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Books in Pharmacology

Elsevier's Pharmacology collection studies how drugs interact with biological systems to improve health and treat disease. It covers pharmacodynamics, exploring drug effects on biology, and pharmacokinetics, studying how the body affects drugs. Branches like Pharmacogenetics. Essential for pharmacologists, this collection offers invaluable insights into drug interactions, efficacy, and safety, crucial for advancing drug development and improving patient outcomes.

BooksJournals

    • Antipsychotic Drugs and Their Side-Effects

      • 1st Edition
      • October 22, 2013
      • Thomas R.E. Barnes
      • English
      • eBook
        9 7 8 1 4 8 3 2 8 8 1 0 9
      In line with other volumes in the Neuroscience Perspectives Series, this volume covers the background, pharmacology, molecular biology, and biochemistry of antipsychotic drugs, together with an overview assessment of the therapeutic considerations. Over the past 40 years, the effectiveness of conventional neuroleptic agents for psychotic illness has been offset by a wide range of adverse side-effects, including motor side-effects like parkinsonism. Studies show that lowering doses may still produce the antipsychotic effect while lessening the risk of side-effects. As all available antispychotic drugs are able to block dopamine, specifically D2 receptors, doses below the threshold level for producing acute motor disorder can still be therapeutically effective. With the identification and characterization of multiple dopamine receptors, the possibility of more selective drugs with better side-effect potential has arisen. Other novel antipsychotic agents include D1 receptor blockers, partial dopamine agonists and non-dopamine drugs such as 5-HT receptor blockers, sigma receptor antagonists and NMDA receptor agonists. This volume reviews both the basic science of the conventional and atypical neuroleptics and their present and potential therapeutic use.

    • Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells

      • 1st Edition
      • October 22, 2013
      • T.E. Gram
      • English
      • eBook
        9 7 8 1 4 8 3 2 8 7 6 2 1
      Research has shown that the lung is capable of metabolically activating xenobiotics into intermediates that can covalently bind to pulmonary tissue. Further, it has been shown that the lung consists of many distinct cell types with the ability to take up and sequester metabolically unchanged drugs and chemicals that are ultimately toxic in effect. This volume reflects the extent of these developments and provides a state-of-the art reference in a rapidly evolving field incorporating both drug metabolism and pulmonary toxicology research.

    • Novel Psychoactive Substances

      • 1st Edition
      • August 6, 2013
      • Paul I. Dargan + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 4 1 5 8 1 6 0
      • eBook
        9 7 8 0 1 2 4 1 5 9 1 1 2
      Novel Psychoactive Substances: Classification, Pharmacology and Toxicology provides readers with background on the classification, detection, supply and availability of novel psychoactive substances, otherwise known as "legal highs." This book also covers individual classes of novel psychoactive substances that have recently emerged onto the recreational drug scene and provides an overview of the pharmacology of the substance followed by a discussion of the acute and chronic harm or toxicity associated with the substance. Written by international experts in the field, this multi-authored book is a valuable reference for scientists, clinicians, academics, and regulatory and law enforcement professionals.

    • Pharmacogenomics

      • 1st Edition
      • February 12, 2013
      • Yui-Wing Francis Lam + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 3 9 1 9 1 8 2
      • eBook
        9 7 8 0 1 2 3 9 8 3 0 3 9
      Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference.

    • Drug Stability for Pharmaceutical Scientists

      • 1st Edition
      • January 30, 2013
      • Thorsteinn Loftsson
      • English
      • Paperback
        9 7 8 0 1 2 4 1 1 5 4 8 4
      • eBook
        9 7 8 0 1 2 4 1 1 5 6 2 0
      Drug Stability for Pharmaceutical Scientists is a clear and easy-to-follow guide on drug degradation in pharmaceutical formulation. This book features valuable content on both aqueous and solid drug solutions, the stability of proteins and peptides, acid-base catalyzed and solvent catalyzed reactions, how drug formulation can influence drug stability, the influence of external factors on reaction rates and much more. Full of examples of real-life formulation problems and step-by-step calculations, this book is the ideal resource for graduate students, as well as scientists in the pharmaceutical and related industries.

    • Platelets and Aspirin-Induced Asthma

      • 1st Edition
      • October 25, 2013
      • Helen Evsyukova
      • English
      • Paperback
        9 7 8 0 1 2 8 0 0 0 3 3 5
      • eBook
        9 7 8 0 1 2 8 0 0 1 0 3 5
      Platelets and Aspirin-Induced Asthma is the first book to be published that reflects research conducted on aspirin-induced asthma pathogenesis. It is examined through positions of neuroimmunoendocrine interactions in organism. The Melatonin hormone plays a key role, being the regulator and coordinator of complicated and interrelated biological processes. This new concept of aspirin-induced asthma pathogenesis suggests new methods for treatment of this disease by means of correcting the melatonin content in the patient’s organism. Investigations into the mechanisms of aspirin-induced asthma as a pathology of melatonin producing cells of platelets helps to determine high-risk groups and develop preventive measures and adequate therapy.

    • Classes of Pesticides

      • 1st Edition
      • October 22, 2013
      • Wayland J. Hayes Jr.
      • English
      • eBook
        9 7 8 1 4 8 3 2 8 8 6 3 5
      Handbook of Pesticide Toxicology, Volume 3: Classes of Pesticides focuses on the properties, toxicity, classes, and reactions of pesticides. The selection first offers information on carbamate insecticides, nitro compounds and related phenolic pesticides, and synthetic organic rodenticides. Discussions focus on miscellaneous synthetic organic rodenticides, fluoroacetic acid and its derivatives, mononitrophenols, dinitrophenols, classification of carbamates, and toxicology of anticholinesterase carbamates. The book then examines herbicides and fungicides and related compounds. Topics include nitrogen heterocyclic fungicides not otherwise classified, hydrazines, hydrozones, and diazo fungicides, anilino and nitrobenzenoid fungicides, antibiotics and botanicals, organic phosphorus herbicides, carbamate herbicides, and herbicidal oils and simple aliphatics. The publication elaborates on miscellaneous pesticides, including repellents, synthetic molluscicides, inhibitors of chitin synthesis, chemosterilants, and synthetic acaricides. The selection is a valuable source of data for researchers interested in pesticide toxicology.

    • Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components

      • 1st Edition
      • May 24, 2013
      • Mahendra Rai + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 3 9 8 5 3 9 2
      • eBook
        9 7 8 0 1 2 4 0 1 7 0 8 5
      Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and their Components offers scientists a single source aimed at fighting specific multidrug-resistant (MDR) microorganisms such as bacteria, protozoans, viruses and fungi using natural products. This essential reference discusses herbal extracts and essential oils used or under investigation to treat MDR infections, as well as those containing antimicrobial activity that could be of potential interest in future studies against MDR microorganisms. The need to combat multidrug-resistant microorganisms is an urgent one and this book provides important coverage of mechanism of action, the advantages and disadvantages of using herbal extracts, essential oils and their components and more to aid researchers in effective antimicrobial drug discovery

    • Protein Kinase Inhibitors in Research and Medicine

      • 1st Edition
      • Volume 548
      • July 1, 2013
      • English
      • Hardback
        9 7 8 0 1 2 3 9 7 9 1 8 6
      • eBook
        9 7 8 0 1 2 3 9 8 4 6 2 3
      This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers protein kinase inhibitors in research and medicine, and includes chapters on such topics as fragment-based screening, broad kinome profiling of kinase inhibitors, and designing drug-resistant kinase alleles.

    • Unexpected Reactions to Modern Therapeutics

      • 1st Edition
      • October 22, 2013
      • Leo Schindel
      • English
      • Paperback
        9 7 8 1 4 8 3 1 7 8 4 0 0
      • eBook
        9 7 8 1 4 8 3 1 9 4 2 1 9
      Unexpected Reactions to Modern Therapeutics: Antibiotics discusses the side-effects of antibiotics, specifically the allergic reactions of the skin and mucous membranes to penicillin. This book contains 12 chapters that address the specific organ reaction to penicillin and the complications of the gastro-intestinal tract after ingestion of chloramphenicol. Some of the topics covered in the book are the inhibition of the bone marrow function and blood changes after receiving doses of chloramphenicol; lesions of the skin and mucous membranes after applying tetracyclines; changes in the hemopoietic system, liver function, and structure after medication of oxy-tetracycline. Other chapters deal with the analysis of antibiotic resistant bacteria and the physiological adverse effects of neomycin. An analysis of the side-effects of erythromycin is provided. The concluding chapters describe the nephrotoxic effects of bacitracin and the epidermal effects of fumagillin. The book can provide useful information to doctors, pharmacologists, students, and researchers.

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