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Advances in Immunology
1st Edition - December 31, 2013
Editor: Frederick W. Alt
Hardback ISBN:9780128001004
9 7 8 - 0 - 1 2 - 8 0 0 1 0 0 - 4
eBook ISBN:9780128002575
9 7 8 - 0 - 1 2 - 8 0 0 2 5 7 - 5
Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the… Read more
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Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.
Informs and updates on all the latest developments in the field
Contributions from leading authorities and industry experts
Immunologists and infectious disease specialists, cell biologists and hematologists
Contributors
Chapter One. Multifarious Determinants of Cytokine Receptor Signaling Specificity
Abstract
1 Introduction
2 Ligand–Receptor Complex Formation: Geometry and Affinity
3 Receptor Dynamics and Endosomal Trafficking
4 Intracellular Protein Levels and Signaling Activation
5 Tuning Cytokine Signaling via Protein Engineering
6 Perspectives
Acknowledgments
References
Chapter Two. Pathogenic Mechanisms of Bradykinin Mediated Diseases: Dysregulation of an Innate Inflammatory Pathway
Abstract
1 Introduction
2 Contact Activation: Factor XII-Dependent Initiation of Bradykinin Formation
3 Assembly on Cell Surfaces: Binding of HK to HUVEC
4 Binding of Factor XII to HUVEC
5 Interaction of gC1qR, Cytokeratin 1, and u-PAR Within HUVEC Cell Membranes
6 Binding to Other Cells
7 Activation of the Kinin Cascade: The Role of Endothelial Cells
8 Inhibition of Contact Activation
9 Inactivation of Bradykinin
10 Further Considerations of the Initiating Site for Bradykinin Formation: Evidence That the PK–HK Complex has Enzymatic Activity
11 Hereditary Angioedema (Types I and II = C1 Inhibitor Deficiency)
12 Bradykinin Formation When C1 INH is Absent/Dysfunctional
13 Type III HAE
14 New Modalities for Treatment of HAE
15 Proteoglycan-Dependent Activation of Factor XII: Theoretical Mechanisms for Bradykinin Production in “Allergic” Diseases; Particularly Anaphylaxis, Chronic Spontaneous Urticaria, and Rhinitis/Asthma
16 Activation of Factor XII by Aggregated Proteins
References
Chapter Three. The Role of Short-Chain Fatty Acids in Health and Disease
Abstract
1 Introduction
2 SCFA Sensing and Signal Transduction
3 Varied Functions of SCFAs
4 Integrative View of the Gut Microbiota, SCFAs, and Disease
5 Perspective
References
Chapter Four. Combined Immunodeficiencies with Nonfunctional T Lymphocytes
Abstract
1 Introduction
2 Immunodeficiency Phenotypes due to Hypomorphic Mutations in SCID-Associated Genes
3 Other Combined Immunodeficiencies with Dysfunctional T Cells
4 Conclusions
References
Chapter Five. The CD200–CD200R1 Inhibitory Signaling Pathway: Immune Regulation and Host–Pathogen Interactions
Abstract
1 Inhibitory Receptors
2 The Inhibitory Receptor CD200R1
3 Perspective
Acknowledgments
References
Chapter Six. Immunopathogenesis of Neuromyelitis Optica
Abstract
1 Introduction
2 Aquaporin-4 Antibodies
3 Innate Immunity
4 Adaptive Immunity
5 Summary
Acknowledgments
References
Index
Contents of Recent Volumes
No. of pages: 276
Language: English
Published: December 31, 2013
Imprint: Academic Press
Hardback ISBN: 9780128001004
eBook ISBN: 9780128002575
FA
Frederick W. Alt
Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.
Affiliations and expertise
Investigator and Director, Program in Cellular and Molecular Medicine, Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA