how epidural bleeding actually works. It can be used to help improve the interpretation of images during management, and to assess degrees of urgency. This book is written for neurosurgeons, neurologists, cerebrovascular physiologists, trauma surgeons, and medical historians.

  • Genomic and Precision Medicine

    Cardiovascular Disease
    • 3rd Edition
    • Geoffrey S. Ginsburg + 1 more
    • English
    Genomic and Precision Medicine: Cardiovascular Disease, Third Edition, focuses on the applications of genome discovery on the broad spectrum of cardiovascular disorders. Each chapter is organized for the application of genomics and personalized medicine tools and technologies to a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field.

  • Advances in Pig Welfare

    • 1st Edition
    • Irene Camerlink
    • English
    Advances in Pig Welfare analyzes current topical issues in the key areas of pig welfare assessment and improvement. With coverage of both recent developments and reviews of historical welfare issues, the volume provides a comprehensive survey of the field. The book is divided into two sections. Part One opens with an overview of main welfare challenges in commercial pig production systems and then reviews pig welfare hot spots from birth to slaughter. Part Two highlights emerging topics in pig welfare, such as pain and health assessment, early socialization and environmental enrichment, pig-human interactions, breeding for welfare, positive pig welfare and pigs as laboratory animals. This book is an essential part of the wider ranging series Advances in Farm Animal Welfare, with coverage of cattle, sheep, pigs and poultry. With its expert editor and international team of contributors, Advances in Pig Welfare is a key reference tool for welfare research scientists and students, veterinarians involved in welfare assessment, and indeed anyone with a professional interest in the welfare of pig.

  • Pharmaceutical Medicine and Translational Clinical Research

    • 1st Edition
    • Divya Vohora + 1 more
    • English
    Pharmaceutical Medicine and Translational Clinical Research covers clinical testing of medicines and the translation of pharmaceutical drug research into new medicines, also focusing on the need to understand the safety profile of medicine and the benefit-risk balance. Pharmacoeconomics and the social impact of healthcare on patients and public health are also featured. It is written in a clear and straightforward manner to enable rapid review and assimilation of complex information and contains reader-friendly features.As a greater understanding of these aspects is critical for students in the areas of pharmaceutical medicine, clinical research, pharmacology and pharmacy, as well as professionals working in the pharmaceutical industry, this book is an ideal resource.

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