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Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wi… Read more
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ContributorsChapter One: Regulation of Immunoglobulin Class-Switch RecombinationAbstract
1 Overview of Genomic Alterations in B Cells
2 Initiation of CSR: S Regions and Germline Transcription
3 Induction of DNA Lesions in CSR: Essential Requirement of AID
4 Processing of Deaminated DNA: Requirements for BER and MMR Proteins
5 Completion of CSR: Synapsis and End-Joining
6 AID Phosphorylation at Serine-38 and a Role Beyond DNA Deamination
7 Multifaceted Regulation of AID Expression and Activity
8 Targeting of AID to the Ig Loci
9 AID Activity Beyond the Ig Loci
10 Perspectives
Acknowledgments
Chapter Two: Two Forms of Adaptive Immunity in VertebratesAbstract
1 Introduction
2 Discovery of VLR
3 Structure of VLR Proteins and Genes
4 Functions of VLR and Lymphocyte Lineages
5 Interplay of VLRB and the Complement System
6 Similarities and Differences in the Two Forms of Adaptive Immunity
7 Evolution of Antigen Receptors
8 Concluding Remarks
Acknowledgments
Chapter Three: Recognition of Tumors by the Innate Immune System and Natural Killer CellsAbstract
1 Introduction
2 Innate Cells and Effector Molecules in Tumor Surveillance
3 Germline-Encoded Receptors Implicated in Tumor Surveillance
4 The Immunogenicity of Cancer: How Alterations Common to Cancer Can Result in Detection by Innate Immune Cells
5 Interplay Between Tumors and Innate Lymphocytes
6 Concluding Remarks
Acknowledgments
Chapter Four: Signaling Circuits in Early B-Cell DevelopmentAbstract
1 Introduction
2 Moving from the pro-B to the pre-B Stage
3 The Interleukin 7 Receptor
4 The preBCR and Its Autonomous Signaling
5 Lessons from Transgenic and Knockout Mouse Studies
6 Signaling Pathways Controlling pre-B-Cell Expansion
7 The Switch from Proliferation to Differentiation
8 pre-B Cells and Tumors
9 Perspectives
Acknowledgments
Chapter Five: Interleukin 10 Receptor SignalingAbstract
1 Introduction
2 IL10 and IL10 Receptor Expression and Regulation
3 Down-stream Signaling Through the IL10 Receptor
4 Regulation of Intestinal Immune Responses by IL10 in Murine Models
5 Regulation of Mucosal Homeostasis by IL10 Receptor Signaling in Mice
6 IL10-Dependent Signaling Shapes the Intestinal Microbiome
7 Impact of IL10 and IL10R Signaling Defects in Humans
8 Conclusions
Acknowledgments
Chapter Six: Development of Mast Cells and Importance of Their Tryptase and Chymase Serine Proteases in Inflammation and Wound HealingAbstract
1 Introduction
2 Development of MCs
3 Secretory Granule Proteases of Human and Mouse MCs
4 MC Involvement in Wound Healing
5 Conclusions and Therapeutic Directions
Acknowledgments
Chapter Seven: Why Does Somatic Hypermutation by AID Require Transcription of Its Target Genes?Abstract
1 The Basic Process of Somatic Hypermutation Before AID
2 History and Structure of AID
3 Control of Expression and Function of AID
4 Is RNA an AID Target?
5 Properties of AID Target Genes
6 SHM of Non-Ig Genes
7 SHM Versus CSR
8 A Revised Model for AID Function in SHM
9 Concluding Remarks
Acknowledgments
IndexContents of Recent Volumes
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