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The Flaviviruses: Structure, Replication and Evolution

  • 1st Edition, Volume 59 - December 10, 2003
  • Latest edition
  • Editors: Karl Maramorosch, Thomas J. Chambers, Aaron J. Shatkin, Thomas P. Monath, Frederick A. Murphy
  • Language: English

Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese en… Read more

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Description

Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat.

Structure, Replication and Evolution is the first volume of The Flaviviruses and presents the latest research covering the conceptual advances on aspects such as the characterization of virus structure, cellular receptors, mechanisms of virus entry, host and viral components of the RNA replicase.

Key features

  • Includes new, detailed information on the evolution, viral structure and replication of the Flavivirus family
  • The only complete reference book on a major virus family
  • Descibes the technologies that have contributed to our current knowledge about Flaviviruses
  • Identifies the major problems faced in understanding the virus-host interactions that result in disease

Readership

Virologists, molecular epidemologists, clinicians and public health specialists, immunologists, and researchers in vaccine development

Table of contents

Taxonomy of the virus family Flaviviridae
Structure and replication
Molecular Biology of the Flaviviruses
Flavivirus Structure and Membrane Fusion
Kunjin RNA replication and applications of Kunjin replicons
Antigenic structure of flavivirus Proteins

5' and 3' non-coding regions in flavivirus RNA
Manipulation of Cell Surface Macromolecules by Flaviviruses
Flavivirus evolution
Origins, Evolution and vecto/host cp-adaptations within the genus Flavivirus
Microevolution and virulence of dengue viruses

Review quotes

"...the chapters are well written, and the editors have ensured continuity of a high standard of writing throughout the set...Given the wealth of information, with contributions by over 60 authors, The Flavaviruses, really is an essential series of books that belongs on every arbovirologists’ bookshelf."—Stephen Higgs, Ph.D., University of Texas Medical Branch, U.S., (2004)

Product details

  • Edition: 1
  • Latest edition
  • Volume: 59
  • Published: December 18, 2003
  • Language: English

About the editors

KM

Karl Maramorosch

Professor Karl Maramorosch works at Rutgers University, New Brunswick, NJ, USA.
Affiliations and expertise
Professor, Rutgers University, New Brunswick, NJ, USA

AS

Aaron J. Shatkin

Affiliations and expertise
Center for Advanced Biotechnology and Medicine, Piscataway, NJ, USA

TM

Thomas P. Monath

Affiliations and expertise
1

FM

Frederick A. Murphy

Frederick A. Murphy, DVM, PhD, is professor, Department of Pathology, University of Texas Medical Branch (UTMB), Galveston. He holds a BS and DVM from Cornell University and a PhD from the University of California, Davis (UC Davis). Formerly he was dean and distinguished professor, School of Veterinary Medicine, and distinguished professor, School of Medicine, UC Davis. Before that he served as director of the National Center for Infectious Diseases, and director of the Division of Viral and Rickettsial Diseases, Centers for Disease Control, Atlanta. He is a member of the Institute of Medicine of the U.S. National Academy of Sciences and is a member of the German National Academy of Sciences and the Belgian Royal Academy of Medicine. He holds an honorary Doctor of Medicine and Surgery from the University of Turku, Finland; an honorary Doctor of Science from the University of Guelph, Canada; an honorary Doctor of Veterinary Medicine from the University of London, United Kingdom; an honorary Doctor of Science from University College Dublin, Ireland; the Presidential Rank Award of the U.S. Government; the PennVet World Leadership Award from the University of Pennsylvania, and the Distinguished Microbiologist Award from the American College of Veterinary Microbiologists. At UTMB, he is a member of the Institute for Human Infections and Immunity, Center for Biodefense and Emerging Infectious Diseases, Galveston National Laboratory, and McLaughlin Endowment for Infection and Immunity. His professional interests include the pathology and epidemiology of highly pathogenic viruses/viral diseases: rabies and the rabies-like viruses, arboviruses, hemorrhagic fever viruses, and other neurotropic viruses. He has been a leader in advancing the concepts of “new and emerging infectious diseases” and “new and emerging zoonoses” and “the threat posed by bioterrorism.” Most recently, he has been working on Internet resources on the history of virology: “The Foundations of Virology” at http://www.utmb.edu/virusimages/.
Affiliations and expertise
professor, Department of Pathology, University of Texas Medical Branch (UTMB), Galveston.

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