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Elsevier

  • Drug Discovery Stories

    From Bench to Bedside
    • 1st Edition
    • Bin Yu + 1 more
    • English
    Drug Discovery Stories: From Bench to Bedside presents a collection of cases on the development of highly successful pharmaceuticals. It delves into the realm of drug discovery, exploring the structural biology and biological functions of the sought-after targets. The book covers the identification of promising compounds, their transformation from hits to leads through meticulous optimization, and the elucidation of how key compounds interact with the target (in essence, providing invaluable insights for drug design). Additionally, it covers essential information such as the pivotal biological and PK data of lead compounds, any noteworthy clinical results, and a comprehensive overview of other candidate compounds.The field of drug discovery and development has experienced rapid evolution, with numerous new drugs receiving approval each year. While several books have been published on this subject, there is a pressing need for a new book series that accurately reflects the current advancements in drug discovery. This book aims to not only cater to the drug discovery community but also engage other communities involved in chemical biology, synthetic chemistry, and pharmacology.

  • Assistive Technologies

    Principles and Practice
    • 6th Edition
    • Janice Miller Polgar + 3 more
    • English
    Master the assistive strategies you need to make confident clinical decisions and help improve the quality of life for people with disabilities. Based on the Human Activity Assistive Technology (HAAT) model developed by Albert Cook, Sue Hussey, and Janice Polgar, Assistive Technologies: Principles and Practice, 6th Edition, provides detailed coverage of the broad range of devices, services, and practices that comprise assistive technology. This text offers a systematic process for ensuring the effective application of assistive technologies — and focuses on the relationship between the human user and the assisted activity within specific contexts. New to this edition is updated and expanded content on autonomous features of wheelchairs and vehicles, electronic aids to daily living, robotics, sustainability issues related to assistive technology, and much more.

  • Marine Molecules from Algae and Cyanobacteria

    Extraction, Purification, Toxicology and Applications
    • 1st Edition
    • Paz Otero Fuertes + 1 more
    • English
    The marine environment is a rich but underexploited source of commercially interesting natural products with different applications. Several marine organisms, such as seaweeds, microalgae, sponges, cyanobacteria, ascidians, and fungi, are sources of natural valuable molecules. These chemical compounds range from small molecules and enzymes to highly complex secondary metabolites that show bioactivities in physiological systems. It is thus of great importance to collect information concerning the discovery of these molecules and their characterization and relation to human diseases. Gathering data about novel technologies and sources to obtain and isolate such as precious molecules as well as new applications for them is extremely appreciated in the chemical field. It is very useful for chemists to obtain these molecules with high purity to be used as analytical standards to calibrate the chromatography equipment. Many of these compounds are not commercially available, so the isolation methods of these molecules from microalgae, seaweeds, and cyanobacteria is a challenging task. The availability of some marine molecules has been a long-term problem due to the difficulty of their synthesis. Because of the complexity of their structure, the total synthesis has been shown to be difficult. Developing protocols to obtain reference standards from natural sources has shown satisfactory results in the chemical industry. Marine Molecules From Algae and Cyanobacteria addresses these topics, highlighting fundamentals of biomolecules, their roll in living organism, structure elucidation, sources, important characteristics, and the industrial applications of these biomaterials for educational (academic) as well as industrial purposes. This book covers all methodologies used in the search of marine natural products: screening of marine molecules by chemical methods like HPLC, LC-MS/MS, the isolation of high-value compounds with biotechnological potential, discovery of new molecules, and the optimization of green extraction procedures of these molecules, such as supercritical fluid extraction and pressurized solvent extraction, and other alternative chemical techniques applied in the exploration for marine compound.

  • Fundamentals of Vacuum Science and System Design for High and Ultrahigh Vacuum, Volume 1

    Introduction to Vacuum and Systems
    • 1st Edition
    • J.R. Gaines + 1 more
    • English
    Fundamentals of Vacuum Science and System Design for High and Ultrahigh Vacuum, Volume 1: Introduction to Vacuum and Systems details the important practical considerations in design of vacuum systems for various vacuum deposition technologies. Topics covered include an introduction to vacuum and end-uses, molecular density in vacuum, molecular flow in various vacuum regimes, characteristics of gas composition at various molecular densities, general principles of gas–solid interactions, vacuum pump technology, pressure sensors, leak detection, and the impact of fundamental design decisions and operating practices on vacuum system performance.The introductory sections are designed to introduce the reader to basic concepts in vacuum technology. More detailed sections provide fundamental descriptions of basic vacuum pumps and pumping mechanisms in current practice and provides insight into the various pros and cons for each approach. System design, assembly, maintenance, and trouble-shooting are reviewed in detail.The book also describes a wide range of pressure measurement approaches, and includes several key characterization techniques, example applications on systems for rough vacuum, high vacuum and ultrahigh vacuum, as well as trade-offs in system design. These perspectives will allow the reader to develop an understanding of all the elements required for a successfully designed, assembled, and operating system.

  • Microplastics

    Origins, Risks, and Mitigation
    • 1st Edition
    • Baljinder Singh + 1 more
    • English
    Microplastics: Origins, Risks, and Mitigation discusses the sources, origin, and health risk assessment of microplastics in the environment. The various contamination indices, like contamination factor, atmospheric behavior, enrichment factor, and marine pollution are also included to provide further context on the state of microplastics in the environment and environmental impacts. The book present reviews on microplastics toxicology research, health hazards, and green remedial solutions for pollution control in terrestrial and aquatic environments, aiming to provide scientists and researchers with the knowledge to combat microplastic pollutants through sustainable means.Covering a variety of approaches, techniques, and scenarios, this book is a key resource for environmental scientists working to address microplastic environmental pollutants. It presents reviews on microplastics toxicology research, health hazards, and green remedial solutions for pollution control in terrestrial and aquatic environments.

  • Imaging in Rheumatology, An Issue of Rheumatic Disease Clinics of North America

    • 1st Edition
    • Volume 50-4
    • Robert M. Fairchild + 1 more
    • English
    In this issue of Rheumatic Disease Clinics, guest editors Drs. Robert M. Fairchild and Kaitlin A. Quinn bring their considerable expertise to the topic of Imaging in Rheumatology. Top experts cover key topics such as CNS imaging in rheumatic disease; axial imaging in spondyloarthritis; imaging challenges and developments in large-vessel vasculitis; imaging in peripheral inflammatory arthritis; imaging in juvenile idiopathic arthritis; and more.

  • Greening Our Economy for a Sustainable Future

    • 1st Edition
    • Simon Grima + 3 more
    • English
    Greening Our Economy for a Sustainable Future examines the green economy by balancing social needs, the environment, and the economy. It argues that different economic models must be developed to address the environment caused by economic expansion. The book not only looks at the opportunities of having a green economy, but also goes into areas such as greenwashing, social washing, sustainability, economics, and more. In addition, it addresses how one can improve well-being through a symbiotic relationship between economic growth and environmental stewardship.

  • Diversity, Equity, and Inclusion in Veterinary Medicine, Part II, An Issue of Veterinary Clinics of North America: Small Animal Practice

    • 1st Edition
    • Volume 54-6
    • Christina V. Tran
    • English
    In this issue of Veterinary Clinics: Small Animal Practice, guest editor Dr. Christina V. Tran brings her considerable expertise to the topic of Diversity, Equity, and Inclusion in Veterinary Medicine, Part II. Top experts discuss the challenges and opportunities faced by the veterinary profession in meeting the needs of an increasingly diverse client base. A look back at the history of DEI efforts offers context for the ongoing need for systemic and organizational change. Articles also explore the connection between areas such as veterinary education, practice management, access to care, animal welfare, and leadership development in veterinary medicine through the lens of diversity, equity and inclusion.

  • Nanostructured Lithium-ion Battery Materials

    Synthesis, Characterization, and Applications
    • 1st Edition
    • Sabu Thomas + 3 more
    • English
    Nanostructured Lithium-ion Battery Materials: Synthesis and Applications provides a detailed overview of nanostructured materials for application in Li-ion batteries, supporting improvements in materials selection and battery performance. The book begins by presenting the fundamentals of Lithium-ion batteries, including electrochemistry and reaction mechanism, advantages and disadvantages of Li-ion batteries, and characterization methods. Subsequent sections provide in-depth coverage of a range of nanostructured materials as applied to cathodes, electrolytes, separators, and anodes. Finally, other key aspects are discussed, including industrial scale-up, safety, life cycle analysis, recycling, and future research trends.This is a valuable resource for researchers, faculty, and advanced students across nanotechnology, materials science, battery technology, energy storage, chemistry, applied physics, chemical engineering, and electrical engineering. In an industrial setting, this book will be of interest to scientists, engineers, and R&D professionals working with advanced materials for Li-ion batteries and other energy storage applications.

  • Digital Twins for Smart Cities and Villages

    • 1st Edition
    • Sailesh Iyer + 3 more
    • English
    Digital Twins for Smart Cities and Villages provides a holistic view of digital twin technology and how it can be deployed to develop smart cities and smart villages. Smart manufacturing, smart healthcare, smart education, smart agriculture, smart rural solutions, and related methodologies using digital twins are discussed, including challenges in deployment, their solutions and future roadmaps. This knowledge, enriched by a variety of case studies presented in the book, may empower readers with new capabilities for new research as well as new tasks and strategies for practical implementation and real-world problem solving.The book is thoughtfully structured, starting from the background of digital twin concepts and basic know-how to serve the needs of those new to the subject. It continues with implementation to facilitate and improve management in several urban contexts, infrastructures, and more. Global case study assessments further provide a deep characterization of the state-of-the-art in digital twin in urban and rural contexts.

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