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Books in Toxicology

Elsevier's Toxicology collection provides essential insights for researchers and scientists into mitigating the adverse effects of contaminants on organisms, covering research, analysis, risk assessment, detection, prevention, diagnosis, and treatment of toxic exposure. Including toxicity testing, environmental toxicology it offers valuable knowledge for addressing public health and safety challenges by examining the adverse effects of contaminants on human health, animals, and the environment.

    • Mitochondrial Dysfunction

      • 1st Edition
      • October 22, 2013
      • Lawrence H. Lash + 1 more
      • English
      • Paperback
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      Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.
    • Essays in Toxicology

      • 1st Edition
      • October 22, 2013
      • Wayland J. Hayes
      • English
      • Paperback
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      Essays in Toxicology, Volume 5 covers essays in toxicology. The book presents essays on nitrosamines; a laboratory model ecosystem to evaluate compounds producing biological magnification; and the metabolism of DDT in human. The text also includes essays on the toxins of Clostridium botulinum; the use of breath analysis in clinical toxicology; and the biochemical toxicology of methanol. Toxicologists, biochemists, microbiologists, pharmacologists, and people involved in the research of toxicology will find the book invaluable.
    • Toxicology and Occupational Medicine

      • 1st Edition
      • October 22, 2013
      • William B. Deichmann
      • English
      • Paperback
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      Toxicology and Occupational Medicine documents the proceedings of the Tenth Inter-American Conference on Toxicology and Occupational Medicine held in Key Biscayne (Miami), Florida, on 22-25 October 1978. The purpose of the conference was the presentation by delegates of research reports on subjects in the broad field of Toxicology and Occupational Medicine, followed by free discussions by all participants. This volume contains 47 papers and begins by tracing the history of the Inter-American Conferences. Subsequent chapters present papers on topics such as legal and scientific concerns over food safety; factors to consider to ensure the validity of the design of the experiment, the procedure for carrying it out, and the method of interpreting the results; and comparison of mutagenic, carcinogenic, and epidemiological data on known human carcinogens. Other papers cover the hidden carcinogen in the manufacture of isopropyl alcohol; developments in protecting workers from chemical hazards on the job; and safety evaluation of cosmetic ingredients.
    • Recent Advances in the Pharmacology of Toxins

      • 1st Edition
      • October 22, 2013
      • H. W. Raudonat
      • English
      • eBook
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      Recent Advances in the Pharmacology of Toxins brings together the proceedings of the Second International Pharmacological Meeting of the International Union of Physiological Sciences, held in Prague, Czechoslovakia, on August 20-23, 1963. The meeting provided a forum for discussing advances in the understanding of the pharmacology of toxins and addressed topics ranging from antagonists of bradykinin to the mode of the spread of tetanus toxin in experimental animals. This volume is comprised of 28 chapters and begins with an analysis of the effects of toxins from microorganisms on mammalian cellular metabolism and structure, followed by a review of SRS-A, a slow-reacting substance of anaphylaxis, as a potential factor in the symptoms produced by venoms and toxins. Subsequent chapters explore the release of pharmacologically active lipids by enzymes contained in toxins; the structure and function of some enzymes in snake venoms, with reference to disulfide linkages; biochemistry and pharmacology of small-molecular compounds of cobra venom; and the role of ganglioside in the mode of action of tetanus toxin. This book will be of particular value to pharmacologists and physiologists.
    • Essays in Toxicology

      • 1st Edition
      • October 22, 2013
      • Wayland J. Hayes
      • English
      • Paperback
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      • eBook
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      Essays in Toxicology, Volume 6 approaches toxicology by very different routes; two essays with materials (plastics and tobacco alkaloids), one deals with the effects of abnormal pressure, one considers the biochemistry of the lung, and one discusses poison control centers and other mechanisms for limiting the injury done by toxic materials. The book presents essays on the topological problems and untoward effects from plastic devices used in medical applications; the metabolism of tobacco alkaloids; and poisons control center. The text also includes essays on the toxicology of hypobaric and hyperbaric environments; as well as the exploitable biochemical approaches for the evaluation of toxic lung damage. Biochemists, physical chemists, neurophysiologists, epidemiologists, and social scientists will find the book invaluable.
    • Advances in Drug Research

      • 1st Edition
      • Volume 22
      • October 22, 2013
      • Bernard Testa
      • English
      • Hardback
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      Advances in Drug Research, Volume 22 focuses on the concepts and facts of drug research. This book is divided into four chapters. Chapter 1 discusses the use of atomic properties and atom-centered indices in QSAR models, while Chapter 2 describes the pharmacokinetics of peptides and proteins. The nuclear receptors, emphasizing the aspects of molecular and genomic pharmacology are elaborated in Chapter 3. The last chapter covers the medicinal chemistry of a vast group of agents acting on nuclear receptors. This publication is valuable to drug researchers and students interested in advances in drugs.
    • Cardiac Pharmacology

      • 1st Edition
      • October 22, 2013
      • R. Douglas Wilkerson
      • English
      • Hardback
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      Cardiac Pharmacology aims to interface basic and clinical knowledge of those interventions used or being studied for use in the treatment of heart disease. The book is divided into four major sections which address intrinsic and neural control of cardiac function, pharmacologic modification of cardiac contractility and cardiac output, the genesis and control of cardiac arrhythmias, and pharmacologic manipulation of myocardial oxygen supply and demand. The last three sections contain a chapter describing the techniques employed in the study of that particular aspect of cardiac function and its alterations by pharmacologic interventions. Cardiologists, pharmacologists, physiologists, and those interested in the area of cardiovascular medicine will find the book insightful.
    • Principles, Methods, and General Applications

      • 1st Edition
      • September 11, 2013
      • Gunter Zweig
      • English
      • Paperback
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      Analytical Methods for Pesticides, Plant Growth Regulators, and Food Additives, Volume 1: Principles, Methods, and General Applications provides information on analytical techniques useful for the determination of pesticides, plant growth regulators, and food additives. The book discusses the potential hazard of minute residues to human and animal health; the principles of formulation and residue analyses; and the principles of food additive analysis. The text also describes the extraction and clean-up procedures; and the principles of toxicological testing methods. The methods for pesticide analysis in meat products; and the formulation and residue analysis in government laboratories are also considered. The book further tackles other methods, such as spectrophotometric methods, chromatography, isotope methods, enzymatic methods; and bioassay. Agricultural toxicologists and people studying pesticides and food additives will find the text invaluable.
    • Neuropsychopharmacology

      • 1st Edition
      • October 22, 2013
      • C. Dumont
      • English
      • Paperback
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      Advances in Pharmacology and Therapeutics, Volume 5: Neuropsychopharmacol... contains the proceedings of the 7th International Congress of Pharmacology held in Paris, France, in 1978. The papers explore advances in the understanding of neuropsychopharmacol... and cover topics ranging from anti-schizophrenic drugs to drug pathways in depression treatment. Pharmacological interferences with nonstriatal dopaminergic systems are also discussed. This volume is comprised of 21 chapters and opens by considering the nanomolar affinity of pre- and post-synaptic dopamine receptors for neuroleptics. The next section deals with drug pathways in the treatment of depression, with particular reference to the biochemical mechanisms of depressive states and the therapeutic effects of some antidepressants. The following chapters examine dopamine receptors in the nucleus accumbens; modulation of mesolimbic dopamine mechanisms via serotonin and GABA; how mesocortical dopaminergic neurons react to stress; and the behavioral consequences of the interaction between morphine, substance P, and nonstriatal dopamine neurons. This book will be of interest to practitioners in biosciences, pharmacology, physiology, psychology, neurology, and medicine.
    • Radiation Research

      • 1st Edition
      • October 22, 2013
      • Oddvar F. Nygaard + 2 more
      • English
      • Hardback
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      Radiation Research: Biomedical, Chemical and Physical Perspectives documents the proceedings of the Fifth International Congress of Radiation Research held in Seattle, Washington, 14-20 July 1974. While the focus of the Congress was on fundamental research, there were several well-attended sessions on the practical aspects of radiation research as it relates to radiotherapy, central station power generation by both nuclear fission and fusion, and the environment. This volume contains 126 papers organized into 31 parts. Beginning with a keynote address and a lecture on the time scale in radiobiology, the subsequent contributions cover a wide range of topics presented over several sessions. Topics discussed during these sessions include energy needs, nuclear power, and the environment; prospects for fusion power; technological applications of radiation; human radiobiology; hazards of radiation exposure relative to other environmental agents; the basic physics of the interactions of radiation with matter; particle penetration phenomena; and radiation effects in frozen media.