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Elsevier

Books in Life sciences

Elsevier's Life Sciences collection helps researchers get comprehensive coverage and up-to-date information on the study of living organisms, their processes, and interrelationships, spanning disciplines like biology, genetics, and biochemistry, and addressing emerging trends such as genomics, biotechnology, and sustainability, essential for advancing knowledge and driving innovation in the field.

  • Encyclopedia of Reproduction

    • 2nd Edition
    • Michael K. Skinner
    • English
    Encyclopedia of Reproduction, Second Edition, Six Volume Set comprehensively reviews biology and abnormalities, also covering the most common diseases in humans, such as prostate and breast cancer, as well as normal developmental biology, including embryogenesis, gestation, birth and puberty. Each article provides a comprehensive overview of the selected topic to inform a broad spectrum of readers, from advanced undergraduate students, to research professionals. Chapters also explore the latest advances in cloning, stem cells, endocrinology, clinical reproductive medicine and genomics. As reproductive health is a fundamental component of an individual’s overall health status and a central determinant of quality of life, this book provides the most extensive and authoritative reference within the field.

  • New Concepts in the Management of Septic Perianal Conditions

    • 1st Edition
    • Riyadh Mohammad Hasan + 1 more
    • English
    New Concepts in the Management of Septic Perianal Conditions provides a comprehensive review of the medically important basic and clinical aspects of perianal diseases in adults. This book presents current, medically important information in the rapidly changing field of anorectal diseases, including significant topics like perianal abscess and fistula. It provides an accurate source of clinically relevant information that is presented clearly and succinctly, making it perfect for the diagnosis, treatment and management of septic perianal conditions.

  • Mitosis and Meiosis Part B

    • 1st Edition
    • Volume 145
    • English
    Mitosis and Meiosis, Part B, Volume 145, a new volume in the Methods in Cell Biology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Unique to this updated volume are chapters on Mitotic live cell imaging at different time scales, the characterization of mitotic spindle by multi-mode correlative microscopy, STED microscopy of mitosis, Correlating light microscopy with serial block face scanning electron microscopy to study mitotic spindle architecture, quantification of three-dimensional spindle architecture, Imaging based assays for mitotic chromosome condensation and dynamics, and more.

  • Cancer Nanotechnology

    • 1st Edition
    • Volume 139
    • English
    Advances in Cancer Research, Volume 139, provides invaluable information on the exciting and fast-moving field of cancer research. Original reviews are presented on a variety of topics relating to the rapidly developing intersection between nanotechnology and cancer research, with unique sections in the new release focusing on Exosomes as a theranostic for lung cancer, Nanotechnology and cancer immunotherapy, Ultrasound imaging agents and delivery systems, Dendronized systems for the delivery of chemotherapeutics, Thermosensitive liposomes for image-guided drug delivery, Supramolecular Chemistry in Tumor Analysis and Drug Delivery, Gold nanoparticles for delivery of cancer therapeutics, and Single cell barcode microchip for cancer research and therapy.

  • Atlas of Hematopathology

    Morphology, Immunophenotype, Cytogenetics, and Molecular Approaches
    • 2nd Edition
    • Faramarz Naeim + 3 more
    • English
    Atlas of Hematopathology: Morphology, Immunophenotype, Cytogenetics, and Molecular Approaches, Second Edition, will appeal to both a wide range of people undergoing training in a variety of medical fields and practicing non-hematopathologis... For clinicians, fellows and residents, correct diagnosis (and therefore correct treatment) of diseases depends on a strong understanding of the molecular basis for the disease, making this book a crucial resource. This atlas contains hundreds of high-quality color images that mirror the findings that fellows and clinicians encounter in practice. In addition, it provides information in a quick, simple and user-friendly manner, attracting both those in training and non- experts. Residents, fellows, practicing clinicians, and researchers in pathology, hematology and hematology/oncology will find this a useful resource.

  • Epigenetics and Psychiatric Disease

    • 1st Edition
    • Volume 157
    • English
    Epigenetics and Psychiatric Disease, Volume 157, the latest volume in the Progress in Molecular Biology and Translational Science series, includes recent developments on a variety of topics, including the Epigenetic landscapes of the adversity-exposed brain, Chromosomal conformations and epigenomic regulation in schizophrenia, Progress in the epigenetics of depression, the epigenetics of circadian rhythms in imprinted neurodevelopmental disorders, DNA methylation mediating substance abuse, mechanisms and therapeutic opportunities, DNA methylation in animals model of psychosis, Epigenetics of early life stress, Epigenetic drugs for mood disorders, and more.

  • Transfusion Medicine for Pathologists

    A Comprehensive Review for Board Preparation, Certification, and Clinical Practice
    • 1st Edition
    • Brian Castillo + 4 more
    • English
    Transfusion Medicine for Pathologists: A Comprehensive Review for Board Preparation, Certification, and Clinical Practice is a concise study guide designed to complement standard textbooks in the field of clinical pathology. Pathology residents and fellows of transfusion medicine will find this book useful as a preparation tool for their exams. In addition, the book is a valuable timesaver for busy residents looking for a focused and compact study guide on transfusion medicine that will also be ideal for practicing pathologists who cross-cover transfusion medicine in their clinical practice.

  • Marine enzymes and specialized metabolism - Part B

    • 1st Edition
    • Volume 605
    • English
    Marine enzymes and specialized metabolism - Part B, Volume 605 in the Methods in Enzymology series, highlights experimental methods on diverse marine enzymes involved in the construction of bioactive natural product molecules. Unique sections in this new release include discussions on polysaccharide-degra... enzymes from marine gastropods, radical SAM epimerases from sponge microbes, DMS/P demethylase in bacteria, reconstitution of particulate methane monooxygenase into membrane mimetics, the structure and function of cyanobactin enzymes, marine cyanobacterial polyketide beta-branching enzymology, marine cyanobacterial PKS-NRPS enzymology and structural biology, biochemical profiling of DMSP lyases, and more.

  • Fibroblast Growth Factors

    • 1st Edition
    • Xiaokun Li
    • English
    Fibroblast Growth Factors presents research and results from the leading global research group on FGF, providing up-to-date and comprehensive coverage of the field. The book describes the history, basic research and growth engineering technology involved with FGFs, while also introducing detailed research methods. It comprises eight chapters that detail successes and problems in relation to wound healing of engineered growth factors and considers injury repair and regeneration, non-mitogenic mutants, structure modification, pathology, physiology, pharmacology, development, FGF/FGFR inhibitors, bioengineering, and new drug development. It will serve as a key reference book for researchers working on FGFs.

  • Genomic Medicine in Emerging Economies

    Genomics for Every Nation
    • 1st Edition
    • George P. Patrinos + 1 more
    • English
    Originally thought to be available only to the world’s wealthiest nations, genomic medicine has developed into a broad range of clinical methods and technologies whose concrete applications are also revolutionizing health systems in many of the world’s resource-limited nations. Genomic Medicine in Emerging Economies: Genomics for Every Nation provides in-depth analysis and key examples of the implementation of medical genomics in low-income nations across the globe, demonstrating how this advancing medical science has already transformed health systems and led to improved patient care in Indonesian, Chilean, Malaysian, Argentinian, Chinese, Sri Lankan, and Colombian populations among others. In addition to defining tools, diagnostics, and treatment pathways at the population-wide level for medical geneticists, genomic researchers, and public health workers to apply in their own work, this book offers an essential, case-study based approach needed to understand how genomic medicine can be used to improve disease-management in a diverse range of economic and social contexts.

  • Applications of Nanocomposite Materials in Drug Delivery

    • 1st Edition
    • Inamuddin + 2 more
    • English
    Applications of Nanocomposite in Drug Delivery discusses and explores the applications of nanocomposites in the area of drug delivery. Starting with a scientific understanding of drug delivery fundamentals, the book explores the utility of nanocomposites in the area of controlled, transdermal, osteo-articular tuberculosis and stimulus sensitive drug delivery applications. The book intricately details and discusses a variety of methods for their preparation, while also highlighting specific applications of nanocomposites in targeted drug delivery.

  • Advances in Applied Microbiology

    • 1st Edition
    • Volume 103
    • English
    Advances in Applied Microbiology, Volume 103, continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas, with this updated volume including chapters on antimicrobial resistance in Campylobacter species, microbial source tracking, modeling phage bacteria interactions, and bacterial anaerobic synthesis gas (syngas) and CO2 + H2 fermentation. Each eclectic volume in this series is supplemented by thematic volumes in areas such as Archaea and sick building syndrome.

  • Perinatal Stem Cells

    Research and Therapy
    • 1st Edition
    • Anthony Atala + 4 more
    • English
    Perinatal Stem Cells provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources, such as amniotic fluid, placenta and placental membranes, the umbilical cord and Wharton’s jelly. It's compiled by leading experts in the field, offering readers detailed insights into sources of perinatal stem cells and their potential for disease treatment. Therapeutic applications of perinatal stem cells include the treatment of in utero and pregnancy related diseases, cardiac disease, liver disease, pulmonary disease, inflammatory diseases, for hematopoietic regeneration, and for neural protection after stroke or traumatic brain injury. In addition, the rapid advance in clinical translation and commercialization of perinatal stem cell therapies is highlighted in a section on Clinical and Industry Perspective which provides insight into the new opportunities and challenges involved in this novel and exciting industry.

  • Hemophilia and Von Willebrand Disease

    Factor VIII and Von Willebrand Factor
    • 1st Edition
    • David Green
    • English
    Hemophilia and Von Willebrand Disease: Factor VIII and Von Willebrand Factor serves as a must-have reference on the important role these essential blood-clotting proteins play in research and clinical medicine. Clinicians and researchers face the daily challenge of staying current on the vast amounts of research that is now generated. The reference to Janus in the title refers to the two roles of the Factor VIII/Von Willebrand Factor Complex: initiation of coagulation and propagation of clot formation. The complex prevents bleeding in hemophilia and Von Willebrand disease but also augments arterial and venous thrombosis.

  • Ancestral DNA, Human Origins, and Migrations

    • 1st Edition
    • Rene J. Herrera + 1 more
    • English
    Ancestral DNA, Human Origins, and Migrations describes the genesis of humans in Africa and the subsequent story of how our species migrated to every corner of the globe. Different phases of this journey are presented in an integrative format with information from a number of disciplines, including population genetics, evolution, anthropology, archaeology, climatology, linguistics, art, music, folklore and history. This unique approach weaves a story that has synergistic impact in the clarity and level of understanding that will appeal to those researching, studying, and interested in population genetics, evolutionary biology, human migrations, and the beginnings of our species.

  • The Cellular Secretome and Organ Crosstalk

    • 1st Edition
    • Juergen Eckel
    • English
    The Cellular Secretome and Organ Crosstalk focuses on the release of peptides and proteins from different organs and their specific functions in metabolic regulation and cell- and organ crosstalk. The book is written for experts in the field, however, for each topic, helpful references are included. The book also includes technical sections that summarize the state-of-the-art of secretome and crosstalk analysis. This book fulfills the need for a resource that comprehensively describes the current knowledge of secretome biology in health and disease. Communication between different organs involves lipids and other small molecules and a host of proteins and peptides comprising the secretome of different organs (organokinome). More than 600 adipokines have been identified, and an increasing number of hepatokines and myokines have recently been discovered with mostly unknown physiological impact. Importantly, an aberrant signature of the organokinome may be critically underlying a variety of metabolic diseases and may determine the individual susceptibility to disease development.

  • Applied Biomechatronics Using Mathematical Models

    • 1st Edition
    • Jorge Garza Ulloa
    • English
    Applied Biomechatronics Using Mathematical Models provides an appropriate methodology to detect and measure diseases and injuries relating to human kinematics and kinetics. It features mathematical models that, when applied to engineering principles and techniques in the medical field, can be used in assistive devices that work with bodily signals. The use of data in the kinematics and kinetics analysis of the human body, including musculoskeletal kinetics and joints and their relationship to the central nervous system (CNS) is covered, helping users understand how the complex network of symbiotic systems in the skeletal and muscular system work together to allow movement controlled by the CNS. With the use of appropriate electronic sensors at specific areas connected to bio-instruments, we can obtain enough information to create a mathematical model for assistive devices by analyzing the kinematics and kinetics of the human body. The mathematical models developed in this book can provide more effective devices for use in aiding and improving the function of the body in relation to a variety of injuries and diseases.

  • Antimicrobial Peptides in Gastrointestinal Diseases

    • 1st Edition
    • Chi Hin Cho
    • English
    Antimicrobial peptides (AMPs), including cathelicidins and defensins are host defence peptides that carry out multiple roles in the gastrointestinal (GI) tract. Antimicrobial Peptides in Gastrointestinal Diseases presents knowledge about the physiological functions and pharmacological actions of AMPs in inflammation, cancer, and further infection of the GI tract. The book provides coverage from the basic research to clinical application for GI diseases. Current research and development of AMPs is presented, opening the way for further work on these peptides, not only in the context of GI diseases, but also for similar pathologies in other organs. AMPs are key to the regulation of human microbiome and second line defence in the GI mucosa, prevent colonization of pathogens and modulation of innate response to invading pathogens, and modify immunological reactions during inflammatory processes and oncogenic development in the GI mucosa. More importantly, AMPs possess diversified anti-microbial actions against various infectious diseases in the GI tract. With these physiological functions and pharmacological actions, AMPs have significant potential as therapeutic agents for the treatment of inflammation, cancer and further infection in the GI tract.

  • The Physiology of Physical Training

    • 1st Edition
    • Zsolt Radák
    • English
    The Physiology of Physical Training provides complete coverage of the physiological and methodological aspects of physical training, providing essential knowledge for anyone involved in exercise physiology. Physiological processes at the cellular level (and for the whole organism) are covered to better explain particular training methods and convey a deeper knowledge and understanding of training techniques. Coverage of exercise training-induced adaptive responses and the most appropriate training methods to bring about targeted adaptive changes are also included. This is the perfect reference for researchers of physiology/kinesiolo... and human kinetics, practicing coaches, graduate students and sports medicine specialists.

  • An Atlas of Comparative Vertebrate Histology

    • 1st Edition
    • Donald B. McMillan + 1 more
    • English
    Atlas of Comparative Vertebrate Histology looks at the histology of a wide range of vertebrates, representative of all the major classes and families, with examples ranging from amphioxus to primates. The authors focus their microscope on commonly seen vertebrates as well as ‘non-standard’ species, such as lamprey, hagfish, dogfish, skate, rock bass, cod, river catfish, toad, amphiuma, leopard and bull frog, garter and brown snake, Coturnix quail and cowbird. The study of comparative histology in the vertebrates helps students and researchers alike understand how various groups have addressed similar problems, opening doors to interesting research possibilities. Not all vertebrates follow the mammalian model of tissue and organ structure. When dealing with unique species, we see some structures taken beyond their ‘normal’ function. Comparative histology allows us to understand the structural responses underlying the physiology unique to each vertebrate group.

  • Planning for a Career in Biomedical and Life Sciences

    Learn to Navigate a Tough Research Culture by Harnessing the Power of Career Building
    • 2nd Edition
    • Avrum I. Gotlieb
    • English
    Planning for a Career in Biomedical and Life Sciences:Learn to Navigate a Tough Research Culture by Harnessing the Power of Career Building, Second Edition, presents useful information, insights and tips to those pursuing a career in the biomedical and life sciences. The book focuses on making educated choices during schooling, training, and the job search in both the academic and non-academic sectors. The book's premise lies in the notion that if users understand the full path of a career in either the biomedical or life science fields, they can proactively plan their career, recognize any opportunities that present themselves, and be well prepared to address important aspects of their own professional development.Topics include choosing a training path, selecting the best supervisor/mentor, and negotiating a job offer. Updates to this edition include an outline of core competencies to achieve success, how to build soft skills and tailor them to specific job opportunities, and how to increase collaborations across disciplines. Additionally, coverage on issues around diversity, health, wellness and work/life balance are expanded. This book is a valuable resource for undergraduate, graduate, medical and postdoctoral students in the biomedical and life sciences, as well as academic faculty and advisors.

  • Chikungunya and Zika Viruses

    Global Emerging Health Threats
    • 1st Edition
    • Stephen Higgs + 2 more
    • English
    Chikungunya and Zika Viruses: Global Emerging Health Threats is the go-to resource for both historical and current information on this important virus that is rapidly increasing its global range. Epidemics since 2005 have spread from Africa and Asia, and through Europe, and an ongoing epidemic has caused nearly two million cases in the Americas. It causes severe crippling arthritis, with symptoms lasting for months or years. As no vaccine or treatment is available, there is international interest in the virus, thus funding opportunities for research have dramatically increased. This book presents our understanding of the virus, bringing comprehensive knowledge in a single source.

  • Smart Wheelchairs and Brain-computer Interfaces

    Mobile Assistive Technologies
    • 1st Edition
    • Pablo Diez
    • English
    Smart Wheelchairs and Brain-Computer Interfaces: Mobile Assistive Technologies combines the fields of neuroscience, rehabilitation and robotics via contributions from experts in their field to help readers develop new mobile assistive technologies. It provides information on robotics, control algorithm design for mobile robotics systems, ultrasonic and laser sensors for measurement and trajectory planning, and is ideal for researchers in BCI. A full view of this new field is presented, giving readers the current research in the field of smart wheelchairs, potential control mechanisms and human interfaces that covers mobility, particularly powered mobility, smart wheelchairs, particularly sensors, control mechanisms, and human interfaces.

  • Human Parasitology

    • 5th Edition
    • Burton J. Bogitsh + 2 more
    • English
    Human Parasitology, Fifth Edition emphasizes a medical perspective that also incorporates functional morphology, physiology, biochemistry and immunology to enhance appreciation of the diverse implications of parasitism. Bridging the gap between classical clinical parasitology texts and traditional encyclopedic treatises, the book will not only appeal to students interested in the medical aspects of parasitology, but also those who are interested in gaining a solid foundation in the biology of parasites. This updated edition has been fully revised to integrate the most recent molecular discoveries about mosquitoes, ticks and other arthropods as vectors, along with the most effective therapeutic regimens for each.

  • Extracellular Matrix and Egg Coats

    • 1st Edition
    • Volume 130
    • English
    Extracellular Matrix and Egg Coats, Volume 130, the latest release in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on The Human Egg’s Zona Pellucida, the Structure of Zona Pellucida Module Proteins, The Fish Egg’s Zona Pellucidam The Chicken Egg’s Zona Pellucidam The Marsupial Egg’s Zona Pellucida, the Evolution of Zona Pellucida Proteins, The Mouse Egg’s Zona Pellucida, Aspects of ECM, ECM and Morphogenesis, Collagen fibril assembly and function, The Ear's Tectorial Membrane, ECM and Cell Fate, and the Aspects of ECM.

  • Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome

    • 2nd Edition
    • Debasis Bagchi + 1 more
    • English
    Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome, Second Edition, provides an overview of the current diabetes epidemic, outlines the consequences of this crisis, and lays out strategies to forestall and prevent diabetes, obesity and other intricate issues of metabolic syndrome. Contributing experts provide up-to-date global approaches to the critical consequences of metabolic syndrome and make the book an important reference for those working with the treatment, evaluation or public health planning for the effects of metabolic syndrome and diabetes. Completely revised with 15 new chapters, the book includes coverage of the roles of gut microbiome in obesity and diabetes, macrovascular and microvascular complications, diabetes, metabolic syndrome and kidney disease, aspects of diabetic cardiomyopathy, diabetes, Alzheimer’s and neurodegenerative diseases, roles of SGLT2 inhibitors in the treatment of type 2 diabetes, novel biomarkers in diabetes, roles of Trigonella foenum-graecumseed extract in type 2 diabetes, beneficial effects of chromium (III) and vanadium supplements in diabetes, prevention of type 1 diabetes, novel drugs in the therapeutic intervention of type 2 diabetes, eHealth and mobile apps for self-management, artificial pancreatic transplantation, non-invasive glucose monitoring, and the app for glucose regulation.

  • A Practical Guide to Writing a Ruth L. Kirschstein NRSA Grant

    • 2nd Edition
    • Andrew D. Hollenbach
    • English
    A Practical Guide to Writing a Ruth L. Kirschstein NRSA Grant, Second Edition, continues to provide F-Series grant applicants and mentors with insider knowledge on the process by which these grants are reviewed, the biases that contribute to the reviews, the extent of information required in an NRSA training grant, and a deeper understanding of the exact purpose of each section of the application. New additions to this edition include coverage of other NIH grants, such as R01, R21, and P20, as well as information on significant modifications to the Biosketch and Letters of Recommendation sections. This book is a solid resource for trainees and their mentors to use as a guide when constructing F30, F31, and F32 grant applications.

  • Mitosis and Meiosis Part A

    • 1st Edition
    • Volume 144
    • English
    Mitosis and Meiosis, Part A, Volume 144, a new volume in the Methods in Cell Biology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Unique to this updated volume are chapters on Analyzing the Spindle Assembly Checkpoint in human cell culture, an Analysis of CIN, a Functional analysis of the tubulin code in mitosis, Employing CRISPR/Cas9 genome engineering to dissect the molecular requirements for mitosis, Applying the auxin-inducible degradation (AID) system for rapid protein depletion in mammalian cells, Small Molecule Tools in Mitosis Research, Optogenetic control of mitosis with photocaged chemical, and more.

  • Human Embryonic Stem Cells in Development

    • 1st Edition
    • Volume 129
    • English
    Human Embryonic Stem Cells in Development, Volume 129, the latest release in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as recapitulating pancreas development from human embryonic stem cells in a dish, modeling mammalian gastrulation with embryonic stem cells, and a section on what stem cells tell us about human germ cell biology. Each chapter is written by an international board of authors.

  • Epigenetics in Human Disease

    • 2nd Edition
    • Trygve O. Tollefsbol
    • English
    Epigenetics in Human Disease, Second Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. In addition to detailing the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, novel epigenetic approaches to treatment are also explored. Fully revised and up-to-date, this new edition discusses topics of current interest in epigenetic research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, and epigenetic mechanisms of imprinting disorders. Further sections explore online epigenetic tools and datasets, early-life programming of epigenetics in age-related diseases, the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer’s disease, respiratory diseases, and many other human maladies.

  • Marine Enzymes and Specialized Metabolism - Part A

    • 1st Edition
    • Volume 604
    • English
    Marine enzymes and specialized metabolism - Part A, Volume 604 highlights experimental methods on diverse marine enzymes involved in the construction of bioactive natural product molecules. These detailed protocols are written by experts who actively study and apply marine enzymes in biosynthesis and biotechnology. Comprehensive chapters in this latest release cover Chemoenzymatic synthesis of starting materials and characterization of halogenases requiring acyl carrier protein tethered substrates, Assaying biradical aryl coupling activity of CYP450 enzymes, the Characterization and application of marine microbial omega-3 polyunsaturated fatty acid synthesis, Catalase-related allene oxide synthase: on a biosynthetic route to fatty acid cyclopentenones, Haloalkane dehalogenases from marine microorganisms, and more.

  • Cushing’s Syndrome, An Issue of Endocrinology and Metabolism Clinics of North America

    • 1st Edition
    • Volume 47-2
    • Adriana G. Ioachimescu
    • English
    This issue of Endocrinology and Metabolism Clinics, edited by Adriana G. Ioachimescu, will focus on Cushing’s Syndrome. Topics include--but are not limited to--1. Diagnosis of Cushing’s syndrome in the modern era, Gene mutations in patients with Cushing’s syndrome, Morbidity in Cushing’s syndrome and impact of treatment, Localization of ACTH-dependent Cushing’s syndrome, Prognostic factors of long-term remission after surgical treatment of Cushing’s disease, Outcomes of pituitary radiation for Cushing’s disease, New molecular targets in Cushing’s disease, Recent advances in subclinical Cushing’s syndrome, Adrenal surgery for Cushing’s syndrome, Adrenocortical carcinoma with hypercortisolism, Ectopic Cushing’s syndrome, Medical therapy for Cushing’s syndrome in the 21st century, Pregnancy in patients with Cushing’s syndrome, Mortality in patients with Cushing’s syndrome, and Cushing’s syndrome in children and adolescents.

  • Nitric Oxide and Other Small Signalling Molecules

    • 1st Edition
    • Volume 72
    • English
    Nitric Oxide and Other Small Signalling Molecules, Volume 72, the latest release in the Advances in Microbial Physiology series, continues the long tradition of topical, important, cutting-edge reviews in microbiology. The book contains updates in the field, with comprehensive chapters covering the Biochemistry of cysteine persulfides, NO signaling in yeast, The Inflammasome: Regulation of Nitric Oxide and Antimicrobial Host Defense, Nitric Oxide, aN Old molecule with NOble functions in Pseudomonas aeruginosa biology, the Emerging roles of nitric oxide synthase in bacterial physiology, and Anaerobic bacterial response to nitrosative stress.

  • G Protein-Coupled Receptors: Emerging Paradigms in Activation, Signaling and Regulation Part B

    • 1st Edition
    • Volume 339
    • English
    International Review of Cell and Molecular Biology reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of 9 years. This great resource ranks high amongst scientific journals dealing with cell biology.

  • Butterfly Wing Patterns and Mimicry

    • 1st Edition
    • Volume 54
    • English
    Butterfly Wing Patterns and Mimicry, Volume 54, provides an essential reference for those interested in molecular Entomology and the study of natural selection. The volume spans work on the genetics of polymorphism in Heliconius butterflies through to a detailed analysis of the role of CRISPR-CAS in dissecting wing patterning. The volume covers both the evolution and fine scale development of both pattern and pigmentation. The role of wing shape is also considered for the first time in a formal analysis. It should be of interest to both experts and students interested in Entomology and its application to fundamental questions in evolution.

  • Gangliosides in Health and Disease

    • 1st Edition
    • Volume 156
    • English
    Gangliosides in Health and Disease, Volume 156, presents the latest information on Gangliosides, a class of glycolipids that are found on all vertebrate cell surfaces, and are particularly abundant in the brain. Individual chapters in this new volume cover Gangliosides as Toxin Receptors, Gangliosides in Cancer Cell Signaling, Gangliosides in inflammation and neurodegeneration, Gangliosides as functional galectin receptors, Gangliosides in signal transduction, Gangliosides in brain tumor immunology, and Gangliosides in axon regeneration and stability, amongst other related topics. This book brings together world experts in ganglioside structure and function who have been assembled to contribute to this thorough update of the field.

  • Multivariate Analysis in the Pharmaceutical Industry

    • 1st Edition
    • Ana Patricia Ferreira + 2 more
    • English
    Multivariate Analysis in the Pharmaceutical Industry provides industry practitioners with guidance on multivariate data methods and their applications over the lifecycle of a pharmaceutical product, from process development, to routine manufacturing, focusing on the challenges specific to each step. It includes an overview of regulatory guidance specific to the use of these methods, along with perspectives on the applications of these methods that allow for testing, monitoring and controlling products and processes. The book seeks to put multivariate analysis into a pharmaceutical context for the benefit of pharmaceutical practitioners, potential practitioners, managers and regulators. Users will find a resources that addresses an unmet need on how pharmaceutical industry professionals can extract value from data that is routinely collected on products and processes, especially as these techniques become more widely used, and ultimately, expected by regulators.

  • Biomechanics of the Spine

    Basic Concepts, Spinal Disorders and Treatments
    • 1st Edition
    • Fabio Galbusera + 1 more
    • English
    Biomechanics of the Spine encompasses the basics of spine biomechanics, spinal tissues, spinal disorders and treatment methods. Organized into four parts, the first chapters explore the functional anatomy of the spine, with special emphasis on aspects which are biomechanically relevant and quite often neglected in clinical literature. The second part describes the mechanics of the individual spinal tissues, along with commonly used testing set-ups and the constitutive models used to represent them in mathematical studies. The third part covers in detail the current methods which are used in spine research: experimental testing, numerical simulation and in vivo studies (imaging and motion analysis). The last part covers the biomechanical aspects of spinal pathologies and their surgical treatment. This valuable reference is ideal for bioengineers who are involved in spine biomechanics, and spinal surgeons who are looking to broaden their biomechanical knowledge base. The contributors to this book are from the leading institutions in the world that are researching spine biomechanics.

  • G Protein-Coupled Receptors: Emerging Paradigms in Activation, Signaling and Regulation Part A

    • 1st Edition
    • Volume 338
    • English
    G Protein-Coupled Receptors: Emerging Paradigms in Activation, Signaling and Regulation, Part A, Volume 337 in the International Review of Cell and Molecular Biology series, reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. This new release includes comprehensive sections on the classical paradigms of GCPR signaling and regulation, the family of small GTPases: Beyond heterotrimeric G proteins, GPCR endocytosis: Arrestins, arrestin-like proteins, signaling from internalized G Protein-Coupled Receptors, GPCR kinases, and more.

  • Introductory Review on Sirtuins in Biology, Aging, and Disease

    • 1st Edition
    • Leonard Guarente + 2 more
    • English
    Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration.

  • Advances in Applied Microbiology

    • 1st Edition
    • Volume 102
    • English
    Advances in Applied Microbiology, Volume 102, the latest release in one of the most widely read and authoritative review sources in microbiology, contains comprehensive reviews of the most current research in applied microbiology. This latest release includes specific chapters on a variety of topics, most notably, Twenty-five Years of Investigating the Universal Stress Protein: Structure, function and applications, Fungal Genomes and Genotyping, Fungi in deep subsurface environments, Spore germination in pathogenic fungi, Host sensing by pathogenic fungi, Advances in the Microbial Ecology of Biohydrometallurgy, and The mycosphere and turnover of contaminants, amongst others.

  • Therapeutic Proteins and Peptides

    • 1st Edition
    • Volume 112
    • English
    Therapeutic Proteins and Peptides, Volume 112 in an ongoing series promotes further research in the discovery of new therapeutic targets that can be affected by therapeutic proteins and peptides to cure or manage symptoms of human diseases, with this release focusing on the Rational Design of Stable Liquid Formulations of Biopharmaceuticals, Formulation strategies for peptides, proteins and antibodies using nanotechnology, the Solution structural dynamics of therapeutic peptides and their adsorption on plasmonic nanoparticles, Enzymatic approaches of protein-polymer conjugation, Chimeric small antibody fragments as a strategy to deliver therapeutic payloads, Smart cell-penetrating peptide-based techniques for cytoplasmic delivery of therapeutic macromolecules, and more.

  • Chemical and Biochemical Approaches for the Study of Anesthetic Function Part B

    • 1st Edition
    • Volume 603
    • English
    Chemical and Biochemical Approaches for the Study of Anesthetic Function, Part B, Volume 603, presents a coherent description of the campaign towards understanding anesthesia. It includes a variety of highly debated topics, including sections on computational approaches, best practices for simulating ligand-gated ion channels interacting with general anesthetics, computational approaches for studying voltage-gated ion channels modulation by general anesthetics, anesthetic parameterization, the kinetic modeling of electrophysiology data, evolving biophysical technologies, fluorescent anesthetics, lipids, membranes and pressure reversal, in vivo technologies, and more.

  • Waste Biorefinery

    Potential and Perspectives
    • 1st Edition
    • Thallada Bhaskar + 4 more
    • English
    Waste Biorefinery: Potential and Perspectives offers data-based information on the most cutting-edge processes for the utilisation of biogenic waste to produce biofuels, energy products, and biochemicals – a critical aspect of biorefinery. The book explores recent developments in biochemical and thermo-chemical methods of conversion and the potential generated by different kinds of biomass in more decentralized biorefineries. Additionally, the book discusses the move from 200 years of raw fossil materials to renewable resources and how this shift is accompanied by fundamental changes in industrial manufacturing technologies (from chemistry to biochemistry) and in logistics and manufacturing concepts (from petrochemical refineries to biorefineries). Waste Biorefinery: Potential and Perspectives designs concepts that enable modern biorefineries to utilize all types of biogenic wastes, and to integrate processes that convert byproduct streams to high-value products, achieving higher cost benefits. This book is an essential resource for researchers and students studying biomass, biorefineries, and biofuels/products/pr... as well as chemists, biochemical/chemical engineers, microbiologists, and biotechnologists working in industries and government agencies.

  • Autophagy and Cardiometabolic Diseases

    From Molecular Mechanisms to Translational Medicine
    • 1st Edition
    • Jun Ren + 2 more
    • English
    Autophagy and Cardiometabolic Diseases: From Moleculer Mechanisms to Translational Medicine covers the science of autophagy in relation to cardiometabolic diseases and the future therapeutic potentials of autophagy regulation in these processes. Processes are not described in isolation, but in concert with other cellular and/or metabolic processes, such as lipogenesis, glucose, energy metabolism and apoptosis. This approach recognizes the multifactorial nature of cardiometabolic diseases, including obesity, diabetes, insulin resistance, hypertension and dyslipidemia. The book provides explanations, while also distinguishing the delicate role for autophagy in pathogenesis and exploring complications for cardiometabolic diseases. By targeting autophagy, it offers new avenues for drug discovery and treatment for cardiometabolic anomalies. It is a perfect resource for cardiology researchers, scientists and medical practitioners.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 85
    • English
    Advances in Clinical Chemistry, Volume 85, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, and is the benchmark for novel analytical approaches in the clinical laboratory.

  • Conn's Handbook of Models for Human Aging

    • 2nd Edition
    • Jeffrey L. Ram + 1 more
    • English
    Conn's Handbook of Models for Human Aging, Second Edition, presents key aspects of biology, nutrition, factors affecting lifespan, methods of age determination, use in research and the disadvantages/advant... of use. Using a multidisciplinary approach, this updated edition is designed as the only comprehensive, current work that covers the diversity in aging models. Chapters on comparative models explore age-related diseases, including Alzheimer's, joint disease, cataracts, cancer and obesity. Also included are new tricks and approaches not available in primary publications. This must-have handbook is an indispensable resource for researchers interested in the mechanisms of aging, gerontologists, health professionals, allied health practitioners and students.

  • Intestinal Stem Cell Niche

    • 1st Edition
    • Volume 2
    • English
    Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice.

  • Targeting Cell Survival Pathways to Enhance Response to Chemotherapy

    • 1st Edition
    • Volume 3
    • English
    Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have been described, and continue to be described, which contribute to cell survival in the face of chemotherapy treatment. Key pathways leading to chemoresistance emanate from growth factor receptors, PI3K, STAT3, anti-apoptotic Bcl-2 family members, autophagy, and the DNA damage response pathway. New advances have underscored the potential of targeting each of these cell survival mechanisms to improve responsiveness to chemotherapy. This book reviews these recent advances and provides a foundational background and hints of new opportunities for basic, translational, and clinical investigators focused on improving therapeutic responses to chemotherapy.

  • Brugada Phenocopy

    The Art of Recognizing the Brugada ECG Pattern
    • 1st Edition
    • Adrian Baranchuk
    • English
    Brugada Phenocopy: The Art of Recognizing the Brugada ECG Pattern details all aspects associated with alternative diagnosis to Brugada Syndrome (BrS). Coverage includes how to identify the proper ECG pattern, what to do to investigate for BrP, and how to avoid misinterpretations and the use of unnecessary and expensive treatments. Chapters are written by experienced professionals, many of whom are colleagues that initially described this condition. This easy to use volume is a must have reference for researchers of cardiology, cardiologists, electrocardiologists... internists, emergency care doctors and students, residents and fellows.

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