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Action and Metabolism
1st Edition - January 1, 1967
Author: R. D. O'Brien
9 7 8 - 1 - 4 8 3 2 - 7 0 6 8 - 5
Insecticides: Action and Metabolism provides a comprehensive review of the action of insecticides and a survey of their metabolism. This book discusses the toxicology of… Read more
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Insecticides: Action and Metabolism provides a comprehensive review of the action of insecticides and a survey of their metabolism. This book discusses the toxicology of insecticides. Organized into 17 chapters, this book begins with an overview of the mechanisms whereby toxicants exert their effects. This text then discusses the insecticidal action of organophosphates, which is described as the toxic organic compounds containing phosphorus. Other chapters consider the mode of action of organophosphates by inhibiting cholinesterase with consequent disruption of nervous activity caused by accumulation of acetylcholine at nerve endings. This book discusses as well the erratic patterns of selective toxicity to insects of the carbamates. The final chapter deals with the real hazard to human health as well as the effects upon wild life of insecticides and chlorinated pesticides. This book is a valuable resource for organic and agricultural chemists, as well as biologists, agriculturists, neurophysiologists, environmental scientists, and research workers.
Preface Chapter 1 Introduction Toxicology Modes of Killing The Causal Chain Leading to Death Background Chemistry Electronic Interpretations Background Neurobiology References Chapter 2 Physical Toxicants Indifferent Narcotics The Cutoff Point The ρ-σ-π Analysis References Chapter 3 Organophosphates: Chemistry and Inhibitory Activity Nomenclature Nonenzymic Reactions Reaction with Cholinesterase References Chapter 4 Organophosphates: Action, Therapy, and Metabolism Mode of Action Therapy Metabolism ReferencesChapter 5 Carbamates Toxicity Mode of Action Mechanism of Cholinesterase Inhibition Metabolism Synergism References Chapter 6 DDT and Related Compounds Structure and Chemistry DDT Analogs Toxicity Mechanism of Action Metabolism of DDT References Chapter 7 Cyclodienes Toxicity Mode of Action Metabolism References Chapter 8 Nicotinoids Toxicity Mechanism of Action Metabolism References Chapter 9 Rotenoids Mode of Action Metabolism References Chapter 10 Pyrethroids Mode of Action Metabolism References Chapter 11 Fluorine Compounds Fluoro-organics Sodium Fluoride ReferencesChapter 12 Lindane and Other Hexachlorocyclohexanes Toxicity Mode of Action Metabolism References Chapter 13 Various Compounds Arsenicals Silica Aerogels Ryanodine DNOC and Dinex References Chapter 14 Synergism, Antagonism, and Other Interactions Inductive Effects Noninductive Effects References Chapter 15 Resistance DDT Resistance Cyclodiene Resistance Lindane Resistance Organophosphate Resistance Carbamate Resistance Conclusion References Chapter 16 Selectivity; Penetration General Principles Contact of Toxicant and Organism Penetration into the Organism Metabolism Penetration to the Target Disposal (Storage and Excretion) Attack upon the Target Consequences of a Successful Attack upon the Target References Chapter 17 Insecticides and Environmental Health Problems of Human Health Effects upon Wildlife References Author Index Subject Index