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Elsevier

Books in Immunology

Elsevier's Immunology collection equips researchers with valuable insights to address the complexities of the immune system and its role in health and disease, offering original research, insightful analysis, and current theory on diagnosing, managing, and advancing treatments for allergies, asthma, and immunologic disorders.

  • Organization and Practice in Tuberculosis Bacteriology

    • 1st Edition
    • C. H. Collins + 2 more
    • English
    Organization and Practice in Tuberculosis Bacteriology focuses on the organization and technical methods of tuberculosis bacteriology. This book discusses the mycobacteria and mycobacterial disease and role and scope of the tuberculosis laboratory in human and veterinary medicine and epidemiology. The organization of tuberculosis laboratory services; collection, preservation and transport of specimens; and examination of direct smears are also elaborated. This text likewise covers the decontamination of specimens, inoculation of culture media, and identification of species and variants of tubercle bacilli. Other topics include the drug sensitivity tests, animal inoculation and assay tests; problems faced in the therapy of tuberculosis, and lipid chromatography. This publication is suitable for biologists, medical practitioners, and clinicians concerned with tuberculosis bacteriology.

  • Immunogenetics

    • 1st Edition
    • Gabriel S Panayi + 1 more
    • English
    Immunogenetics is a 12-chapter book that begins with the elucidation of the major histocompatibility complex genes and their role in autoimmune and infectious diseases. Subsequent chapters explore the human major histocompatibility complex, including implications of their complement genes for linkage disequilibrium and disease associations. This book also describes the genetics of human immunoglobulins; T-cell clones; genes of the major histocompatibility complex of the mouse; and the generation, characterization, and use of monoclonal antibodies of murine and human origin. Specific diseases are also discussed; these include spondoarthritides, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, and autoimmune thyroid disease. This book will be of beneficial value to specialists in infectious diseases, endocrinology, connective tissue diseases, and neurology, as well as to medical scientists in immunology and molecular biology.

  • Clinical Tumor Immunology

    • 1st Edition
    • Joseph Wybran + 1 more
    • English
    Clinical Tumor Immunology contains the proceedings of the Symposium of Clinical Tumor Immunology held in Brussels, Belgium, on May 26-29, 1975) and organized by the European Organization for Research on Treatment of Cancer in cooperation with the Department of Immunology of the University Hospital of Brussels. The papers explore progress in the field of clinical tumor immunology and cover topics ranging from general mechanisms in tumor immunity to tumor antigens and immunotherapy. A classification of leukemias and lymphomas is also presented. Comprised of 48 chapters, this book begins with an overview of the biological activities of the circulating thymic hormone, followed by a discussion on macrophage secretions affecting the growth of other cells. The reader is then introduced to immune cellular mechanisms at the site of the tumor; the use of the leukocyte migration technique in studies of tumor-directed cellular immunity in malignant melanoma; and immunological approaches to the identification of leukemic cells. Subsequent chapters deal with preclinical approaches in tumor immunochemotherapy; mediation of immune responses to human tumor antigens with "immune" RNA; and the role of transfer factor in human cancer. This monograph will be of interest to oncologists and immunologists.

  • Immunological Surveillance

    • 1st Edition
    • Macfarlane Burnet
    • English

  • International Congress for Microbiology

    Moscow, 1966
    • 1st Edition
    • Sam Stuart
    • English
    IX International Congress for Microbiology discusses the genetic regulation of microbial metabolism. This book presents the recommendations and suggestions on the nomenclature and classification of viruses. Organized into eight parts encompassing 72 chapters, this compilation of papers starts with an overview of the genetic code, which expresses the relationship between nucleotide triplets in messenger RNA and amino acids in proteins. This text then discusses the two aspects of the regulation of the physiology of Escherichia coli. Other chapters explore the ergot alkaloids and examine the problem of ergot alkaloid production and biosynthesis. This book discusses as well the antibiotic inhibitors of protein synthesis that are major clinical drugs, including chloramphenicol, tetracycline, streptomycin, erythromycin, and other aminoglycosides. The final chapter deals with karyological investigation of the cells during transformation by Rous virus (RSV), which shows that these cells retain a diploid character. This book is a valuable resource for epidemiologists, microbiologists, and experts in infectious diseases.

  • Cell Biology of the B Cell Receptor

    • 1st Edition
    • Volume 123
    • Hidde Ploegh
    • English
    Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

  • Vaccines

    New Approaches to Immunological Problems
    • 1st Edition
    • Ronald W. Ellis
    • English
    Vaccines: New Approaches to Immunological Problems presents the advances in the range of strategies and approaches for producing vaccines. The book is comprised of 20 chapters that cover the properties of different vaccines. The coverage of the text includes vaccines for cholera, malaria, helminth, and influenza. The book also discusses topics about the key elements of modern technologies that can be applied to different vaccines, such as active immunization strategies using anti-idiotypic antibodies; passive immunoprophylaxis with human monoclonal antibodies; and immunological adjuvants and their mode of action. The text will be of great use to scientists involved in the research and development of vaccines, such as molecular biologists, biochemists, and virologists.

  • Proceedings of the Fifth International Seaweed Symposium, Halifax, August 25–28, 1965

    • 1st Edition
    • E. Gordon Young + 1 more
    • English

  • Proceedings of the First International Congress of Parasitology

    Roma, 21-26 September 1964
    • 1st Edition
    • Augusto Corradetti
    • English

  • Immunology in Clinical Medicine

    • 3rd Edition
    • J. L. Turk
    • English
    Immunology in Clinical Medicine is an introduction to immunology in clinical medicine, with emphasis on immunological concepts underlying disease processes. The effect of drugs known to suppress immunological processes are considered especially in relation to whether they operate by really suppressing immunological processes or whether they have other actions. Comprised of 17 chapters, this book begins with an overview of the nature of the immune response, followed by a discussion on reactionS in the tissues mediated by humoral antibodies. The reader is then introduced to reactions in the tissues caused by the cell-mediated immune response; immunological processes in infective diseases; and the concept of autoimmunity and its relation to disease. Subsequent chapters focus on the immunology of diseases such as cancer, skin diseases, connective tissue diseases, and diseases of the intestinal tract, respiratory tract, liver, and amyloidosis. The final chapter is devoted to the role of the clinical immunologist in patient care and therapy. This monograph is intended for students and practitioners of clinical medicine.

  • Bacteriology for Nurses

    • 2nd Edition
    • Geoffrey A. Taylor
    • English
    Bacteriology for Nurses provide nurses and others who are associated with medicine with a simple outline of basic bacteriology and the applications of bacteriology to medicine and to nursing. The fundamentals of medical bacteriology, namely the anatomy and physiology of bacteria, infection, and the body defenses against infection are discussed. The bacteria which cause common diseases of various sites in the body, such as the respiratory tract and the gastrointestinal tract, are considered together. Only common and important infections are included. Comprised of 15 chapters, this book begins with a historical background on bacteriology, followed by a discussion on the biology of bacteria. A classification of bacteria is then presented, and infections caused by bacteria are described. Subsequent chapters focus on body defenses against bacterial infections; rickettsiae and viruses; pyogenic and chronic bacterial infections; and collection of bacteriological specimens as part of bacteriological diagnosis. Infections of the respiratory tract, gastrointestinal tract, and the nervous system are also analyzed. The final chapter is devoted to elementary parasitology. This monograph will be of interest to nurses as well as immunologists, bacteriologists, pathologists, physiologists, clinicians, and research workers in the field of medicine.

  • Basic Immunology

    • 1st Edition
    • E. R. Gold + 1 more
    • English
    Basic Immunology focuses on substances that take part in serological reactions, including antigens, antibodies, and the physicochemical nature of immunological reactions. The selection first elaborates on the basic notions of immunity, antigens, immunoglobulins, and the production of antibody. Discussions focus on factors which increase the immune response, production of antibody, biological properties of immunoglobulins, evolution and control of immunoglobulin structure, antigenicity, specific immunity, and resistance. The text then takes a look at the complement system, antigen-antibody reactions, and immediate hypersensitivity. The book ponders on cell-mediated immunity and delayed hypersensitivity, transplantation immunology, and tumor immunology. Topics include production of immunity to neoplasms, immunological aspects of carcinogenesis and growth of established tumors, immunotherapy for experimental neoplasms, donor selection in human-organ transplantation, elicitation of delayed hypersensitivity, and the role of humoral factors in the transfer of delayed hypersensitivity. The selection is a valuable reference for medicine students and researchers interested in basic immunology.

  • Analytical Microbiology

    • 1st Edition
    • Frederick Kavanagh
    • English
    Analytical Microbiology focuses on the processes, methodologies, developments, and approaches involved in analytical microbiology, including microbiological, antibiotic, and amino acid assays and dilution methods. The selection first offers information on the theory of antibiotic inhibition zones, microbiological assay using large plate methods, and dilution methods of antibiotic assays. Discussions focus on serial dilution assay, requirements for accurate assay, microbiological assay of riboflavin, laws of adsorption and partition, mechanisms of antibiotic action, and biological considerations affecting the use of statistical methods. The text then ponders on the elements of photometric assaying and automation of microbiological assays. The manuscript elaborates on antibiotic substances, vitamins, and amino acids. Topics include assay organisms, validity, specificity, reliability, and calculation of results of amino acid assays, bacitracin, chloramphenicol, dihydrostreptomycin, erythromycin, neomycin, and streptomycin. The selection is a dependable reference for researchers interested in analytical microbiology.

  • Immunological and Blood Products

    Pharmaceutical Monographs
    • 1st Edition
    • Mary Dawson + 1 more
    • J. B. Stenlake
    • English
    Pharmaceutical Monographs, Volume 5: Immunological and Blood Products provides an introduction to immunology and immunological products. This monograph describes various tissue culture techniques, which are important both in the preparation and standardization of certain immunological products. Organized into two parts encompassing 13 chapters, this volume begins with an overview of the types of immunity. This text then examines the substances which when introduced parenterally into the tissues, stimulates the production of an antibody. Other chapters consider antibodies as substances appearing in the blood or body fluids in response to the stimulus provided by the introduction of an antigen. This monograph discusses as well the preparations capable of stimulating active immunity. The final chapter deals with the causation of hemolytic disease of the newborn. This monograph is a valuable resource for medical students as well as undergraduate students of pharmacy. Students of veterinary medicine will also find this book extremely useful.

  • Fertilization

    Comparative Morphology, Biochemistry, and Immunology
    • 1st Edition
    • Charles B. Metz + 1 more
    • English
    Fertilization: Comparative Morphology, Biochemistry, and Immunology, Volume I focuses on the many aspects of the physiological mechanisms of fertilization in different forms of life. The selection first tackles the problems and procedures of comparative gametology and syngamy and sperm motility. Discussions focus on the morphology of cilia and flagella, extraneous chemical and physical factors, motility in male and female reproductive tests, problems of the quantitative and qualitative control of fertility, and patterns of reproduction. The text then ponders on sperm metabolism and mechanisms of gametic approach in plants. The manuscript takes a look at gamete surface components and their role in fertilization, acrosome reaction and lysins, and membrane fusion in relation to sperm-egg association. Topics include gametic association, acrosome formation during spermiogenesis, fine-structure studies of acrosomal changes, specificity of fertilization, and amphibian fertilization. The book also examines the activation of the egg and parthenogenesis in vertebrates. The selection is a valuable reference for readers interested in the processes involved in fertilization.

  • Immunocytochemistry

    Practical Applications in Pathology and Biology
    • 1st Edition
    • Julia M. Polak + 1 more
    • English
    Immunocytochemistry: Practical Applications in Pathology and Biology focuses on the processes, principles, methodologies, and approaches involved in the applications of immunocytochemistry in pathology and biology. The selection first takes a look at the development and scope of immunocytochemistry; techniques and practice used in immunocytochemistry; and raising and testing antibodies for immunocytochemistry. The book then ponders on raising antibodies to small peptides, use of semithin frozen sections in immunocytochemistry, and colloidal gold probes in immunocytochemistry. Discussions focus on the production of gold probes, localization of mouse serum albumin in the mammary gland, immunogens and the immune response, production of antisera, and antibody specificity in immunocytochemistry. The publication takes a look at double immunoenzymatic labelling, lectin histochemistry, immunocytochemical localization of noradrenaline, adrenaline, and serotonin, and immunocytochemistry of cell and tissue cultures. Immunocytochemistry in endocrine pathology and indirect immunofluorescence in the study and diagnosis of organ-specific autoimmune diseases are also discussed. The selection is a dependable source of information for researchers interested the practical applications of immunocytochemistry in pathology and biology.

  • A Text - Book of Bacteriology

    • 4th Edition
    • R. W. Fairbrother
    • English
    A Textbook of Bacteriology, Fourth Edition provides information pertinent to the medical aspects of bacteriology. This book presents the importance of sulfonamide compounds in the treatment of many bacterial diseases. Organized into three parts encompassing 38 chapters, this edition begins with an overview of the salient features of the development of bacteriology. This text then explores the food requirements of the bacteria as well as the elements necessary for the synthesis of the bacterial protoplasm. Other chapters consider the numerous and complex factors involved in the reproduction of bacteria. This book discusses as well the presence of antitoxins in the serum of an individual, which is an indication of increased resistance to infection with the homologous organism. The final chapter deals with serological reactions that are most widely used, namely, agglutination, precipitation, and complement-fixation. This book is a valuable resource for medical students, physicists, bacteriologists, chemists, biochemists, and research workers.

  • An Introduction to Parasitology

    • 1st Edition
    • John M. Watson
    • J. B. Stenlake
    • English
    Pharmaceutical Monographs, Volume 2: An Introduction to Parasitology focuses on the principles, methodologies, and approaches involved in parasitology, including treatment, infections, and parasitism. The book first offers information on the nature of parasitism, characteristics of parasites, relationship of parasites to hosts, physiology and ecology of parasites, infection, transmission and dissemination of parasites, and resistance and immunity to parasitic infections. The text then examines protozoology and helminthology. Discussions focus on the nature and classification of parasitic worms, biology of parasitic worms, pathogenic effects of parasitic worms, and nature and classification of Protozoa. The manuscript ponders on entomology, malacology, and diagnosis, treatment, and prevention. Topics include classification of mollusks, bionomics and control, nature and classification of Arthropoda of medical and veterinary importance, mosquitoes, bugs, fleas, and mites and ticks. The publication is a vital reference for researchers interested in parasitology.

  • Malaria

    Immunology and Immunization
    • 1st Edition
    • Julius P. Kreier
    • English
    Malaria: Volume 3, Immunology and Immunization is a collection of papers dealing with malaria parasites, the methods for measuring the immunological response to plasmodia, and the vertebrates host's immune response to plasmodia. Some papers discuss immunization against sporozoites, against the exoerythrocytic stages of malaria parasites, against asexual blood-inhabiting stages of plasmodia, as well as gamete immunization in malaria. One paper describes various separation methods to isolate malaria parasites and their constituents. Another paper discusses in detail the theory and practice of methods used in measuring antibody responses which occur during plasmodial infections, including the antibody response against sporozoites, exoerythrocytic forms, and in the different blood stages. Another paper explains the vertebrate host's immune response to plasmodial infection as a homeostatic physiological response changing along with the progression of the disease. The changes in the dynamic cellular cascade are different as the disease progresses causing death, than when these lead to recovery. Another paper enumerates the parameters which determine malarial infectiousness from one individual to another such as the time of onset, duration, intensity of the blood infections, as well as the maturity, longevity, and rate of production of gametocytes. Pharmacologists, general medical practitioners, investigators, and laboratory technicians involved in malarial research will find the collection very useful.

  • Immunological Methods

    Volume IV
    • 1st Edition
    • Ivan Lefkovits + 1 more
    • English
    Immunological Methods, Volume IV provides information pertinent to the methods in immunological research. This book focuses on cells, clones, and cell lines, as well as on their components and secreted products. Organized into 21 chapters, this volume begins with an overview of hybridoma methodology as the most celebrated immunological method. This text then discusses cell fusion, hybridoma technology, and everything related to monoclonal antibodies. Other chapters consider another molecular biology method, which describes the procedure required for establishing a partitioned cDNA-library. This book provides as well a comprehensive analysis of mRNA populations in which every messenger species appears as a distinct element, and so provides accurate answers to questions concerning genetic complexity. The final chapter provides an example of how transgenic mice can be used to study the development of T cell repertoires. This book is a valuable resource for cell biologists, scientists, immunologists, and research workers.

  • Immunological Methods

    Volume III
    • 1st Edition
    • Ivan Lefkovits + 1 more
    • English
    Immunological Methods, Volume III provides information pertinent to the fundamental aspects of immunological methods. This book presents recombinant DNA technology as applied to immunology. Organized into 25 chapters, this volume begins with an overview of the major histocompatibility complex. This text then examines the use of monoclonal antibodies in the identification of lymphocyte membrane antigens and explains the use of monoclonal antibodies in histocompatibility typing. Other chapters consider the methods in two-dimensional electrophoretic analysis of proteins and another to lymphokines that support B cells. This book discusses as well the production and expansion of cloned B and T cell lines and hybridomas. The final chapter deals with the sophisticated methodology used with particular animal species, namely, birds, sheep, and amphibians to probe specific immunological questions. This book is a valuable resource for immunologists and investigators with extensive experience in using immunological methods. Protein chemists and biologists will also find this book useful.

  • Proceedings of the First International Congress of Parasitology

    Roma, 21-26 September 1964
    • 1st Edition
    • Augusto Corradetti
    • English
    Proceedings of the First International Congress of Parasitology, Volume One focuses on the advancements of processes, methodologies, approaches, and reactions involved in parasitology. The selection first offers information on the role of molluscan hosts in trematode speciation; ecological analysis of the fluke fauna of birds in the USSR; digenetic trematodes of fishes as indicators of the ecology, phylogeny, and zoogeography of their hosts; and aspects of the biology of a monogenean skin parasite. The text then examines bacterial flora as one of the etiological factors influencing the establishment of parasites in the bowel of their host, responses of helminths to temperature gradients, and reservoir parasitism in helminths. The publication takes a look at the physical and biochemical characteristics of helminth glycogens; effect of insulin on glucose uptake and glycogen synthesis in the liver fluke Fasciola hepatica L.; regulation of glycogen synthesis in the liver fluke Fasciola hepatica L.; and changes in catalase activity during embryonation of Ascaris eggs and its relationship to respiration and cytochrome oxidase activity. The selection is a vital reference for researchers interested in parasitology.

  • Immunological Influence on Human Fertility

    Proceedings of the Workshop on Fertility in Human Reproduction, University of Newcastle, Australia, July 11-13, 1977
    • 1st Edition
    • Barry Boettcher
    • English
    Immunological Influence on Human Fertility covers the proceedings of the Workshop on Fertility in Human Reproduction, held at the Department of Biological Science, University of Newcastle, Australia on July 11 -13, 1977. The book focuses on topics on the immunological control of human and animal fertility. The selection first discusses the zona pellucida as a possible target in immunocontraception, immunological aspects of vasectomy, and the clinical significance of antibodies to spermatozoa. Topics include performance and significance of the SCMC-test, antibodies and fertility after vasovasostomy, vasectomy and the blood-testis barrier, cellular immune response, active and passive immunization, and tissue and species specificity. The book then tackles the nature of the barrier to autoimmunity in the excurrent ducts of the mammalian testis, immune activities of the male and female reproductive tracts, and isolation of spermatozoal antigens. The manuscript examines the immunological capacity of the male genital tract, clinical significance of antibodies to antigens of the reproductive tract, immunological aspects of vasectomy, and antigens of human trophoblasts. The text also takes a look at the immunological and anti-tumor effects of orchidectomy, immune infertility and approaches to treatment, natural insemination as an immune phenomenon, and modified seminal plasma antigens and subfertility. The selection is a valuable source of information for researchers wanting to study the immunological control of human and animal fertility.

  • Physical and Chemical Methods

    Methods in Immunology and Immunochemistry, Vol. 2
    • 1st Edition
    • Curtis A. Williams + 1 more
    • English
    Methods in Immunology: Volume II, Physical and Chemical Methods is a collection of papers dealing with electrophoresis, analytical ultracentrifugation, dialysis, ultrafiltration, cellulose ion exchangers, and chromatographic separation of macromolecules on porous gels. Some papers explain the applications of radioisotopes, optical analysis, and chemical analysis of proteins, carbohydrates, lipids, and nucleic acid. One paper describes the theory of electro-migration. Factors such as electrical charge or frictional coefficients govern the rate of migration of charged particles in an electric field. The differences found in their velocities can be used to separate substances or analyze them. Mobility is a characteristic property of molecules and can also be influenced by the composition of the medium or solution. Dialysis separates solvents too large to diffuse through a barrier from smaller solutes; ultrafiltration (reverse osmosis) forces solvent and solutes up to a certain critical size through the barrier by a high pressure on one side. The book notes that the membrane never becomes plugged in dialysis because of some opposite movement of the solvent. Another paper points out that the significance of radioactive tracers in immunochemistry employed to identify and label macromolecules functioning as antigens and antibodies. The collection can prove valuable to bio-chemists, cellular biologists, micro-biologists, developmental biologists, and scientists involved in immunological research.

  • An Introduction to General Virology

    • 1st Edition
    • Thomas M. Bell
    • English
    An Introduction to General Virology provides information pertinent to all aspects of virology. This book discusses the viruses affecting plants and insects. Organized into 25 chapters, this book begins with an overview of prevention of disease that can be effected by the immunization of susceptible hosts to produce circulating antibodies that neutralize viral infectivity. This text then discusses the general properties of the viruses. Other chapters consider the methods of preparing tissue cultures and explain the methods used for titrations of serum antibodies and serological identification of viruses. This book discusses as well the spread of diseases, the various invasion routes of the body, and the multitude of viruses which cause respiratory symptoms and which cannot easily be conquered. The final chapter deals with the types of vaccine in use. This book is a valuable resource for undergraduates in Medicine and Science and for postgraduates in the class of Public Health.

  • Bacterial Immunoglobulin–Binding Proteins

    Applications in Immunotechnology
    • 1st Edition
    • Michael D. P. Boyle
    • English
    Bacterial Immunoglobulin-Bindi... Proteins: Applications in Immunotechnology, Volume 2 covers the state of knowledge of bacterial immunoglobulin-bindi... proteins. The book focuses on practical approaches to isolation, characterization, and use of bacterial immunoglobulin-bindi... proteins. The majority of these studies involve the type I Fc-binding protein (staphylococcal protein A) and the type III Fc-binding protein (streptococcal protein G). Physiological chemists, pediatricians, and microbiologists will find the book invaluable.

  • Progress in Immunology

    First International Congress of Immunology
    • 1st Edition
    • Bernard Amos
    • English
    Progress in Immunology: First International Congress of Immunology is a collection of papers and summaries of the workshops conducted at the First International Congress of Immunology. The proceedings review significant advances that have been made in the field of immunology and covers topics ranging from the structure and genetics of antibodies to lymphocyte membranes and the role of antibodies and complexes in immune tissue damage. Cell cooperation in the immune response is also examined. This volume is organized into 15 sections and begins with a discussion on the structure of immunoglobulins and results of experiments which support the domain hypothesis and the evolution of immunoglobulins by gene duplication, along with the presence of genetic markers in V regions. The reader is then introduced to expansion and contraction in the evolution of immunoglobulin gene pools; receptors for C3 on B lymphocytes and their possible role in the immune response; and subpopulations of thymus cells and thymus-derived lymphocytes. Tne remaining sections focus on effector mechahisms of cell-mediated immunity; genetic control of immune responsiveness; immune disorders in humans such as glomerulonephritis and rheumatoid arthritis; and viruses involved in immunopathology. This book is dedicated to immunologists.

  • Bacteria and Bacteriophage

    A Compilation from the GenBank® and EMBL data libraries
    • 1st Edition
    • Edwin J. Atencio + 2 more
    • English
    Nucleotide Sequences 1986/1987, Volume V: Bacteria and Bacteriophage presents data that reflect the information found in GenBank Release 44.0 of August 1986. This book provides information pertinent to the unique international collaboration between two leading nucleotide sequence data libraries, one based in Europe and one in the United States. Organized into two sections, this volume begins with an overview of the sequences, some basic identifying information, and some of the biological annotations. This text then discusses the EMBL Nucleotide Sequence Data Library, an international center of fundamental research with its main focus in the fields of cell biology, molecular structures, instrumentation, and differentiation. This book discusses as well the GenBank database established in 1982 by the National Institute of General Medical Sciences (NIGMS) of the U.S National Institutes of Health (NIH). This book is a valuable resource for molecular biologists and other investigators collecting the large number of reported DNA and RNA sequences and making them available in computer-readable form.

  • Analytical Microbiology

    Volume II
    • 1st Edition
    • Frederick Kavanagh
    • English
    Analytical Microbiology, Volume II is a six-chapter work that covers the significant changes and improvements made in the theory and practice of analytical microbiology. The first chapter is devoted to the theoretical aspects of assaying of specific compounds. These topics are followed by discussions of the theoretical and practical aspects of diffusions assays, as well as the theoretical developments of photometric methods of assay, including their improvement resulting from automation. A chapter explores the assay methods for various antibiotic groups. Another chapter discusses the advances in assay technology and analytically important interrelations among the folic acid complex. The last chapter describes a simple diffusion method designed for the assay of certain amino acids in a wide variety of samples. This book will prove useful to analytical microbiologists.

  • Agglutination, Complement, Neutralization, and Inhibition

    Methods in Immunology and Immunochemistry, Vol. 4
    • 1st Edition
    • Curtis A. Williams + 1 more
    • English
    Methods in Immunology and Immunochemistry, Volume IV: Agglutination, Complement, Neutralization, and Inhibition provides information pertinent to direct and indirect agglutination reactions. This book covers a variety of topics, including complement-fixation procedures, isolation of complement components, hemolytic intermediates, complement-related proteins, and neutralization reactions. Organized into three chapters, this volume begins with an overview of test-tube agglutinations that are preferred for blood grouping with saline agglutinins that require more than a few minutes for agglutination. This text then describes blood group antibodies that agglutinate red blood cells suspended in saline. Other chapters consider the classical pathway of complement utilization. This book discusses as well the complexity of events leading to hemolysis of erythrocytes by complement. The final chapter deals with the ability of antitoxin to neutralize diphtheria toxin and explains the quantitative relationships between antigen and antibody. This book is a valuable resource for immunologists, scientists, and research workers.

  • Reactions of Antibodies with Soluble Antigens

    Methods in Immunology and Immunochemistry, Vol. 3
    • 1st Edition
    • Curtis A. Williams + 1 more
    • English
    Methods in Immunology and Immunochemistry, Volume III: Reactions of Antibodies with Soluble Antigens provides information pertinent to antigen–antibody and hapten–antibody reactions in vitro, in free solution and in gels. This book presents the development of research in immunology and immunochemistry. Organized into three chapters, this volume begins with an overview of protein–antiprotein reactions. This text then discusses the inhibitory activity of protein fragments, which suggested that antigenic combining sites of proteins were limited regions of the whole antigen molecule. Other chapters consider the measurement of inhibitory activity, which is still the principal assay to characterize antigenic sites of proteins. This book discusses as well the immunological techniques prior to the development of gel-diffusion methods. The final chapter deals with fluorescence labeling techniques that provide powerful approaches for exploring the thermodynamic and kinetic parameters of antigen–antibody interactions. This book is a valuable resource for mathematicians and immunologists.

  • Antigen-Antibody Reactions In Vivo

    Methods in Immunology and Immunochemistry, Vol. 5
    • 1st Edition
    • Curtis A. Williams + 1 more
    • English
    Methods in Immunology and Immunochemistry, Volume V: Antigen-Antibody Reactions In Vivo deals primarily with immune phenomena in tissues or in cell preparations. This book covers a variety of topics, including anaphylaxis, tolerance, immune suppression with chemical agents, radiation effects, antibody synthesis in vitro, immunological methods, and applied electron microscopy. Organized into 10 chapters, this volume begins with an overview of systemic anaphylaxis investigations in other more resistant species. This text then presents the analysis of mechanisms involved in the pathogenesis of the Arthus phenomenon, which shed light on the understanding of other lesions of hypersensitivity. Other chapters consider the effects of antigen–antibody interaction on connective tissue. This book discusses as well the degree and duration of acquired tolerance. The final chapter deals with the application of electron microscopy in the elucidation of the mechanisms of immune reactions. This book is a valuable resource for immunologists, students, and research workers.

  • Progress in Immunology VI

    Sixth International Congress of Immunology
    • 1st Edition
    • B Cinader + 1 more
    • English
    Progress in Immunology VI: Sixth International Congress of Immunology contains the proceedings of the Sixth International Congress of Immunology held in 1986. The papers review advances that have been made in the field of immunology and cover topics ranging from ontogeny and differentiation of B and T lymphocytes to diversification of immunoglobulins and T cell receptors. Antigen presentation and processing, the complement system, and regulation of the immune response are also discussed. Comprised of 105 chapters, this book first explores the developmental biology of the immune system by focusing on the origins of selective theories of antibody formation and the clonal selection hypothesis. Clonal selection and the problem of immunologic tolerance are also considered. Subsequent chapters deal with the structure and function of recognition structures; B cell subsets and B cell activation; T cell subsets and T cell activation; lymphokines and growth factors; and autoimmune disorders. The remaining sections are devoted to oncogenesis and tumor immunity; the response of the host to the environment; and host-graft relationship. This monograph will be of interest to immunologists and biologists.

  • The Biology of B-Lactam Antibiotics

    • 1st Edition
    • Robert B. Morin + 1 more
    • English
    The Biology of ß-Lactam Antibiotics

  • Aspects of Developmental and Comparative Immunology

    Proceedings of the 1st Congress of Developmental and Comparative Immunology, 27 July - 1 August 1980, Aberdeen
    • 1st Edition
    • J. B. Solomon
    • English
    Aspects of Developmental and Comparative Immunology contains the proceedings of the 1st Congress of Developmental and Comparative Immunology, held from July 27 to August 1, 1980 in Aberdeen, Scotland. The papers explore various aspects of developmental and comparative immunology and cover topics ranging from the major histocompatibility complex (MHC) and membrane immunoglobulins to idiotypes and diversity, comparative ontogeny, and evolution of lymphoid organ function. Comprised of 105 chapters, this volume begins with an overview of how the host immune system utilizes polymorphic MHC antigens as the principal tool for pseudo-self versus true self distinction. The reader is then introduced to the immunology of earthworms, membrane immunoglobulins, idiotypes, and diversity. Subsequent chapters focus on the evolution of lymphoid organs in vertebrates; differentiation clocks in comparative immunology of mammals and birds; immunorecognition in invertebrates such as insects and gastropods; and the phylogeny of leucocytes in vertebrates and invertebrates. The remaining sections deal with stem cells, immune responses of gut-associated lymphoepithelial tissue, and the ontogeny of resistance to infection as well as the ontogeny of killer cells. Finally, the immunology of fish, amphibians, reptiles, chickens, and mammals is examined. This monograph will be of interest to immunobiologists.

  • The Value of BCG and TNF in Autoimmunity

    • 1st Edition
    • Denise Faustman
    • English
    The Value of BCG and TNF in Autoimmunity provides an overview of current research and thinking related to tumor necrosis factor (TNF) induction and the use of the bacillus Calmette-Guérin (BCG) vaccine as potential treatment approaches to diverse forms of autoimmunity. BCG, commonly known as an anti-tuberculosis vaccine, is being explored in worldwide clinical trials as an approach to the treatment of certain forms of autoimmunity. The scope of research behind this therapeutic approach spans from the basic science of TNF signaling to research in diverse autoimmune disciplines, such as type 1 diabetes and multiple sclerosis. Overall, the book focuses on the lessons that can be learned from the researchers' individual experiences and data, and provides a rationale for bringing the inexpensive, generic BCG vaccine to the forefront of clinical trials in different forms of autoimmunity.

  • Advances in Immunology

    • 1st Edition
    • Volume 122
    • Frederick W. Alt
    • English
    Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

  • Advances in Immunology

    • 1st Edition
    • Volume 121
    • Frederick W. Alt
    • English
    Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

  • Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

    Volume 3 - Role in Specific Diseases
    • 1st Edition
    • M. A. Hayat
    • English
    Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst encouraging researchers to explore their potentially important connections. Volume 3 explores the role of autophagy in specific diseases and developments, including: Crohn’s Disease, Gaucher Disease, Huntington’s Disease, HCV infection, osteoarthritis, and liver injury. A full section is devoted to in-depth exploration of autophagy in tumor development and cancer. Finally, the work explores the relationship between autophagy and apoptosis, with attention to the ways in which autophagy regulates apoptosis, and the ways in which autophagy has been explored in Lepidoptera, elucidating the use of larval midgut as a model for such exploration. From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases. Volumes in the Series Volume 1: Molecular Mechanisms. Elucidates autophagy’s association with numerous biological processes, including cellular development and differentiation, cancer, immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer’s, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Volume 2: Role in General Diseases. Describes the various aspects of the complex process of autophagy in a myriad of devastating human diseases, expanding from a discussion of essential autophagic functions into the role of autophagy in proteins, pathogens, immunity, and general diseases. Volume 3: Role in Specific Diseases. Explores the role of autophagy in specific diseases and developments, including: Crohn’s Disease, Gaucher Disease, Huntington’s Disease, HCV infection, osteoarthritis, and liver injury, with a full section devoted to in-depth exploration of autophagy in tumor development and cancer, as well as the relationship between autophagy and apoptosis.Volume 4: Mitophagy. Presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson Disease, cardiac aging, and skeletal muscle atrophy. Volume 5: Role in Human Diseases. Comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy’s effects in various cardiovascular, metabolic, and neurodegenerative disorders.Volume 6: Regulation of Autophagy and Selective Autophagy. Provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Volume 7: Role of Autophagy in Therapeutic Applications. Provides coverage of the latest developments in autophagosome biogenesis and regulation; the role of autophagy in protein quality control; the role of autophagy in apoptosis; autophagy in the cardiovascular system; and the relationships between autophagy and lifestyle. Volume 8: Autophagy and Human Diseases. Reviews recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, and introduces new, more effective therapeutic strategies, in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation.Volume 9: Necrosis and Inflammation in Human Diseases. Emphasizes the role of Autophagy in necrosis and inflammation, explaining in detail the molecular mechanism(s) underlying the formation of autophagosomes, including the progression of Omegasomes to autophagosomes.

  • Primer to the Immune Response

    • 2nd Edition
    • Tak W. Mak + 2 more
    • English
    Written in the same engaging conversational style as the acclaimed first edition, Primer to The Immune Response, 2nd Edition is a fully updated and invaluable resource for college and university students in life sciences, medicine and other health professions who need a concise but comprehensive introduction to immunology. The authors bring clarity and readability to their audience, offering a complete survey of the most fundamental concepts in basic and clinical immunology while conveying the subject’s fascinating appeal. The content of this new edition has been completely updated to include current information on all aspects of basic and clinical immunology. The superbly drawn figures are now in full color, complemented by full color plates throughout the book. The text is further enhanced by the inclusion of numerous tables, special topic boxes and brief notes that provide interesting insights. At the end of each chapter, a self-test quiz allows students to monitor their mastery of major concepts, while a set of conceptual questions prompts them to extrapolate further and extend their critical thinking. Moreover, as part of the Academic Cell line of textbooks, Primer to The Immune Response, 2nd Edition contains research passages that shine a spotlight on current experimental work reported in Cell Press articles. These articles also form the basis of case studies that are found in the associated online study guide and are designed to reinforce clinical connections.

  • The Autoimmune Diseases

    • 5th Edition
    • M. Eric Gershwin + 1 more
    • English
    Since publication of the 4th Edition of The Autoimmune Diseases in 2006, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This fully revised 5th Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels and includes expanded coverage of autoinflammatory disease and autoimmune responses to tumors.

  • Clinical Chemistry, Immunology and Laboratory Quality Control

    A Comprehensive Review for Board Preparation, Certification and Clinical Practice
    • 1st Edition
    • Amitava Dasgupta + 1 more
    • English
    All pathology residents must have a good command of clinical chemistry, toxicology, immunology, and laboratory statistics to be successful pathologists, as well as to pass the American Board of Pathology examination. Clinical chemistry, however, is a topic in which many senior medical students and pathology residents face challenges. Clinical Chemistry, Immunology and Laboratory Quality Control meets this challenge head on with a clear and easy-to-read presentation of core topics and detailed case studies that illustrate the application of clinical chemistry knowledge to everyday patient care. This basic primer offers practical examples of how things function in the pathology clinic as well as useful lists, sample questions, and a bullet-point format ideal for quick pre-Board review. While larger textbooks in clinical chemistry provide highly detailed information regarding instrumentation and statistics, this may be too much information for students, residents, and clinicians. This book is designed to educate senior medical students, residents, and fellows, and to "refresh" the knowledge base of practicing clinicians on how tests are performed in their laboratories (i.e., method principles, interferences, and limitations).

  • Nanoparticles and the Immune System

    Safety and Effects
    • 1st Edition
    • Diana Boraschi + 1 more
    • English
    Nanoparticles and the Immune System provides a reference text for toxicologists, materials scientists and regulators and covers the key issues of interaction of nanomaterials with the immune system. The book discusses several issues that toxicologists and regulators need to know: identification of endpoints that are relevant for assessing hazard, evaluating impact on immunologically frail populations, and how to evaluate chronic/cumulative effects. In addition, the book addresses the possibility of turning the immunomodulating properties of certain nanomaterials to our advantage for amplifying immune responses in certain diseases or preventive strategies (e.g. vaccination).

  • Autoantibodies

    • 3rd Edition
    • Yehuda Shoenfeld + 2 more
    • English
    Autoimmune diseases are characterized by the occurrence of antibodies reacting with self-constituents of the body. The fully updated third edition of Autoantibodies is an in-depth review of the main autoantibodies identified up to now, with particular emphasis on those that display a diagnostic or prognostic clinical value. The new edition covers recent scientific advances, diagnostic techniques, and therapeutic technologies. Each chapter is focused on a single family of autoantibodies. This important reference contains historical notes, definitions, origins and sources of antigens recognized genetic associations, mediated pathogenic mechanisms, methods of detection, as well as clinical utility (disease prevalence and association, diagnostic value, sensitivity and specificity, prognostic value). This is an ideal reference for anyone involved in the field of autoimmune diseases.

  • Biological DNA Sensor

    The Impact of Nucleic Acids on Diseases and Vaccinology
    • 1st Edition
    • Ken Ishii + 1 more
    • English
    Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete and concise picture on the topic so you can understand this area of study and make more informed choices for your respective research needs. Chapters are authored by researchers who are renowned for their research focus, ensuring that this book provides the most complete views on the topics.

  • Mims' Pathogenesis of Infectious Disease

    • 4th Edition
    • Anthony A. Nash + 3 more
    • English
    The newly revised edition of this work provides an up-to-date description of the mechanisms of infection and disease production in a clear and logical manner. Dealing in an integrated manner with all microorganisms, the factors common to all infectious diseases are set out. Molecular biology, pathology, and immunology are brought together to explain how an infectious agent causes disease, and how the body reacts to it.

  • Antibody Techniques

    • 1st Edition
    • Vedpal S. Malik + 1 more
    • English
    The applicability of immunotechniques to a wide variety of research problems in many areas of biology and chemistry has expanded dramatically over the last two decades ever since the introduction of monoclonal antibodies and sophisticated immunosorbent techniques. Exquisitely specific antibody molecules provide means of separation, quantitative and qualitative analysis, and localization useful to anyone doing biological or biochemical research.This practical guide to immunotechniques is especially designed to be easily understood by people with little practical experience using antibodies. It clearly presents detailed, easy-to-follow, step-by-step methods for the widely used techniques that exploit the unique properties of antibodies and will help researchers use antibodies to their maximum advantage.

  • Calcium Disorders

    Butterworths International Medical Reviews: Clinical Endocrinology
    • 1st Edition
    • David Heath + 1 more
    • English
    Clinical Endocrinology 2: Calcium Disorders presents an extensive examination of the treatment of postmenopausal and senile osteoporosis. It discusses the acquired disorders of vitamin D metabolism. It addresses the prevention of osteoporosis. Some of the topics covered in the book are the classification of rickets; mechanisms of homeostasis; transepithelial transport of phosphate anion; definition of mendelian rickets; treatment of; classification of androgens and synthetic anabolic agents; and assessment of parathyroid function. The measurement of parathyroid hormone is fully covered. An in-depth account of the indirect assessment of parathyroid activity is provided. The acquired disorders of Vitamin D metabolism are completely presented. A chapter is devoted to the aetiological views of rickets and osteomalacia. Another section focuses on the treatment and prevention of rickets and osteomalacia. The analysis of renal osteodystrophy, hypercalcemia, and familial hypocalciuric hypercalcemia are briefly covered. The book can provide useful information to doctors, endocrinologists, students, and researchers.

  • Interleukin-1 in the Brain

    • 1st Edition
    • Nancy J. Rothwell
    • English
    Interest in interleukin-1 (IL-1) has increased dramatically over the last decade, but has been largely restricted to immunologists, cell biologists and those studying inflammation and cancer. However, it has recently been recognized that the brain directly controls or modulates many aspects of immune function, while molecules classically associated with the immune system, such as interleukin-1, are synthesised within the brain and act directly on the central nervous system to modify local and systemic functions. Thus, this topic is relatively new to neurobiologists, and this book is the first comprehensive description of current knowledge on interleukin-1 in the brain, including its location, synthesis and receptors, actions on behaviour, fever, metabolism, neuroendocrine function, electrical activity of the brain, nerve growth factor, and relationship to clinical indications. The book is organised into three sections. The first reviews the data available on the neural localisation of IL-1 and the nature of its central receptors. The main part of the book examines the different neural effects of IL-1 and the mechanisms which are involved in these actions, comparing IL-1 where possible to other inflammatory cytokines which also have neurotrophic effects. The final section evaluates the possible role of IL-1 in neural plasticity and neuronal degeneration.

  • A History of Modern Immunology

    The Path Toward Understanding
    • 1st Edition
    • Zoltan A. Nagy
    • English
    A History of Modern Immunology: A Path Toward Understanding describes, analyzes, and conceptualizes several seminal events and discoveries in immunology in the last third of the 20th century, the era when most questions about the biology of the immune system were raised and also found their answers. Written by an eyewitness to this history, the book gives insight into personal aspects of the important figures in the discipline, and its data driven emphasis on understanding will benefit both young and experienced scientists. This book provides a concise introduction to topics including immunological specificity, antibody diversity, monoclonal antibodies, major histocompatibility complex, antigen presentation, T cell biology, immunological tolerance, and autoimmune disease. This broad background of the discipline of immunology is a valuable companion for students of immunology, research and clinical immunologists, and research managers in the pharmaceutical and biotechnology industries.

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