Advances in Drug Research

Contributors

Preface: "All Mimsy Were the Borogoves"

Atom Description in QSAR Models: Development and Use of an Atom Level Index


1 Introduction


2 An Atom Level Description of Structure


3 Formulation of an Atom-Centered Index


4 Information from Electrotopological State Values


5 QSAR Strategy


6 Applications to Drug QSAR Problems


7 Discussion

References

Pharmacokinetics of Peptides and Proteins: Opportunities and Challenges


1 Introduction


2 Physicochemical Factors and Passive Distribution


3 Clearance


4 Transport of Peptides Across Mucosal Surfaces


5 Conclusions

References

Towards Genomic Pharmacology: From Membranal to Nuclear Receptors


1 Introduction


2 Regulation of Gene Expression


3 Nuclear Receptors


4 Induced Changes in Gene Expression


5 The Nucleus as a Target for Drug Action


6 Signal Pathways: From Membrane to Nuclear Receptors


7 Future Prospects

References

Medicinal Chemistry of Steroids: Recent Developments


1 Introduction


2 Steroid Receptors


3 Steroid-Converting Enzymes: The Case of 3-Oxo-Δ5-Steroid Isomerase


4 Inhibitors of Steroid-Converting Enzymes


5 Oestrogen Receptor-Based Imaging Agents


6 Conclusions and Future Developments

References

Subject Index

Cumulative Index of Authors

Cumulative Index of Titles