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Elsevier

Books in Immunology

Elsevier's Immunology collection equips researchers with valuable insights to address the complexities of the immune system and its role in health and disease, offering original research, insightful analysis, and current theory on diagnosing, managing, and advancing treatments for allergies, asthma, and immunologic disorders.

  • Current Research on Biofilm Mediated Chronic Diseases

    Immunological Background and Clinical Interpretations
    • 1st Edition
    • Dibyajit Lahiri + 3 more
    • English
    Current Research on Biofilm Mediated Chronic Diseases: Immunological Background and Clinical Interpretations is an in-depth exploration of the complex interplay between biofilms, the immune system, and chronic diseases. These microbial communities, encased in self-produced extracellular polymeric substances (EPS), adhere to surfaces and resist environmental stresses, including host immune responses and antimicrobial agents.This comprehensive book investigates the formation, characteristics, and profound impact of biofilms on human health. Coverage spans the fundamentals of biofilm formation, immune evasion, and antimicrobial resistance (AMR); the role of biofilms in chronic diseases including periodontal disease, chronic wounds, and respiratory and urinary tract infections; their involvement in cancer development and neural disorders via the gut-brain axis; emerging therapeutic strategies such as nanotechnology, phage therapy, and immunomodulatory approaches; and the growing application of artificial intelligence (AI) and machine learning to biofilm-immune interactions and personalized medicine.Current Research on Biofilm Mediated Chronic Diseases: Immunological Background and Clinical Interpretations provides essential insights for researchers, undergraduates, and postgraduates seeking to understand and combat the challenges posed by biofilms in chronic disease pathology. This book offers valuable knowledge on recent techniques for detecting and mitigating antimicrobial resistance (AMR) and biofilm formation, making it an indispensable resource for scientists and clinicians alike.

  • Sarcoma Immunology and Immunotherapy

    From Cellular Mechanisms to Clinical Translation
    • 1st Edition
    • Joseph Crompton
    • English
    Sarcoma Immunology and Immunotherapy offers a timely and comprehensive review of the rapidly evolving field of sarcoma immunology and immunotherapy. This book serves as an essential resource for healthcare professionals, scientists, and patients, providing insights into the immunologic features of sarcoma and the latest immune-based treatments. Focussing on the recent advances, the book discusses the sarcoma microenvironment and the development of innovative immunotherapies tailored for sarcoma patients. Readers will benefit from a thorough overview of existing knowledge, encompassing foundational concepts in sarcoma immunology, a detailed examination of laboratory research, and a complete summary of ongoing immunotherapy trials. This holistic approach ensures a robust understanding of the current landscape in sarcoma research and treatment. By equipping readers with essential background information and comprehensive reviews, this book fosters a deeper understanding of sarcoma immunology and therapeutic strategies. It empowers healthcare professionals and scientists to stay abreast of critical studies, ultimately enhancing patient care and outcomes in this challenging field.

  • Decoding the JAK-STAT Pathway

    Emerging Insights and Clinical Applications Across Diseases
    • 1st Edition
    • Meenakshi Dhanawat + 1 more
    • English
    Decoding the JAK-STAT Pathway: Emerging Insights and Clinical Applications Across Diseases offers a comprehensive exploration of one of the most vital molecular signaling pathways in human health and immune regulation. This reference addresses the critical need for an integrated resource that connects fundamental immunological mechanisms with translational and clinical applications, particularly in autoimmune, inflammatory, and infectious diseases. The book covers the pathway’s physiological roles in cytokine signaling, immune homeostasis, and cellular communication, as well as its dysregulation in conditions such as rheumatoid arthritis, inflammatory bowel disease, neuroinflammation, and viral infections. Its chapters feature contributions from global experts, detailing recent advances in targeted therapies, including JAK inhibitors, and their potential for personalized medicine. The content is organized to highlight disease-specific roles, therapeutic strategies, and emerging research directions, making it an essential resource for immunologists, biomedical scientists, clinicians, and pharmaceutical researchers seeking an authoritative, up-to-date guide to the molecular and clinical aspects of JAK-STAT signaling. By elucidating how this pathway influences immune responses and disease progression, the book facilitates a deeper understanding of immune regulation and offers insights into novel treatment approaches, ultimately supporting advancements in immunotherapy and precision medicine across diverse patient populations worldwide.

  • Microbiome and Tumorigenesis

    Dysbiosis in Different Cancers
    • 1st Edition
    • Volume 1
    • Sanjana Mehrotra + 1 more
    • English
    Microbiome and Tumorigenesis: Dysbiosis in Different Cancers examines the intricate relationship between the human microbiome and cancer. Organized into three parts, the book opens with the conceptual and ecological foundations of the human microbiome and dysbiosis, tracing how microbial imbalance contributes to tumor development. The second part examines how microbiome dysbiosis drives carcinogenesis, covering its effects on tumor immunity, the dual role of microbial metabolites as both oncogenic drivers and protective effectors, and the contribution of fungal and viral dysbiosis to cancer development and treatment. The third part surveys dysbiosis across organ-specific cancers, including gastrointestinal, skin, oral, lung, head and neck, liver, and gynecologic malignancies. This book is a valuable resource for researchers, clinicians, and students seeking to understand the complex interplay between the microbiome and cancer, with insights into potential therapeutic strategies and future research directions.

  • The Inflammatory Ecosystem and Inflammazones

    Mapping the Complex Terrain of Inflammatory Diseases
    • 1st Edition
    • Erwei Song + 1 more
    • English
    The Inflammatory Ecosystem and Inflammazones: Mapping the Complex Terrain of Inflammatory Diseases offers a groundbreaking framework for understanding inflammation across multiple spatial and molecular levels. The book introduces the concept of distinct inflammazones—local, regional, distal, and systemic—and explores how their interactions influence disease development, progression, and resolution. This holistic approach integrates cellular, molecular, microbiome, and systemic responses, addressing a critical gap in current knowledge and advancing diagnostics and therapies for diseases like autoimmunity and cancer. The book is organized into six sections, starting with foundational principles and progressing through mechanisms of local, regional, and systemic inflammazones.It covers key components such as cytokines, chemokines, immune cells, and the roles of non-immune cells like fibroblasts and epithelial cells. The final sections focus on systems-level insights, including inflammaging, metabolism, and multi-omics technologies, culminating in strategies for personalized medicine and clinical translation. Each chapter combines cutting-edge research with clinical relevance, making complex concepts accessible and actionable.

  • Emerging Trends and Imminent Applications in Immunology and Pharmaceutical Biotechnology

    • 1st Edition
    • Swagat Kumar Das + 2 more
    • English
    Emerging Trends and Imminent Applications in Immunology and Pharmaceutical Biotechnology delves into historical perspectives, current trends, and future projections for research and development of immunological and biopharmaceutical products. Sections explore immunostimulants, natural and synthetic immunostimulants in aquaculture and animal husbandry, immunomodulators, immune boosters, pre- and probiotics in health promotion, cutting-edge immunological techniques for disease diagnosis, immunotherapy in cancer treatment, and transplantation immunology. Following chapters explore the impact on pharmaceutical biotechnology, with discussions on traditional and modern approaches in drug delivery, in silico drug delivery modeling, biocomposites and their pharmaceutical applications, recent advances in monoclonal antibodies production, vaccine development, and much more. Finally, the book covers the pivotal role of AI, machine learning, and data analytics in the clinical study of immunotherapy and pharmaceutical drugs, thus paving the way for enhanced research and development efficiency. Researchers in industry and academia alike will gain valuable insights into the novel principles behind designing and developing immunological and drug products, making this title an essential resource.

  • Glycobiology of the Immune System and Disease

    • 1st Edition
    • Shyamasree Ghosh + 1 more
    • English
    Glycobiology of the Immune System and Disease explores the integration of state-of-the-art glycobiology and immunology to raise awareness of the multifaceted roles of glycans and lectins in the immune system. Glycobiology is a rapidly growing field in biology, with relevance to biomedicine, biotechnology and basic research. Considering the central role that glycans play in immune interactions, glycoproteins and carbohydrates are becoming the targets of next-generation therapeutics, vaccines and diagnostics. Programmed remodeling of host glycans can modulate infection, autoimmunity, and cancer, while microbial glycoconjugates can serve as canonical innate receptor agonists that induce B cell and T cell activation. This important reference investigates microbial and mammalian glycans and their protein-binding partners (lectins) and shows the role they play in all innate and adaptive immune responses. With its comprehensive overview of the field, it is an important resource for academicians, graduate and post graduate students as well as professors and faculty in the field of research in glycobiology and immunology.

  • Immunity and Immunotherapy in Inflammatory Bowel Diseases (IBD)

    Mechanisms and Innovations
    • 1st Edition
    • Deepa S. Mandlik + 1 more
    • English
    Covers detailed disease mechanisms and the full spectrum of immune cell biology, through to advanced clinical applications The book highlights the latest advances in immunotherapy, including cell-based and next-generation treatments. Immunity and Immunotherapy in Inflammatory Bowel Diseases (IBD): Mechanisms and Innovations bridges laboratory research with clinical practice, addressing diagnostics, biomarkers and real-world patient care. It tackles current challenges in IBD, such as therapy resistance, the integration of AI and multi-omic approaches. What sets this book apart is its extensive, up-to-date coverage of all immunotherapeutic strategies, such as monoclonal antibodies, cytokine inhibitors, JAK inhibitors, cell-based therapies, and novel targets such as CAR-T cells and immune checkpoint modulators. It also addresses emerging technologies, personalized medicine, resistance mechanisms, safety, and the gut microbiome, providing a holistic view of current and future directions in IBD immunotherapy.

  • Immunotherapy for Autoimmune Disorders

    Innovations and Insights
    • 1st Edition
    • Arun Kumar Singh + 4 more
    • English
    Immunotherapy for Autoimmune Disorders: Innovations and Insights revolutionizes the therapeutic paradigm for autoimmune illnesses, offering new perspectives over traditional medication therapies. This complete and accessible resource examines how immunotherapy teaches the immune system to detect and fight targeted cells, enhancing the body's immune response by providing additional components to strengthen its defense mechanisms. The book covers a wide range of topics, including the pathophysiology, diagnosis, and classification of autoimmune diseases, the immunopathogenesis of these disorders, and the development and application of monoclonal antibodies. It explores immune checkpoint inhibitors, T-cell modulation therapies, cytokine targeting therapies, B-cell depletion strategies, and more.Additionally, it addresses immunomodulatory agents, small molecules, personalized immunotherapy approaches, and the application of immunotherapeutic strategies for specific autoimmune diseases. Future directions and emerging therapies, as well as regulatory and ethical considerations, are also discussed. This is essential reading for medical professionals, researchers, and students seeking to learn about immunotherapy as an alternative approach to treating autoimmune disorders.

  • Building Blocks of Neuroimmunometabolism

    From Molecular Pathways to Therapeutic Strategies
    • 1st Edition
    • Sachchida Nand Rai + 2 more
    • English
    Building Blocks of Neuroimmunometabolis... From Molecular Pathways to Therapeutic Strategies offers an authoritative exploration of the intricate relationship between the immune system and neurodegenerative diseases. This essential resource addresses the critical gap in understanding how immune responses and metabolic processes jointly influence the onset and progression of conditions such as Alzheimer’s, Parkinson’s, and multiple sclerosis. The book provides an examination of key molecular pathways and cellular interactions, emphasizing the role of immunometabolism in disease mechanisms. Beginning with an introduction to the concept of immunometabolism, it explores the connections between the immune and nervous systems, setting the stage for understanding neurodegenerative diseases.In addition, the book discusses pivotal topics such as the role of microglia and macrophages in neuroinflammation, the metabolic regulation of T cells, and the impact of oxidative stress and mitochondrial dysfunction. The gut-brain axis is examined for its influence on brain health, alongside innovative therapeutic strategies targeting immunometabolic pathways and lifestyle interventions.

  • The Dual Role of Inflammation in Cancer

    • 1st Edition
    • Surajit Pathak + 1 more
    • English
    The Dual Role of Inflammation in Cancer Genesis and Therapy explores the pivotal role inflammation plays in the development and progression of cancer. The book delves into how chronic inflammation creates a microenvironment that supports tumor growth by promoting cellular proliferation, survival, and migration while suppressing immune responses. It traces historical observations, linking inflammation to cancer while also examining how inflammatory cells and mediators contribute to various stages of tumorigenesis. In addition, it discusses the implications of inflammation on cancer treatment, highlighting the potential of anti-inflammatory agents and immunotherapy in targeting the inflammatory tumor microenvironment.By elucidating on the intricate relationship between inflammation and cancer, the book aims to pave the way for more effective and personalized cancer treatment strategies. As such, it is a valuable resource for researchers in immunology and oncology.

  • The Microbiome and Cancer Treatment

    Overcoming Resistance and Enhancing Efficacy
    • 1st Edition
    • Sadhna Aggarwal + 3 more
    • English
    The Microbiome and Cancer Treatment: Overcoming Resistance and Enhancing Efficacy delves into the intricate relationship between the microbiome and cancer treatment, highlighting the microbiome's critical role in drug resistance and therapeutic efficacy. The book's chapters are meticulously organized to provide a deep understanding of how the microbiome interacts with the immune system and influences cancer development and response to therapies. This book opens new avenues for investigation by providing a better understanding of the mechanisms of resistance and the role of microbiome alterations in chemoresistance.Sect... also address the complex "chicken-or-egg" relationship between microbiome alterations and chemoresistance. A diverse blend of chapters foster interdisciplinary collaboration across fields such as immunology, microbiology, oncology, and pharmacology, promoting holistic approaches to cancer treatment. Readers will benefit by gaining awareness and a better understanding of how the microbiome impacts health, particularly in the context of cancer, leading to more informed health choices.

  • Microglial Advances in Neurodegenerative Diseases

    • 1st Edition
    • Volume 171
    • English
    Microglial Advances in Neurodegenerative Diseases, Volume 170 in the Advances in Immunology series, presents current developments and comprehensive reviews focused on the role of microglia and neuroinflammation in neurological and psychiatric disorders. This volume brings together contributions from leading researchers, offering up-to-date insights into microglial biology in health and disease, as well as their involvement in major neurodegenerative conditions. Chapters in this new release explore Cross-talk between Tau and Neuro-glia Axis of Alzheimer’s Disease, Microglia in Health and Disease, Amyloid-beta (Aβ) and Neuroinflammation in Microglia, Chemokine Receptor CX3CR1 Interacts with Tau and Regulates Microglial Activity in Alzheimer’s Disease, and much more.Additional chapters explore Human-Induced Pluripotent Stem Cells in Psychiatric Disorders, GPCR-Mediated Internalization and Endosomal Sorting of the Tau–GPCR Complex in Microglia, iPSC-Derived Microglia: A Cellular Platform for Tau and Alzheimer’s Disease Immunotherapy, Advancements in Invasive and Non-Invasive Neuromodulation for Parkinson’s Disease, LRRK2-I1371V Disrupts Microglial Membrane Homeostasis and Enhances α-Synuclein Toxicity, Microglial Advances in Parkinson’s Disease, Microglial Advances in Alzheimer’s Disease, and more.

  • Microbiome in Head and Neck Cancer: Pathogenesis, Diagnosis and Therapeutic Implications

    Part A
    • 1st Edition
    • Volume 169
    • English
    Microbiome in Head and Neck Cancer: Pathogenesis, Diagnosis and Therapeutic Implications, Volume 169 in the Advances in Immunology series, presents an authoritative exploration on how microbial communities contribute to the initiation, progression, and treatment of head and neck cancers. Chapters highlight The Microbiome of the Head and Neck Region, Overview Head and Neck Microbiota and the Factors Influencing the Head and Neck Microbiome, Mechanistic Pathways of Dysbiosis in Cancer Development, Oral Microbiota and OPMDs, Oral Potentially Malignant Disorders (OPMDs): An Overview, Oral Microbiota and Oral Cancer, Oral Squamous Cell Carcinoma (OSCC): An Overview, and much more.Additional chapters cover the Role of the Oral Microbiome in Oral Cancer (OSCC), Microbiome as a Prognostic Indicator in Oral Cancer, Diagnostic and Therapeutic Applications, Microbiome-Based Diagnostic Approaches, Modulating the Head and Neck Microbiome for Cancer Prevention, Microbiome-Targeted Therapeutics in Head and Neck Cancer, Artificial Intelligence in Microbiome Data Analysis: Applications in Head and Neck Cancer, and Challenges and Future Directions in Head & Neck Microbiome Research.

  • Systemic Lupus Erythematosus

    Basic, Applied and Clinical Aspects
    • 3rd Edition
    • George C. Tsokos
    • English
    Systemic Lupus Erythematosus: Basic, Applied and Clinical Aspects has been an essential resource for scientists and clinicians in this field since its original publication in 2015. The third edition of this work has been completely updated and expanded with the latest scientific and clinical developments in Systemic Lupus Erythematosus (SLE) to date. Contributors at the forefront of each topic come together to enhance content on epidemiology and diagnosis, pathogenesis, mechanisms of tissue damage, clinical aspects of the disease, antiphospholipid syndrome, and treatments. Also added is the latest information on new treatments, criteria, monogenic forms of lupus, insights on the role of microbiome, and advances in understanding disease pathogenesis. This must-have reference is an indispensable resource for specialists in the diagnosis and management of patients with SLE as well as early career or experienced investigators studying basic aspects of the disease. It is a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease, and a key reference work for hospital libraries.

  • Advances in Immunology

    • 1st Edition
    • Volume 168
    • English
    Advances in Immunology, Volume 168, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Sample topics in this new release include Alarmins in mucosal tissues and how they regulate health and disease, and more.

  • Innovative Nanotechnology: Transforming Skin Cancer Diagnosis and Treatment

    • 1st Edition
    • Volume 169
    • English
    Innovative Nanotechnology: Transforming Skin Cancer Diagnosis and Treatment, Volume 169 in the Advances in Cancer Research series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this new release include an Introduction to Nanotechnology in Dermatology, Basics of Skin Cancer: Types, Diagnosis, and Current Challenges, Current Challenges in Skin Cancer Diagnosis and Treatment, Nanocarriers for Drug Delivery in Skin Cancer, Nanotechnology in Skin Cancer Diagnosis, Therapeutic Nanoparticles and Targeted Therapy, and much more.Additional chapters cover Nanotechnology in Photodynamic and Photothermal Therapy for Skin Cancer, Challenges in Translating Nanotechnology from Research to Clinical Practice, Nanotechnology and Immunotherapy Synergies in Skin Cancer, Patient-Centric Approaches and Personalized Nanomedicine in Skin Cancer, The Role of Theranostics and Nanotheranostics in Skin Cancer Management, Preclinical and Clinical Trials in Nanotech Skin Cancer Treatment, Safety, Ethical, and Regulatory Considerations in Nanotechnology for Skin Cancer, and many more interesting chapters on topics of current interest.

  • Vaccinology and Immunizations

    • 1st Edition
    • Jahangir Moini + 2 more
    • English
    Vaccinology and Immunizations is a thorough resource on the immune system, the history of vaccines, vaccine preparation, the process of vaccine approval, and the prevention and eradication of diseases. It also includes chapters on vaccine safety and errors, and complete information on pediatric and adult immunizations. There is also discussion on elderly immunology and immunization for people who are seeking to travel abroad, as well as timely information about COVID-19.Its focus on the innate and adaptive defense systems of the body will ensure understanding of human immunity and how immunizations are effective. There is a variety of available titles related to vaccinology and immunizations, but many are now outdated.Vaccinology and Immunizations provides a new, updated resource that is widely needed, and will be welcomed by students of undergraduate, graduate and master level in vaccinology or immunology, and would also be of interest to nurses, researchers, and pharmacists.

  • Immunity to Immunotherapy in Cancer

    Mechanisms and Limitations
    • 1st Edition
    • Mukesh Nandave + 1 more
    • English
    Immunity to Immunotherapy in Cancer: Mechanisms and Limitations explores the intricate interplay between cancer therapy and the immune system, addressing why some patients do not respond to immunotherapy and scientific solutions in development. The book examines molecular strategies of immune evasion within the tumor microenvironment, providing insights into factors like tumor heterogeneity and immune checkpoint mechanisms that contribute to resistance. Highlighting promising approaches such as combination therapies, personalized medicine, and novel immunotherapeutic agents, the book aims to enhance patient outcomes and advance cancer immunotherapy.Design... as a comprehensive guide for professionals and researchers, this textbook offers an overview of the latest scientific discoveries and practical applications in cancer therapy. It serves as an invaluable resource for scientists, doctors, academicians, and students, presenting a path toward more effective, non-toxic, and customized cancer treatments. This book is essential for anyone interested in the future of cancer therapy.

  • Inflammation and Cancer

    Mechanisms, Diagnosis, and Therapeutic Strategies
    • 1st Edition
    • Anoop Kumar + 4 more
    • English
    Inflammation and Cancer: Mechanisms, Diagnosis, and Therapeutic Strategies delves into the intricate relationship between inflammation and cancer, a crucial area of contemporary biomedical research. Sections provide an overview of inflammation's role in cancer, discussing molecular connections and signaling pathways. Chapters explore inflammatory pathways in various cancers, including breast, oral, lung, prostate, skin, and gastrointestinal cancers. The book also covers tumorigenesis, metastasis, preventive strategies, inflammatory biomarkers for cancer diagnosis, and innovative therapeutic designs. Final chapters focus on the dual role of platelets, targeting tumor-associated macrophages, novel treatment approaches, and recent advances in the field.This title offers substantial benefits to researchers, clinicians, and healthcare professionals by providing a thorough understanding of the cellular and molecular pathways linking inflammation and cancer, aiding in the development of effective anti-cancer immunotherapies. By highlighting the latest research and potential therapeutic strategies, this book serves as an essential resource for anyone dedicated to combating cancer through innovative and informed immunotherapeutic approaches.

  • Inflammatory Arthritis Beyond the Joints

    Comorbidities and other Manifestations
    • 1st Edition
    • Volume 18
    • Fabiola Atzeni + 1 more
    • English
    Inflammatory Arthritis Beyond the Joints, Volume 18 in Elsevier’s Handbook for Systemic Autoimmune Diseases series, provides an extensive review of the most recent research on various comorbidities and EAMs associated with inflammatory arthritis. The book emphasizes early detection, which is crucial for improving patient quality of life and survivability outcomes, as many adults with inflammatory arthritis also suffer from other chronic conditions. The book's chapters cover comorbidities and EAMs in both early and late disease stages.They delve into the mechanisms behind the development of these conditions and examine the impact of new treatment strategies specific to inflammatory arthritis and related diseases, including cardiovascular disease, metabolic syndrome, metabolic bone disease, infection, neoplasia, respiratory disease, gastrointestinal disorders, kidney issues, mental health conditions, and neurological diseases. This book serves as a valuable reference for researchers and clinicians focused on inflammatory arthritis and its associated conditions.

  • Inmunología

    • 10th Edition
    • David Male + 2 more
    • Spanish
    Nueva edición de uno de los textos de referencia en inmunología de nuestro portfolio en el que se abordan de forma equilibrada e integrada los conceptos pertenecientes a la inmunología básica y clínica. La estructura general de esta edición de Inmunología es la misma que la de la novena edición, Las secciones 1 y 2 describen el funcionamiento del sistema inmunitario. La sección 3 se ocupa de las respuestas inmunitarias contra los microorganismos patógenos (la función principal del sistema inmunitario), y las secciones 4 a 6 abordan aspectos de inmunología clínica, como las enfermedades autoinmunitarias, la inmunodeficiencia, los trasplantes, la inmunología tumoral y la hipersensibilidad. Todos los capítulos se han actualizado por completo e incluyen numerosos diagramas nuevos. Especial atención merecen los Caps. 17,18,20 y 22 por su profunda actualización en temas relativos a las nuevas vacunas de mRNA, inmunización pasiva, autoinmunidad, nuevos anticuerpos y nuevas terapias celulares y los nuevos descubrimientos a raíz de la epidemia de Covid. Las secciones de razonamiento crítico que siguen a cada capítulo requieren la comprensión del material presentado y de las implicaciones en un entorno de laboratorio o clínico, y sirven como base para el debate en el aula. Otro importante instrumento pedagógico son los resúmenes que recogen los puntos clave de cada capítulo, así como los numerosos esquemas, diagramas y figuras. La nueva edición ofrece contenido adicional online en español a través de la plataforma e-book+. Incluye apartados, tablas y figuras adicionales, así como una colección de 15 videos.

  • Myasthenia Gravis

    Disease, Diagnosis and Management
    • 1st Edition
    • Bhupendra G. Prajapati + 2 more
    • English
    Myasthenia Gravis: Disease, Diagnosis and Management is a comprehensive resource that explores recent advancements in diagnosing and treating Myasthenia Gravis, a rare autoimmune disease affecting the neuromuscular junction. With contributions from global experts, this book addresses the increasing prevalence of Myasthenia Gravis, reflecting the latest in diagnostic techniques and novel therapies such as complement inhibitors and FcRn antagonists. It aims to support healthcare professionals in delivering optimal care through evidence-based insights and patient-centered approaches. The book is divided into several chapters, beginning with an overview of the pathogenesis and immunoregulatory defects in Myasthenia Gravis. Subsequent chapters cover diagnostic methods, non-immunosuppressiv... treatments, and biological therapies targeting the immune system. Key topics include the role of intravenous immunoglobulin (IVIg) and plasma exchange (PLEX) in severe exacerbations, thymectomy, molecular mechanisms, and the potential of hematopoietic stem cell transplants. The book also delves into precision medicine, AI applications, clinical trial considerations, and novel therapeutics like anti-FcRn antibodies. Management strategies for ocular Myasthenia Gravis, and a holistic view of living with the disease are also discussed. Myasthenia Gravis: Disease, Diagnosis and Management is invaluable for healthcare providers, physicians, immunologists, ophthalmologists, rheumatologists, physical therapists, pharmacists, and translators. It offers a modern guide to understanding and managing Myasthenia Gravis, integrating clinical expertise with the latest research to improve patient outcomes.

  • Advances in Management of Pediatric Brain Tumors

    • 1st Edition
    • Volume 167
    • English
    Advances in Management of Pediatric Brain Tumors, Volume 167 encapsulates the latest developments in the field for various types of pediatric brain tumors. By examining these survival gaps, the volume offers insights into strategies for improving outcomes and bridging the gap in care on a global scale. Chapters in this new release include Pediatric-type diffuse low grade gliomak, Pediatric-type diffuse high grade glioma/Diffuse Midline glioma, Ependymoma, Choroid plexus tumors, Embryonal tumors/medulloblasto... Craniopharyngioma and other sellar-region tumors, and much more.Other sections cover Germ cell tumors, Immunotherapy for pediatric brain tumors, Emerging interventional treatments in the management of pediatric brain tumors, and Management of pediatric brain tumors in low-middle income countries.

  • The Immunology of the Pig

    • 1st Edition
    • Ian R. Tizard
    • English
    The Immunology of the Pig is a comprehensive and detailed exploration of the immune systems of domestic pigs, offering an invaluable resource for researchers, veterinarians, and students in the fields of immunology, veterinary medicine, and biomedical science. This text covers both the innate and adaptive immune systems of pigs, highlighting the unique features that make them an excellent model for human immune system studies. By examining the applied immunity of pigs, including available vaccines and immune-mediated diseases, this book addresses a critical need for understanding porcine immunology in both agricultural and biomedical contexts. The book is meticulously structured to cover a wide range of topics. It begins with the evolutionary origins and domestication of pigs, providing a historical context that enriches the understanding of their immune systems. Subsequent chapters explore key aspects of porcine immunology, including piglet ontogeny, reproduction, and lactation; innate immunity; hematology; cytokine functions; antigen processing cells; and lymphoid organs. Detailed discussions on the major histocompatibility complex, innate lymphoid cells, B and T cell systems, and immunity on body surfaces offer a thorough insight into the complex mechanisms at play. Additionally, the text addresses the microbiota's role, vaccination strategies, and immunity to various bacterial, viral, and parasitic diseases, rounding out a holistic view of porcine immune health.The Immunology of the Pig is an essential reference for anyone involved in veterinary science, immunology, or biomedical research. It provides a deep dive into the pig's immune system, presenting a wealth of information that is both scientifically rigorous and practically applicable. By understanding the parallels between porcine and human immune systems, researchers can leverage this knowledge to advance medical science, particularly in the areas of xenotransplantation and disease modeling. This book is a vital tool for advancing our understanding of immunology and improving health outcomes for both pigs and humans.

  • Encyclopedia of Immunobiology

    • 2nd Edition
    • Paul Kaye
    • English
    Encyclopedia of Immunobiology, Second Edition, Five Volume Set covers the full range of Immunology, presenting topics logically and making extensive use of "hot links" to refer the reader to related content. The new edition is not just an update of the original title; it vastly expands fields like immunotherapy, immunity to viral infection, vaccine development, inflammatory responses, and high throughput analyses. Containing 350 chapters written by world-leading experts, this edition integrates all concepts coherently and logically to paint a comprehensive picture of the evolving field of Immunology.The immune system, complex and multi-layered, has evolved to differentiate between "self" and foreign pathogens, providing protection against infections while dysregulation can cause diseases like autoimmunity, allergies, and inflammatory disorders. This understanding has led to numerous therapeutic interventions crucial for human health improvement.

  • Advances in DNA and mRNA-Based strategies for Cancer Immunotherapy: Part B

    • 1st Edition
    • Volume 166
    • English
    Advances in Immunology, Volume 166, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology.

  • Reproductive Immunogenetics: A Molecular and Clinical Overview

    Immune Cells and Immunotherapeutics in Recurrent Pregnancy Loss
    • 1st Edition
    • Shafat Ali + 2 more
    • English
    Immunogenetics: A Molecular and Clinical Overview: Immunogenetic Factors and Signaling Pathways in Recurrent Miscarriage, Volume Four provides an overview of the scientific knowledge, achievements, and findings in the field of immunogenetics of recurrent pregnancy loss. With a strong focus on the role immune cells can play in recurrent pregnancy loss, the book also examines immune therapeutic aspects. In seventeen chapters, the book describes the roles of several different signaling pathways and the role of JLA and microRNAs in recurrent pregnancy loss. Several chapters are dedicated to the role autoimmune antibodies play in recurrent pregnancy loss. This book is a valuable resource for health professionals, scientists, researchers, and all those who wish to broaden their knowledge in the allied field.

  • Advances in DNA and mRNA-Based Strategies for Cancer Immunotherapy: Part A

    • 1st Edition
    • Volume 165
    • English
    Advances in DNA and mRNA-Based Strategies for Cancer Immunotherapy, Volume 165 in the Advances in Immunology series, presents current developments and comprehensive reviews in DNA and mRNA vaccines: Significant therapeutic approach against cancer management, Nanoparticles for mRNA-based cancer immunotherapy, Nucleic acid Delivery as a therapeutic approach in cancer immunotherapy, Plasmid DNA and mRNA: Delivery approaches and challenges, Viral & Non-viral Delivery of mRNA against Cancer Cell, Progress in Modifying and Delivering mRNA therapies for Cancer Immunotherapy, and more.Other chapters cover mRNA-Based Cancer Vaccines: A Novel Approach to Melanoma Treatment, Therapeutic mRNAs for cancer immunotherapy: from structure to delivery, Harnessing the immune system: Insights into cancer vaccines, Lipid Nanoparticle-Mediate... mRNA Delivery in Cancer Immunotherapy, Immunotherapy Perspectives in the Era of B-Cell Editing in Cancer Treatment, Personalized Precision: Revolutionizing Cancer Treatment with mRNA-Based Vaccines in Melanoma Therapy, Revolutionizing Cancer Treatment: Exploring Novel Immunotherapeutics, Checkpoints, bispecifics, and Vaccines in Development, and more.

  • Metabolites as Signals in Immunity and Inflammation

    • 1st Edition
    • Zbigniew ZasÅ‚ona + 2 more
    • English
    Metabolites as Signals in Immunity and Inflammation describes the revolution in the definition of the word metabolism, highlighting changes in thinking about the whole field of immunology. These changes occur thanks to breakthrough experiments in basic research, and with the help of new technologies that allow for the testing of immunology hypotheses. In recent years, a substantial number of findings have been made around immunometabolism. What is emerging is a complex interplay between metabolic reprogramming and immunity, which is providing an extra dimension to our understanding of the immune system in health and disease.

  • Handbook of Food Allergen Detection and Control

    • 2nd Edition
    • Simon Flanagan
    • English
    Handbook of Food Allergen Detection and Control, Second Edition continues to be an essential resource of scientific and technical information in the food and analytical communities. This book provides information on current and emerging technologies for detecting and reducing allergens to improve allergen control overall. Written by experts in the field, it offers a wide scientific perspective on allergens and includes hot topics such as food allergen labeling and consumer perspectives on food allergen labels. Chapters are fully revised to include the latest information in the industry, including practical applications of new methods and control strategies. The book is useful for anyone in the food supply chain.The book reviews current and emerging technologies for detecting and reducing allergens, as well as issues such as traceability, regulation, and consumer attitudes. Following an introductory chapter by a distinguished expert, Part One covers allergen management throughout the food chain. Part Two details current and emerging methods of allergen detection in food, with Part Three covering methods for reducing and eliminating allergens in food. Finally, Part Four focuses on the control and detection of individual food allergens and the risks each one presents in food manufacturing.

  • The Immunology of the Domestic Ruminants

    Cattle, Sheep, and Goats
    • 1st Edition
    • Ian R. Tizard
    • English
    The Immunology of Domestic Ruminants: Cattle, Sheep, and Goats provides a thorough examination of the immune systems of these animals. It explores their normal immune functions and their roles in combating infectious and parasitic diseases, chronic inflammatory conditions, and immunodeficiency disorders. The book incorporates new data from the bovine genome project and highlights significant breed differences. Both innate and adaptive immunity are systematically covered, offering insights into basic and applied aspects of bovine immunology. In addition to detailing the immunology of major bacterial, viral, and parasitic diseases in cattle, the book reviews bovine vaccines and emphasizes the importance nutrition.This essential resource caters to professionals in large animal research and practice, providing comprehensive information on the immunology of domestic cattle, sheep, and goats.

  • Advances in Immunology

    • 1st Edition
    • Volume 164
    • English
    Advances in Immunology, Volume 164, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology.

  • Programa para mejorar la gestión del dolor crónico

    12 sesiones para reaprender a vivir plenamente
    • 1st Edition
    • Carolina BAEZA-VELASCO + 1 more
    • Spanish
    Este libro está pensado para el paciente, concebido como una auténtica guía práctica, es una herramienta de seguimiento y de motivación que le ayudará a centrarse en su objetivo, a no cejar en sus esfuerzos por mitigar el dolor cotidiano y a recuperar la calidad de vida. Las distintas intervenciones psicológicas incluidas no pretenden curar el dolor, sino ayudar a los pacientes a desarrollar recursos psicológicos y a adoptar herramientas eficaces para afrontar mejor el sufrimiento.

  • Advances in Immunology

    • 1st Edition
    • Volume 163
    • English
    Advances in Immunology, Volume 163, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Sample chapters include The role of autophagy in RIP1 mediated cell death and intestinal inflammation, IL-17 family cytokines in inflammatory or autoimmune kin diseases, and more.​​​​​​

  • The Immunology of the Cat

    • 1st Edition
    • Ian R. Tizard
    • English
    The Immunology of the Cat makes available the first single-source, comprehensive review of the feline immune system, reporting on all immunologic aspects of diseases of the cat and its relatives and relating recent basic science to important clinical issues. The book opens with the evolution, domestication, and development of the cat then provides detailed information on immunity to infectious diseases, feline allergic diseases, the top feline autoimmune diseases, and feline immunodeficiencies. Content examines feline vaccines, hypersensitivity, cancer, nutrition, and the aged cat. Professionals in veterinary research and practice will appreciate complete information on all aspects of feline immunology in one essential resource.

  • Microbes, Microbial Metabolism and Mucosal Immunity

    An Overview
    • 1st Edition
    • Tanima Bose
    • English
    Microbes, Microbial Metabolism and Mucosal Immunity: An Overview presents a concise and well-vetted treatise on the study of microbiome and microbial metabolites. This volume is up-to-date with the most recent developments from the last decade. It encompasses the interaction of immunity and microbes — and their metabolites — from different mucosal organs including gastrointestinal system, lung, oral cavity, eye. Along with the efficiency of the immune system in inhibiting the growth and proliferation of microbes, the volume discusses how the mediators of the immune system can be targeted to develop therapies.This book presents the latest methods, gives broad and systematic coverage of most mucosal systems and diseases, and takes a fresh perspective that looks at the functional aspects of change in the microbiome. The study of microbiome and microbial metabolites and their roles in host mucosal immunology is a rapidly developing area of research. One major way in which the microbiome influences the host is through altered metabolism. Metabolites, readily available to the host, engender significant consequences. Microbial metabolites have been shown to impact the disease processes in both proximal and distal organs, including the brain in several neurocognitive disorders.

  • The Rose and Mackay Textbook of Autoimmune Diseases

    • 7th Edition
    • M. Eric Gershwin + 2 more
    • English
    **Selected for 2026 Doody's Core Titles in Allergy/Clinical Immunology**The Rose-Mackay Textbook of Autoimmune Diseases, Seventh Edition is a comprehensive reference that emphasizes the "3 P’s" of 21st Century medicine: precision, prediction, and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients.This new edition continues its success with 75% of the content revised, updated, or completely new. This edition is a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune disease, as well as to scientists who want to follow developments in the field.

  • Advances in Immunology

    • 1st Edition
    • Volume 162
    • English
    Advances in Immunology, Volume 162, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology.

  • Regulatory T cells and Autoimmune Diseases

    • 1st Edition
    • Mitesh Kumar Dwivedi + 1 more
    • English
    Regulatory T Cells and Autoimmune Diseases addresses recent findings concerning the role of Tregs in the pathogenesis of autoimmune diseases as well as their therapeutic applications. In particular, this book deals with various Treg-based mechanisms that can lead to autoimmune disease and covers different aspects linking Tregs with autoimmune mechanisms involved in disease development by discussing animal models and human studies.This book specifically focuses on Treg-based therapeutics and their targets to manage all known autoimmune rheumatic, central nervous system, bowel, liver, thyroid, kidney, myopathic, skin, blood and blood vessel, and eye diseases and aims to provide a must-have reference for designing therapeutic strategies to treat these autoimmune diseases. Additionally, this book covers vaccine-induced effects on the functioning of Tregs and development of CAR Treg therapy for autoimmune diseases and concludes with current challenges and future prospects of Treg-based therapeutics. This book is carefully designed to meet the requirements of both basic and advanced researchers in the area and provide new dimensions and insight into regulatory T cells’ role in autoimmune disease pathogenesis and therapy.

  • Inmunologia basica

    Funciones y trastornos del sistema inmunitario
    • 7th Edition
    • Abul K. Abbas + 2 more
    • Spanish
    Nueva edicion del texto derivado de la obra de referencia en Inmunologia, "Abbas, Inmunologia molecular y celular" en el que se presenta de una forma concisa y visual el nivel de informacion adecuado para el estudiante que se enfrenta por primera vez a la asignatura. Destaca su gran riqueza y calidad iconografica. La inclusion de tablas, esquemas, puntos clave en negrita y preguntas de autoevaluacion. En cuanto a las principales novedades cabe destacar la inclusion de contenidos nuevos y ampliados sobre pandemias, COVID-19 e inmunidad de reba?o, resistencia y susceptibilidad a COVID-19, vacunas de ARN y vacunas hibridas, inmunoterapia tumoral, respuestas inmunitarias innatas a los virus, mecanismos de tolerancia inmunologica e inmunoterapia para enfermedades autoinmunes, alergicas y otras enfermedades inflamatorias y el cancer. La nueva edicion ofrece acceso a material adicional online en ingles a traves de e-book+

  • Nanomedicine in Cancer Immunotherapy

    • 1st Edition
    • Prashant Kesharwani
    • English
    Nanomedicine in Cancer Immunotherapy bridges the two disciplines of nanotechnology and immunology, summarizing the latest research into novel cancer treatments, often personalized to the patient. The book covers a wide range of nanomaterial types for use in cancer immunotherapy, including hydrogel, lipid, exosome, gold and peptide nanoparticles. The preparation, application, pros and cons of each nanomaterial class is reviewed, helping the reader understand the potential for each to tailor their own selections. Nanovaccines are also covered, along with a clinical evaluation and market analysis of nanomedicines for immunotherapy, offering an important clinical and commercial overview of this rapidly developing field.This book is an interesting reference for those working in the fields of nanotechnology, immunology, and cancer therapeutics, as well as clinicians with an interest in novel nano-based cancer treatments.

  • Molecular Biology of B Cells

    • 3rd Edition
    • Tasuku Honjo + 4 more
    • English
    Molecular Biology of B Cells, Third Edition provides a comprehensive reference on how B cells are generated, selected, activated, and engaged in antibody production. These developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. The book offers an integrated view of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. This new edition provides updated research on B cell development and function, the use of therapeutic antibodies in cancer and infectious disease, and more. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, this updated release is a definitive resource, vital for researchers across molecular biology, immunology, and genetics.

  • Infection and Autoimmunity

    • 3rd Edition
    • Naim Mahroum + 2 more
    • English
    In 2020 we lost Noel Rose, co-editor of the classic Infection and Autoimmunity. To honor and respect his work, a group of experts in the field have taken the initiative to make this book perpetual. The third edition of Infection and Autoimmunity updates all the recent and leading papers on infection and autoimmunity, in addition to a dedicated section on to the correlation between SARS-CoV-2 infection and autoimmunity. From the very beginning of the COVID-19 pandemic, numerous papers have been published, including studies conducted by the editors and authors of the book, on COVID-19 and autoimmunity, and therefore this knowledge has been incorporated into this new edition. The addition and extended coverage on SARS-CoV-2/COVID-19 and autoimmunity are pivotal for the third edition of the book due to the COVID-19 pandemic. Medical students and practitioners, as well as academic staff in medical schools globally, are enthusiastic in searching for better understanding of the correlation between infection and autoimmunity in general, and the long-term effects of SARS-CoV-2 and COVID-19 on the immunce system in particular, especially in terms of autoimmunity related to the virus.

  • Advances in Immunology

    • 1st Edition
    • Volume 160
    • English
    Advances in Immunology, Volume 160, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology.

  • Advances in Immunology

    • 1st Edition
    • Volume 158
    • Frederick W. Alt + 1 more
    • English
    Advances in Immunology, Volume 158, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology.

  • Translational Neuroimmunology, Volume 7

    Neuroinflammation
    • 1st Edition
    • Nima Rezaei + 1 more
    • English
    Translational NeuroImmunology: Neuroinflammation updates on bench to bedside studies on neurological disorders that have immunological etiologies. The book covers neuroimmunology and the principles of autoimmune and autoinflammatory neurological disorders, with multiple sclerosis as the main focus. The immunopathology, genetics and epigenetics, microbiome, diagnosis and treatment of multiple sclerosis will be explained in ten chapters. A chapter also examines distinct aspects of pericytes, with final discussions on the neurologic manifestations, diagnostic approaches and treatments of the various neuroimmune disorders and lessons learned from translational research on non-human primates and zebrafish. All sections are presented in an accessible, practical format, making this volume a valuable resource for immunologists, neurologists and researchers in translational biomedical research.

  • Pancreatic Cancer: Basic Mechanisms and Therapies

    • 1st Edition
    • Volume 159
    • English
    Pancreatic Cancer: Basic Mechanisms and Therapies, Volume 159 in the Advances in Cancer Research, presents the latest release in this ongoing, well-regarded serial with invaluable information on the exciting and fast-moving field of cancer research. Pancreatic cancer (PC) is the third leading cause of cancer-related deaths in the United States. Greater than 90% PCs are Pancreatic ductal adenocarcinomas (PDAC) which have a dismal estimated 5-year overall survival of only 11%. PDAC is predicted to become the second leading cause of mortality in the United States by 2030. In the clinic, the PDAC patients often present with incurable disease at the time of first diagnosis. This cancer is particularly lethal because of its propensity to spread quickly to distant organs including the lymphatic system. PDAC metastasis occurs shortly after tumor initiation and is caused by a complex interaction between autonomous tumor cells and cellular elements of the tumor microenvironment. Although PDAC remains a challenging disease to treat and a leading cause of cancer-related deaths, progress is being made in disease etiology and pathogenesis, and intensive research is focused on developing optimal treatment approaches for patients. Considering the continuous progress being made in understanding PDAC pathogenesis and designing new therapies, it was considered timely to develop an up-to-date thematic issue of Advances in Cancer Research (ACR) focused on PDAC. In this thematic issue, we have included ten review articles by experts that cover cancer disparities, PDAC pathobiology, the roles of the tumor microenvironment, tumor heterogeneity, PC stem cells, genetic and signaling events critical for PDAC pathogenesis, Immunotherapy and chemoresistance in PDAC, and different PDAC mouse models. This special issue highlights recent research progress in PDAC, which bridges the gap between basic and clinical research.

  • Advances in Immunology

    • 1st Edition
    • Volume 157
    • Frederick W. Alt + 1 more
    • English
    Advances in Immunology, Volume 157, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Chapters in this new release include Antigen receptor structure and signaling, T cells in the brain inflammation, The molecular mechanism of RIG-I/MDA5 activation and signaling, GSDMD biology, cGAS-STING pathway, The CARD8 inflammasome in HIV infection, and much more.

  • In Silico Approach Towards Magnetic Fluid Hyperthermia of Cancer Treatment

    Modeling and Simulation
    • 1st Edition
    • Muhammad Suleman
    • English
    In Silico Approach Towards Magnetic Fluid Hyperthermia in Cancer Treatment: Modeling and Simulation presents mathematical modeling and simulation approaches contrary to costly and time consuming in-vivo and in-vitro studies. Finite element method-based models of all hyperthermia processes of liver, brain and breast tumors are simulated on COMSOL Multiphysics software. Problems of constant versus variable heat sources, the backflow problem, the enhanced permeation and retention effect, the flow around Happel’s sphere in cells model structure, the deformation effect in poroelastic brain tumor, 3D flow through porous tissue, the reacting nanofluid flows, and optimization of parameters have been simulated for quantitative analysis. This important reference aids in hyperthermia treatment planning in clinical applications and provides an important compendium for practitioners as well as non-medical practicing scientists and engineers and is resource for both research and medical practice in hyperthermia treatment planning in clinical applications.

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