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Elsevier

Clinical Challenges in Therapeutic Drug Monitoring

Special Populations, Physiological Conditions and Pharmacogenomics

  • 1st Edition - May 17, 2016
  • Latest edition
  • Editors: William Clarke, Amitava Dasgupta
  • Language: English

Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomics focuses on critical issues in therapeutic drug monitorin… Read more

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Description

Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomic

s focuses on critical issues in therapeutic drug monitoring including special requirements of therapeutic drug monitoring important to special populations (infants and children, pregnant women, elderly patients, and obese patients). The book also covers issues of free drug monitoring and common interferences in using immunoassays for therapeutic drug monitoring.

This book is essential reading for any clinician, fellow, or trainee who wants to gain greater insight into the process of therapeutic drug monitoring for individual dosage adjustment and avoiding drug toxicity for certain drugs within a narrow therapeutic window. The book is written specifically for busy clinicians, fellows, and trainees who order therapeutic drug monitoring and need to get more familiar with testing methodologies, issues of interferences, and interpretation of results in certain patient populations.

Key features

  • Offers busy clinicians, pathologists, and trainees a concise resource on the key aspects and critical issues in therapeutic drug monitoring
  • Focuses on patient populations such as infants and children, pregnant women, elderly patients, and obese patients, who have special requirements in therapeutic drug monitoring
  • Explores special topics in therapeutic drug monitoring including free drug monitoring and common immunoassay interference
  • Explains how individual dosage adjustments can prevent drug toxicity for certain drugs within a narrow therapeutic window

Readership

Fellows and residents of pathology and internal medicine, practicing clinicians in pathology, family medicine and internal medicine, as well as laboratory professionals

Table of contents

Overview of Therapeutic Drug Monitoring

Immunoassays and Issues with Interference in Therapeutic Drug Monitoring

Application of Chromatography Combined with Mass Spectrometry in Therapeutic Drug Monitoring

Clinical Utility of Free Drug Monitoring

Therapeutic Drug Monitoring of Newer Antiepileptic Drugs

Therapeutic Drug Monitoring of Antiretrovirals

Therapeutic Drug Monitoring in Infants and Children

Therapeutic Drug Monitoring in Pregnancy

Therapeutic Drug Monitoring in the Elderly

Therapeutic Drug Monitoring in Obese Patients

Special Issues in Therapeutic Drug Monitoring in Patients with Uremia, Liver Disease, and Critically Ill Patients

Integrating Therapuetic Drug Monitoring and Pharmacogenomics

Warfarin Pharmacogenomics

Drug Monitoring in Alternative Matrices

Integrating and Supporting Therapeutic Drug Monitoring in a Hospital System

Product details

  • Edition: 1
  • Latest edition
  • Published: May 17, 2016
  • Language: English

About the editors

WC

William Clarke

William Clarke received his PhD in Analytical Chemistry from the University of Nebraska in Lincoln in 2000, followed by a post-doctoral fellowship in Clinical Chemistry at the Johns Hopkins School of Medicine, ending in 2002. In addition, he received an MBA focused on Medical Services Management from the Carey School of Business at Johns Hopkins in 2007. He is an Associate Professor in the Department of Pathology, as well as the director of both Point-of-Care Testing and Clinical Toxicology for The Johns Hopkins Hospital. Dr. Clarke is board certified in Clinical Chemistry by the American Board of Clinical Chemistry, and is a Fellow of the National Academy of Clinical Biochemistry. Dr. Clarke has published, as author or co-author, over 100 peer-reviewed manuscripts and book chapters. He is the Editor of the book Contemporary Practice in Clinical Chemistry, and the Co-Editor-in-Chief for the journal Practical Laboratory Medicine.
Affiliations and expertise
Associate Professor of Pathology, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, MD, USA

AD

Amitava Dasgupta

Amitava Dasgupta received his Ph. D in chemistry from Stanford University and completed his fellowship training in Clinical Chemistry from the Department of Laboratory Medicine at the University of Washington School of Medicine at Seattle. He is board certified in both Toxicology and Clinical Chemistry by the American Board of Clinical Chemistry. Currently, he is a tenured Full Professor of Pathology and Laboratory Medicine at the University of Kansas Medical Center and Director of Clinical Laboratories at the University of Kansas Hospital. Prior to this appointment he was a tenured Professor of Pathology and Laboratory Medicine at the University of Texas McGovern medical School from February 1998 to April 2022. He has 252 papers to his credit. He is in the editorial board of four journals including Therapeutic Drug Monitoring, Clinica Chimica Acta, Archives of Pathology and Laboratory Medicine, and Journal of Clinical Laboratory Analysis.

Affiliations and expertise
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, United States

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