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Books in Toxicology

Elsevier's Toxicology collection provides essential insights for researchers and scientists into mitigating the adverse effects of contaminants on organisms, covering research, analysis, risk assessment, detection, prevention, diagnosis, and treatment of toxic exposure. Including toxicity testing, environmental toxicology it offers valuable knowledge for addressing public health and safety challenges by examining the adverse effects of contaminants on human health, animals, and the environment.

  • Introduction to the Principles of Drug Design

    • 1st Edition
    • June 14, 2016
    • H. J. Smith + 1 more
    • English
    Introduction to the Principles of Drug Design provides a framework of fundamental drug design and principles into which drugs following on developments may be fitted. This book presents the rationales behind the design of drugs. Organized into nine chapters, this book begins with an overview of how the body handles a drug in terms of absorption, metabolism, distribution, and excretion. This text then examines the critical drug activity at the receptor site, which is usually related to blood and other distribution fluid levels. Other chapters consider the factors involved in binding a drug, metabolite, or substrate to a receptor. The final chapter deals with the design of chemotherapeutic agent for clinical use in the treatment of human infections. This book is intended for use in undergraduate pharmacy courses in medicinal chemistry and as an aid in similar courses in biochemistry and pharmacology. Graduates in chemistry just entering the pharmaceutical industry will also find this book useful.

  • Molecular Biological Markers for Toxicology and Risk Assessment

    • 1st Edition
    • June 8, 2016
    • Bruce A. Fowler
    • English
    Molecular Biological Markers for Toxicology and Risk Assessment provides an introduction to the exciting field of biomarkers and their use in toxicology and risk assessment. In recent years, new classes of molecular biomarkers capable of detecting early manifestations of ongoing chemical-induced cell injury and cell death have been developed as a result of advances in analytical chemistry, molecular biology, and computational modeling. The interplay between these emergent tools of science has resulted in new insights into initial mechanisms of chemical-induced toxicity and carcinogenicity. Molecular Biological Markers for Toxicology and Risk Assessment guides the reader through a broad range of molecular biological markers, including the "omic" biomarkers, and provides an examination of the various elements in the evolution of these modern tools. It then explores possible ways in which these markers may be applied to advance the field of chemical risk assessment. Since molecular biomarkers and related technologies are inherently complex, the book concludes with a section on risk communication in order that readers may appreciate both the strengths and limitations of molecular biological marker approaches to risk assessment practice.

  • Pharmacology for Student and Pupil Nurses and Students in Associated Professions

    • 2nd Edition
    • June 6, 2016
    • Bernard R. Jones
    • English
    Pharmacology for Student and Pupil Nurses and Students in Associated Professions is based on lectures that have been updated and presented to nurses in training for the State Registration and State Enrolment Examinations and to Students in Dispensing. This book describes therapies and drug trends in the industry, as well as many types of drugs, their administration, dosage, usage, and effects. Functions of the pertinent human anatomy are included to illustrate the absorption of these drugs. This book includes a section on patient counseling; the use of the International System of Units (SI); and the immune-response process related to specialized fields of treatment. Patient counseling is undertaken for patients who will continue treatment at home. The nurse gives proper advice on the administration of the patient's medicine. SI was adopted to enhance the standardization of the unit of measurement for volume, weight, temperature, and length. This standard includes the use of the terms Celsius, millimole, and joule and the way of writing abbreviations and numbers in the Metric system. The immune-response process deals with the mechanism and related aspects concerning the two groups of cytotoxics, antimitotics and antimetabolites. The side effects of these drugs when used, for example, in chemotherapy, are discussed. This book will prove useful to pharmacists, student pharmacy technicians, professors of pharmacology, practitioners of general medicines, and specialists with interests in drug therapy.

  • Current Concepts in Kinin Research

    Proceedings of the Satellite Symposium of the 7th International Congress of Pharmacology, Paris, 22 July 1978
    • 1st Edition
    • June 6, 2016
    • Gert L. Haberland + 1 more
    • English
    Current Concepts in Kinin Research contains the proceedings of the Satellite Symposium of the 7th International Congress of Pharmacology held in Paris on July 22, 1978. The book is organized into four parts. Part I explains the functions and mechanisms of the kinin system. Part II focuses on kallikreins and the methods of their determination. Part III describes the intrinsic blood clotting and plasma kinin formation. The last part deals with the characterization of plasma kininogens.

  • Genetic Toxicology Testing

    A Laboratory Manual
    • 1st Edition
    • May 26, 2016
    • Ray Proudlock
    • English
    Genetic Toxicology Testing: A Laboratory Manual presents a practical guide to genetic toxicology testing of chemicals in a GLP environment. The most commonly used assays are described, from laboratory and test design to results analysis. In a methodical manner, individual test methods are described step-by-step, along with equipment, suggested suppliers, recipes for reagents, and evaluation criteria. An invaluable resource in the lab, this book will help to troubleshoot any assay problems you may encounter to optimise quality and efficiency in your genetic toxicology tests. Genetic Toxicology Testing: A Laboratory Manual is an essential reference for those new to the genetic toxicology laboratory, or anyone involved in setting up their own.

  • Thresholds of Genotoxic Carcinogens

    From Mechanisms to Regulation
    • 1st Edition
    • May 20, 2016
    • Takehiko Nohmi + 1 more
    • English
    Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation brings together current opinion and research activities from Japan, the US, and Europe on the subject of genotoxic thresholds. In regulation, it is an adage that genotoxic carcinogens have no thresholds for action, and that they impose cancer risk on humans even at very low levels. This policy is frequently called into question as humans possess a number of defense mechanisms including detoxication, DNA repair, and apoptosis, meaning there is a threshold at which these genotoxic carcinogens take action. The book examines these potential thresholds, describing the potential cancer risks of daily low-level exposure, the mechanisms involved (such as DNA repair, detoxication, translesion DNA synthesis), chemical and statistical methods of analysis, and the ways in which these may be utilized to inform policy. Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation is an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation.

  • Clinical Challenges in Therapeutic Drug Monitoring

    Special Populations, Physiological Conditions and Pharmacogenomics
    • 1st Edition
    • May 17, 2016
    • William Clarke + 1 more
    • English
    Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomics focuses on critical issues in therapeutic drug monitoring including special requirements of therapeutic drug monitoring important to special populations (infants and children, pregnant women, elderly patients, and obese patients). The book also covers issues of free drug monitoring and common interferences in using immunoassays for therapeutic drug monitoring. This book is essential reading for any clinician, fellow, or trainee who wants to gain greater insight into the process of therapeutic drug monitoring for individual dosage adjustment and avoiding drug toxicity for certain drugs within a narrow therapeutic window. The book is written specifically for busy clinicians, fellows, and trainees who order therapeutic drug monitoring and need to get more familiar with testing methodologies, issues of interferences, and interpretation of results in certain patient populations.

  • Atlas of Histology of the Juvenile Rat

    • 1st Edition
    • May 4, 2016
    • George A Parker + 1 more
    • English
    Atlas of Histology of the Juvenile Rat should be of interest to toxicologic pathologists, toxicologists, and other biological scientists who are interested in the histomorphology of juvenile rats. For several decades the laboratory rat has been used extensively in nonclinical toxicology studies designed to detect potential human toxicity of drugs, agrochemicals, industrial chemicals, and environmental hazards. These studies traditionally have involved young adult rats that are 8-10 weeks of age as studies are started. It is becoming increasingly apparent that children and young animals may have different responses to drug/chemical exposures, therefore, regulatory agencies are emphasizing toxicology studies in juvenile animals. While the histologic features of organs from young adult and aged laboratory rats are well known, less is known about the histologic features of organs from juvenile rats. Final histologic maturity of many organs is achieved postnatally, thus immature histologic features must be distinguished from chemical- or drug-related effects. While this postnatal organ development is known to exist as a general concept, detailed information regarding postnatal histologic development is not readily available. The Atlas includes organs that are typically sampled in nonclinical toxicology studies and presents the histologic features at weekly intervals, starting at birth and extending through postnatal day 42.

  • Mustard Lung

    Diagnosis and Treatment of Respiratory Disorders in Sulfur-Mustard Injured Patients
    • 1st Edition
    • May 3, 2016
    • Mostafa Ghanei + 1 more
    • English
    Mustard Lung: Diagnosis and Treatment of Respiratory Disorders in Sulfur-Mustard Injured Patients brings together the details regarding pathophysiology, medication, and protective issues to provide a comprehensive look at health problems associated with sulfur mustard injury. It provides a bench-to-bedside look at the long term complications of vesicant exposure in humans as well as how mustard gas exposure affects lung function. By providing guidelines and approaches for the diagnosis, pathogenesis, and treatment of SM injury cases, this book is helpful for a wide range of medical researchers and clinicians. For decades, chemical respiratory disorders were diagnosed and managed traditionally similar to other chronic respiratory diseases. However, the exact nature of chemical respiratory disorders is different and needs to be treated as such.

  • Pharmacology of Oriental Plants

    Proceedings of the First International Pharmacological Meeting, Stockholm, 22-25 August, 1961
    • 1st Edition
    • April 20, 2016
    • K. K. Chen + 1 more
    • English
    Pharmacology of Oriental Plants is a collection of papers that details the advancement in research of the pharmacological properties of oriental plants. The topics included in the text cover the chemical behavior and mode of action of plants. Several studies also tackle the medicinal properties of plants that undergo a specific process. The book will be of great use to pharmacologists, botanists, biochemists, horticulturists, and physicians. Advocates of natural and alternative medicine will also find the text interesting.

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