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Books in Toxicology

Elsevier's Toxicology collection provides essential insights for researchers and scientists into mitigating the adverse effects of contaminants on organisms, covering research, analysis, risk assessment, detection, prevention, diagnosis, and treatment of toxic exposure. Including toxicity testing, environmental toxicology it offers valuable knowledge for addressing public health and safety challenges by examining the adverse effects of contaminants on human health, animals, and the environment.

BooksJournals

    • Titrations in Nonaqueous Solvents

      • 1st Edition
      • December 2, 2012
      • Huber Walter
      • English
      • Paperback
        9 7 8 0 1 2 4 3 3 5 4 7 9
      • eBook
        9 7 8 0 3 2 3 1 5 8 6 0 2
      Titrations in Nonaqueous Solvents discuss the theory, practice, and data on acidic and basic strength of nonaqueous solvents. This book is organized into three parts encompassing six chapters. The first part considers the general principles of acids and bases and methods of end-point determination. This part also covers the fundamentals, advantages, and limitations of titration instruments, such as potentiometers, burets, titration vessels, and electrodes. The classification of titration solvents according to their functions as color indicators and titrant solutions is provided in this part. The remaining parts describe the analytical procedures for acidity and basicity of nonaqueous solvents. These parts also provide a tabulated data on the acidic and basic strengths, stability, and dissociation constants of various titration solvents. Analytical chemists, and analytical chemistry teachers and students will find this book invaluable.

    • Pesticide Biotransformation and Disposition

      • 1st Edition
      • January 1, 2012
      • Ernest Hodgson
      • English
      • Hardback
        9 7 8 0 1 2 3 8 5 4 8 1 0
      • eBook
        9 7 8 0 1 2 3 8 5 4 8 2 7
      Biotransformation of Pesticides is an updated, "one-stop" resource for academic, industry and regulatory scientists involved in research and regulatory activities related to pesticide biotransformation and human health. This book provides an in depth look at how pesticides are biotransformed, which is essential to understanding exposure, dose, toxicity and health risks. This essential reference contains the biotransformation of pesticides from uptake to excretion, including toxicokinetics and emphasizes metabolism in non-target species, including experimental animals and humans.

    • Nerve Agents Poisoning and its Treatment in Schematic Figures and Tables

      • 1st Edition
      • March 15, 2012
      • Jiri Bajgar
      • English
      • Paperback
        9 7 8 0 3 2 3 2 8 2 4 9 9
      • Hardback
        9 7 8 0 1 2 4 1 6 0 4 7 7
      • eBook
        9 7 8 0 1 2 3 9 1 4 8 2 8
      Organophosphate compounds, first synthesized in the 1800s, have been used for insecticides, pesticides, and in war and terrorism, such as the 1995 Tokyo subway poisoning. This book provides an in-depth examination of the effects of organophosphates and nerve agents and offers therapeutic and prophylactic countermeasures. Beginning with an overview of milestones in the use of toxic chemicals and chemical warfare agents, the formulae and toxicities of compounds are given, along with tables outlining animal toxicities. Data on various compounds’ inhibitions and subsequent accumulations are also provided. Along with data on organophosphates and nerve agents, possible first aid and medical responses are compared among potential responses in the United States and other countries in the east and west. Using clear schematics and tables, this book provides a detailed account of the most common organophosphates and nerve agents, ideas of how to countermeasure their effects, and offers detailed suggestions for where research needs to proceed in the future. This book will prove useful to students, researchers, and military personnel needing to know more about how to deal with nerve agents.

    • Veterinary Toxicology

      • 2nd Edition
      • March 15, 2012
      • Ramesh C. Gupta
      • English
      • eBook
        9 7 8 0 1 2 3 8 5 9 2 7 3
      Veterinary Toxicology, 2nd Edition, is a unique single reference that teaches the basic principles of veterinary toxicology and builds upon these principles to offer an essential clinical resource for those practicing in the field. This new edition brings together insights from qualified and well-experienced authorities across all areas of veterinary toxicology to provide an authoritative and in-depth look at all facets of veterinary toxicology, including target organ toxicity, melamine and cyanuric acid, toxicogenomics, chemical terrorism and nanoparticles. While most comparable texts are primarily directed toward the field of human toxicology, this is the one text needed to thoroughly prepare future veterinarians on the newest approaches for diagnosing poisoning cases in all animals from chemicals and plants of a diverse nature as a result of inadvertent, accidental, or malicious intents. It is thoroughly updated with new chapters and the latest coverage of topics not tackled in any previous books such as target organ toxicity, radiation and radioactive materials, FDA regulatory issues, and ethics in veterinary toxicology. There are also expanded discussions on international topics such as epidemiology of animal poisonings and regulatory guidelines and poisonous plants in Europe. Problem solving strategies are offered for treatment. This volume will be of interest to practitioners, professors and students of veterinary medicine and veterinary toxicology, poison control centers, marine biologists, environmentalists and animal scientists.

    • Enzymatic Basis of Detoxication Volume 2

      • 1st Edition
      • December 2, 2012
      • William B. Jakoby
      • English
      • Paperback
        9 7 8 0 1 2 3 9 5 9 1 8 8
      • eBook
        9 7 8 0 3 2 3 1 3 8 2 0 8
      Enzymatic Basis of Detoxication, Volume II, reviews the state of knowledge on foreign compound metabolism at the level of what specific enzymes can do. The book attempts to provide a holistic view of the information gleaned from work with specific, purified enzymes encompassing as many mammalian sources as have been studied. The book is organized into two parts. Part I on conjugation reactions and related systems includes studies on the properties of glucuronide formation; the physiological function, assay, and purificatgion of function of bilirubin-glucuronos... glucuronosyltransfer... the roles of N- and O-methylation reactions and glutathione transferases in detoxication; and amino acid conjugation. Part II presents studies on hydrolytic systems, covering the role of epoxide hydrolase, carboxylesterases, and amidases in detoxication and the regulatory effects of these enzymes. This book provides pharmacologists and toxicologists with the biochemical view of detoxication, and biochemists with the corresponding pharmacological and toxicological aspects.

    • Enzymatic Basis of Detoxication Volume 1

      • 1st Edition
      • December 2, 2012
      • William B. Jakoby
      • English
      • Paperback
        9 7 8 0 1 2 3 9 5 8 8 3 9
      • eBook
        9 7 8 0 3 2 3 1 3 7 9 8 0
      Enzymatic Basis of Detoxication, Volume I focuses on the catalytic mechanisms and physiological expression of the enzymes that are involved in the detoxication of foreign compounds. The book explores foreign compound metabolism at the level of what specific enzymes can do. This book is organized into three sections and comprised of 17 chapters. The discussion begins with an overview of detoxication and covers both catalytic and non-catalytic removal of foreign substances, along with the general properties of the enzymes that are active in detoxication. The reader is then introduced to the physiological aspects of detoxication, paying particular attention to the kinetic aspects of metabolism and elimination of foreign compounds in animals, human genetic variation in detoxication enzymes, and how such enzymes are induced. The next section focuses on mixed function oxygenase systems and includes chapters on cytochrome P-450 and the detoxication reactions it catalyzes. The book also considers other oxidation-reduction systems, with reference to alcohol dehydrogenase, aldehyde reductase, aldehyde oxidizing enzymes, ketone reductases, xanthine oxidase and aldehyde oxidase, glutathione peroxidase, and superoxide dismutases. The final chapter is devoted to monoamine oxidase, its properties, substrate specificity, inhibitors, kinetics and mechanism, and multiple forms. Pharmacologists, toxicologists, and biochemists will find this book extremely helpful.

    • Adverse Effects of Engineered Nanomaterials

      • 1st Edition
      • January 25, 2012
      • Bengt Fadeel + 2 more
      • English
      • Paperback
        9 7 8 0 1 2 8 1 0 3 3 3 3
      • Hardback
        9 7 8 0 1 2 3 8 6 9 4 0 1
      • eBook
        9 7 8 0 1 2 3 8 6 9 7 6 0
      Adverse Effects of Engineered Nanoparticles: A Disease-Oriented Approach provides a systematic evaluation of representative engineered nanomaterial (ENM) of high volume production and of high economic importance. Each class of nanomaterials discussed includes information on what scientists, industry, regulatory agencies and the general public need to know about nanosafety. This book, written by leading international experts in nanotoxicology and nanmoedicine, gives a comprehensive view of the health impact of ENM, focusing on their potential adverse effects in exposed workers, consumers and patients. The beneficial applications, both diagnostic and therapeutic, of ENM are also highlighted. This book fills an important need in terms of bridging the gap between experimental findings and human exposure to ENM, and the clinical and pathological consequences of such exposure in the human population.

    • Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products

      • 2nd Edition
      • December 2, 2012
      • R.D. Kimbrough + 1 more
      • English
      • Paperback
        9 7 8 0 4 4 4 5 6 5 6 5 5
      • eBook
        9 7 8 0 4 4 4 5 9 8 9 2 9
      The chemical industry is increasingly faced with problems arizing from chemicals produced during the manufacture of halogenated biphenyls or phenols. Knowledge of these chemicals and their destructive properties is sporadic, and the acute toxicity of this group varies widely. This informative revised edition presents the chemistry, environmental pollution problems, animal toxicology and information about structure-activity relationships. A brief overview is given of worker exposure and occupational illness. The book is divided into three parts: chemistry and environmental contamination; experimental toxicology; and human exposure and effects. Because of the great deal of interest in these compounds much new research work has been conducted since the first edition of this book was published. This revised edition has retained the effectiveness and clarity of the first edition, while being supplemented with new information, condensed old information, and examples of recent incidents.

    • Xenobiotics and Inflammation

      • 1st Edition
      • December 2, 2012
      • Schook + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 4 1 2 0 6 3 1
      • eBook
        9 7 8 0 3 2 3 1 4 0 3 6 2
      The affect of xenobiotics on host resistance in general and specific immune functions has become the focus of much current research. This book synthesises current information on how chemicals (xenobiotics) can affect the immune system to cuse dysfunction, focusing on the process of inflammation. It provides a much needed, single-source reference for researchers investigation the mechanisms responsible for altered host resistance following exposture to xenobiotics. Emphasis is placed on the roles of cytokines and growth factors in the inflammatory process and how such processes are altered and modulated by xenobiotics. This volume contains information pertinent to those exploring cell growth, angiogenesis, hematopoetic differentiation, and recruitment to and proliferation of cells in various tissue sites. This volume brings together experts in inflammation, cytokines, cell growth, immunology and toxicology to provide a highly yseful volume modulated by chemicals. Divided into three sections, the book offers an organ system approach to understanding inflammation and xenobiotics.

    • Pyrethrum

      • 1st Edition
      • December 2, 2012
      • John Casida
      • English
      • Paperback
        9 7 8 0 1 2 4 3 1 6 8 6 7
      • Hardback
        9 7 8 0 1 2 1 6 2 9 5 0 2
      • eBook
        9 7 8 0 3 2 3 1 5 4 9 0 1
      Pyrethrum: the Natural Insecticide covers the papers presented at the 1972 ""International Symposium on Recent Advances with Pyrethrum the Natural Insecticide"" held in conjunction with the American Institute of Biological Sciences Silver Anniversary Meeting at the University of Minnesota, Minneapolis. It deals with all aspects of pyrethrum, including its history, production, chemistry, biochemistry, toxicology, pharmacology, and agricultural applications. The introductory part addresses the early history of pyrethrum, its recognition as a modern insecticide, and its worldwide production. The chemistry and biochemistry parts discuss the composition, isolation, structure, synthesis, biosynthesis, metabolism, and action on enzyme systems of natural pyrethrins extracted from pyrethrum flower. The book also examines the toxicology of pyrethrum and its constituents to mammals, fish, and wildlife, as well as tests for possible teratogenic, carcinogenic, mutagenic, and allergenic activities. Finally, it discusses the domestic and agricultural applications of pyrethrum. Considering its desirable features, researchers find pyrethrum unsurpassed by any type of synthetic organic insecticide and even by the best synthetic analogs or pyrethroids.

Related subjects

Analytic forensic toxicology

Carcinogenic and genetic toxicology

Cardiovascular toxicology

Hepatic gastrointestinal toxicology

Immunotoxicology

Metal toxicology

Neurobehavioral toxicology

Occupational toxicology

Pesticide toxicology

Plant and animal toxins

Radiation toxicology

Regulatory toxicology

Renal toxicology

Reproductive endocrine toxicology

Respiratory toxicology

Risk assessment

Solvent and vapor toxicology

Toxicology environmental

Toxicology general

Toxicology principles

Toxicology testing and evaluation