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Elsevier

Books in Virology

Offering comprehensive coverage of virus structure, replication, and immune response, this portfolio supports virologists, clinicians, and researchers. It features emerging viruses, vaccine development, and antiviral therapies, addressing global challenges such as pandemics, viral resistance, and zoonotic transmission, fostering innovations in disease prevention and control.

  • Desk Encyclopedia of General Virology

    • 1st Edition
    • Marc H.V. van Regenmortel + 1 more
    • English
    This volume, derived from Encyclopedia of Virology, provides an overview of the development of virology during the last ten years. Entries detail the nature, origin, phylogeny and evolution of viruses. It then moves into a summary of our understanding of the structure and assembly of virus particles and describes how this knowledge was obtained. Genetic material of viruses and the different mechanisms used by viruses to infect and replicate in their host cells are highlighted. The volume is rounded out with an overview of some major groups of viruses with particular attention being given to our current knowledge of their molecular biology.

  • Advances in Virus Research

    • 1st Edition
    • Volume 74
    • English
    Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews providing a valuable overview of the current field of virology. The impact factor for 2008 is 4.886, placing it 4th in the highly competitive category of virology.

  • Advances in Virus Research

    • 1st Edition
    • Volume 73
    • Karl Maramorosch + 2 more
    • English
    Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews providing a valuable overview of the current field of virology. The impact factor for 2007 is 3.120, placing it 9th in the highly competitive category of virology.

  • Vaccines for Biodefense and Emerging and Neglected Diseases

    • 1st Edition
    • Alan D.T. Barrett + 1 more
    • English
    The last 20 years has seen a rapid increase in infectious diseases, particularly those that are termed "emerging diseases" such as SARS, "neglected diseases" such as malaria and those that are deemed biothreats such as anthrax. It is well-recognized that the most effective modality for preventing infectious diseases is vaccination. This book provides researchers with a better understanding of what is currently known about these diseases, including whether there is a vaccine available or under development. It also informs readers of the key issues in development of a vaccine for each disease.

  • Advances in Virus Research

    • 1st Edition
    • Volume 72
    • English
    Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews providing a valuable overview of the current field of virology. The impact factor for 2006 is 3.48 placing it 7th in the highly competitive category of virology.

  • The Dictionary of Virology

    • 4th Edition
    • Brian W.J. Mahy
    • English
    Completely revised and updated to take into account the new taxonomy and grouping changes made by the International Committee on Taxonomy of Viruses in their 8th Report, The Dictionary of Virology provides an authoritative and concise list of all viruses affecting vertebrate species, from humans to fish.

  • HIV Prevention

    A Comprehensive Approach
    • 1st Edition
    • Kenneth H. Mayer + 1 more
    • English
    HIV/AIDS continues to be the pandemic of our times and there has not been a comprehensive medically based AIDS prevention book published in the last 5 years. It is estimated that 36 to 45 million people including 2-3 million children already are infected worldwide and an additional 4-7 million more are infected each year. There are about 6,000 new infections daily and about 12 million AIDS orphans. People receiving AIDS treatments feel well and have no detectable viral load, but still can infect others. And even when a vaccine is found, it will take many years before it can be administered across the developing world.

  • Encyclopedia of Virology

    • 3rd Edition
    • B.W.J. Mahy + 1 more
    • English
    Encyclopedia of Virology, Third Edition continues its success as the largest single reference source of current research in virology. Unique in its use of concise “mini-review” articles, this praised work covers biological, molecular, and medical topics concerning viruses in animals, plants, bacteria and insects. Now in five volumes, this new edition has been extensively revised and updated to reflect the 50% increase in identified and accepted viruses since the year 2000. With over 25% new chapters and over 1000 illustrations, this edition takes into account the new developments in virology research by including information on new emerging diseases such as avian flu, SARS and West Nile and the ability of some viruses to be used as agents of bioterrorism. Edited by leading Virologists Mahy and van Regenmortel, this third edition remains the number one all-inclusive source of information for virology researchers, students, and reference departments of academic, medical, and corporate libraries.

  • Advances in Virus Research

    • 1st Edition
    • Volume 71
    • English
    Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews providing a valuable overview of the current field of virology. The impact factor for 2006 is 3.48 placing it 7th in the highly competitive category of virology.

  • Origin and Evolution of Viruses

    • 2nd Edition
    • Esteban Domingo + 2 more
    • English
    New viral diseases are emerging continuously. Viruses adapt to new environments at astounding rates. Genetic variability of viruses jeopardizes vaccine efficacy. For many viruses mutants resistant to antiviral agents or host immune responses arise readily, for example, with HIV and influenza. These variations are all of utmost importance for human and animal health as they have prevented us from controlling these epidemic pathogens. This book focuses on the mechanisms that viruses use to evolve, survive and cause disease in their hosts. Covering human, animal, plant and bacterial viruses, it provides both the basic foundations for the evolutionary dynamics of viruses and specific examples of emerging diseases.

  • HIV I: Molecular Biology and Pathogenesis: Clinical Applications

    • 2nd Edition
    • Volume 56
    • English
    Although it is one of the most-widely studied viruses, many mysteries still remain about HIV. Covering the latest advances and challenges associated with clinical application of new antiviral drugs and vaccines, this revised edition is a companion to Murad: HIV-1: Molecular Biology and Pathogenesis, Second Edition. Leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus.

  • Human Viruses in Water

    Perspectives in Medical Virology
    • 1st Edition
    • Volume 17
    • Albert Bosch
    • English
    This book provides overviews and updates on basic research, diagnosis, epidemiology, and public health on enteric viruses, as well as on treatment and intervention to prevent their waterborne transmission. Data are presented and interpreted by leading researchers in the field in 13 chapters. An essential resource for virologists, epidemiologists, medical and public health professionals, graduate students and postdoctoral scientists at various levels of their careers.

  • Advances in Virus Research

    • 1st Edition
    • Volume 70
    • English
    Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews providing a valuable overview of the current field of virology. In 2004, the Institute for Scientific Information released figures showing that the series has an Impact Factor of 2.576, with a half-life of 7.1 years, placing it 11th in the highly competitive category of Virology.

  • Viruses and Human Disease

    • 2nd Edition
    • Ellen G. Strauss + 1 more
    • English
    Completely revised and updated, the new edition of this groundbreaking text integrates basic virology with pathophysiological conditions to examine the connection between virology and human disease. Most virology textbooks focus on the molecular biology involved without adequate reference to physiology. This text focuses on viruses that infect humans, domestic animals and vertebrates and is based on extensive course notes from James Strauss’ virology class at the California Institute of Technology taught for over 30 years. Expertly depicting in color the molecular structure and replication of each virus, it provides an excellent overview for students and professionals interested in viruses as agents of human disease.

  • Advances in Antiviral Drug Design

    • 1st Edition
    • Volume 5
    • E. De Clercq
    • English
    Regularly reviewing the "state-of-the-art" developments in the antiviral drug research field, this latest volume spans the conceptual design and chemical synthesis of new antiviral compounds. It discusses their structure-activity relationship, mechanism and targets of action, pharmacological behavior, antiviral activity spectrum, and therapeutic potential for clinical use.

  • HIV-1: Molecular Biology and Pathogenesis: Viral Mechanisms

    • 2nd Edition
    • Volume 55
    • English
    This volume covers the latest advances in the mechanisms of pathogenesis of the HIV-1 virus on target cells. Its companion volume, Advances in Pharmacology 56, shows how new developments in understanding the virus translate to the clinical setting.

  • Rabies

    Scientific Basis of the Disease and its Management
    • 2nd Edition
    • Alan C. Jackson + 1 more
    • Alan C. Jackson
    • English
    Rabies is the most current and comprehensive account of one of the oldest diseases known that remains a significant public health threat despite the efforts of many who have endeavored to control it in wildlife and domestic animals. During the past five years since publication of the first edition there have been new developments in many areas on the rabies landscape. This edition takes on a more global perspective with many new authors offering fresh outlooks on each topic. Clinical features of rabies in humans and animals are discussed as well as basic science aspects, molecular biology, pathology, and pathogenesis of this disease. Current methods used in defining geographic origins and animal species infected in wildlife are presented, along with diagnostic methods for identifying the strain of virus based on its genomic sequence and antigenic structure. This multidisciplinary account is essential for clinicians as well as public health advisors, epidemiologists, wildlife biologists, and research scientists wanting to know more about the virus and the disease it causes.

  • Advances in Virus Research

    • 1st Edition
    • Volume 69
    • English
    Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews providing a valuable overview of the current field of virology.In 2004, the Institute for Scientific Information released figures showing that the series has an Impact Factor of 2.576, with a half-life of 7.1 years, placing it 11th in the highly competitive category of Virology.

  • Emerging Viruses in Human Populations

    • 1st Edition
    • Volume 16
    • Edward Tabor
    • English
    Infectious diseases are an ever present threat to humans. In recent years, the threat of these emerging viruses has been greater than ever before in human history, due in large part to global travel by larger numbers of people, and to a lesser extent to disruptions in the interface between developed and undeveloped areas. The emergence of new deadly viruses in human populations during recent decades has confirmed this risk. They remain the third leading cause of deaths in the US and the second world-wide. Emerging Viruses in Human Populations provides a comprehensive review of viruses that are emerging or that threaten to emerge among human populations in the twenty-first century. It discusses the apprehension over emerging viruses that has intensified due to concerns about bioterrorism.

  • Rubella Viruses

    • 1st Edition
    • Volume 15
    • Jangu Banatvala + 1 more
    • English
    This latest volume provides a comprehensive review of the latest developments and research studies on the pathogenesis and molecular biology of human congenital infections. It reviews current diagnostic techniques and epidemiological data while describing the progress in research and understanding of continuing prevention of congenital infections and prognosis.

  • Respiratory Syncytial Virus

    • 1st Edition
    • Volume 14
    • English
    Respiratory syncytial virus (RSV) was first identified half a century ago in 1956. Following its discovery, the virus soon became recognised as a major viral pathogen causing extensive outbreaks of respiratory tract infections in both the very young and in vulnerable adults. It is an unusual virus in that it can cause repeated reinfections throughout life. The topics covered within this volume are wide ranging in scope from the most basic molecular biology of the virus to the clinical picture of RSV in the developing world. The internationally recognised experts were invited not only to review the present state of knowledge but also to give their perspective on the current situation and to identify the gaps and future requirements for research in an effort to stimulate new cross-cutting approaches to tackle this major viral pathogen.

  • Congenital and Other Related Infectious Diseases of the Newborn

    • 1st Edition
    • Volume 13
    • English
    This book is directed toward the molecular composition, pathogenesis, diagnosis, treatment and control of congenital and other related diseases of the newborn that are caused by a variety of viruses. These viruses comprise several families that include Herpesviridae (HSV-1, HSV-2, HSV-6, HSV-7, CMV and varcilla-zoster); Parvoviridae (parvovirus B19); Lentiviridae (HIV); Hepadnaviridae (HBV); Flaviviridae (HCV); and Togaviridae (RV). Leading researchers in childhood diseases and virology from Brazil, Germany, Ireland, Italy, Japan, Spain, and the United States of America report on the up-to-date advances in the molecular virology, immunology, biochemistry, pathology, diagnosis, prevalence and treatment of selected congenital and other related diseases of the newborn.

  • Insect Viruses

    Biotechnological Applications
    • 1st Edition
    • Volume 68
    • English
    Baculoviruses are perhaps unique among viruses in the breadth of their biotechnological applications: these insect specific viruses are used not only for insect pest management purposes, but also as laboratory research tools for production of recombinant proteins and for protein display, and as potential vectors for human gene therapy. In addition to highlighting recent advances, this volume provides a comprehensive review of the biotechnological applications of these and other insect viruses in both the academic and private sectors.

  • Advances in Virus Research

    • 1st Edition
    • Volume 65
    • English
    Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews providing a valuable overview of the current field of virology.In 2004, the Institute for Scientific Information released figures showing that the series has an Impact Factor of 2.576, with a half-life of 7.1 years, placing it 11th in the highly competitive category of Virology.

  • Rinderpest and Peste des Petits Ruminants

    Virus Plagues of Large and Small Ruminants
    • 1st Edition
    • William P. Taylor
    • Thomas Barrett + 1 more
    • English
    Rinderpest and Peste des Petits Ruminants tells the story of how, by the year 2010, scientists are set to globally eradicate one of the great historic plagues that has ravaged human livestock for centuries. Descriptions of the disease in Europe date back to the 4th century and it was regularly re-introduced following wars and other civil unrest until late in the 19th century. It was introduced with devastating effect into Africa towards the end of the 19th century and is now widespread across sub-Saharan Africa, the Middle East and Southern Asia. Its causative agent, rinderpest virus, a morbillivirus very closely related to human measles virus, decimates the cattle population along with those of other susceptible domestic ruminants and many wildlife species wherever it is present.

  • Virus Taxonomy

    VIIIth Report of the International Committee on Taxonomy of Viruses
    • 1st Edition
    • Claude M. Fauquet + 4 more
    • English
    Virus Taxonomy is a standard and comprehensive source for the classification of viruses, created by the International Committee of the Taxonomy of Viruses. The book includes eight taxonomic reports of the ICTV and provides comprehensive information on 3 taxonomic orders of viruses, 73 families, 9 subfamilies, 287 genera, and 1938 virus species. The book also features about 429 colored pictures and diagrams for more efficient learning. The text is divided into four parts, comprised of 16 chapters and presenting the following features: • Compiled data from numerous international experts about virus taxonomy and nomenclature • Organized information on over 6000 recognized viruses, illustrated with diagrams of genome organization and virus replication cycle • Data on the phylogenetic relationships among viruses of the same and different taxa • Discussion of the qualitative and quantitative relationships of virus sequences The book is a definitive reference for microbiologists, molecular biologists, research-level virologists, infectious disease specialists, and pharmaceutical researchers working on antiviral agents. Students and novices in taxonomy and nomenclature will also find this text useful.

  • Virus Structure and Assembly

    • 1st Edition
    • Volume 64
    • Polly Roy
    • English
    Written by experts in their field, Virus Structure and Assembly summarizes our current state of knowledge in the field of virus structure and assembly, comparing and contrasting the mechanisms adopted by viruses with a wide diversity of genome and host. It will serve as an invaluable reference for researchers in virology, microbiology, epidemiology, molecular biology, and public health.

  • The AIDS Pandemic

    Impact on Science and Society
    • 1st Edition
    • Kenneth H. Mayer + 1 more
    • English
    The AIDS Pandemic explores the ways in which HIV/AIDS has, and continues to transform the wide range of related disciplines it touches. Novel perspectives are provided by a unique panel of internationally recognised experts who cover the unprecedented impact onf AIDS on culture, demographics and politics around the world, including how it affected the worlds' economy, health sciences, epidemiology and public health. This important far- reaching analysis uses the lessons learned from a wide array of disciplines to help us understand the current status and evolution of the pandemic, as it continues to evolve.

  • Viral Haemorrhagic Fevers

    • 1st Edition
    • Volume 11
    • English
    In recent years there has been a resurgence of interest in studying infectious diseases, especially given the alarming increase in the numbers of emerging diseases now confronting medical and veterinary science. Viral Haemorrhagic Fevers describes the progress in research and our understanding of these agents against a backdrop of continuing fear these viruses engender among health care workers and the public alike. It discusses how the study of these viral agents is directly applicable to other emerging diseases, particularly in relation to how containing these outbreaks requires a high degree of collaboration between different specialists. Primarily aimed at healthcare workers, clinicians and microbiologists, this book provides a rapid overview as to the nature of these widely varying agents linked only by their propensity of causing serious human disease.

  • Advances in Virus Research

    • 1st Edition
    • Volume 63
    • English
    The Advances in Virus Research series covers a diverse range of in-depth reviews providing a valuable overview of the current field of virology. This eclectic volume contains six reviews covering topics relating to plant viruses, evolution of viruses with hosts and cell recognition by viruses.

  • Advances in Virus Research

    • 1st Edition
    • Volume 62
    • English
    The Advances in Virus Research series covers a diverse range of in-depth reviews providing a valuable overview of the current field of virology.This eclectic volume contains six reviews covering topics relating to plant viruses, evolution of viruses with hosts and cell recognition by viruses.

  • The Flaviviruses: Detection, Diagnosis and Vaccine Development

    • 1st Edition
    • Volume 61
    • English
    Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat. Detection, Diagnosis and Vaccine Development, the third volume of The Flaviviruses details the current status of technologies for detection and differentiation of these viruses, their use in surveillance and outbreak investigation, and also reviews the latest clinical research.

  • Advances in Antiviral Drug Design

    • 1st Edition
    • Volume 4
    • E. De Clercq
    • English
    The fourth volume of Advances in Antiviral Drug Design is keeping up with the recent progress made in the broad field of antiviral drug research and encompasses six specific directions that have opened new avenues for the treatment of HIV and other virus infections.First, as the introductory chapter, the different new anti-HIV agents that are now in preclinical or clinical development are reviewed by E. De Clercq. This includes new NRTIs, NNRTIs and PIs, but also HIV entry/fusion inhibitors as well as integrase inhibitors, and some of these agents, such as the NRTI emtricitabine [(-)FTC] and the PI atazanavir, may soon be licensed for clinical use.Second, high expectations are vested in the potential therapeutic usefulness of inhibitors of HIV integration, a point of no return in the life cycle of HIV, and this approach is highlighted by D.J. Hazuda and S.D. Young.Third, as all currently available PIs can be described as "peptidomimetic", and, therefore, expected to demonstrate overlapping virus-drug resistance and side effect profiles, it would be interesting to see how a non-peptidic protease inhibitor such as tipranavir behaves, and this is covered by D. Mayers, K. Curry, V. Kohlbrenner and S. McCallister.Fourth, neuraminidase inhibitors such as zanamivir (that has to be inhaled) and oseltamivir (that can be administered via the oral route) have gained a definitive status as antiviral drugs useful for both therapy and prophylaxis of influenza A and B virus infections; as they target a specific influenza viral enzyme, neuraminidase (or sialidase), they may be expected to block newly emerging influenza viruses as well, and the design of neuraminidase inhibitors has received due attention of H. Jin and C.U. Kim.Fifth, while the major current efforts in antiviral drug development have shifted from herpesviruses towards HIV and hepatitis viruses [hepatitis B virus (HBV), hepatitis C virus (HCV)], it is interesting to note that by switching from the classical five-membered sugar or acyclic nucleoside strategy, J. Wang, M. Froeyen and P. Herdewijn have gone "upstream" in designing six-membered carbocyclic nucleosides as potential anti-herpesvirus agents.Sixth, following up on the nucleotide prodrug strategy introduced above under ix, to deliver the biologically active nucleotides inside the cells, C. Meier has elaborated on a particular class of such pronucleotides, namely that of the cyclosaligenyl pronucleotides, an approach that should have far reaching implications for compounds effective against HIV, HBV and other viruses.The six topics covered in this fourth volume of Advances in Antiviral Drug Design are in the front line of the present endeavors towards the design and development of new therapeutic agents for virus infections. They pertain to the combat against three of the most important viral pathogens of current times: HIV, HBV, influenza virus and herpesviruses.

  • Frontiers in Viral Hepatitis

    • 1st Edition
    • R.F. Schinazi + 2 more
    • English
    Frontiers in Viral Hepatitis provides a compilation of the research from over 40 key opinion leaders in the field of Hepatitis. The book focuses on the latest advances in the search for new, more effective therapeutic options and related topics in viral hepatitis. These include regulatory issues, epidemiology, and emerging viruses; immunology and vaccines; viral hepatitis B and C infections in children; genetics pathology and viral diagnosis; cell systems and animal models; novel therapeutics for hepatitis B and C; resistance and therapeutic strategies in humans; and prevention and treatment options for hepatocellular carcinoma.The breadth of information published in this volume provides insight into current prevention and treatment options. Recent advances in our understanding of the molecular biology, immunology and pathogenesis of hepatitis viruses have accelerated at a remarkable rate, offering a more comprehensive perspective on hepatitis.

  • The Flaviviruses: Structure, Replication and Evolution

    • 1st Edition
    • Volume 59
    • English
    Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat. Structure, Replication and Evolution is the first volume of The Flaviviruses and presents the latest research covering the conceptual advances on aspects such as the characterization of virus structure, cellular receptors, mechanisms of virus entry, host and viral components of the RNA replicase.

  • Viral Hepatitis Molecular Biology Diagnosis and Control

    • 1st Edition
    • Volume 10
    • English
    The last forty years have witnessed the discovery of five human hepatitis viruses: hepatitis virus A, B, C, D, and E, and two related blood-borne viruses: GB virus C and TT virus. Viral Hepatitis provides a comprehensive overview of the latest developments and research studies in human viral hepatitis. Written by leading international scientists in the field, this book covers topics ranging from the history of these viruses to their molecular biology, diagnosis, epidemiology and control. It will be an invaluable reference source for hepatitis researchers, reference and diagnostic laboratories, clinicians, public health officers and graduate and medical students.

  • Antiviral Nucleosides

    Chiral Synthesis and Chemotherapy
    • 1st Edition
    • C.K. Chu
    • English
    • Up-to-date review on the chemistry and biology of nucleosides• Modern synthetic methodology• Comprehensive coverage of antiviral nucleosidesThis book summarizes the recent advances in nucleosides chemistry and chemotherapy over the past 10-15 years. It covers recently discovered nucleoside antiviral agents, their therapeutic aspects and biochemistry, and also extensive reviews on their chiral synthesis.

  • Virus Structure

    • 1st Edition
    • Volume 64
    • English
    Virus Structure covers the full spectrum of modern structural virology. Its goal is to describe the means for defining moderate to high resolution structures and the basic principles that have emerged from these studies. Among the topics covered are Hybrid Vigor, Structural Folds of Viral Proteins, Virus Particle Dynamics, Viral Gemone Organization, Enveloped Viruses and Large Viruses.

  • Viral Gastroenteritis

    • 1st Edition
    • Volume 9
    • U. Desselberger + 1 more
    • English
    Viruses are increasingly recognised as the cause of acute gastroenteritis in man, particularly in children. This book provides overviews and updates on current issues relating to basic research, clinical diagnosis, immunology, epidemiology, treatment and prevention of infections with gastroenteritis viruses.Data are presented and interpreted by leading research groups in 33 chapters spread over 6 sections. The book will be of interest to virologists, gut physiologists, immunologists, epidemiologists, vaccinologists, paediatricians and physicians (infectious diseases), and public health physicians. It will also capture the interests of medical and natural science students and postdoctoral scientists at various levels of their careers.

  • Perspectives in Medical Virology

    • 1st Edition
    • Volume 1
    • Brian Evans
    • English

  • Human Papilloma Viruses

    • 1st Edition
    • Volume 8
    • D.J. McCance
    • English
    This book describes up-to-date information on the pathogenesis and molecular biology of human papillomaviruses and describes the mechanistic role of the viruses in epithelial cancers. Included in the book are chapters on the epidemiology of human papillomaviruses, the factors that control replication and transcription and the viral proteins, which are involved in modulating the biology of the host cell leading to cancer. Details of the immune response to the viruses and potential vaccine strategies are discussed.

  • Recent Advances in Nucleosides: Chemistry and Chemotherapy

    • 1st Edition
    • C.K. Chu
    • English
    The book covers up-to-date information on nucleosides and antiviral chemotherapy contributed by the world experts in the field of nucleoside. This book is the result of a meeting honoring Dr. Jack J. Fox, who was one of the pioneers in nucleoside chemistry and chemotherapy. This book consists of 15 excellent chapters in the area, which include topics from recent synthetic methodologies, nucleoside kinase implicated in chemotherapy and drug design, excellent reviews on antiviral agents, nucleoside metabolism/mode of action in parasites, new compounds under clinical and pre-clinical trials, IMPDH inhibitors to review on nucleoside prodrugs.

  • Influenza

    • 1st Edition
    • Volume 7
    • C.W. Potter
    • English
    Since the influenza virus was first isolated in the laboratory some 70 years ago, the disease has been the subject of intense study, and our knowledge has escalated as the newer techniques of medicine and science have made further advances possible. At the present time, our information of the disease and the virus that causes it is probably more detailed than for any other virus infection, perhaps excluding the human immunodeficiency virus. The subject of influenza divides itself into a number of specialities, and such is the pace of research and the depth of our knowledge, that workers in one area may have little understanding of the advances made in others.This volume of Perspectives in Medical Virology has enlisted twelve internationally recognised researchers on specific aspects on the subject of influenza to write a summary of the important developments in the past and offer their views on the problems that remain to be addressed. It is hoped that their emphasis, reservations and projections are of value to future research, and offer directions for a better understanding of the virus, the disease it causes, the production of vaccines and the development of therapeutic agents so that at some date in the future this infection can be brought under control.

  • Advances in Virus Research

    • 1st Edition
    • Volume 58
    • English
    This latest volume in the Advances in Virus Research series presents articles on topics such as the role of lipid rafts in virus assembly and budding; novel vaccine strategies; treatment of arenavirus infections; the evaluation of drug resistance in HIV infection; perspectives on polydnavirus origin and evolution; bateriophage 29 DNA packaging; the potential of plant viral vectors and transgenic plants for subunit vaccine production; and the interaction of orthopoxviruses with interferon-treated cultured cells. This timely and informative compilation of articles will be of interest to researchers in the fields of virology, immunology, microbiology, and plant science.

  • Viruses and Liver Cancer

    • 1st Edition
    • Volume 6
    • E. Tabor
    • English
    Hepatocellular carcinoma (HCC) is one of the most important complications of chronic viral hepatitis. It usually results in a fatal outcome if not discovered in its earliest stages. Its close association with the hepatitis B and C viruses makes it one of the first human cancers for which there is strong evidence of a viral cause. For this reason it provides a model for studying viral carcinogenesis in humans.In some countries, HCC is one of the most common tumors of adult men. In addition, there is evidence that the incidence of this cancer has doubled in the past 15 to 20 years in many countries, and the incidence has doubled every 20 years for the past half century in Japan. In some studies, the increase has been shown to be due primarily to cases associated with HCV infection.Molecular studies of HCC show that mutations in oncogenes, in various cellular repair pathways, and in tumor suppressor genes together appear to contribute to the development of this cancer. In HCCs associated with hepatitis B virus, the virus itself can interact with tumor suppressor proteins and other cellular signals in ways that probably permit HCC to develop even when there are no mutations in the genes for these signals.This work discusses the latest concepts in molecular biology and the study of HCC which have led to dramatic breakthroughs in our understanding of how it develops.

  • Adenoviral Vectors for Gene Therapy

    • 1st Edition
    • David T. Curiel + 1 more
    • English
    Adenoviral Vectors for Gene Therapy provides detailed and comprehensive coverage of these important therapeutic agents. The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be considered prior to the initiation of human clinical gene therapy trials. The broad scope of this unique volume provides the reader with a complete understanding of the development and use of adenoviral vectors.

  • Tumor Suppressing Viruses, Genes, and Drugs

    Innovative Cancer Therapy Approaches
    • 1st Edition
    • Hiroshi Maruta
    • English
    Tumor Suppressing Viruses, Genes, and Drugs profiles the new generation of cancer treatments now in development. The book examines the innovative new approaches of viral, gene, and signal therapies that promise to replace or enhance conventional methods such as surgery, radiation, and chemotherapy. The timely information presented by this book should be of interest to anyone concerned with advancing cancer treatment beyond current medical practices.

  • Advances in Virus Research

    • 1st Edition
    • Volume 57
    • English
    The collection of articles in this volume include Animal Circoviruses; Evolutions, Epidemiology and Dispersal of Flaviviruses; Hantavirus Infections in Europe; Forest Insect Pests; and Whiteflies: Vectors and Victims of Geminivirus.

  • A Dictionary of Virology

    • 3rd Edition
    • Bozzano G Luisa
    • English
    This third edition of A Dictionary of Virology offers an authoritative, concise, and up-to-date list of all viruses affecting vertebrate species, from humans to fish. It has been completely revised since the 1997 edition to include 25% more entries, including many completely new viruses. The entries have been restructured so that all viruses are listed and classified in accordance with the standards set by the 7th Report of the ICTV. The extensive cross-referencing and illustrative tables further enhance the utility of this reference.

  • Neurovirology: Viruses and the Brain

    • 1st Edition
    • Volume 56
    • English
    This volume is the first in a planned series of thematic volumes for Advances in Virus Research. It covers the etiology, pathogenetic mechanisms, and clincial consequences of human neurotropic viruses. Buchmeier is a virologist, Campbell an immunologist, and both are extremely well known in their fields.

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