Limited Offer
Save 50% on book bundles
Immediately download your ebook while waiting for your print delivery. No promo code needed.
Vitamin B12
- 1st Edition, Volume 119 - March 23, 2022
- Editor: Gerald Litwack
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 9 2 2 3 - 7
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 9 2 2 4 - 4
Vitamin B12, Volume 119 in the Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteVitamin B12, Volume 119 in the Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in the Vitamins and Hormones series
- Updated release includes the latest information on Vitamin B12
Undergraduates, graduates, academics, and researchers in the field of vitamins and hormones
- Cover image
- Title page
- Table of Contents
- Copyright
- Former Editors
- Contributors
- Preface
- Chapter One: Insertion of cobalt into tetrapyrroles
- Abstract
- 1: Introduction
- 2: Aerobic B12 biosynthesis
- 3: Anaerobic B12 biosynthesis
- 4: Conclusions and future directions
- References
- Chapter Two: Application of bioorganometallic B12 in green organic synthesis
- Abstract
- 1: Vitamin B12
- 2: B12 inspired reactions
- 3: Electrochemical reactions catalyzed by vitamin B12 derivative
- 4: Conclusion and future directions
- Acknowledgments
- References
- Chapter Three: Cobamide remodeling
- Abstract
- 1: Introduction
- 2: Cobamide diversity and distribution
- 3: Cobamide remodeling proteins
- 4: Conclusions and outlook
- References
- Chapter Four: Cubilin, the intrinsic factor-vitamin B12 receptor
- Abstract
- 1: Introduction
- 2: Expression sites of cubilin, Lrp2 and Amn
- 3: Cubilin, the intrinsic factor-vitamin B12 receptor
- 4: Amnionless
- 5: Megalin/Lrp2
- 6: The receptor complex CUBN/AMN, LRP2 and their partners (Fig. 2)
- 7: Cubilin in the kidney
- 8: Cubilin and receptor-mediated endocytosis
- 9: Cubilin/Amn, Lrp2, DAB2
- 10: Regulation of cubilin expression
- 11: Cubilin in vitamin B12 homeostasis vitamin B12 (Fig. 3)
- 12: Cobalamin absorption and transport (Fig. 4)
- 13: Renal handling of vitamin B12
- 14: IGS or juvenile megaloblastic anemia (Fig. 5)
- 15: Cubilin in pathology
- 16: Cubilin dysfunction in Fanconi-Bickel, Dent and Lowe syndromes
- 17: Cubilin in diabetes, the vitamin D/micronutrient connection
- 18: Cubilin in neural tube defects
- 19: Cubilin as a risk variant and/or prognostic factor in cancer progression
- 20: Cubilin in animal studies
- 21: Breed-specific cubilin mutations in dogs
- 22: Conclusion
- References
- Chapter Five: Membrane transport of cobalamin
- Abstract
- 1: Introduction
- 2: Membrane transport systems in bacteria
- 3: Transport of cobalamin in humans
- 4: Concluding remarks
- References
- Chapter Six: Vitamin B12 photoreceptors
- Abstract
- 1: Introduction to photoreceptors and their chromophores
- 2: Vitamin B12 structure, chemistry, photochemistry
- 3: Vitamin B12, a precious biological cofactor
- 4: B12-based photoreceptors
- 5: Concluding remarks
- Acknowledgments
- References
- Chapter Seven: Photolytic properties of B12-dependent enzymes: A theoretical perspective
- Abstract
- 1: Introduction
- 2: Summary of experimental results
- 3: Computational approach
- 4: Importance of axial bonding in construction of S1 PES
- 5: Photolytic properties of cobalamins
- 6: Summary and outlook
- References
- Chapter Eight: Antivitamins B12
- Abstract
- 1: Introduction
- 2: Vitamin B12 and organometallic B12-cofactors
- 3: Antivitamins B12
- 4: Summary and outlook
- Acknowledgments
- References
- Chapter Nine: Vitamin B12 absorption and malabsorption
- Abstract
- 1: Introduction
- 2: Origin, food content and availability of vitamin B12
- 3: Physiology of vitamin B12 absorption (Fig. 1)
- 4: Causes of vitamin B12 malabsorption (Table 2)
- 5: Measurements of vitamin B12 malabsorption in humans
- References
- Chapter Ten: Intracellular processing of vitamin B12 by MMACHC (CblC)
- Abstract
- 1: Overview of cellular metabolism of cobalamins
- 2: Structure and stability of CblC
- 3: Enzymatic activity of CblC
- 4: Regulation of CblC expression and clinical phenotypes mimicking cblC disease
- 5: Future directions
- References
- Chapter Eleven: Telomere length and vitamin B12
- Abstract
- 1: Telomeres
- 2: Nutrition and telomere length
- 3: Role of vitamin B12 in telomere homeostasis
- 4: Conclusion
- Acknowledgments
- References
- Chapter Twelve: Vitamin B12 and chronic kidney disease
- Abstract
- 1: Vitamin B12 and chronic kidney disease: An overview
- 2: Vitamin B12 and the homocysteine metabolic pathway in chronic kidney disease
- 3: Vitamin B12 and chronic kidney disease in clinical practice
- 4: Vitamin B12 and chronic kidney disease: Evidence gaps and future directions
- References
- Chapter Thirteen: Inherited defects of cobalamin metabolism
- Abstract
- 1: Introduction
- 2: Diagnosis of inborn errors affecting cobalamin metabolism
- 3: Inborn errors affecting intestinal cobalamin absorption
- 4: Defects affecting cobalamin transport
- 5: Cellular cobalamin uptake
- 6: Lysosomal membrane cobalamin transport
- 7: The cblC disorder
- 8: Regulation of MMACHC expression
- 9: Partitioning cobalamin between the cytoplasm and mitochondria
- 10: Methylmalonyl-CoA isomerization in the mitochondria
- 11: Homocysteine remethylation
- References
- Chapter Fourteen: Behavioral profile of vitamin B12 deficiency: A reflection of impaired brain development, neuronal stress and altered neuroplasticity
- Abstract
- 1: Introduction and background
- 2: Neuropathology and behavioral abnormalities in human disorders
- 3: Behavioral abnormalities in animal models
- 4: Regions of the brain involved and the physiologic basis of behavioral alterations
- 5: Genes and pathways involved
- 6: Conclusions and future directions
- Acknowledgments
- References
- Chapter Fifteen: Vitamin B12 deficiency
- Abstract
- 1: Overview
- 2: Basics of vitamin B12 biochemistry and physiology
- 3: Pathophysiology and pathobiochemistry of vitamin B12 deficiency
- 4: Prevention and treatment of B12 deficiency
- 5: Conclusion and future directions
- References
- Further reading
- Chapter Sixteen: Metabolism-mediated thrombotic microangiopathy and B12
- Abstract
- 1: Introduction
- 2: TTP-TMA
- 3: B12 dysmetabolism and TMA-like syndrome
- 4: The triad of TMA in B12 deficiency and dysmetabolism
- 5: Diagnosis
- 6: Treatment
- 7: Conclusions
- References
- Chapter Seventeen: Neuropsychiatric manifestations in vitamin B12 deficiency
- Abstract
- 1: Vitamin B12 and neuropsychiatry
- 2: Neurobiology of vitamin B12 related neuropsychiatric manifestations
- 3: Neuropsychiatric manifestations of vitamin B12 deficiency
- 4: Treatment of neuropsychiatric manifestation due to vitamin B12 deficiency
- 5: Conclusion
- References
- Chapter Eighteen: Vitamin B12 and predatory behavior in nematodes
- Abstract
- 1: Introduction: The ecological diversity of nematodes
- 2: Caenorhabditis elegans—A model system approach for modern biology
- 3: Pristionchus pacificus—A model for complex trait formation
- 4: P. pacificus predation, cannibalism and phenotypic plasticity
- 5: The role of vitamin B12 for the predatory behavior in P. pacificus
- 6: The role of vitamin B12 for the development and physiology of P. pacificus and C. elegans
- 7: Vitamins as limiting factors for nematode growth—A genomic perspective (from laboratory to natural habitats)
- References
- Chapter Nineteen: Determination of cobalamin and related compounds in foods
- Abstract
- 1: Cobalamin
- 2: Cobalamin sources for humans
- 3: Determination of cobalamin in foods
- 4: Inactive cobalamins and related compounds in foods
- 5: Conclusions and future directions
- Acknowledgments
- References
- No. of pages: 522
- Language: English
- Edition: 1
- Volume: 119
- Published: March 23, 2022
- Imprint: Academic Press
- Hardback ISBN: 9780323992237
- eBook ISBN: 9780323992244
GL
Gerald Litwack
Dr. Litwack has authored 3 textbooks on biochemistry and hormones (one with John Wiley & Sons and 2 with Academic Press/Elsevier) and he has edited more than 70 volumes in the Vitamins & Hormones series (Academic Press/Elsevier); he has edited 14 volumes entitled Biochemical Actions of Hormones (Academica Press); He has edited (with David Kritchevsky) Actions of Hormones on Molecular Processes (Academic Press)
Affiliations and expertise
Emeritus Founding Chair and Professor, Geisinger Commonwealth School of Medicine, United States
Emeritus Professor, Rutgers University, United States