Antiviral Nucleosides
Chiral Synthesis and Chemotherapy
- 1st Edition - August 31, 2011
- Latest edition
- Editor: C.K. Chu
- Language: English
• Up-to-date review on the chemistry and biology of nucleosides• Modern synthetic methodology• Comprehensive coverage of antiviral nucleosidesThis book summarizes the recent advanc… Read more
• Up-to-date review on the chemistry and biology of nucleosides• Modern synthetic methodology• Comprehensive coverage of antiviral nucleosides
This book summarizes the recent advances in nucleosides chemistry and chemotherapy over the past 10-15 years. It covers recently discovered nucleoside antiviral agents, their therapeutic aspects and biochemistry, and also extensive reviews on their chiral synthesis.
1. Recent Advances in Antiviral Nucleosides. (G. Gumina, Y. Choi, C.K. Chu). Introduction. Structural features of nucleosides as antiviral agents. 2'-Deoxy nucleosides and related analogs. 2',3'-Dideoxy nucleosides and related analogues. 2',3'-Unsaturated nucleosides and related analogues. Nucleosides with a heterocyclic sugar ring moiety. 3- or 4-Membered ring nucleosides. Acyclonucleosides. Ribofuranosyl nucleosides. References. 2. Chiral synthesis of antiviral nucleosides from carbohydrate templates. (G. Gumina, S. Olgen, C.K. Chu). Introduction. 4'-Thiofuranose nucleosides. Iso- and apio nucleosides. Oxathiolane and dioxolane nucleosides. Cyclopentyl carbocyclic nucleosides. Cyclopropyl carbocyclic nucleosides. C-Nucleosides. Fluorinated nucleosides. Acyclonucleosides. Miscellaneous nucleosides. References. 3. Oxathiolane and dioxolane nucleosides: Synthesis and antiviral activity. (G. Gumina, J.S. Cooperwood, C.K. Chu). Introduction. Oxathiolane nucleosides. Synthesis. Antiviral activity. Combination therapy. Dioxolane nucleosides. Synthesis. Antiviral activity. References.
- Edition: 1
- Latest edition
- Published: August 31, 2011
- Language: English
CC
C.K. Chu
Affiliations and expertise
College of Pharmacy, University of Georgia, Athens, GA, USARead Antiviral Nucleosides on ScienceDirect