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Books in Life sciences

Elsevier's Life Sciences collection helps researchers get comprehensive coverage and up-to-date information on the study of living organisms, their processes, and interrelationships, spanning disciplines like biology, genetics, and biochemistry, and addressing emerging trends such as genomics, biotechnology, and sustainability, essential for advancing knowledge and driving innovation in the field.

BooksJournals

    • Fifty Years of Peeling Away the Lead Paint Problem

      • 1st Edition
      • September 24, 2022
      • David E. Jacobs
      • English
      • Paperback
        9 7 8 0 4 4 3 1 8 7 3 6 0
      • eBook
        9 7 8 0 4 4 3 1 8 7 3 7 7
      Fifty Years of Peeling Away the Lead Paint Problem: Saving Our Children's Future with Healthy Housing documents the history of childhood lead poisoning from paint between 1970 and 2022. Tracing the failure of the medical model (treatment after exposure) that marked the 1970s and 1980s and its replacement with a prevention housing-focused effort, the book documents the changes in health, housing and environmental science and policy. It is the first book to examine how the lead poisoning law in the U.S. was passed in 1992 and later implemented, with implications for the future, in particular, the emergence of a healthy housing movement. The book describes the roles played by Congress, various administrations, agencies, local governments, the private sector, researchers, and a popular citizen's movement, especially parents. The role of the courts is discussed, including a controversial lead paint case on research ethics in Baltimore through an environmental justice lens. This book is the first to examine another recent case in California, where ten local jurisdictions established a precedent by successfully suing the lead paint industry to help pay for abatement.

    • Epigenetics and DNA Damage

      • 1st Edition
      • Volume 33
      • August 14, 2022
      • Miriam Galvonas Jasiulionis
      • English
      • Paperback
        9 7 8 0 3 2 3 9 1 0 8 1 1
      • eBook
        9 7 8 0 3 2 3 9 1 0 8 2 8
      Although scientists recognize the role of epigenetic mechanisms in DNA damage response, the complex, mechanistic interplay between chromatin regulation and DNA repair is still poorly understood. Comprehending how these processes are connected in time and space and play out in developmental processes may reveal novel directions for new research and disease treatment. Epigenetics and DNA Damage, a new volume in the Translational Epigenetics series, offers a thorough grounding in the relationship between DNA Damage, epigenetic modifications, and chromatin regulation. Early chapters address the basic science of DNA damage and its association with various epigenetic mechanisms, including DNA methylation, post-translational histone modifications, histone variants, chromatin remodeling, miRNAs, and lncRNAs. This is followed by a close discussion of DNA damage and epigenetics in metabolism, aging, cellular differentiation, immune function, stem cell biology, and cancer, tying recent research to translational application in disease understanding. Later chapters examine possible epigenetic therapies combining DNA damage induction and epigenetic alteration, as well as instructive chapters on how to analyze DNA damage and epigenetic alterations in new research.

    • MicroRNA

      • 1st Edition
      • July 19, 2022
      • Junjie Xiao
      • English
      • Paperback
        9 7 8 0 3 2 3 8 9 7 7 4 7
      • eBook
        9 7 8 0 3 2 3 8 8 5 5 8 4
      MicroRNA: From Bench to Bedside provides an in-depth, expansive overview of microRNA from fundamentals to clinical practice. It presents researchers with detailed insights on the topic of microRNA, exploring foundational knowledge that is followed by methodologies and the latest technologies for research and potential theragnostic and therapeutic applications for specific diseases. The book consists of eight parts, beginning with an introduction to microRNA and the current state of the field, followed by sections on biogenesis and maturation of microRNA, and methodology and bioinformatics, where chapters focus on isolation and detection techniques. Sections then move on to molecular mechanisms and gene regulation, considering topics such as transcriptional regulation and epigenetic regulation, as well as the role of microRNA as biomarkers. Additionally, microRNA and human disease and microRNA-based therapeutics are explored, focusing on a wide range of diseases such as cancer, age-related disease, cardiovascular disease, microRNA targeted therapy in hepatitis and therapeutic strategies for diabetes. The book concludes with a discussion on advances and future perspectives in microRNA investigation.

    • Epigenetics in Organ Specific Disorders

      • 1st Edition
      • Volume 34
      • December 2, 2022
      • English
      • Paperback
        9 7 8 0 1 2 8 2 3 9 3 1 5
      • eBook
        9 7 8 0 1 2 8 2 3 9 3 2 2
      **Selected for Doody’s Core Titles® 2024 in Clinical Genetics**Epigenetic... in Organ Specific Disorders, a new volume in the Translational Epigenetics series, provides a foundational overview and nuanced analysis of epigenetic gene regulation distinct to each organ type and organ specific disorders, fully elucidating the epigenetics pathways that promote and regulate disease. After a brief introduction, chapter authors compare epigenetic regulations across normal and disease conditions in different organ tissues, exploring similarities and contrasts. The role of epigenetic mechanisms in stem cells, cell-matrix interactions and cell proliferation, cell migration, cellular apoptosis, necrosis, pyknosis, tumor suppression, and immune responses across different organ types are examined in-depth.Organ specific epigenetic mechanisms and biomarkers of early use in developing drugs, which can selectively target the organ of interest, are also explored to enable new precision therapies.

    • De Novo Peptide Design

      • 1st Edition
      • September 17, 2022
      • Vibin Ramakrishnan + 2 more
      • English
      • Paperback
        9 7 8 0 3 2 3 9 9 9 1 7 5
      • eBook
        9 7 8 0 3 2 3 9 8 5 4 3 7
      De novo Peptide Design: Principles and Applications presents the latest developments in the fields of therapeutic peptides and bio-nanotechnology. The title focuses on the design of peptides, particularly how peptides may be tailored to specific functions. It includes computational and experimental protocols to assist in the design of peptides. Sections cover the basics of protein and peptide structure, modeling and simulation, solid phase peptide synthesis, peptide-based antibiotics, drug delivery, peptide nanomaterials, aromatic interactions directing nano-assembly, protein/peptide aggregation, therapeutic interventions against protein/peptide aggregation diseases, peptide based hydrogels, computational tools and algorithms for peptide design, and experimental protocols in peptide chemistry. In addition, the book covers key aspects in peptide design, providing a solution for researchers working within the 'peptidic universe' to create new therapeutic agents.

    • Biomedical Engineering Design

      • 1st Edition
      • February 19, 2022
      • Joseph Tranquillo + 2 more
      • English
      • Paperback
        9 7 8 0 1 2 8 1 6 4 4 4 0
      • eBook
        9 7 8 0 1 2 8 1 6 6 2 5 3
      *Textbook and Academic Authors Association (TAA) Most Promising New Textbook Award Winner, 2024*Biomedical Engineering Design presents the design processes and practices used in academic and industry medical device design projects. The first two chapters are an overview of the design process, project management and working on technical teams. Further chapters follow the general order of a design sequence in biomedical engineering, from problem identification to validation and verification testing. The first seven chapters, or parts of them, can be used for first-year and sophomore design classes. The next six chapters are primarily for upper-level students and include in-depth discussions of detailed design, testing, standards, regulatory requirements and ethics. The last two chapters summarize the various activities that industry engineers might be involved in to commercialize a medical device.

    • Roadmap to Successful Digital Health Ecosystems

      • 1st Edition
      • February 12, 2022
      • Evelyn Hovenga + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 8 2 3 4 1 3 6
      • eBook
        9 7 8 0 1 2 8 2 3 6 3 9 0
      Roadmap to Successful Digital Health Ecosystems: A Global Perspective presents evidence-based solutions found on adopting open platforms, standard information models, technology neutral data repositories, and computable clinical data and knowledge (ontologies, terminologies, content models, process models, and guidelines), resulting in improved patient, organizational, and global health outcomes. The book helps engaging countries and stakeholders take action and commit to a digital health strategy, create a global environment and processes that will facilitate and induce collaboration, develop processes for monitoring and evaluating national digital health strategies, and enable learnings to be shared in support of WHO’s global strategy for digital health. The book explains different perspectives and local environments for digital health implementation, including data/information and technology governance, secondary data use, need for effective data interpretation, costly adverse events, models of care, HR management, workforce planning, system connectivity, data sharing and linking, small and big data, change management, and future vision. All proposed solutions are based on real-world scientific, social, and political evidence.

    • A Mathematical Approach to Special Relativity

      • 1st Edition
      • September 9, 2022
      • Ahmad Shariati
      • English
      • Paperback
        9 7 8 0 3 2 3 9 9 7 0 8 9
      • eBook
        9 7 8 0 3 2 3 9 9 7 0 9 6
      A Mathematical Approach to Special Relativity introduces the mathematical formalisms of special and general relativity. Developed from the author’s experience teaching physics to students across all levels, the valuable resource introduces key concepts, building in complexity and using increasingly advanced mathematical tools as it progresses. Without assuming a background in calculus, the text begins with symmetry, before delving more deeply into Galilean relativity. Throughout, the book provides examples and useful "Guides to the Literature." This unique text emphasizes the experimental consequences and verifications of the underpinning theory in order to provide students with a solid foundation in this key area.

    • Hepatic Fibrosis

      • 1st Edition
      • April 23, 2022
      • Pablo Muriel
      • English
      • Paperback
        9 7 8 0 3 2 3 9 9 7 6 4 5
      • eBook
        9 7 8 0 3 2 3 9 5 2 8 9 7
      Hepatic Fibrosis: Mechanisms and Targets is a complete volume of liver extracellular matrix biology, including molecular signaling pathways, cells and factors that modulate fibrogenesis and fibrosis. The book uses an integrated approach toward the molecular and cellular mechanisms involved in the synthesis and degradation of hepatic fibrotic tissue, emphasizing the possible molecular targets to fight fibrosis. This important reference describes, in detail and didactically, the cellular and molecular events that are conducive to fibrosis that leads to cirrhosis, hepatocellular carcinoma and death. The provided information allows readers to understand the molecular mechanisms of hepatic fibrogenesis to accelerate the development of new therapies.

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