Interleukin-1 in the Brain
- 1st Edition - October 26, 1992
- Imprint: Pergamon
- Editor: Nancy J. Rothwell
- Language: English
- eBook ISBN:9 7 8 - 1 - 4 8 3 2 - 8 7 7 6 - 8
Interest in interleukin-1 (IL-1) has increased dramatically over the last decade, but has been largely restricted to immunologists, cell biologists and those studying inflammation… Read more
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Request a sales quoteInterest in interleukin-1 (IL-1) has increased dramatically over the last decade, but has been largely restricted to immunologists, cell biologists and those studying inflammation and cancer. However, it has recently been recognized that the brain directly controls or modulates many aspects of immune function, while molecules classically associated with the immune system, such as interleukin-1, are synthesised within the brain and act directly on the central nervous system to modify local and systemic functions. Thus, this topic is relatively new to neurobiologists, and this book is the first comprehensive description of current knowledge on interleukin-1 in the brain, including its location, synthesis and receptors, actions on behaviour, fever, metabolism, neuroendocrine function, electrical activity of the brain, nerve growth factor, and relationship to clinical indications. The book is organised into three sections. The first reviews the data available on the neural localisation of IL-1 and the nature of its central receptors. The main part of the book examines the different neural effects of IL-1 and the mechanisms which are involved in these actions, comparing IL-1 where possible to other inflammatory cytokines which also have neurotrophic effects. The final section evaluates the possible role of IL-1 in neural plasticity and neuronal degeneration.
For neurobiologists and all those with an interest in cytokines in general and interleukin-1 in particular.
Foreword. Location of interleukin-1 in the nervous system, M. Schultzberg. Brain interleukin-1 receptors: mapping, characterization and modulation, F. Haour et al. Interleukin-1&Bgr; activation of the central nervous system, P. E. Gottschall et al. Electrophysiological studies of the effects of Interleukin-1 and &agr;-interferon on the EEG and pituitary-adrenocortical activity, D. Saphier. The immune-hypothalamo-pituitary adrenal axis: its role in immunoregulation and tolerance to self-antigens, F. Berkenbosch et al. The pyrogenic action of cytokines, C. M. Blatteis. Metabolic responses to interleukin-1, N. J. Rothwell. Behavioural effects of cytokines, R. Dantzer et al. Interleukin-1 involvement in the regulation of sleep, M. R. Opp & J. M. Krueger. Regulation of the synthesis of nerve growth factor (NGF) by interleukin-1 (IL-1): facts and questions, M. Meyer et al. Cytokines and neuronal degeneration, E. E. Wollman et al. Index.
- Edition: 1
- Published: October 26, 1992
- No. of pages (eBook): 0
- Imprint: Pergamon
- Language: English
- eBook ISBN: 9781483287768
NR
Nancy J. Rothwell
Affiliations and expertise
University of Manchester School of Biological Sciences, U.K.Read Interleukin-1 in the Brain on ScienceDirect