GTPases Regulating Membrane Targeting and Fusion
- 1st Edition, Volume 403 - December 13, 2005
- Imprint: Academic Press
- Editors: W. E. Balch, Channing J. Der, Alan Hall
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 1 8 2 8 0 8 - 0
- eBook ISBN:9 7 8 - 0 - 0 8 - 0 8 8 4 3 2 - 5
Rab GTPases now comprise a family of >63 members. They are emerging as the key hub element controlling the membrane architecture of eukaryotic cells. They are intimately in… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteRab GTPases now comprise a family of >63 members. They are emerging as the key hub element controlling the membrane architecture of eukaryotic cells. They are intimately involved in vesicle targeting and fusion in both the endocytic and exocytic pathways and direct the assembly and disassembly of protein complexes that include regulators (GEFs and GAPs), effectors (tethers/motors) and fusion components (SNAREs) that control membrane targeting and fusion. During the last 3 years the field has virtually exploded with the identification and characterization of many new Rab proteins and their effectors.
Our understanding of how Rab GTPases control membrane function remains at its infancy. This volume of Methods in Enzymology, GTPases Regulating Membrane Targeting and Fusion, provides a wealth of new concepts, approaches and tools to study Rab proteins in the test tube and in living cells that will be of strong benefit to both established laboratories and new investigators in the field to elucidate Rab GTPase function in cellular development, differentiation and proliferation.
- Comprehensive overview of Rab GTPase phylogeny and systems biology
- Identification and characterization of Rab GEFs, GAPs and effectors
- General methodologies to study Rab GTPase function in vitro and in vivo using biochemical, molecular and microscopy approaches
Biochemists, biophysicists, cell biologists, molecular biologists, geneticists, developmental biologists.
- Edition: 1
- Volume: 403
- Published: December 13, 2005
- No. of pages (Hardback): 912
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780121828080
- eBook ISBN: 9780080884325
WB
W. E. Balch
Affiliations and expertise
The Scripps Research Institute, La Jolla, CA, USACD
Channing J. Der
Affiliations and expertise
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USAAH
Alan Hall
Affiliations and expertise
University College of London, U.K.Read GTPases Regulating Membrane Targeting and Fusion on ScienceDirect