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Elsevier

Primer to the Immune Response

  • 2nd Edition - December 23, 2013
  • Latest edition
  • Authors: Tak W. Mak, Mary E. Saunders, Bradley D. Jett
  • Language: English

Written in the same engaging conversational style as the acclaimed first edition, Primer to The Immune Response, 2nd Edition is a fully updated and invaluable resource for c… Read more

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Description

Written in the same engaging conversational style as the acclaimed first edition, Primer to The Immune Response, 2nd Edition is a fully updated and invaluable resource for college and university students in life sciences, medicine and other health professions who need a concise but comprehensive introduction to immunology. The authors bring clarity and readability to their audience, offering a complete survey of the most fundamental concepts in basic and clinical immunology while conveying the subject’s fascinating appeal.

The content of this new edition has been completely updated to include current information on all aspects of basic and clinical immunology. The superbly drawn figures are now in full color, complemented by full color plates throughout the book. The text is further enhanced by the inclusion of numerous tables, special topic boxes and brief notes that provide interesting insights. At the end of each chapter, a self-test quiz allows students to monitor their mastery of major concepts, while a set of conceptual questions prompts them to extrapolate further and extend their critical thinking. Moreover, as part of the Academic Cell line of textbooks, Primer to The Immune Response, 2nd Edition contains research passages that shine a spotlight on current experimental work reported in Cell Press articles. These articles also form the basis of case studies that are found in the associated online study guide and are designed to reinforce clinical connections.

Key features

  • Complete yet concise coverage of the basic and clinical principles of immunology
  • Engaging conversational writing style that is to the point and very readable
  • Over 200 clear, elegant color illustrations
  • Comprehensive glossary and list of abbreviations

Readership

Undergraduate medical students and graduate students taking the following courses: Introduction to Immunology, Immunology, Clinical Immunology, Medical Immunology, Medical Microbiology, Microbiology and Immunology, and Immunology and Disease

Table of contents

Part I: Basic Immunology

1. Introduction to the Immune Response
Abstract
A Historical Orientation
B The Nature of the Immune Response
C Types of Immune Responses: Innate and Adaptive
D Interplay between the Innate and Adaptive Responses
E Clinical Immunology
Would You Like To Read More?


2. Components of the Immune System
A Cells of the Immune System
B How Leukocytes Communicate
C Lymphoid Tissues
D Cellular Movement in the Immune System


3. Innate Immunity
A Non-Inducible Innate Mechanisms
B Inducible Innate Mechanisms


4. The B Cell Receptor: Proteins and Genes
A Immunoglobulin Proteins
B Immunoglobulin Genes
C Antibody–Antigen Interaction


5. B Cell Development, Activation and Effector Functions
A B Cell Development: Maturation Phase
B B Cell Development: Differentiation Phase
C Effector Functions of Antibodies
D Immunoglobulin Isotypes in Biological Context
E Sources of Laboratory and Clinical Antibodies


6. The Major Histocompatibility Complex
A Overview of the Major Histocompatibility Complex
B MHC Class I and Class II Proteins
C MHC Class I and Class II Genes
D Physiology of the MHC


7. Antigen Processing and Presentation
A Overview of Antigen Processing and Presentation
B Nature of Cells That Can Activate T Cells
C Major Antigen Processing and Presentation Pathways
D Other Methods of Antigen Presentation


8. The T Cell Receptor: Proteins and Genes
A TCR Proteins and Associated Molecules
B TCR Genes
C TCR–Antigen Interaction


9. T Cell Development, Activation and Effector Functions
A T Cell Development
B T Cell Activation
C Th Cell Differentiation and Effector Function
D Tc Cell Differentiation and Effector Function
E Termination of Effector T Cell Responses
F Memory T Cells


10. Regulation of Immune Responses in the Periphery
A Lymphocyte Tolerance in the Periphery
B Regulation of Lymphocyte Responses in the Periphery
C Special Tolerance Situations
D Experimental Tolerance


11. NK, γδ T and NKT Cells
A Natural Killer (NK) Cells
B γδ T Cells
C NKT Cells


12. Mucosal and Cutaneous Immunity
A Mucosal Immunity
B Cutaneous Immunity

Part II: Clinical Immunology

13. Immunity to Infection
A General Features of Host–Pathogen Encounters
B Immunity to Extracellular Bacteria
C Immunity to Intracellular Bacteria
D Immunity to Viruses
E Immunity to Parasites
F Immunity to Fungi
G Prions


14. Vaccination
A Introduction
B Vaccine Design
C Types of Vaccines
D Adjuvants and Delivery Vehicles
E Prophylactic Vaccines
F Vaccines in the Real World
G Future Directions


15. Immunodeficiency
A Primary Immunodeficiency
B HIV Infection and Acquired Immunodeficiency Syndrome (AIDS)


16. Tumor Immunology
A Tumor Biology
B Tumor Antigens
C Immune System Function in the Tumor Microenvironment
D Conventional Cancer Therapy
E Immunotherapy


17. Transplantation
A The Nature of Transplantation
B The Molecular Basis of Graft Rejection
C Solid Organ Transplantation
D Minimizing Graft Rejection
E Hematopoietic Stem Cell Transplantation
F Blood Transfusions


18. Immune Hypersensitivity
A Type I Hypersensitivity: IgE-Mediated or Immediate
B Type II Hypersensitivity: Direct Antibody-Mediated Cytotoxic Hypersensitivity
C Type III Hypersensitivity: Immune Complex-Mediated Hypersensitivity
D Type IV Hypersensitivity: Delayed Type or Cell-Mediated Hypersensitivity


19. Autoimmune Diseases
A What is an Autoimmune Disease?
B Mechanisms Underlying Autoimmune Diseases
C Examples of Autoimmune Diseases
D Determinants of Autoimmune Diseases
E Therapy of Autoimmune Diseases
F Autoinflammatory Disorders


20. Hematopoietic Cancers
A Overview of the Biology and Treatment of Hematopoietic Cancers
B Leukemias
C Myelomas
D Lymphomas

Appendix
A. Selected Landmark Discoveries in Immunology
B. Nobel Prizes Awarded for Work in Immunology
C. Comparative Immunology
D. Selected CD Markers
E. Cytokines, Chemokines and Receptors
F. Selected Immunological Techniques

I Experimental Techniques Using Antibodies
II The Polymerase Chain Reaction
III HLA Typing Techniques
IV Laboratory Mouse Strains

Review quotes

"This immensely useful book will be of great value to students studying immunology modules within a wide range of undergraduate programmes, as well as those with a biological background who are keen to update themselves..."—The Biologist,Vol 61, No 6

"…a great resource for college and university students in life sciences, medicine and other health professions who need a concise but comprehensive introduction to immunology…The content of this new edition has been updated to include current information on all aspects of basic and clinical immunology. Drawn figures are now in full color, complemented by full color plates throughout the book."—Anticancer Research 34, 2014

"Primer to The Immune Response contains all the essential knowledge the undergraduate and medical student needs to know on B cell development, activation and effector functions."—Zhenyu Hao, University of Toronto"Medical students, in particular, will find it a valuable guide and friendly companion in finding their way through the maze of complications surrounding the autoimmune diseases."—Noel Rose, Director, Johns Hopkins Center for Autoimmune Disease Research

Product details

  • Edition: 2
  • Latest edition
  • Published: January 28, 2014
  • Language: English

About the authors

TM

Tak W. Mak

Tak W. Mak is the Director of the Campbell Family Institute for Breast Cancer Research in the Princess Margaret Hospital, Toronto, Canada, and a University Professor in the Departments of Medical Biophysics and Immunology, University of Toronto. He was trained at the University of Wisconsin in Madison, the University of Alberta, and the Ontario Cancer Institute. He gained worldwide prominence in 1984 as the leader of the team that first cloned the genes of the human T cell antigen receptor. His group went on to create a series of genetically altered mice that have proved critical to understanding intracellular programs governing the development and function of the immune system, and to dissecting signal transduction cascades in various cell survival and apoptotic pathways. His current research remains centered on mechanisms of immune recognition/regulation, malignant cell survival/death, inflammation in autoimmunity and cancer, and metabolic adaptation in tumor cells. Dr. Mak has published over 700 papers and holds many patents. He has been granted honorary doctoral degrees from universities in North America and Europe, is an Officer of the Orders of Canada and Ontario, and has been elected a Foreign Associate of the National Academy of Sciences (U.S.), a Fellow of the Royal Society of London (U.K.), and a Fellow of the AACR Academy. Dr. Mak has won international recognition as the recipient of the Emil von Behring Prize, the King Faisal International Prize for Medicine, the Gairdner Foundation International Award, the Sloan Prize of the General Motors Cancer Foundation, the Novartis Prize in Immunology, the Robert Noble Prize, the Killam Prize, the Stacie Prize, the McLaughlin Medal, and the Paul Ehrlich and Ludwig Darmstaedter Prize.
Affiliations and expertise
The Campbell Family Institute for Breast Cancer Research, Ontario, Canada

MS

Mary E. Saunders

Mary E. Saunders holds the position of Scientific Editor for the Campbell Family Institute for Breast Cancer Research, Toronto, Canada. She completed her B.Sc. degree in Genetics at the University of Guelph, Ontario, and received her Ph.D. in Medical Biophysics at the University of Toronto. Dr. Saunders works with Dr. Mak and members of his laboratory on the writing and editing of scientific papers for peer-reviewed journals as well as on various grant applications and book projects. She takes pride and pleasure in producing concise, clear, highly readable text and making complex scientific processes readily understandable.
Affiliations and expertise
The Campbell Family Institute for Breast Cancer Research, Ontario, Canada

BJ

Bradley D. Jett

Bradley D. Jett is the James Hurley Professor of Biology at Oklahoma Baptist University (OBU) in Shawnee, Oklahoma, USA. He completed his B.S. degree in Biology from OBU, followed by his Ph.D. in Microbiology and Immunology from the University of Oklahoma College of Medicine. After a postdoctoral fellowship at Washington University in St. Louis, Missouri, he joined the faculty at the University of Oklahoma College of Medicine. His research interests are primarily focused on host-parasite relationships. Much of his published work relates to the virulence factors of Gram-positive bacteria such as Enterococcus, Staphylococcus and Bacillus, as well as the host immunological responses to these infections. In his current full-time, undergraduate teaching position at his alma mater, he has been awarded Oklahoma Baptist University’s Promising Teacher Award and the Distinguished Teaching Award.
Affiliations and expertise
Oklahoma Baptist University, Oklahoma, USA

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