Journals in Toxicology
Journals in Toxicology
Life Sciences
Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed.The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.Manuscripts should present novel preclinical findings addressing questions of biological significance to human disease. Studies that fail to do so may be rejected without review. Quantitative conclusions must be based on truly quantitative methods. Life Sciences does not publish work on the actions of biological extracts of unknown chemical composition. Compounds studied must be of known chemical structure and concentration. The study must be reproducible; materials used must be available to other researchers so they can repeat the experiment. Clinical studies may be considered if they expand understanding of mechanism, but the journal does not encourage clinical trial reports.Four common reasons for rejection include: out of scope (the manuscript does not conform to the goal of identification of mechanisms related to therapy for human disease); too preliminary (manuscript is based on a limited amount of experimental data diminishing significance); lack of novelty (manuscript is well done but does not address a significant question); unidentified structure (actions of biological extracts of unknown chemical composition).- ISSN: 0024-3205
Research in Social and Administrative Pharmacy
Widely recognized journal of the International Collaboration of Pharmacy Journal Editors (ICPJE) in comportment with the Granada Statements, Research in Social and Administrative Pharmacy (RSAP) publishes high-quality, peer-reviewed content in health services research specifically as it relates to some aspects of the medication use process. The medication use process includes (but is not limited to) the prescribing, preparation, dispensing, administration, adherence to, evaluation, monitoring, and outcomes associated with legend or with over-the-counter medications, incorporating the concept of clinical pharmacy which optimize utilization of medicines to achieve person-centered and public health goals. The medication use process includes attitudes, perspectives, knowledge, and behaviors of any actor in this process, including prescribers, pharmacists, pharmacy personnel, other health practitioners, patients, and caregivers.In twelve issues per year, RSAP features original scientific reports, comprehensive review articles, proposed models, and provocative commentaries in the social and administrative pharmaceutical sciences.Topics of interest outcomes evaluation of drug products programs, or services pharmacoepidemiology medication adherencedisease managementmedication use policydrug marketingevaluation of educational paradigms that could impact practice and/or patient behaviorother topics related to public health in the context of pharmacy or medication use.RSAP proffers new models to guide existing research, make methodological arguments, or describe the results of rigorous theory-building research. Practice and education research are considered, with preference given to papers evaluating theoretical constructs and to those that might shape policy.The International Collaboration of Pharmacy Journal Editors - ICPJE The ICPJE shares commonalities and goals to improve the medication use process and the outcomes emanating from this endeavor. The ICPJE refers to ‘pharmacy’ as the medication use process. However, research articles, reviews, and commentaries, can refer to any actor involved, as well as any evaluation (e.g. pharmaceoepidemiolog... of the drug products themselves or systems employed, to optimize the use process. Each journal of the ICPJE has an established niche and is optimally suited for certain types of manuscripts.- ISSN: 1551-7411
Toxicology
Affiliated with the German Toxicology SocietyToxicology as a multidisciplinary, data-rich field has witnessed the availability of a cutting-edge technologies to investigate mechanisms underlying adverse consequences of exposures to xenobiotic chemicals, particularly as it relates to human health. Toxicology fully embraces these advancements by serving as a hub for exchange of information regarding state-of-the-art developments in the broad field of contemporary toxicology. Journal scope emphasis is on human-relevant and mechanistic research at all levels of biological organization, ranging from the molecular scale to the organismal level. The publication priority for Toxicology is on original high-quality research and review papers on any topic relevant to toxicology, in particular related to hazard identification, all that are subject to rigorous peer-review. The Toxicology target audience includes undergraduates to full professionals in academic, industrial and regulatory settings in any part of the world.Notes from the EditorsIn order to support interpretation of published findings to human health, the journal requires inclusion of specific statements within the ABSTRACT and METHODS sections of each submitted article:ABSTRACT:The experimental system (e.g., in vivo species, cell culture, etc.) including the exposure dose or concentration and duration that produces an effect, if an effect is observed, must be described in the ABSTRACT to the manuscript.MATERIALS AND METHODS:The relevance of the experimental system and exposure dose or concentration and duration in terms of potential human exposures must be described in the Materials and Methods section of the manuscript. Justification of the exposure cannot be based solely on previous publications, but rather the comparison must be to either estimated, anticipated, or measured human exposures.The authors must identify the chemicals by CAS number, their source and purity; the method of randomization for group sampling, the number of experimental sample replicates in each treatment group, and provide a proper description of the statistical analysis of data that was employed.Journal Policy:TOXICOLOGY does not publish results from exposures to uncharacterized chemical mixtures or extracts from natural products. All exposures must be fully characterized analytically. Justification for this policy is that it is near impossible for other investigators to replicate findings of a study wherein the chemical composition of the exposure is not completely characterized.TOXICO... does not publish purely descriptive safety studies or studies describing the therapeutic efficacy of cytotoxic agents without strong emphasis on end-points relating to a proposed mechanism of toxicity.- ISSN: 0300-483X
Reproductive Toxicology
Reproductive Toxicology is affiliated with the European Teratology SocietyDrawing from a large number of disciplines, Reproductive Toxicology publishes timely, original research on the influence of chemical and physical agents on reproduction. Written by and for obstetricians, pediatricians, embryologists, teratologists, geneticists, toxicologists, andrologists, and others interested in detecting potential reproductive hazards, the journal is a forum for communication among researchers and practitioners. Articles focus on the application of in vitro, animal and clinical research to the practice of clinical medicine.All aspects of reproduction are within the scope of Reproductive Toxicology, including the formation and maturation of male and female gametes, sexual function, the events surrounding the fusion of gametes and the development of the fertilized ovum, nourishment and transport of the conceptus within the genital tract, implantation, embryogenesis, intrauterine growth, placentation and placental function, parturition, lactation and neonatal survival.Adverse reproductive effects in males will be considered as significant as adverse effects occurring in females. To provide a balanced presentation of approaches, equal emphasis will be given to clinical and animal or in vitro work.Typical end points that will be studied by contributors include:InfertilityS... dysfunctionSpontaneo... abortionMalformation... histogenesisStillbir... growth retardationPrematuri... abnormalitiesPerinat... mortality- ISSN: 0890-6238
Toxicology in Vitro
Affiliated with the American Association for Cellular and Computational Toxicology and the European Society for Toxicology in Vitro.Toxicology in Vitro publishes original research papers, reviews and workshop reports focusing on the application and use of in vitro and in silico systems for toxicological evaluations (collectively described as New Approach Methodologies (NAM)). This includes the utilisation or the development of NAMs for assessing the potential adverse effects of chemicals for human safety assessment. In vitro techniques include primary cells, tissue slices, cell lines and stem cells (adult, embryonic and induced Pluripotent cells) or subcellular preparations thereof. Our journal strongly supports the Reduction, Refinement and Replacement (3R) of animals in toxicology evaluations.This is a wide topic and thus we have certain preferences including:Developmen... of in vitro techniques and their application to research and regulatory use (i.e. 3R principle.Mechanisti... underpinning of data.Ability to translate outcome to human safety assessment.We strongly encourage :The use of normal (non-transformed) human cells (where appropriate).Reporti... the Short Tandem Repeat (STR) profile of the cells used (especially when cells have been provided as a gift or generated in house).Free access to raw (or primary) data.Appropriate model characterisation.The use (or reduction) of animal free components, including serum. [Especially when the system was already developed under such conditions, such as the HK-2 cell line].Attention to detailed methodology and appropriate statistics. [Readers need to know how you did the experiment, how many times, how many replicates etc?]Reporting the source of the compounded tested, catalogue no. and lot no. Where the chemical has been purified or synthesised a full analytical report is expected.Quantificat... of compounds in exposure medium and/or cells over time (biokinetics).We do not accept solely in vivo investigations and rarely accept animal in vivo, in vitro hybrid papers, except where the animal data was critical in the interpretation or validation of the in vitro data (and not merely confirmatory).We generally discourage investigations relating:Unidentifie... mixtures - for example in plant extracts.Solely pharmacological investigations (e.g. demonstrating your chemical kills cancer cells in vitro is not generally acceptable).Use of non-human cells when human equivalents exist and are available.The lack of adherence to established protocols, without direct explanation.Reportin... cytotoxicity alone, with no mechanistic underpinning and/or no estimation of chemical exposure.- ISSN: 0887-2333
Food and Chemical Toxicology
Affiliated with the Chinese Society of ToxicologyFood and Chemical Toxicology (FCT) is an internationally renowned journal that publishes original research articles and reviews on toxic effects and toxic mechanisms of natural or synthetic chemicals occurring in the human environment (present in food and/or the human environment). The scope of the journal includes drugs, consumer chemicals/products (e.g. cosmetics); agricultural chemicals/products (e.g. pesticides) and industrial chemicals (e.g relevant to occupational exposure). Areas such as safety evaluation of novel foods and ingredients, biotechnologically-d... products and nanomaterials are included in the scope of the journal. In these cases, a comprehensive characterisation of the materials under evaluation is necessary. FCT also encourages submission of papers on inter-relationships between nutrition and toxicology and on in vitro techniques, particularly those fostering the 3 Rs.In addition, the journal also publishes Special Issues focussed on selected subject areas. These issues typically involve new areas of interest or concern and there will be some flexibility in the papers considered in terms of scope.The principal aim of the journal is to publish high impact, scholarly work and to serve as a multidisciplinary forum for research in Toxicology. Papers submitted will be judged on the basis of scientific originality and contribution to the field, quality and subject matter.Contributors who do not heed the requirements outlined in the instructions to authors and Editorials risk manuscript rejection without further consideration.Studie... should address at least one of the following:Adverse physiological/bioche... or pathological changes induced by specific defined substances,New techniques for assessing potential toxicity,Mechanisms underlying toxic phenomena,Toxicologi... examinations of specific chemicals or consumer products, both those showing adverse effects and those demonstrating safety, that meet current standards of scientific acceptability.Author... must clearly and briefly identify what novel toxic effect (s) or toxic mechanism (s) of the chemical are being reported and what their significance is in the abstract.Studies that consider time- and dose-response effects are likely to be considered more reliable and therefore considered more favourably.Manuscrip... describing research involving the following areas will not be considered:materials... of only local interest,materials/s... for which the chemical composition is not clearly defined,only pharmacological properties or potentially beneficial effects, chemical analyses of toxins in foods without addressing the toxic implication to humans [i.e. a risk assessment should be included],unrealisti... human doses, inappropriate route(s) of exposure, or in vitro experiments that do not reflect serum levels in humans without a compelling justification.FCT is committed to the highest standards. Only papers that have not been previously published, that fit in the above-mentioned scope, and which have been reviewed by experts in the field prior to publication will be considered for eventual publication. Cover letters must be included and state that the manuscript is new and original and not under consideration for publication elsewhere. Co-authors should be individuals who have contributed substantially to the content of the papers. All authors must declare any potential conflict of interest and all financial support.Any papers offered re-submission after review must contain a separate letter containing a response to all the points raised by the Editors and reviewers.- ISSN: 0278-6915
Toxicology Letters
Official Journal of EUROTOXAffiliated with Austrian Society of ToxicologyAn international journal for the rapid publication of novel reports on a range of aspects of toxicology, especially mechanisms of toxicity.Toxicology Letters serves as a multidisciplinary forum for research in toxicology. The prime aim is the rapid publication of research studies that are both novel and advance our understanding of a particular area. In addition to hypothesis-driven studies on mechanisms of mammalian toxicity, Toxicology Letters welcomes seminal work in the following areas:In silico toxicologyToxicokine... pharmacokinetic (PBPK) modelingSystems toxicologyPredictive toxicology3R research in toxicologyNew approach methodology (NAMs)Adverse outcome pathways (AOPs)Integrated testing strategiesSystematic and narrative reviews and mini-reviews in various areas of toxicology will be published. Clinical, occupational and safety evaluation, hazard and risk assessment, regulatory toxicology, impact on man, animal and environment studies of sufficient novelty to warrant rapid publication will be considered. Toxicology Letters also publishes editorials, commentaries and contemporary issues in toxicology.The following types of work are not within the scopes of Toxicology Letters:Ecotoxicolog... studiesCase studiesChemopreventi... studiesPharmacologic... investigationsAuthor... are advised to follow the ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments; https://arriveguidel... and the OECD guidance document on Good In Vitro Method Practices (GIVIMP; https://www.oecd.org... In vitro or in vivo investigations conducted at concentrations or doses of no relevance to human or animal exposure will not be considered. Routes of exposure other than those relevant to human or animal exposure need to be justified. Assessment of dose-response should be an integral component of any toxicological research report. Unless adequately justified, studies conducted at a single dose level may not be considered. Test materials must be chemically defined and characterized. Investigations of chemically undefined plant extracts or uncharacterized nanoparticles will not be considered.- ISSN: 0378-4274
Environmental Toxicology and Pharmacology
Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man.Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals.In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.- ISSN: 1382-6689
Toxicology and Applied Pharmacology
Toxicology and Applied Pharmacology publishes original scientific research of relevance to animals or humans pertaining to the action of chemicals, drugs, or chemically-defined natural products.Regular articles address mechanistic approaches to physiological, pharmacologic, biochemical, cellular, or molecular understanding of toxicologic/patholog... lesions and to methods used to describe these responses. Safety Science articles address outstanding state-of-the-art preclinical and human translational characterization of drug and chemical safety employing cutting-edge science. Highly significant Regulatory Safety Science articles will also be considered in this category. Papers concerned with alternatives to the use of experimental animals are encouraged.Short articles report on high impact studies of broad interest to readers of TAAP that would benefit from rapid publication. These articles should contain no more than a combined total of four figures and tables. Authors should include in their cover letter the justification for consideration of their manuscript as a short article.TAAP also issues a standing call for outstanding Invited Review Articles. Potential authors should contact the Editor-In-Chief and complete an Invited Review Proposal Form before preparing or submitting their Review Article.- ISSN: 0041-008X
NeuroToxicology
Affiliated with the International Neurotoxicology AssociationNeuroToxi... specializes in publishing peer-reviewed original research papers describing the effects of toxic substances on the nervous system across the lifespan as determined in humans and/or experimental models (in vivo, in vitro, in silico). The Journal welcomes papers dealing with the neurotoxic effects of occupationally and environmentally relevant exposures to agents (chemical, physical, biological, pharmacological or naturally occurring), singly or in mixtures, including complex mixtures, such as air pollution. Papers describing neurotoxic outcomes associated with natural disasters, industrial accidents, and terrorist attacks are also welcome.Experimental (animal, in vitro, in silico) papers focused on the neurotoxic effects of undefined commercial formulas (i.e., pesticide formulations) will be considered only if the authors report the chemical composition of the formulation and/or determine whether neurotoxic effects are due to the active chemical ingredient(s), carrier, or combination. For human studies, the components of formulations or other mixtures should be identified, but if not available, the source of exposure (i.e. commercial formulation, air pollution, wildfires, hurricanes, and other natural or industrial disasters) should be described as fully as possible.NeuroToxico... welcomes papers describing interventions for mitigating or reversing neurotoxic outcomes, but will accept papers reporting on neuroprotective or neurorestorative properties of formulations, botanical extracts, or other natural products only if full chemical identification and purification information of the active molecule(s) is provided. NeuroToxicology does not accept case reports.- ISSN: 0161-813X
