
Biotechnological Production of Bioactive Phytochemicals of Medicinal Value
A Comprehensive Treatise
- 1st Edition - July 11, 2024
- Imprint: Elsevier
- Editors: Anabela Romano, P. B. Kavi Kishor, Penna Suprasanna, T. Pullaiah, A. Ranga Rao
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 2 1 8 1 8 - 7
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 1 8 1 9 - 4
Biotechnological Production of Bioactive Phytochemicals of Medicinal Value: A Comprehensive Treatise covers a broad variety of methods for secondary metabolites productio… Read more

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Request a sales quoteBiotechnological Production of Bioactive Phytochemicals of Medicinal Value: A Comprehensive Treatise covers a broad variety of methods for secondary metabolites production (both pharmaceuticals and cosmeceuticals), compiling state-of-the-art material about the current knowledge of in vitro production for a large number of bioactive phytochemicals. Plants are a source of bioactive compounds and specialty chemicals such as ginsenosides; paclitaxel, artemisinin, veregen and nutraceuticals. Biopharmaceuticals are important in human healthcare, and herbal actives are gaining importance all over the world. With natural resources dwindling, in vitro production of secondary compounds on a commercial scale is being more and more required.
Besides providing an alternative technology to bypass difficulties, the plant tissue culture (used in a broad sense to include cell, tissue, and organ culture) offers many advantages. In vitro technology also facilitates novel means of conserving the genetic diversity of the germplasm of medicinal plants through cryopreservation, production of novel compounds through biotransformation, somatic hybridization, and selective gene transfer through recombinant DNA technology for enhancing metabolite production.
- Compiles state-of-the-art material about in vitro production for several bioactive phytochemicals
- Incorporates the most recent developments in the field
- Covers a broad variety of secondary metabolites
Graduate students and researchers working with Medicinal Chemistry, Organic Chemistry and Pharmacology
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Preface
- Chapter 1. Plants to pharmacy: recapitulation of natural compounds transmuting human health
- Abstract
- 1.1 Introduction
- 1.2 Plants as a source for diverse pharmaceutically important compounds
- 1.3 Production of bioactive compounds on an industrial scale
- 1.4 Factors affecting the accumulation of secondary plant products in vitro
- 1.5 Nanoparticles and secondary plant product accumulation
- 1.6 Future focus
- Acknowledgments
- Author contribution
- Conflict of interest
- References
- Chapter 2. Production of bioactive metabolites in in vitro cultures of saffron (Crocus sativus L.)
- Abstract
- 2.1 Introduction
- 2.2 Phytochemistry of Crocus sativus
- 2.3 Chemical and genetic diversity in Crocus sativus
- 2.4 Production of saffron metabolites through biotechnology techniques
- 2.5 Biological activity of in vitro cultures of Crocus sativus
- 2.6 Conclusions and future perspectives
- Acknowledgments
- Conflict of interest
- References
- Chapter 3. In vitro production of industrial valued bioactive secondary metabolites from selected medicinal plants of Sri Lanka
- Abstract
- 3.1 Introduction
- 3.2 The plant of immortality: Aloe vera
- 3.3 Munronia pinnata (Wall.) Theob
- 3.4 Curcuma longa L. (Turmeric)
- 3.5 Gyrinops walla Gaertn. for agarwood production
- Acknowledgments
- Author contributions
- References
- Chapter 4. In vitro production of secondary metabolites by Thymus plants
- Abstract
- 4.1 Introduction
- 4.2 Secondary metabolites of Thymus plants
- 4.3 Micropropagation of Thymus plants
- 4.4 In vitro production of secondary metabolites by Thymus plants
- 4.5 Concluding remarks
- Acknowledgments
- References
- Chapter 5. In vitro production of anthocyanins
- Abstract
- Abbreviations
- 5.1 Introduction
- 5.2 Natural anthocyanin production
- 5.3 Demand
- 5.4 In vitro anthocyanin production methods
- 5.5 Scaling up in vitro anthocyanin production
- 5.6 Conclusion and future perspectives
- References
- Chapter 6. Prospecting phytochemical and biological of seedling extract of Libidibia ferrea (Fabaceae) produced from in vitro propagation
- Abstract
- 6.1 Introduction
- 6.2 Material and Methods
- 6.3 Results
- 6.4 Discussion
- 6.5 Conclusion
- Acknowledgment
- Conflict of interest
- References
- Chapter 7. Properties, biotechnological production, and applications of rhinacanthins
- Abstract
- 7.1 Introduction
- 7.2 Sources of Rhinacanthins
- 7.3 Chemistry and biosynthesis of rhinacanthins
- 7.4 Biotechnological production of rhinacanthins
- 7.5 Pharmaceutical applications of rhinacanthins
- 7.6 Conclusion
- References
- Chapter 8. Nanoparticle-mediated elicitation of plant secondary metabolites, in vitro and in vivo
- Abstract
- Abbreviation
- 8.1 Introduction
- 8.2 Secondary metabolite elicitation using nanomaterials
- 8.3 Nanoparticle exposure, absorption, and transport mechanisms in plant cells and tissues
- 8.4 Conclusion
- References
- Chapter 9. Recent trends in in vitro production of alkaloids from Rauvolfia serpentina
- Abstract
- List of abbreviations
- 9.1 Introduction
- 9.2 Rauvolfia serpentina
- 9.3 Bioactive compounds from Rauvolfia serpentina
- 9.4 Biosynthesis of terpenoid indole alkaloids in Rauvolfia serpentina
- 9.5 Alkaloid production in in vitro cultures of Rauvolfia serpentina
- 9.6 Conclusions and future prospects
- Acknowledgment
- References
- Chapter 10. Experimental strategies to enhance in vitro production of plant secondary metabolites
- Abstract
- 10.1 Introduction
- 10.2 Production of secondary metabolites in organ cultures
- 10.3 Synthesis of secondary metabolites using callus cultures
- 10.4 Synthesis of secondary metabolites through cell suspension culture
- 10.5 Elicitation of secondary metabolites in hairy root cultures
- 10.6 Agrobacterium and Ri transferred DNA genes
- 10.7 Scaling up of hairy roots and bioreactors
- 10.8 Conclusion
- References
- Chapter 11. An overview of the in vitro synthesis of anthraquinones in plant cell and organ cultures and elicitation strategies
- Abstract
- 11.1 Introduction
- 11.2 Biosynthesis of anthraquinones
- 11.3 Chemistry of anthraquinones
- 11.4 Classification of anthraquinones
- 11.5 Occurrence of anthraquinones
- 11.6 Anthraquinone synthesis in plants through in vitro cultures
- 11.7 Elicitation of anthraquinone synthesis
- 11.8 Conclusions
- References
- Chapter 12. Secondary metabolite production in transgenic cultures: an overview over the last decade
- Abstract
- 12.1 Introduction
- 12.2 SM production in transgenic cultures and transgenic plants expressing rol gene(s)
- 12.3 SM production in hairy root cultures (HRCs)
- 12.4 SM production in transgenic cultures via. metabolic engineering (ME)
- 12.5 Challenges and opportunities associated with SM production in transgenic cultures
- 12.6 Conclusions
- Acknowledgments
- References
- Chapter 13. In vitro production of phytoecdysteroids in plants
- Abstract
- 13.1 Introduction to phytoecdysteroids
- 13.2 Phytoecdysteroids diversity in different plant species
- 13.3 Biosynthetic pathways of phytoecdysteroids
- 13.4 In vitro production of phytoecdysteroids
- 13.5 Enhancement of phytoecdysteroids using different strategies
- 13.6 Conclusions
- References
- Chapter 14. Bacosides neurotropic molecules production by tissue cultures of Bacopa monnieri (L.) Wettst.
- Abstract
- Abbreviations
- 14.1 Introduction
- 14.2 Biochemical spectrum of B. monnieri
- 14.3 Biosynthesis of bacosides
- 14.4 Bacosides: potent neurotropic molecules
- 14.5 In vitro production of bacosides
- 14.6 Conclusion and future prospects
- Acknowledgments
- References
- Chapter 15. Application of different tissue culture techniques for in vitro production of gymnemic acid: factors, approaches, and challenges to achieve higher yield
- Abstract
- 15.1 Introduction
- 15.2 Biosynthesis of gymnemic acid from acetyl CoA
- 15.3 Mechanism of action of gymnemic acid
- 15.4 Enhanced production of gymnemic acid through plant tissue culture techniques
- 15.5 Factors affecting the production of gymnemic acid
- 15.6 Conclusions
- Acknowledgments
- Author contributions
- Funding
- References
- Chapter 16. Adoption of biotechnologies for Withania somnifera (L.) Dunal for sustainable utilization
- Abstract
- 16.1 Introduction
- 16.2 New varieties of Withania developed by CSIR-CIMAP
- 16.3 Importance of W. somnifera in traditional medicine
- 16.4 Importance of W. somnifera in modern medicine
- 16.5 Phytochemical composition of Withania
- 16.6 Biosynthesis pathway of withanolide
- 16.7 Metabolic engineering approaches for the production of withanolide
- 16.8 In vitro production of withanolides
- 16.9 Conclusion and future prospects
- Acknowledgments
- References
- Chapter 17. In vitro cultures of some Asclepiadaceae members: a source for the production of secondary metabolites
- Abstract
- Abbreviations
- 17.1 Introduction
- 17.2 Role of tissue culture in synthesis of secondary metabolites
- 17.3 In vitro studies of medicinally important members of Asclepiadaceae
- 17.4 Synthesis of secondary metabolites through in vitro cultures
- 17.5 Important secondary metabolites of the selected asclepiadaceae members
- 17.6 Conclusions
- References
- Chapter 18. In vitro studies and hairy root development with reference to secondary metabolite production in medicinally important Solanum erianthum D. Don
- Abstract
- 18.1 Introduction
- 18.2 Phytochemical composition of S. erianthum
- 18.3 In vitro production of solasodine
- 18.4 Hairy root culture and solasodine production
- 18.5 Conclusion and future prospects
- Acknowledgments
- References
- Chapter 19. A nonsteroidal antiinflammatory drug boswellic acid from Boswellia serrata Roxb.
- Abstract
- 19.1 Introduction
- 19.2 Oleo-gum resin
- 19.3 Strategies for augmented production of active metabolites
- 19.4 Synthesis of boswellic acid isomers and their activity
- 19.5 Genes used to synthesize boswellic acids in suitable host
- 19.6 Prospects
- Acknowledgment
- References
- Chapter 20. Accumulation of anticancer compounds in cultured cells and hairy roots
- Abstract
- 20.1 Introduction
- 20.2 Chemical and natural compounds that have antitumor activity
- 20.3 Anticancer compounds from callus and suspension cultures
- 20.4 Conclusions and perspectives
- Acknowledgments
- Author contributions
- Funding
- Data availability
- References
- Chapter 21. Applications of radiations and mutagenesis for the enhancement of plant secondary metabolites
- Abstract
- 21.1 Introduction
- 21.2 Radiations and chemical mutagens
- 21.3 Secondary metabolites
- 21.4 Enhancement of secondary metabolites using elicitation and mutagenesis
- 21.5 Conclusions and future prospective
- References
- Chapter 22. In vitro hepatoprotective lignan production from Phyllanthus species
- Abstract
- 22.1 Introduction
- 22.2 Lignans
- 22.3 Lignan biosynthetic pathway
- 22.4 In vitro propagation
- 22.5 Callus cultures
- 22.6 Lignan production in in vitro grown cultures
- 22.7 Genetic manipulation in Phyllanthus
- 22.8 Conclusions and future prospects
- Acknowledgments
- References
- Chapter 23. Cardiotonic glycosides production in Digitalis: application of in vitro culture and transgenic approaches
- Abstract
- 23.1 Introduction
- 23.2 In vitro culture and cardenolide production
- 23.3 Polyploidization, gamma irradiation, and in vitro cardenolides production
- 23.4 Cardenolide biosynthesis pathway
- 23.5 Hairy root cultures
- 23.6 Transgenic plants and cardenolide synthesis
- 23.7 Conclusion and future prospects
- References
- Chapter 24. Production of bioactive compounds from cell and organ cultures of Centella asiatica
- Abstract
- 24.1 Introduction
- 24.2 Biosynthesis of centellosides from Centella asiatica
- 24.3 In vitro production of centellosides and other important secondary metabolites
- 24.4 Genetic transformation studies in Centella asiatica
- 24.5 Bioreactor scale studies for the production of centellosides
- 24.6 Conclusions and prospects
- Acknowledgments
- References
- Index
- Edition: 1
- Published: July 11, 2024
- Imprint: Elsevier
- No. of pages: 900
- Language: English
- Paperback ISBN: 9780443218187
- eBook ISBN: 9780443218194
AR
Anabela Romano
PK
P. B. Kavi Kishor
PS
Penna Suprasanna
TP
T. Pullaiah
AR