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Elsevier

Books in Life sciences

  • Handbook of Human Stress and Immunity

    • 1st Edition
    • Ronald Glaser + 1 more
    • English
    In 1964, George Solomon coined the term psychoneuroimmunolog... In the intervening 30 years, this term has emerged into a dynamic field of study which investigates the unique interactions between the nervous, endocrine, and immune systems. The Handbook of Human Stress and Immunity is a comprehensive reference for this dynamic new field. Focusing on how stressors impact the central nervous system and the resulting changes in immune responses, the Handbook is the first to describehow stress specifically affects human immune systems. It discusses how stress generally makes people more susceptible to infection, how personal support systems can counteract the physiological effects of stress, and how stress, or lack of stress, affects the aging process. Chapters are authored by the leading names in the field and cover such diseases as autoimmune disease, viral pathogenesis, herpes, HIV, and AIDS.

  • Clinical Immunobiology

    • 1st Edition
    • Volume 3
    • Fritz H. Bach + 1 more
    • English
    Clinical Immunobiology, Volume 3 covers a variety of methods used for assaying the immune status of an individual. This volume is composed of 21 chapters and begins with a presentation of the background and issues to which clinical tests would be applied. The succeeding chapters outline the methodological procedures used in the analyses. Other chapters present some examples of the kinds of data that can be generated with the procedures used and provide guidelines for interpretation of the tests. The remaining chapters discuss the value of the immunological test procedures in differential diagnosis and analysis of diseases. These chapters also explore the usefulness of these procedures in prognosis of disease and the consequences of immunological manipulation undertaken for treatment or prevention of disease. This book will be of great value to clinical immunobiologists, biochemists, and researchers.

  • Genetics and Biochemistry of Antibiotic Production

    • 1st Edition
    • Colin Stuttard + 1 more
    • English
    * Emphasizes the molecular genetics of antibiotic production * Provides the latest information on the organization of genes encoding the biosynthetic pathway * Explores the mechanisms governing their expression and regulation * Examines the role of resistance genes in protecting organisms from their own lethal productsGenetics and Biochemistry of Antibiotic Production brings together the most up-to-date information on the genetic and biochemical mechanisms involved in antibiotic production. A collection of internationally recognized authors provide the latest information on the organization, function and regulation of genes responsible for antibiotic synthesis in a range of bacteria. This unique book groups antibiotics according to their biosynthetic affiliation, providing a background into evolutionaryrelation... while raising intriguing questions about the raison d'etre of antibiotics in nature.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 17
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 17 is a six-chapter text that covers the most prevalent problems in lipoprotein mechanism research works. The opening chapters examine the metabolic role of high-density lipoproteins (HDL), specifically the role of HDL in cholesterol transport. The next chapter discusses cholesterol metabolism in various types of clinical hyperlipidemias and describes cholesterol turnover as a function of hypercholesterolemia... hypertriglyceridemia... or a combination of the two. Other chapters deal with the hypocholesterolemic effect of polyunsaturated fats on man, as well as the mechanism of lipid peroxidation in mitochondrial membranes and its effects on alterations in cellular processes. The closing chapter relates to membrane phenomena, with particular emphasis to the study of membrane structure by means of membrane-cooperative enzymes. This chapter also explores the application of allosterism as a tool for membrane research. This book will prove useful to lipid and enzyme chemists, biochemists, and researchers.

  • The Structure of Mitochondria

    • 1st Edition
    • E. A. Munn
    • English
    The Structure of Mitochondria provides an extensive account of the structure of mitochondria. This book illustrates the variety of mitochondrial structure revealed by electron microscopy of intact cells. Organized into nine chapters, this book begins with an overview of the application of electron microscopy to the study of the structure of cells and their mitochondria. This text then explains the short-term changes of the type revealed by phase contrast microscopy of living cells. Other chapters consider the rationale behind the procedures generally employed for the isolation of mitochondria and other sub-cellular components. This book discusses as well the important component of mitochondria. The final chapter describes the interesting similarities of mitochondria, chloroplasts, and bacteria and the bearing these have on the concept about the way in which the relationships between mitochondria and the rest of the eukaryotic cell have evolved. This book is a valuable resource for biologists, physiologists, and bacteriologists.

  • Immunological Tolerance

    A Reassessment of Mechanisms of the Immune Response
    • 1st Edition
    • Maurice Landy + 1 more
    • English
    Immunological Tolerance: A Reassessment of Mechanisms of the Immune Response presents the basic biological phenomena of immunological tolerance. This book discusses immunology as a critical field for the analysis of molecular features of mammalian cell genetics, biosynthesis, differentiation, and interactions among cell types. Organized into six chapters, this book begins with an overview of the relationship between antigen structure and its ability to induce tolerance. This text then examines the essentiality of antigen for the proliferation of activated antibody-forming clones and discusses the role of antibody in homeostasis and suppression. Other chapters consider the restoration and transfer of immunological responsiveness by thoracic duct lymphocytes. This book discusses as well the distribution of antigen in tissues and cells. The final chapter deals with the origin of carrier antibody and the significance of maternal transfer of antibodies and antigens. This book is a valuable resource for immunologists, microbiologists, scientists, and clinicians.

  • Guide to Biochemistry

    • 1st Edition
    • James C. Blackstock
    • English
    Guide to Biochemistry provides a comprehensive account of the essential aspects of biochemistry. This book discusses a variety of topics, including biological molecules, enzymes, amino acids, nucleic acids, and eukaryotic cellular organizations. Organized into 19 chapters, this book begins with an overview of the construction of macromolecules from building-block molecules. This text then discusses the strengths of some weak acids and bases and explains the interaction of acids and bases involving the transfer of a proton from an acid to a base. Other chapters consider the effectiveness of enzymes, which can be appreciated through the comparison of spontaneous chemical reactions and enzyme-catalyzed reactions. This book discusses as well structure and function of lipids. The final chapter deals with the importance and applications of gene cloning in the fundamental biological research, which lies in the preparation of DNA fragments containing a specific gene. This book is a valuable resource for biochemists and students.

  • Transgenesis and Targeted Mutagenesis in Immunology

    • 1st Edition
    • English
    Investigations into the field of immunology are rapidly expanding with the use of genetically altered mice at the embryonic stage. This breakthrough laboratory guide provides a complete study of transgenesis and targeted mutagenesis in laboratory mice that will be valued by researchers looking for fresh observations and interpretations when designing future experiments.

  • Sex Chromosomes

    • 1st Edition
    • Ursula Mittwoch
    • English
    Sex Chromosomes focuses on the study of sex chromosomes, including human chromosomal abnormalities, behavior and characteristics of chromosomes, and cell division. The book first offers information on the chromosomal basis of sex determination, as well as development of the cell theory, mitosis, fertilization, meiosis, and discovery of sex chromosomes. The publication also ponders on the mitosis, meiosis, and formation of gametes. Discussions focus on the special characteristics of sex chromosomes, abnormalities of cell division, and sexual differentiation. The manuscript reviews sex chromosomes in plants, Drosophila, and Lepidoptera. The book also examines sex-chromosome mechanisms that differ the classic type; sex chromosomes in fishes, amphibia, reptiles, and birds; and sex chromosomes in man. Discussions focus on normal human sex chromosomes, Turner's syndrome, Klinefelter's syndrome, true hermaphrodites, testicular feminization, and pseudohermaphrodites... Sex chromosomes in mammals other than man, including monotremata, marsupialia, insectivora, rodentia, and carnivora, are discussed. The publication is a dependable reference for readers interested in the study of sex chromosomes.

  • The Oxygen Evolving System of Photosynthesis

    • 1st Edition
    • Yorinao Inoue + 2 more
    • English
    The Oxygen Evolving System of Photosynthesis documents the proceedings of an international symposium entitled ""Photosynthetic Water Oxidation and Photosystem II Photochemistry,"" held at The Institute of Physical and Chemical Research (RIKEN), Wako, Saitama, Japan, 15-17 March 1983. Several other papers from authorities in this field are also included. This book provides in a systematic fashion the most current thoughts and insights into the field of photosynthetic oxygen evolution. The volume contains 46 chapters organized into five parts. Part I deals with the subunit structure of photosystem II reaction center pigment proteins and the charge separation (generation of positive and negative charges, P680+ and Pheo-). Part II examines the components and their function on the donor side. Part III discusses the biochemistry of the water oxidation enzyme system, polypeptide composition, and functional reconstitution. Part IV take up the functions of chloride and bicarbonate in electron transport and the mechanism of photoactivation in latent or Tris-inactivated chloroplasts. Part V discusses the fate of reducing equivalents going through the two-electron gate mechanism, together with the biochemistry of the quinone components on the acceptor side.

  • Insecticides

    Action and Metabolism
    • 1st Edition
    • R. D. O'Brien
    • English
    Insecticides: Action and Metabolism provides a comprehensive review of the action of insecticides and a survey of their metabolism. This book discusses the toxicology of insecticides. Organized into 17 chapters, this book begins with an overview of the mechanisms whereby toxicants exert their effects. This text then discusses the insecticidal action of organophosphates, which is described as the toxic organic compounds containing phosphorus. Other chapters consider the mode of action of organophosphates by inhibiting cholinesterase with consequent disruption of nervous activity caused by accumulation of acetylcholine at nerve endings. This book discusses as well the erratic patterns of selective toxicity to insects of the carbamates. The final chapter deals with the real hazard to human health as well as the effects upon wild life of insecticides and chlorinated pesticides. This book is a valuable resource for organic and agricultural chemists, as well as biologists, agriculturists, neurophysiologists, environmental scientists, and research workers.

  • Bioenergetics

    • 1st Edition
    • Volume 22
    • Marcel Florkin + 1 more
    • English
    Comprehensive Biochemisty, Volume 22: Bioenergetics focuses on comprehensive biochemistry that provides a chemical approach to the understanding of the phenomena of life. This book is devoted to certain aspects of organic and physical chemistry, aspects considered pertinent to the interpretation of biochemical techniques, and chemistry of biological compounds and mechanisms. The topics discussed include the methods and scope of quantum biochemistry, long range dipole-dipole transfer, and characteristics of the charge-transfer absorption band. The dye-sensitized photoconductivity, facilitation of solute diffusion by catalytic carriers, and coupling of primary and secondary translocation are also covered in this publication. This volume is valuable to biochemists and researchers concerned with biogenetics.

  • Assembly Instructions for Polypeptide Models

    Academic Press/Molecular Design Inc. Precision Molecular Models
    • 1st Edition
    • Edward J. Barrett
    • English
    Assembly Instructions for Polypeptide Models provides assembly procedures for? polypeptide chains and for modeling the ?-helix and the parallel and antiparallel ?-pleated sheets. This text is divided into nine chapters and starts with a brief introduction to the basic unit of polypeptide or protein structure, which is the amino acid. The subsequent chapters deal with the components of the model system, including the torsion angles and the asymmetric ?-carbon atom. The remaining chapters present specific instructions for the construction of free amino acids, polypeptide end groups, side chain groups, secondary structures, and side chain torsion angles. This book will prove useful to protein and peptide scientists, organic chemists, and biochemists.

  • Methods in Virology

    Volume III
    • 1st Edition
    • Karl Maramorosch + 1 more
    • English
    Methods in Virology, Volume III focuses on the advancements of methods employed in virology, including immunological, microscopic, and serological techniques and transformation assays. The selection first offers information on the analysis of protein constituents and lipid components of viruses. Discussions focus on the applications of the existing methodology to lipid-containing viruses; physical methods for the characterization of virus proteins; renaturation of virus proteins and reconstitution of viruses; and chemical methods for the characterization of virus proteins. The text then elaborates on RNA polymerase, immunological techniques for animal viruses, and serological techniques for plant viruses. The book tackles the plaque assay of animal viruses, transformation assays, and the methods for selecting RNA bacteriophage. Topics include identification of the nucleic acid, assay methods for particular viruses, general consideration of the plaque assay method, virus-dilution media and procedures, monolayer assay methods, and incubation and staining of plates and counting of plaques. The manuscript also takes a look at the structural studies of viruses, microscopic techniques, electron microscopy of isolated virus particles and their components, and the application of thin sectioning. The selection is a vital source of data for researchers interested in the methods employed in virology.

  • Clinical Biochemistry of Domestic Animals

    • 3rd Edition
    • Jiro J. Kaneko
    • English
    Clinical Biochemistry of Domestic Animals, Third Edition, represents a major revision of the previous editions. Since the publication of the first edition of ""Clinical Biochemistry of Domestic Animals,"" veterinary clinical biochemistry has enjoyed a virtual explosion of new knowledge commensurate with the increased importance of companion animals, the livestock industry, and experimental animals. This third edition brings together some of the most important areas of clinical biochemistry pertinent to these sectors. For this purpose, new chapters on the reproductive hormones and clinical enzymology have been added, in addition to a rewriting of the chapters on renal function and plasma proteins and extensive revisions of all other chapters. The volume contains 18 chapters and opens with discussions of carbohydrate and lipid metabolism and associated disorders. This is followed by separate chapters on serum proteins and the dysproteinemias; porpyhrins; clinical enzymology; liver, pancreatic, and kidney function; and the physiology and pathophysiology of body fluids. Subsequent chapters deal with pituitary, adrenal, and thyroid function; skeletal muscle function; calcium, phosphorus, magnesium, and iron metabolism; the mechanisms of homeostasis; and cerebrospinal fluid physiology.

  • Bioenergetics 2

    • 1st Edition
    • David G. Nicholls + 1 more
    • English
    Bioenergetics 2 aims to clarify topics such as the thermodynamics of bioenergetic processes and the stoichiometries of energy coupling reactions. The book discusses chemiosmotic energy transduction; ion transport across energy-conserving membranes; and quantitative bioenergenetics as the measurement of driving forces. The text also describes the chemiosmotic proton circuit; the respiratory chain; the photosynthetic generators of protonmotive force; and the ATP synthase. The secondary transport of products across the membrane, as well as the structures of the bacterial photosynthetic reaction center and bacteriorhodopsin are also considered. Biochemists will find the book invaluable.

  • Thrombosis and Bleeding Disorders

    Theory and Methods
    • 1st Edition
    • Nils U. Bang + 2 more
    • English
    Thrombosis and Bleeding Disorders compiles the laboratory and research aspects of thrombosis and hemorrhagic disorders in humans. This book presents reviews of the underlying theory, physiology, and biochemistry of hemostasis and thrombosis, including the enzymology of blood coagulation and fibrinolysis. This compilation is divided into three levels of specific purposes. First is to provide the most reliable and widely accepted laboratory assays of undisputed diagnostic clinical value, which provides newcomers in the field and experienced workers in the coagulation laboratory with a reference manual to everyday work in a clinically-oriented environment. Second is to review and sketch in outline the theoretical sections focusing on mechanisms. Finally, this text aims to include a systematic review of the most successful purification techniques for individual coagulation factors and moieties of the fibrinolytic enzyme system. This publication is beneficial to medical students and clinicians concerned with human blood coagulation.

  • Bacterial Metabolism

    • 1st Edition
    • H. W. Doelle
    • English
    Bacterial Metabolism focuses on metabolic events that occur in microorganisms, as well as photosynthesis, oxidation, polysaccharide formation, and homofermentation. The book first discusses the thermodynamics of biological reactions, photosynthesis and photometabolism, and chemosynthesis. Free energy, photosynthesis, enzymes, and terminology in bacterial metabolism are elaborated. The manuscript then examines acetic acid bacteria and lactic acid bacteria. Discussions focus on lactate, ethanol, glucose, and glycerol metabolism, glycol oxidation, homofermentation, polysaccharide formation, and electron transport systems. The publication takes a look at pseudomonadaceae and nitrogen metabolism as an energy source for anaerobic microorganisms. Topics include metabolism of pairs of amino acids, single amino acid metabolism, oxidation of glycolate and malonate, and oxygenases. The book is a dependable source of information for readers interested in bacterial metabolism.

  • Bacterial Physiology and Metabolism

    • 1st Edition
    • J. R. Sokatch
    • English
    Bacterial Physiology and Metabolism focuses on research on bacteria, as well as metabolism of carbohydrates, fermentation, and oxidation of acids. The book first offers information on nutrition and growth of bacterial cultures, including requirements for growth, nutritional classification of bacteria, measurement of bacterial growth, and synchronous growth of bacterial cultures. The manuscript then considers the chemical composition of bacteria, oligosaccharide catabolism, and transport of sugars. The publication takes a look at the fermentation of sugars and aerobic metabolism of carbohydrates. Discussions focus on Embden-Meyerhof fermentations, miscellaneous pathways, and hexose, pentose, polyol, and hexuronic acid oxidation. The text also elaborates on oxidation of organic acids, electron transport, oxidation of hydrocarbons, and protein and amino acid catabolism. The text is a dependable reference for readers interested in bacterial physiology and metabolism.

  • Artificial Neural Networks, 2

    Proceedings of the 1992 International Conference on Artificial Neural Networks (ICANN-92) Brighton, United Kingdom, 4-7 September, 1992
    • 1st Edition
    • I. Aleksander + 1 more
    • English
    This two-volume proceedings compilation is a selection of research papers presented at the ICANN-92. The scope of the volumes is interdisciplinary, ranging from the minutiae of VLSI hardware, to new discoveries in neurobiology, through to the workings of the human mind. USA and European research is well represented, including not only new thoughts from old masters but also a large number of first-time authors who are ensuring the continued development of the field.

  • Handbook of Amylases and Related Enzymes

    Their Sources, Isolation Methods, Properties and Applications
    • 1st Edition
    • The Amylase Research Society The Amylase Research Society o
    • English
    This handbook, published to mark the 20th anniversary of The Amylase Research Society of Japan, presents a concise account of the properties and applications of amylases and related enzymes. Enzymes are discussed with reference to their source, isolation method, properties, inhibition, kinetics and protein structure. This information is then applied in the description and interpretation of their use in industry. As well as amylases, other enzymes capable of catalyzing reactions with starch and glycogen, and the further conversion of amylase reaction products for industrial applications are discussed. The text is supported by numerous explanatory figures and tables, and each section is fully referenced.

  • Current Topics in Bioenergetics

    Volume 10
    • 1st Edition
    • D. Rao Sanadi
    • English
    Current Topics in Bioenergetics, Volume 10 provides information pertinent to the developments in the study of dynamic mechanisms in functioning muscle by following fluctuations in kinetic states. This book explores the method that permits analysis of cyclic rotational motions in cross-bridge formation and has considerable potential in other bioenergetics systems. Organized into six chapters, this volume begins with an overview of the structure and function of muscles. This text then examines the bioenergetic aspects of nitrogen fixation. Other chapters consider one aspect of the regulation of the in vivo activity of organelles, namely, the regulation of mitochondrial activities at the level of substrate. This book discusses as well the status of the controversial findings on the proton–oxygen ratios in mitochondria and the mechanism of H+ pumping in oxidative reactions. The final chapter deals with the usefulness of bacterial mutants in the study of cell metabolism. This book is a valuable resource for biologists and biochemists.

  • Perspectives in Virology

    Antiviral Mechanisms
    • 1st Edition
    • Volume 9
    • Morris Pollard
    • English
    Perspectives in Virology IX: Antiviral Mechanisms is a collection of scientific papers presented at the Ninth Gustav Stern Symposium on Perspectives in Virology: Antiviral Mechanisms, held at Notre Dame, Indiana in February 1974. The majority of the papers in this volume concentrate on the different ways the human body defends itself against viral attack. Others deal with artificial means of interfering with the life cycle of viruses. Topics covered in this compendium include defective interfering (DI) particles as antiviral agents; detection and identification by immune electron microscopy of fastidious agents associated with respiratory illness, acute nonbacterial gastroenteritis, and hepatitis A; and synthetic vaccines. Cellular immune response in viral infections; transfer factor and cellular immunity to viral infection; and studies on adenine rabinoside are presented as well. Virologists, microbiologists, pathologists, pharmacologists, and researchers in the fields of medicine and pathology will find the book insightful and informative.

  • Biotechnology of Blood

    • 1st Edition
    • Jack Goldstein
    • English
    Biotechnology of Blood presents research on applications of biotechnology to blood and its components. The book is organized into four parts. Part I begins with an overview of the blood business in order to provide background of the industry, to identify problems, and perhaps some solutions that rely on the scientific advances made possible by biotechnology. This is followed by studies on the storage and preservation of red blood cells; autologous blood salvage procedures; the development procedures to provide a constant supply of blood group O; and the development of blood substitutes. Part II on plasma fractions includes studies on the preparation of plasma fractions, recombinant antihemophilic factors, and fibrinogen. Part III on the regulation of blood cell products includes studies such as hematopoietic stem cell processing and storage; and long-term bone marrow cell cultures. Part IV on blood-borne diseases examines the inactivation of viruses found with plasma proteins and viruses found with cellular components.

  • Enzymes of the Arterial Wall

    • 1st Edition
    • John Esben Kirk
    • English
    Enzymes of the Arterial Wall is a comprehensive up-to-date monograph, and is the first publication dealing specifically with quantitative determinations of enzyme activities in human and animal vascular tissue. All available information concerning this subject is included. This summary of all current knowledge will be very useful to scientists who lack extensive library facilities and knowledge of foreign languages necessary for a thorough and time-consuming personal search of the original literature. A systematic description is made of 98 different enzymes; nearly all enzymes in the carbohydrate metabolic pathways are included. Brevity of discussion has made it possible to incorporate all available data. The results represent 27,200 quantitative biochemical assays performed with reliable analytical techniques on both normal and arteriosclerotic tissue; 70 enzymic procedures are described. The framework for the arrangement of facts throughout the book was designed to make information easily accessible. Each enzyme is described separately, using the sequence of The Commission on Enzymes of The International Union of Biochemistry, and is followed by literature references with full titles.

  • Microbiology in Clinical Practice

    • 2nd Edition
    • D. C. Shanson
    • English
    Microbiology in Clinical Practice presents the infections and syndromes caused by micro-organisms. It discusses the management of infective diseases and aetiological agents. It addresses the latex agglutination, immunofluorescent, monoclonal antibody, and nucleic acid probe investigations. Some of the topics covered in the book are the classification and pathogenicity of microbes; classification of bacteria; classification of viruses; classification of fungi; general principles of antimicrobial chemotherapy; antibiotic sensitivity tests; procedures in the laboratory for microbiological diagnosis; and the mode of action of antimicrobial drugs. The resistance to antimicrobial drugs are covered. The microbiological investigations of septicaemia are discussed. The text describes the human immunodeficiency virus infection and AIDS in infants. A study of the congenital immunodeficiency and impaired resistance to infection is presented. A chapter is devoted to the predisposing factors for anaerobic infections. Another section focuses on the infections of the central nervous system. The book can provide useful information to doctors, pathologists, neurologists, students, and researchers.

  • Raw Materials Purchasing

    An Operational Research Approach
    • 1st Edition
    • Volume 4
    • B. G. Kingsman
    • English
    A systematic study of commodity purchasing analysed from an operational research viewpoint and based on numerous case studies.

  • Immunological Methods

    • 1st Edition
    • Ivan Lefkovits + 1 more
    • English
    Immunological Methods a compendium of basic research techniques being used in one of the largest immunology research institutes, the Basel Institute for Immunology, with particular emphasis given to new methodology. The procedures have been described by individuals judged to be highly expert in their specialties. In many instances the methods developed or adapted to unique uses by the contributors have not previously been described in detail. The book contains 34 chapters covering techniques for detection, isolation, and purification of antibodies (including dansylation, two-dimensional chromatography, isoelectric focusing, polyacrylamide gel electrophoresis, and isotachophoresis); measurement of equilibrium constants (equilibrium dialysis, filtration, and sedimentation); and isotope and fluorescent labeling and detection of cell-surface components. Techniques such as isotope laboratory maintenance; chemical modification of proteins, haptens, and solid supports, and haptenation of viable biological carriers; production of antisera against allotypes and histocompatibility antigens and production of antibody with clonai dominance; histocompatibility and MLR testing; and cell separation by haptenated gels and by velocity sedimentation of rosette-forming cells are also discussed. Other chapters cover detection of antibody-secreting and alloantigen-binding cells; immune responses in vitro and their analysis by limiting dilution; production of T-cell factors; hybridoma production by cell fusion; maintenance of cell lines and cloning in semisolid media; and the mathematical analysis of immunological data.

  • Structure and Functions of Contractile Proteins

    Revisions, Additions, and a Foreword to the English-Language Edition Prepared by the Author
    • 1st Edition
    • Boris F. Poglazov
    • English
    Structure and Functions of Contractile Proteins focuses on the analysis of problems on the structure and functions of contractile proteins in which substantial progress has been achieved. The book first offers information on the protein constitution of myofibrils and myosin, including adenosinetriphosphat... activity, reaction with actin, and myosin molecule. The text also ponders on the polymerization of actin, tropomyosin, and the theory of contraction. Discussions focus on model experiments and molecular basis of contraction; structural interrelations of muscle proteins; features of the process of polymerization of actin; and size of the actin molecule. The text elaborates on the contractile proteins of the elementary motor structures of cells, as well as the chemical composition and physicochemical and enzymic properties of flagella and cilia; achromatin apparatus and movement of chromosomes; and structure of the flagella and cilia. Motor apparatus of bacteriophage and features of the movement of protoplasm and the mechanism of permeability are also discussed. The manuscript is a reliable source of data for readers interested in the structure and functions of contractile proteins.

  • Biotechnological Innovations in Food Processing

    • 1st Edition
    • BIOTOL + 2 more
    • English
    A thorough examination of the ways in which recent biotechnological developments have led to improvements in food processing. Deals with biotechnology based processes currently in use by or available to the food industry. Building on a series of case studies selected to illustrate the diversity of applications it clearly shows that biotechnology can and will benefit the food industry.The need for a cost-effective training scheme for new and existing staff at all levels has been met by the University of Greenwich (formerly Thames Polytechnic) and the Open University of the Netherlands. As part of the European Community Education and Technology Training initiative (COMETT) and in conjunction with a number of other leading UK and European universities, they have developed BIOTOL, a training scheme in biotechnology using open learning materials, which will provide tailor-made courses, flexible in content, pace and place.

  • Centrifugation in Density Gradients

    • 1st Edition
    • C. A. Price
    • English
    Centrifugation in Density Gradients provides information pertinent to the fundamental aspects of density gradient centrifugation. This book discusses the benefits of density gradient centrifugation to membrane-bound particles. Organized into nine chapters, this book begins with an overview of the method of differential or fractional centrifugation. This text then explores the physical basis of density gradient centrifugation. Other chapters deal with the nuts and bolts of density gradient centrifugation, the construction and composition of gradients, the properties and operation of centrifuge systems, and certain arcane but highly useful procedures. This book discusses as well density gradient centrifugation in the analytical ultracentrifuge. The final chapter deals with a collection of protocols for separating particles ranging in size from whole cells to macromolecules. This book is intended to be suitable for readers who need to separate biological particles. Biologists, chemists, biochemists, cytologists, physiologists, scientists, and research workers will also find this book useful.

  • Food Texture and Viscosity: Concept and Measurement

    • 1st Edition
    • Malcolm C. Bourne
    • English
    Food Science and Technology: A Series of Monographs: Food Texture and Viscosity: Concept and Measurement focuses on the texture and viscosity of food and how these properties are measured. The publication first elaborates on texture, viscosity, and food, body-texture interactions, and principles of objective texture measurement. Topics include area and volume measuring instruments, chemical analysis, multiple variable instruments, soothing effect of mastication, reasons for masticating food, rheology and texture, and the rate of compression between the teeth. The book then examines the practice of objective texture measurement and viscosity and consistency, including the general equation for viscosity, methods for measuring viscosity, factors affecting viscosity, tensile testers, distance measuring measurements, and shear testing. The manuscript takes a look at the selection of a suitable test procedure and sensory methods of texture and viscosity measurement. Discussions focus on nonoral methods of sensory measurement; correlations between subjective and objective measurements; variations on the texture profile technique; and importance of sensory evaluation. The publication is a vital source of information for food experts and researchers interested in food texture and viscosity.

  • Laboratory Methods in Microbiology

    • 1st Edition
    • W. F. Harrigan + 1 more
    • English
    Laboratory Methods in Microbiology is a laboratory manual based on the experience of the authors over several years in devising and organizing practical classes in microbiology to meet the requirements of students following courses in microbiology at the West of Scotland Agricultural College. The primary object of the manual is to provide a laboratory handbook for use by students following food science, dairying, agriculture and allied courses to degree and diploma level, in addition to being of value to students reading microbiology or general bacteriology. It is hoped that laboratory workers in the food manufacturing and dairying industries will find the book useful in the microbiological aspects of quality control and production development. The book is organized into two parts. Part I is concerned with basic methods in microbiology and would normally form the basis of a first year course. Abbreviated recipes and formulations for a number of typical media and reagents are included where appropriate, so that the principles involved are more readily apparent. Part II consists of an extension of these basic methods into microbiology as applied in the food manufacturing, dairying and allied industries. In this part, the methods in current use are given in addition to, or in place of, the ""classical"" or conventional techniques.

  • Water-Soluble Vitamins, Hormones, Antibiotics

    • 1st Edition
    • Volume 11
    • Marcel Florkin + 1 more
    • English
    Comprehensive Biochemisty, Volume 11: Water-Soluble Vitamins, Hormones, Antibiotics deals with the organic and physical chemistry of the major organic constituents of living material. This book provides a sound treatment of the important biological high polymers, emphasizing their shape and physical properties. A number of substances peculiar to plants, certain isoprenoids, flavonoids, tannins, lignins, and plant hormones are also covered. This publication likewise discusses the fate of thiamine in living organisms, biologically active isoalloxazines, and auxins with a heterocyclic ring system. Other topics include the yolk-formation hormone of the corpora allata, biochemical aspect of the antibiotics, and miscellaneous antibiotics derivable from amino acids. This volume is a good source for biochemists and specialists conducting work on water-soluble vitamins, hormones, and antibiotics.

  • Protides of the Biological Fluids

    Proceedings of the Twenty-Ninth Colloquium, 1981
    • 1st Edition
    • Volume 29
    • H. Peeters
    • English
    Protides of the Biological Fluids: An International Review Series Devoted to Proteins and Related Studies, Volume 29: Membrane Proteins, Receptor Ligand Interactions, Monoclonal Antibodies, New Methods focuses on membrane proteins, receptor-ligand interactions, and monoclonal proteins as a reagent. The selection first offers information on H-Y and sex determination and aspects of the difficulties to purify membrane proteins. Topics include solubilization by acylation, influence of supporting media on the aggregation of proteins, solubilization with detergents and organic solvents, and membrane proteins - giant detergent molecules. The text then examines the application of group-specific reagents for hydrophobic labeling and crosslinking of membrane proteins and comparison of secreted and membrane-bound human immunoglobulins M and D. The publication tackles sialoglycoproteins (glycophorins) in the plasma membranes of different cells and their receptor functions and the structures and antigenic properties of human erythrocyte membrane sialoglycoproteins. Discussions focus on the primary structure of human erythrocyte glycophorins, molecular structure of the MN bloodgroup substance, and genetic variants of glycophorin A. The book also takes a look at the glycoproteins of the human syncytiotrophoblasti... plasma membrane and structure and function of a membrane glycoprotein encoded in the adenovirus genome. The selection is a valuable reference for readers interested in membrane proteins, receptor ligand interactions, and monoclonal antibodies.

  • Microbial Transformations of Steroids

    A Handbook
    • 1st Edition
    • William Charney + 1 more
    • English
    Microbial Transformations of Steroids: A Handbook aims to provide those who wish to use microbial transformations of steroids with a single source book starting from 1937 to the present. The handbook first offers information on the history of the microbial transformations of organic compounds, including earliest works on the study of nonsteroids and steroids; significance of discovery of anti-inflammatory action of cortisone; first hydroxylations and dehydrogenations; manufacture of natural and synthetic corticosteroids; and trends in research. The text then ponders on chemical classification of microbial transformations of steroids, as well as the role of enzymes in microbial transformations and the classes of reactions. The publication elaborates on the construction and use of the table. Topics include order of the table, nomenclature, description of the transformation leading to the product, yield, organism, and constants. The book also focuses on taxonomy and use of the table, including system of classification, specific notes on divisions of the table, and source of cultures. The handbook is a valuable source of data for readers interested in the microbial transformations of steroids.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 8
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 8 covers the significant progress in understanding the lipid chemistry and biochemistry of plants and animals. This volume contains seven chapters and begins with a discussion of the various aspects of cholesterol turnover in man and the possible mode of action of hypocholesterolemic regimens. The next chapters deal with the arterial composition and metabolism, with particular emphasis to esterified fatty acids and cholesterol, as well as the important role of essential fatty acids in mammalian development, health, and disease. A chapter emphasizes the participation of lipids in membrane structure. The remaining chapters explore the chemistry and biochemistry of phospholipids and glycolipids. These chapters also consider rumen metabolism and the surface chemistry of lipids. This book will prove useful to biochemists, organic chemists, physicians, and researchers.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 1
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 1 provides information pertinent to the structure and behavior of lipids through sulfolipids. This book presents the advances on fat absorption and transport. Organized into 10 chapters, this volume begins with an overview of the methods for the analysis of glycerine mixtures that require the determination of the fatty acid composition of the whole mixture and of its component fraction. This text then examines lipids as molecules of biological interest having little or no solubility in water. Other chapters cover the advances in cholesterol metabolism, Vitamin E as it affects lipid metabolism, and a discussion on atherosclerosis. This book discusses as well all areas of lipid research ranging from physical chemistry to physiology and pathology. The final chapter deals with sulfolipid, which appears to be concentrated in the lamellar membranes of the chloroplasts of plants. This book is a valuable resource for physical chemists, biologists, and pathologists.

  • The Retinoids: v. 2

    • 1st Edition
    • BAERT ET BAERT ET AL
    • English
    The Retinoids is a collection of papers that deals with the biochemistry and metabolism of the retinoids and of specific retinoid-binding proteins that are found in plasma and in cells. Some papers describes the biosynthesis and metabolism of retinol, with plasma retinol-binding protein, with intracellular retinoid-binding proteins, as well as with the metabolism and role of retinoids in the eye. Other papers review the metabolism of retinoic acid and synthetic retinoids, the cellular and molecular mechanisms of action of the retinoids, and applied biology of the retinoids. Several papers discuss toxicology, teratology, immunology, and the applications of retinoids in the fields of cancer and dermatology. One paper describes the transport of retinoic acid and other acidic retinoids in plasma in association with serum albumin. Another paper hypothesizes that vitamin A affects differentiation at the cellular level and addresses how tissue specificity of this action can arise. One paper examines the role of retinoid-binding proteins in vertebrate visual system, particularly how these proteins transport retinoids in the serum, cell sap, and interstitial spaces of the eye. The collection can prove useful for biologists, microbiologists, cellular biologists, students and professors of biology, oncology, ophthalmology or dermatology.

  • Carbohydrates

    • 1st Edition
    • Volume 5
    • Marcel Florkin + 1 more
    • English
    Comprehensive Biochemisty, Volume 5: Carbohydrates deals with the organic and physical chemistry of the major organic constituents of living material. This book discusses the general structure of monosaccharides, detection and estimation of aldonic acids, intramolecular rearrangement of N-glycosides, and preparation of sugar phosphates. The deacetylation of glycoside acetates, naturally occurring oligosaccharides of human milk, and molecular weight of polysaccharides are also elaborated. This text likewise covers the biogenesis and fate of pectic substances in plant tissues, complex polysaccharides of gram-positive bacteria, galactosaminoglycan of Aspergillus parasiticus, and chemical structure of heparin sulfate. This volume is a good source for biochemists and researchers conducting work on carbohydrates.

  • The Chlorophylls

    • 1st Edition
    • Leo P. Vernon + 1 more
    • English
    The Chlorophylls reviews developments in study of chlorophylls, and at the same time summarizes the state of knowledge in the more established areas of the physics, chemistry, and biology of chlorophylls. The book is organized into four sections. The first section deals with the chlorophylls as chemical entities, and treats their isolation, analysis, chemistry, and synthesis. The second concerns chlorophylls in real and colloidal solution and in the solid state in vitro, and includes the effects of aggregation on visible, infrared, and NMR spectral properties. The third section treats the biosynthesis, organization, and properties of chlorophylls in the plant and bacterial cell, and the fourth is concerned with the photochemical and photophysical behavior of chlorophylls in vitro and in vivo. It is hoped that this work will help those investigating selected aspects of chlorophyll to keep abreast of other methods and approaches, and will provide the interested scientist with a modern, conceptually organized treatment of the subject.

  • Ion Transport in Prokaryotes

    • 1st Edition
    • Barry P. Rosen + 1 more
    • English
    Ion Transport in Prokaryotes provides an advance treatise on ion transport and prokaryotic organisms. This book is divided into three main topics—cation transport systems, anion transport systems, and plasmid-encoded transport systems. This compilation specifically discusses the proton transport and proton-motive force in prokaryotic cells, potassium transport in bacteria, and bioenergetic functions of sodium ions. The calcium transport in prokaryotes, phosphate transport in prokaryotes, and transport of organic acids in prokaryotes are also elaborated. This text likewise covers the chloride, nitrate, and sulfate transport in bacteria and bacterial magnesium, manganese, and zinc transport. This publication is recommended for biologists, specialists, and students interested in the bacterial ion transport system.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 14
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 14 is a five-chapter text that covers other important aspects of lipid chemistry, including an enzyme controlling cholesterol biogenesis, fatty acid activation, and lipid synthesis. The first chapter concerns with the control of activity of ?-hydroxy-?-methylgl... coenzyme A reductase. The second chapter deals with the specificity, localization, and function of fatty acid activation. The third chapter describes the interaction between polyene antibiotics and sterols. This chapter specifically tackles some antibiotic activity to understand membrane function and in vivo hypolipidemic activity. The fourth chapter focuses on the lipids in plant cultures, while the fifth chapter looks into the methods of synthesis of acylglycerols and phosphoglycerides. This book will prove useful to lipid chemists, biochemists, and researchers.

  • Bacteriocins of Lactic Acid Bacteria

    • 1st Edition
    • Dallas G. Hoover + 1 more
    • English
    Bacteriocins of Lactic Acid Bacteria is based on the 1990 Annual Meeting of the Institute of Food Technologists held in Dallas, Texas. It describes a number of well-characterized bacteriocins and, where possible, discusses practical applications for those that have been defined thus far from the lactic acid bacteria. The book begins with an introductory overview of naturally occurring antibacterial compounds. This is followed by discussions of methods of detecting bacteriocins and biochemical procedures for extraction and purification; genetics and cellular regulation of bacteriocins; bacteriocins based on the genera of lactic acid bacteria Lactococcus, Lactobacillus, Pediococcus, and Leuconostoc, and related bacteria such as Carnobacterium and Propionibacterium; and the regulatory and political aspects for commercial use of these substances. The final chapter sets out the prognosis for the future of this dynamic area. The information contained in this book should benefit those with interest in the potential for industrial use of bacteriocins as preservative ingredients. Anyone interested in lactic acid bacteria or the biosynthesis, regulation, and mechanisms of inhibition of these proteinaceous compounds will also appreciate the material presented. These include food scientists, microbiologists, food processors and product physiologists, food toxicologists, and food and personal product regulators.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 13
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 13 is a four-chapter text that emphasizes the biological aspects of lipoproteins. The first chapter reviews the status of lipoprotein metabolism, specifically the functional, structural, and metabolic interrelationships of lipoproteins. The second chapter covers aspects of lipid metabolism in diabetes and the stresses that can cause alterations in carbohydrate metabolism. The third chapter discusses the developments in understanding the physicochemical basis of gallstone formation. The fourth chapter deals with the biosynthesis and composition of milk fat. This chapter also presents a summary of some of the important features of milk fat production processes. This book will prove useful to lipid chemists, biochemists, physicians, and researchers.

  • Nucleotide Metabolism

    An Introduction
    • 1st Edition
    • J. Frank Henderson + 1 more
    • English
    Nucleotide Metabolism: An Introduction is a textbook exclusively focusing on the study of the aspects of nucleotide metabolism. The book intends to present the chemistry and metabolism of nucleotides, one of the oldest subjects of biochemistry. The text is divided in two parts. Part I considers the general aspects of nucleotide metabolism such as the history of the discovery of nucleotides; functions of nucleotides in cells; and group-transfer reactions during nucleotide metabolism. Part II deals with the synthesis, formation, and conversion of purine ribonucleotides. Biochemists, pharmacologists, and researchers in the fields of medicine and pharmaceuticals will find the book invaluable.

  • The Foundations of Genetics

    • 1st Edition
    • F. A. E. Crew
    • J. M. Dodd + 1 more
    • English
    The Foundations of Genetics describes the historical development of genetics with emphasis on the contributions to advancing genetical knowledge and the various applications of genetics. The book reviews the work of Gregor Mendel, his Law of Segregation, and of Ernst Haeckel who suggested that the nucleus is that part of the cell that is responsible for heredity. The text also describes the studies of W. Johannsen on "pure lines," and his introduction of the terms gene, genotype, and phenotype. The book explains the theory of the gene and the notion that hereditary particles are borne by the chromosomes (Sutton-Boveri hypothesis). Of the constituent parts of the nucleus only the chromatin material divides at mitosis and segregates during maturation. Following studies confirm that the chromatin material, present in the form of chromosomes with a constant and characteristic number and appearance for each species, is indeed the hereditary material. The book describes how Muller in 1927, showed that high precision energy radiation is the external cause to mutation in the gene itself if one allele can mutate without affecting its partner. The superstructure of genetics built upon the foundations of Mendelism has many applications including cytogenetics, polyploidy, human genetics, eugenics, plant breeding, radiation genetics, and the evolution theory. The book can be useful to academicians and investigators in the fields of genetics such as biochemical, biometrical, microbial, and pharmacogenetics. Students in agriculture, anthropology, botany, medicine, sociology, veterinary medicine, and zoology should add this text to their list of primary reading materials.

  • Introduction to Genetics

    Science of Heredity
    • 1st Edition
    • A. J. S. McMillan
    • English
    Introduction to Genetics: Science of Heredity presents a linear programmed text about hereditary and genetics. This book discusses a variety of topics related to heredity and genetics, including chromosomes, genes, Mendelism, mitosis, and meiosis. Organized into six chapters, this book begins with an overview of some of the experiments that first provide an understanding of heredity and laid the foundation of the science of genetics. This text then provides detailed information about the cell and explains how the essential parts of it reproduce and divide. Other chapters consider how the chromosome theory can explain not only the facts of Mendelism, but also the many complications that arise in genetics. This book discusses as well the problems that can happen during the process of mitosis and meiosis. The final chapter deals with the practical problems that confront the plant breeder. This book is a valuable resource for teachers and students of biology.

  • Gene Activity in Early Development

    • 1st Edition
    • Eric H. Davidson
    • English
    Gene Activity in Early Development reviews the state of knowledge regarding genomic function in the programming and operation of what Bonnet, in 1762, described as "the miracle of epigenesis." The book is divided into four sections. Section I is concerned with gene activity in early embryogenesis, with the time of onset and the nature of embryo genome control, and with recent attempts to analyze the shifting patterns of gene expression as development proceeds. Section II reviews various classic and recent studies relevant to the phenomenon of cytoplasmic localization of morphogenetic potential and discusses the significance, from a contemporary vantage point, of this often neglected area of developmental biology. Section III deals with genomic function in oogenesis, beginning with a general survey of what could be described loosely as the natural history of the oocyte nucleus, and proceeding to current attempts to understand the character and the ultimate function of the oocyte gene products. Section IV discusses various aspects of the general problem of gene regulation in animal cells.

  • The Antibody Molecule

    • 1st Edition
    • Alfred Nisonoff + 2 more
    • F. J. Dixon + 1 more
    • English
    The Antibody Molecule reviews the literature leading to current knowledge of the structure of immunoglobulins. The book begins by outlining some of the basic structural characteristics of immunoglobulins without citing the references on which the information is based. Separate chapters follow covering the chemical nature of the active site of an antibody molecule and mechanisms of interaction with hapten; the general structural features and properties of the various classes of human immunoglobulin; and amino acid sequences of human and mouse L chains and of human and rabbit H chains. Subsequent chapters deal with the evolution of the immunoglobulin classes; special properties of mouse, guinea pig, rabbit, and horse immunoglobulins; idiotypic specificities of immunglobulins; and the genetic control of antibodies. This book is meant for immunologists who have not personally observed the development of this exciting period in the history of immunology. It will also provide useful supplemental reading for the serious student or investigator who wishes to become familiar with the nature of the antibody molecule, its genetic control, and mode of action.

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