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T Cell Subsets

Cellular Selection, Commitment and Identity

  • 1st Edition, Volume 83 - May 20, 2004
  • Editors: Frederick W. Alt, H. Cantor, Laurie Glimcher
  • Language: English
  • Hardback ISBN:
    9 7 8 - 0 - 1 2 - 0 2 2 4 8 3 - 8
  • eBook ISBN:
    9 7 8 - 0 - 0 8 - 0 5 5 1 9 5 - 1

This first thematic issue, of the Advances in Immunology series, highlights the remarkable new insights into the mechanisms that govern development and function of T cell lineag… Read more

T Cell Subsets

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This first thematic issue, of the Advances in Immunology series, highlights the remarkable new insights into the mechanisms that govern development and function of T cell lineages. Recent developments in the understanding of the genetic and epigenetic mechanisms that regulate development of the two major T cell lineages will have a fundamental impact on a number of research fields -immunology, cell biology, hematology and stem cell research. All of these groups have a vested interest in comprehending issues such as stem cell self renewal, progenitor plasticity, lineage commitment and cellular identity. Immunologists have a special interest in the mechanisms that allow selection of a T cell repertoire whose members integrate genetic information for T cell receptor, co-receptor and specialized immunologic function, since this process lies at the core of adaptive immunity.T Cell Subsets is a timely and invaluable review for immunologists, cell biologists hematologists and stem cell researchers