Skip to main content
Elsevier
View Cart

Books in Life sciences

Elsevier's Life Sciences collection helps researchers get comprehensive coverage and up-to-date information on the study of living organisms, their processes, and interrelationships, spanning disciplines like biology, genetics, and biochemistry, and addressing emerging trends such as genomics, biotechnology, and sustainability, essential for advancing knowledge and driving innovation in the field.

BooksJournals

    • GTPases Regulating Membrane Targeting and Fusion

      • 1st Edition
      • Volume 403
      • December 13, 2005
      • English
      • Hardback
        9 7 8 0 1 2 1 8 2 8 0 8 0
      • eBook
        9 7 8 0 0 8 0 8 8 4 3 2 5
      Rab GTPases now comprise a family of >63 members. They are emerging as the key hub element controlling the membrane architecture of eukaryotic cells. They are intimately involved in vesicle targeting and fusion in both the endocytic and exocytic pathways and direct the assembly and disassembly of protein complexes that include regulators (GEFs and GAPs), effectors (tethers/motors) and fusion components (SNAREs) that control membrane targeting and fusion. During the last 3 years the field has virtually exploded with the identification and characterization of many new Rab proteins and their effectors. Our understanding of how Rab GTPases control membrane function remains at its infancy. This volume of Methods in Enzymology, GTPases Regulating Membrane Targeting and Fusion, provides a wealth of new concepts, approaches and tools to study Rab proteins in the test tube and in living cells that will be of strong benefit to both established laboratories and new investigators in the field to elucidate Rab GTPase function in cellular development, differentiation and proliferation.

    • The Biology of the Eye

      • 1st Edition
      • Volume 10
      • December 9, 2005
      • Jorge Fischbarg
      • English
      • Paperback
        9 7 8 0 4 4 4 5 4 7 4 7 7
      • Hardback
        9 7 8 0 4 4 4 5 0 9 2 5 3
      • eBook
        9 7 8 0 0 8 0 4 7 6 0 9 4
      Acknowledgement This book is the result of a collective effort. Due to an oversight, mention of three of the contributors who played an especially decisive role in bringing the work to fruition was omitted from the book. They should share fully in the intellectual credits accruing from this publication. I would therefore like to acknowledge and thank the following for their outstanding contributions to editing the work: Dr. Morten Dornonville la Cour (MD, Dr. Med. Sci.) solicited and edited the chapters on retina, RPE, choroid, vitreous, immunology, and sclera. Dr. la Cour is a Lecturer, Eye Department, Copenhagen University Hospital, specializes in vitreoretinal surgery, and frequently lectures in the international scene. A trained mathematician, he has done research in retinal pigment epithelial physiology in the laboratories of Drs. Thomas Zeuthen and Sheldon Miller. Dr. Friedrich P.J. Diecke and Dr. Elliott M. Kanner also provided invaluable editorial assistance. Dr Diecke, who was formerly Professor and Chairman of the Department of Physiology, UMDNJ-New Jersey Medical School, is a Professor Emeritus at that institution. His research has concentrated on membrane transport mechanisms in lens epithelial cells, corneal endothelial cells and peripheral nerve and on the regulation of vascular smooth muscle contraction. Dr. Elliott M. Kanner was born in Canada in 1970. He graduated from Yale University in 1992 with a BS/MS degree in Molecular Biophysics and Biochemistry. He received his PhD degree from the Rockefeller University in 1999 and his MD degree from Weill/Cornell in 2001. He is currently an Ophthalmology resident at Columbia University. Jorge Fischbarg, December 2005 This book explores the many recent novel ideas about the eye in a systematic and synthetic way. It includes both basic sciences and applications towards clinical research. Chapters include both anatomical and functional descriptions of the different ocular tissues and treatments of a few subjects of practical importance for ophthalmologists. This book is intended for students in basic biomedical science interested in the eye, as well as ophthalmologists a comprehensive source on recent developments in ocular research.

    • Handbook of the Psychology of Aging

      • 6th Edition
      • December 9, 2005
      • James E. Birren + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 1 0 1 2 6 5 6
      • eBook
        9 7 8 0 0 8 0 4 5 6 0 7 2
      • eBook
        9 7 8 0 0 8 0 9 1 6 9 0 3
      Handbook of the Psychology of Aging, 6e provides a comprehensive summary and evaluation of recent research on the psychological aspects of aging. The 22 chapters are organized into four divisions: Concepts, Theories, and Methods in the Psychology of Aging; Biological and Social Influences on Aging; Behavioral Processes and Aging; and Complex Behavioral Concepts and Processes in Aging. The 6th edition of the Handbook is considerably changed from the previous edition. Half of the chapters are on new topics and the remaining half are on returning subjects that are entirely new presentations by different authors of new material. Some of the exciting new topics include Contributions of Cognitive Neuroscience to Understanding Behavior and Aging, Everyday Problem Solving and Decision Making, Autobiographical Memory, and Religion and Health Late in Life.The Handbook will be of use to researchers and professional practitioners working with the aged. It is also suitable for use as a textbook for graduate and advanced undergraduate courses on the psychology of aging.The Handbook of the Psycology of Aging, Sixth Edition is part of the Handbooks on Aging series, including Handbook of the Biology of Aging and Handbook of Aging and the Social Sciences, also in their 6th editions.

    • Handbook of Evaluation Methods for Health Informatics

      • 1st Edition
      • December 7, 2005
      • Jytte Brender McNair
      • English
      • Paperback
        9 7 8 0 1 2 3 7 0 4 6 4 1
      • eBook
        9 7 8 0 0 8 0 5 3 3 4 5 2
      The Handbook of Evaluation Methods for Health Informatics provides a complete compendium of methods for evaluation of IT-based systems and solutions within healthcare. Emphasis is entirely on assessment of the IT-system within its organizational environment. The author provides a coherent and complete assessment of methods addressing interactions with and effects of technology at the organizational, psychological, and social levels. It offers an explanation of the terminology and theoretical foundations underlying the methodological analysis presented here. The author carefully guides the reader through the process of identifying relevant methods corresponding to specific information needs and conditions for carrying out the evaluation study. The Handbook takes a critical view by focusing on assumptions for application, tacit built-in perspectives of the methods as well as their perils and pitfalls.

    • Reproductive and Hormonal Aspects of Systemic Autoimmune Diseases

      • 1st Edition
      • Volume 4
      • December 7, 2005
      • Michael Lockshin + 1 more
      • English
      • Hardback
        9 7 8 0 4 4 4 5 1 8 0 1 9
      • Paperback
        9 7 8 0 4 4 4 5 4 7 4 8 4
      • eBook
        9 7 8 0 0 8 0 4 6 0 9 5 6
      This volume of the Handbook of Systemic Autoimmune Diseases series represents a medical collaboration focusing primarily on female aspects of rheumatic diseases. This collaboration recognizes the need to understand and optimally manage the care of women with autoimmune conditions that may affect their reproduction and hormonal status. This handbook will prove useful to clinicians and researchers alike. It covers practical points, ranging from which anti-rheumatic medications are safe in pregnancy to how to counsel women with scleroderma contemplating pregnancy.

    • Manipulation and Expression of Recombinant DNA

      • 2nd Edition
      • December 6, 2005
      • Sue Carson + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 0 8 8 4 1 8 6
      • eBook
        9 7 8 0 0 8 0 4 5 6 5 4 6
      This manual is an indispensable tool for introducing advanced undergraduates and beginning graduate students to the techniques of recombinant DNA technology, or gene cloning and expression. The techniques used in basic research and biotechnology laboratories are covered in detail. Students gain hands-on experience from start to finish in subcloning a gene into an expression vector, through purification of the recombinant protein.The second edition has been completely re-written, with new laboratory exercises and all new illustrations and text, designed for a typical 15-week semester, rather than a 4-week intensive course. The “project” approach to experiments was maintained: students still follow a cloning project through to completion, culminating in the purification of recombinant protein. It takes advantage of the enhanced green fluorescent protein—students can actually visualize positive clones following IPTG induction.

    • Multidisciplinary Approaches to Theory in Medicine

      • 1st Edition
      • Volume 3
      • December 6, 2005
      • English
      • Hardback
        9 7 8 0 4 4 4 5 1 8 0 6 4
      • Paperback
        9 7 8 0 4 4 4 5 5 0 4 1 5
      • eBook
        9 7 8 0 0 8 0 4 5 9 7 2 1
      This volume will be a collection of chapters from authors with wide experience in their research field. The purpose is to produce a coherent book that reflects the common theme of theory in medical thinking and multidisciplinary research practice. In this context "theory" relates to frameworks of concepts, facts, models etc that help to inform practitioners (clinicians, scientists and engineers) both within their own fields and as they seek to share dialogue with colleagues from other fields. Multidisciplinary Approaches to Theory in Medicine will therefore be integrative across a broad spectrum of fields within medicine. To achieve this the chapters will be associated with others in a number of meaningful ways. Each chapter will share a number of points of contact that will include at least two of the following: Similar biomedical area (e.g., immunity, neuroscience, endocrinology, pathology, oncology, haematology, …) Similar multidisciplinary theoretical contexts (e.g., modelling, analysis, description, visualization, complex systems, …) Similar multidisciplinary medical issues and questions (e.g., clinical practice, decision making, informatics, …)

    • Encyclopedia of Heart Diseases

      • 1st Edition
      • December 5, 2005
      • M. Gabriel Khan
      • English
      • Hardback
        9 7 8 0 1 2 4 0 6 0 6 1 6
      • eBook
        9 7 8 0 0 8 0 4 5 4 8 1 8
      The Encyclopedia of Heart Diseases is an accurate and reliable source of in-depth information on the diseases that kill more than 12 million individuals worldwide each year. In fact, cardiovascular diseases are more prevalent than the combined incidence of all forms of cancer, diabetes, asthma and leukemia. In one volume, this Encylopedia thoroughly covers these ailments and also includes in-depth analysis of less common and rare heart conditions to round out the volume's scope. Researchers, clinicians, and students alike will all find this resource an invaluable tool for quick reference before approaching the primary literature.

    • Advances in Insect Physiology

      • 1st Edition
      • Volume 32
      • December 2, 2005
      • English
      • Hardback
        9 7 8 0 1 2 0 2 4 2 3 2 0
      • eBook
        9 7 8 0 0 8 0 4 5 6 0 9 6
      Advances in Insect Physiology publishes eclectic volumes containing important, comprehensive and in-depth reviews on all aspects of insect physiology. It is an essential reference source for invertebrate physiologists and neurobiologists, entomologists, zoologists and insect biochemists. First published in 1963, the serial is now edited by Steve Simpson (Oxford University, UK).

    • Multiple Aspects of DNA and RNA: from Biophysics to Bioinformatics

      • 1st Edition
      • Volume 82
      • December 2, 2005
      • English
      • Hardback
        9 7 8 0 4 4 4 5 2 0 8 1 4
      • Paperback
        9 7 8 0 4 4 4 5 5 0 6 2 0
      • eBook
        9 7 8 0 0 8 0 4 6 1 5 4 0
      This book is dedicated to the multiple aspects, that is, biological, physical and computational of DNA and RNA molecules. These molecules, central to vital processes, have been experimentally studied by molecular biologists for five decades since the discovery of the structure of DNA by Watson and Crick in 1953. Recent progresses (e.g. use of DNA chips, manipulations at the single molecule level, availability of huge genomic databases...) have revealed an imperious need for theoretical modelling. Further progresses will clearly not be possible without an integrated understanding of all DNA and RNA aspects and studies.The book is intended to be a desktop reference for advanced graduate students or young researchers willing to acquire a broad interdisciplinary understanding of the multiple aspects of DNA and RNA. It is divided in three main sections:The first section comprises an introduction to biochemistry and biology of nucleic acids. The structure and function of DNA are reviewed in R. Lavery's chapter. The next contribution, by V. Fritsch and E. Westhof, concentrates on the folding properties of RNA molecules. The cellular processes involving these molecules are reviewed by J. Kadonaga, with special emphasis on the regulation of transcription. These chapters does not require any preliminary knowledge in the field (except that of elementary biology and chemistry).The second section covers the biophysics of DNA and RNA, starting with basics in polymer physics in the contribution by R. Khokhlov. A large space is then devoted to the presentation of recent experimental and theoretical progresses in the field of single molecule studies. T. Strick's contribution presents a detailed description of the various micro-manipulation techniques, and reviews recent experiments on the interactions between DNA and proteins (helicases, topoisomerases, ...). The theoretical modeling of single molecules is presented by J. Marko, with a special attention paid to the elastic and topological properties of DNA. Finally, advances in the understanding of electrophoresis, a technique of crucial importance in everyday molecular biology, are exposed in T. Duke's contribution.The third section presents provides an overview of the main computational approaches to integrate, analyse and simulate molecular and genetic networks. First, J. van Helden introduces a series of statistical and computational methods allowing the identification of short nucleic fragments putatively involved in the regulation of gene expression from sets of promoter sequences controlling co-expressed genes. Next, the chapter by Samsonova et al. connects this issue of transcriptional regulation with that of the control of cell differentiation and pattern formation during embryonic development. Finally, H. de Jong and D. Thieffry review a series of mathematical approaches to model the dynamical behaviour of complex genetic regulatory networks. This contribution includes brief descriptions and references to successful applications of these approaches, including the work of B. Novak, on the dynamical modelling of cell cycle in different model organisms, from yeast to mammals.

Related subjects

Biochemistry biophysics

Biotechnology

Endocrinology

Life sciences general

Molecular biology cellular biology and genetics

Physiology