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Books in Toxicology

Elsevier's Toxicology collection provides essential insights for researchers and scientists into mitigating the adverse effects of contaminants on organisms, covering research, analysis, risk assessment, detection, prevention, diagnosis, and treatment of toxic exposure. Including toxicity testing, environmental toxicology it offers valuable knowledge for addressing public health and safety challenges by examining the adverse effects of contaminants on human health, animals, and the environment.

BooksJournals

    • Drug-Induced Liver Disease

      • 3rd Edition
      • April 18, 2013
      • Neil Kaplowitz + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 3 8 7 8 1 7 5
      • eBook
        9 7 8 0 1 2 3 8 7 8 1 8 2
      This field has shown tremendous growth in recent years, primarily due to the recognition that drug-induced liver disease is the most common cause of liver failure and one of the major contributors to the withdrawal of drugs developed by the pharmaceutical industry. Drug-Induced Liver Disease, 3rd edition is a comprehensive reference that covers mechanisms of injury, diagnosis and management, major hepatotoxins, regulatory perspectives and much more. Written by highly respected authorities, this new edition is an updated and definitive reference for clinicians and scientists in academia, the pharmaceutical industry and government settings. This book contains 4 new chapters on key topics in the area and provides a current and extensive review of the latest developments concerning the toxicology, pharmacology, genetics and immunology of drug-induced liver disease.

    • Biochemical and Neurophysiological Correlation of Centrally Acting Drugs

      • 1st Edition
      • October 22, 2013
      • E. Trabucchi + 2 more
      • English
      • Paperback
        9 7 8 1 4 8 3 1 6 9 5 7 6
      • eBook
        9 7 8 1 4 8 3 1 8 5 3 8 5
      Section on Pharmacology of the International Union of Physiological Sciences (SEPHAR), Proceedings of the Second International Pharmacological Meeting, August 20-23, 1963, Volume 2: Biochemical and Neurophysiological Correlation of Centrally Acting Drugs focuses on the composition, reactions, and applications of centrally acting drugs. The selection first offers information on the physiology of striopallidum in relation to extrapyramidal function and disorders and actions of dopa and dopamine in relation to function of the central nervous system. Discussions focus on correlation of behavioral and clinical states with metabolism of dopamine, functions of dopamine in the brain, and the central pharmacology of dopamine. The text then examines the role of brain dopamine (3-hydroxytyramine) in Parkinsonism, including behavior of dopamine in the extrapyramidal centers in patients with Parkinson's disease; brain dopamine and the extrapyramidal symptomatology of Parkinson's disease; and parallelism between Parkinson's disease and the Parkinson-like state induced by reserpine in man. The publication ponders on pharmacological studies on tremorine and metabolism of tremorine. The manuscript also takes a look at the contribution on the pathophysiology of intentional tremor; failure of Antiparkinson drugs to antagonize hypothermia in tremorine-treated rats; and significance of dopamine in psychomotor stimulant action. The selection is a dependable source of data for readers interested in centrally acting drugs.

    • Handbook of Toxicologic Pathology

      • 1st Edition
      • October 22, 2013
      • Wanda M Haschek + 1 more
      • English
      • eBook
        9 7 8 1 4 8 3 2 8 8 6 1 1
      This is the first comprehensive reference work on toxicologic pathology, an emerging field that integrates the mechanisms of toxic injury with the resulting pathology. Chapters deal systematically with organ-specific toxic injury, describing the mechanisms of injury, morphological expression of the injury, and evaluation of the pathology. Additional chapters introduce the field to the uninitiated and address such topics as techniques used for morphological evaluation, risk assessment, and regulatory aspects. The Handbook of Toxicologic Pathology will quickly establish itself as the classic reference work in this field for years to come.

    • Pharmacology of the Coronary Circulation

      • 1st Edition
      • October 22, 2013
      • Natalia V. Kaverina
      • English
      • Paperback
        9 7 8 1 4 8 3 1 6 9 5 4 5
      • eBook
        9 7 8 1 4 8 3 1 8 5 3 5 4
      Pharmacology of the Coronary Circulation focuses on the effects of pharmacological substances on the circulation of the heart, physiology of coronary circulation, effects of adrenomimetic, cholinergic, and ganglion-blocking agents, phenothiazine derivatives, analgesics, nitrites, and nitrates on cardiac vessels and results of clinical trials on Chloracizine. The publication first offers information on the physiology of the coronary circulation and the effects of pharmacological substances on the coronary circulation, including myotropic and neutropic substances and other substances. The book then examines the effects of adrenomimetic substances and cholinergic substances on the coronary circulation. The manuscript evaluates the effects of ganglion-blocking substances and analgesic substances on the coronary circulation. Topics include nicotine, etraethylammonium, hexamethonium, pentamine, and mecamine. The publication then takes a look at the effects of phenothiazine derivatives on the coronary circulation; importance of reflex reactions in connection with the development of acute coronary insufficiency; and effects of pharmacological substances on reflex reactions in the coronary vessels. The book is a dependable reference for readers interested in the pharmacology of the coronary circulation.

    • Monographs on Fragrance Raw Materials

      • 1st Edition
      • October 22, 2013
      • D. L. J. Opdyke
      • English
      • Paperback
        9 7 8 1 4 8 3 1 1 5 5 5 9
      • eBook
        9 7 8 1 4 8 3 1 4 7 9 7 0
      Monographs on Fragrance Raw Materials contains a collection of monographs originally appearing in Food and Cosmetics Toxicology from the first issues in 1973 to the last ones in 1978. The monographs are organized in alphabetical order, as a regular feature of Food and Cosmetics Toxicology. This monograph will prove valuable to many readers of Food and Cosmetics Toxicology, as well as to the wider community of scientists and interested consumers.

    • Drug Design

      • 1st Edition
      • October 22, 2013
      • E. J. Ariëns
      • English
      • Paperback
        9 7 8 1 4 8 3 2 0 2 6 6 2
      • eBook
        9 7 8 1 4 8 3 2 1 6 0 9 6
      Drug Design, Volume VII covers the design of agents such as blood substitutes, pesticides derived from insect pheromones, and herbicides related to the auxin-type plant hormones. The book discusses the design of artificial blood substitutes and auxin-type herbicides; the use of insect pheromones as a basis for the development of more effective selective pest control agents; and the development and application of new steric substituent parameters in drug design. The text also describes the use of computer technology in drug design. Pharmacologists, chemists, biochemists, and people involved in drug design and manufacture will find the book invaluable.

    • Thorium-232 and Uranium-238

      • 1st Edition
      • October 22, 2013
      • A. A. Letavet + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 1 2 0 5 9 1
      • eBook
        9 7 8 1 4 8 3 1 5 3 0 1 8
      The Toxicology of Radioactive Substances, Volume 4: Thorium-232 and Uranium-238 deals with the toxic properties of two radioactive elements, thorium-232 and uranium-238, as well as their soluble and insoluble compounds. Emphasis is placed on their biological effects and the late sequelae of their administration, especially in the case of insoluble compounds. Some of the results of laboratory studies on the acute and chronic effects of the very poorly soluble uranium compound U3O8 are presented. This volume is comprised of 12 chapters and opens with an overview of certain aspects of the toxicology of insoluble compounds of thorium-232 and uranium-238, followed by a discussion on the comparative toxicity of soluble and insoluble compounds of thorium-232. Subsequent chapters explore the absorption, distribution, and excretion of certain soluble compounds of natural thorium; the behavior of thorium dioxide in rats after intratracheal and intraperitoneal administration; the effect of thorium dioxide on the peripheral blood of rats; and photometric determination of low amounts of thorium in biological materials. Changes in the peripheral blood following chronic and acute poisoning with U308 are also considered. This book will be of interest to chemists and toxicologists.

    • Drugs and Enzymes

      • 1st Edition
      • October 22, 2013
      • Bernard B. Brodie + 1 more
      • English
      • eBook
        9 7 8 1 4 8 3 2 2 3 5 1 3
      Second International Pharmacological Meeting, Volume 4: Drugs and Enzymes is a collection of papers presented at the Second International Pharmacological Meeting on August 20-23, 1963. This volume is organized into two sections encompassing 41 chapters. The first section discusses the relationship between biochemical effects of drugs in vitro and their pharmacological effect in vivo. This section specifically examines the correlation between the action of substances on isolated smooth muscle and on the central nervous system, as well as the behavior of a centrally-acting drug and enzyme in the ion movement in the system. The second section surveys the biochemical mechanisms of drug toxicity. Considerable chapters in this section are devoted to the effect of drug toxicity, such as altered drug metabolism, enzyme induction, morphological changes, hepatic effects, and photosensitivity. This book will prove useful to pharmacologists, neurologists, biochemists, and researchers who are interested the fields of drugs and drug toxicity.

    • Bioreduction in the Activation of Drugs

      • 1st Edition
      • October 22, 2013
      • P. Alexander + 2 more
      • English
      • Paperback
        9 7 8 1 4 8 3 1 7 5 0 2 7
      • eBook
        9 7 8 1 4 8 3 1 9 0 8 3 9
      Bioreduction in the Activation of Drugs covers the proceedings of the Second Biochemical Pharmacology Symposium. The book presents papers that cover the applications of bioreduction in drug activation, along with its concerns. The text first presents materials about enzymology, such as overview of enzyme systems involved in bioreduction of drugs and in redox cycling, and reductive role of glutathione in the redox cycling of oxidizable drugs. Next, the book covers papers on bacterial and parasites infection, which include reduction by the gut microflora of animals and human and reduction of nitroimidazoles in vitro and DNA damage. The remaining articles deal with cancer treatment, such as hypoxia-mediated nitro-heterocyclic drugs in the radio- and chemotherapy of cancer, and the biological properties of reduced nitroheterocyclics and possible underlying biochemical mechanisms. The text will be of great use to researchers and practitioners of medicine, pharmacology, and biochemistry.

    • Receptors and Centrally Acting Drugs Pharmacokinetics and Drug Metabolism

      • 1st Edition
      • October 22, 2013
      • E. S. Vizi + 2 more
      • English
      • Paperback
        9 7 8 1 4 8 3 1 1 8 9 9 4
      • eBook
        9 7 8 1 4 8 3 1 5 1 4 1 0
      Advances in Pharmacological Research and Practice, Volume 2: Receptors and Centrally Acting Drugs presents the proceeding of the 4th Congress of the Hungarian Pharmacological Society, held in Budapest, Hungary in 1985. This book presents a comprehensive view of the developments in the fields of receptors and centrally acting drugs as well as in pharmacokinetics and drug metabolism. Organized into two sections encompassing 25 chapters, this volume begins with an overview of prejunctional regulation of neuromuscular transmission. This text then explores the whole-body autoradiography that is used extensively in toxicological research and screening. Other chapters consider the three major classes of models used in pharmacokinetics. This book discusses as well the various aspects of melanin–drug interactions. The final chapter deals with the investigation on the melanin affinity of amphetamine derivatives. This book is a valuable resource for pharmacologists, pharmacokineticists, and researchers.

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