Current Concepts in Drug Metabolism and Toxicology
- 1st Edition, Volume 63 - June 12, 2012
- Imprint: Academic Press
- Editor: Gabrielle M. Hawksworth
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 2 8 2 2 1 - 5
- Hardback ISBN:9 7 8 - 0 - 1 2 - 3 9 8 3 3 9 - 8
- eBook ISBN:9 7 8 - 0 - 1 2 - 3 9 8 3 5 9 - 6
This new volume of Advances in Pharmacology explores the current concepts in drug metabolism and toxicology. Chapters cover the Keap1-Nrf2 cell defense pathway, animal models of… Read more
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Request a sales quoteThis new volume of Advances in Pharmacology explores the current concepts in drug metabolism and toxicology. Chapters cover the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.
- Explores the current concepts in drug metabolism and toxicology
- Chapters cover such areas as the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity
- An essential resource for pharmacologists, immunologists and biochemists alike
Pharmacologists, immunologists, and biochemists
Contributors
Membrane Transporters in Drug Development
I Introduction
II Key Features of Transporters
III Transporters and the Pharmaceutical Industry
IV Studying and Contextualizing Transporter Interactions: Application and Interpretation of Data
V The Transporter Toolkit, its Opportunities and Challenges
VI Conclusion
Acknowledgments
Abbreviations
The Keap1–Nrf2 Cell Defense Pathway – A Promising Therapeutic Target?
I Introduction
II The Keap1–Nrf2 Cell Defense Pathway
III Activation of Nrf2 as a Potential Therapeutic Strategy
IV Inhibition of Nrf2 as a Potential Therapeutic Strategy
V Conclusion
Abbreviations
Animal Models of Idiosyncratic Drug Reactions
I Introduction
II Animal Models of Skin Rash
III Animal Models of Liver Toxicity
IV Animal Models of Hematological Toxicity
V Animal Models of Generalized Hypersensitivity Reactions
VI Animal Models of Generalized Autoimmunity
VII Conclusion
Abbreviations
Genetic Polymorphisms Affecting Drug Metabolism
I Introduction
II Recent Advances in the Pharmacogenetics of Cytochromes P450
III Recent Advances in the Pharmacogenetics of Non-P450 Metabolism
IV Clinical Relevance of Polymorphic Metabolism – Some Contemporary Examples
V Conclusion
Abbreviations
Arylamine N-Acetyltransferases – from Drug Metabolism and Pharmacogenetics to Identification of Novel Targets for Pharmacological Intervention
I Introduction
II NAT Enzyme Mechanism
III NAT Genes and Pharmacogenetics
IV The Genomic Distribution and Function of NATs
V NAT Gene Expression and Regulation
VI Development of NAT Inhibitors
VII Conclusion
Abbreviations
Human Pluripotent Stem Cells for Modeling Toxicity
I Introduction
II The Use of Human Stem Cells in Developmental Toxicity
III The Use of Human Stem Cells in Cardiotoxicity
IV The Use of Human Stem Cells in Hepatotoxicity
V The Use of Human Stem Cells in Neurotoxicity
VI Conclusion
Abbreviations
Disposition of Biologics
I Introduction
II Routes of Administration
III Mechanisms of Biologics Distribution and Clearance, The Importance of Active Processes
IV Distribution Studies with Biologics and Relevance to Toxicology Studies
V Metabolism of Biologics
VI Consideration of Immunogenicity – Changes in Disposition and Impact on Toxicology
VII Conclusion
Abbreviations
Index
Recent Volumes in the Serial
- Edition: 1
- Volume: 63
- Published: June 12, 2012
- No. of pages (Hardback): 304
- No. of pages (eBook): 304
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780323282215
- Hardback ISBN: 9780123983398
- eBook ISBN: 9780123983596
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