Antidiabetic Drug Discovery from Natural Products provides up-to-date and in-depth information, practical understanding, and guidance in a comprehensive, systematic and easy-to-understand manner to scientists, researchers, and graduate students on important and emerging biochemical topics related to current antidiabetic drug discovery research. This book analyzes and studies natural active substances and their medicinal chemistry in preventing and treating diabetes and its complications. It covers a wide range of critical issues to assist chemists in the discovery and development of safer, more affordable treatments, from identifying promising leads from medicinal plants to the extraction and synthesis of bioactive compounds.Following an introduction to bioactive chemical compounds from plants with antidiabetic effects, the book describes the discovery and extraction of antidiabetic drugs and antioxidants from natural sources. It also examines antidiabetic plants before delving deeper into the chemistry behind major medicinal substances and their derivatives like Mangiferin and Resveratrol, discussing both current and prospective uses.
Advances in Organometallic Chemistry, Volume 83, the latest release in this longstanding serial, is known for its comprehensive coverage of topics in organometallic synthesis, reactions, mechanisms, homogeneous catalysis, and more. Chapters in this new release include Pd-catalysis: a useful tool in the field of polymer synthesis. Recent advances and applications, Modern Mechanistic Approaches for the Depolymerization of Commodity Plastics via Homogeneous Metal Catalysis, Functionalization of fullerenes by transition metal catalyzed cyclization reactions, and Synergistic Metal-Ligand Reactivity in Half-Sandwich Complexes of Fe, Co, and Ni for Bond Activation and Catalysis.
Phytochemicals for Health presents the state of the art in the field of Phytochemicals. It highlights how, following the interactions of plants and the environment, an analytical approach for standardization and quality control is of fundamental importance to product quality control.Parts I and II cover the main problems relatied to natural products (plants, extraction, quantitative analysis, relationship with the surrounding environment). Part III presents the main classes of organic compounds identified and reported, and Part IV includes inorganic compounds. It also includes a chapter covering all the natural compounds that have become Active Principle Ingredients (API), highlighting next challenges.Phytochemicals for Health is a valuable tool for senior scientists working in natural products field interested in investigating the correlation between chemical profile and biological activity in order to obtain a product that is safe for human health.
Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry.Studies in Natural Products Chemistry, volume 84 covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.
Advances in Heterocyclic Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.
The Alkaloids: Chemistry and Biology, Volume 93, the latest release in a series that has been exploring the topic for over 60 years, delves into key aspects of alkaloid chemistry, biology, and pharmacology. This volume discusses the chemistry of quinoline and quinazoline alkaloids, guanidine alkaloids from marine sponges, the chemistry and biology of stemona alkaloids, and the chemistry and biology of pyrazole and indazole alkaloids.
Discovery and Development of Anti-Prostate Cancer Agents from Natural Products presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations. This new volume in the Natural Products Drug Discovery series focuses on molecules of natural origin and their synthetic analogues that show promising potential to act as anti-prostate cancer and chemotherapeutic agents. Combining foundational background information on cancer mechanisms with details of medicinal structures from natural products, this volume compiles the latest developments from across interdisciplinary fields.It will serve as a valuable resource for researchers working to discover promising leads for the development of novel pharmaceuticals for prostate cancer, highlighting several key structures from natural products and exploring possible future developments in the area.
Organic Syntheses Based on Named Reactions: A Practical Encyclopedic Guide to Over 800 Transformations, Fourth Edition is an indispensable reference companion for chemistry students and researchers. The book provides an overview of name reactions based on reaction types and products formed and presents schemes, procedures and references in a simple, one-page format that offers a brief, representative procedure for each name reaction. The book is illustrated with real synthetic examples from literature, with about 3,400 references to primary literature that direct users to additional information. Extensive indexes (name, reagent, reaction) and a very useful functional group transformation index help the reader fully navigate this extensive collection of important reactions.With its comprehensive coverage, superb organization and quality of presentation, this new edition belongs on the shelf of every organic chemist.
Basic to Modern Strategies of Synthetic Organic Chemistry offers fresh perspectives and interests to professionals engaged in organic synthesis in various fields. The book starts with sections for review and understanding of reactions and proceeds with more in-depth knowledge in organic synthesis, including examples of total synthesis. Sections provide a systematic learning of organic reactions, with a focus on the relatively simple yet somewhat complex approach to compound synthesis. Furthermore, this reference will serve as a useful resource for graduate students to enhance their understanding and review of organic chemistry and synthesis.It includes examples of total synthesis that helps pursuing further studies. Additionally, the book provides an introduction to environmental and economic considerations in synthesis, which has become an important issue in recent years, especially for those working in fine chemicals and the pharmaceutical industry. The book also introduces flow chemistry, along with an overview of the processes and equipment used.
Antimicrobial Peptides: A Roadmap for Accelerating Discovery and Development covers the most important efforts of scientists and engineers worldwide to accelerate the process of discovery, production, and eventual market penetration of more potent antimicrobial peptides. These efforts have been fueled by emerging technologies such as artificial intelligence and data science, molecular and CFD simulations, easy-to-use process simulation packages, microfluidics, 3D-printing, among many others. Such technologies can now be implemented and scaled up quickly and at relatively low cost in low-budget production facilities, critical to moving to sustainable and marketable products worldwide.Discovering novel antimicrobial peptides rationally and cost-effectively has emerged as one of the significant challenges of modern biotechnology. Thus far, this process has been tedious and costly, resulting in molecules with activities far below those needed to address the current challenge of microbial resistance to antibiotics that takes the lives of thousands of people around the world every year. Finally, the book also highlights how multidisciplinary teams have assembled to address the challenges of manufacturing, biological testing, and clinical trials to finally reach complete translation.