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  • The Oncobiology of the Prostate

    • 1st Edition
    • Volume 3
    • D.P. Wood + 1 more
    • English
    Prostate cancer (PCa) is the most common newly diagnosed cancer among men in the United States today. With the advent of the prostate-specific antigen (PSA) test, the number of newly diagnosed cases has increased tremendously. The rates of PCa have increased so dramatically over the last decade that the age-adjusted incidence rate of PCa is no greater than that for any other cancer among men in the United States. Although PCa rates have risen steadily since 1973, there has been a dramatic acceleration in the late 1980s which has been associated with the introduction and use of PSA for screening and early detection. There is now some evidence that the rates may be levelling off and even decreasing in some areas. After lung cancer, PCa is the leading cause of death due to cancer in men in the United States. Although PCa can occur in younger men, it is essentially a cancer of elderly men. The highest rates of PCa in the world occur among African-American men in the United States. African-Americans have higher rates than Caucasians at all age levels in the United States, and adjusting for social-economic status does not appear to account for this difference to any appreciable extent. There is no clear reason why PCa rates are so much greater among African-Americans compared with Caucasians in the United States. The reported rates in Africans are substantially lower than those of an African-American, suggesting that environmental factors have an influence on PCa. In spite of this substantial impact on our society. PCa remains a relatively understudied disease, with an essentially unknown etiology. The reviews contained in this book are by no means exhaustive. We have, however, attempted to provide information regarding the pathology of prostate cancer, the status of diagnostic and prognostic markers, as well as a discussion of our understanding of the molecular basis for the disease. The biology of prostate cancer is covered with a discussion on the role of apoptosis in prostate cancer and the suggestion of it being the target for new therapeutic development, as well as the role played by integrins and angiogenesis. The status of current therapies, both hormonal and chemotherapy, are also discussed. This volume should provide a useful background for individuals wishing to commence an in-depth understanding of prostate cancer.

  • The Renal Circulation

    • 1st Edition
    • Volume 9
    • W.P. Anderson + 2 more
    • English

  • Geoscience After IT

    A View of the Present and Future Impact of Information Technology on Geoscience
    • 1st Edition
    • Volume 17
    • T.V. Loudon
    • English
    Most geoscientists are aware of recent IT developments, but cannot spend time on obscure technicalities. Few have considered their implications for the science as a whole. Yet the information industry is moving fast: electronic delivery of hyperlinked multimedia; standards to support interdisciplinary and geographic integration; new models to represent and visualize our concepts, and control and manage our activities; plummeting costs that force the pace. To stay on course, the scientist needs a broad appreciation of the complex and profound interactions of geoscience and IT, not previously reviewed in a single work.The book brings together ideas from many sources, some probably unfamiliar, that bear on the geoscience information system. It encourages readers to give thought to areas that, for various reasons, they have taken for granted, and to take a view on forces affecting geoscience, the consequences for themselves and their organisations, and the need to reconsider, adapt and rebuild.Practicing geoscientists with a general interest in how IT will affect their work and influence future directions of the science; geoscientists familiar with IT applications in their own specialist field who need a broader perspective; and students or educators specializing in IT applications in geoscience who require a top-down overview of their subject will find this title valuable. The IT background from this book should help geoscientists build a strategy for the new century.

  • Geological Exploration in Murzuq Basin

    • 1st Edition
    • D. Worsley
    • M.A. Sola
    • English
    The Murzuq Basin is a large intracratonic sag basin located in southwestern Libya. Exploration efforts started in this vast and remote Saharan region already in 1957 and 60 exploratory wells have been drilled to date, resulting in over 20 discoveries with around 4,000 million barrels of oil in place. Most discoveries have been made in Ordovician sandstone reservoirs sourced by hot shales of the Lower Silurian Tanezzuft Formation. Oil is already being produced and exported from the area, but the basin's total hydrocarbon potential is still poorly understood. Recent exploration - especially the major discovery and initial development of the Giant "Elephant" Field - has greatly increased interest for the area's potential. Many petroleum geologists and companies now believe that the basin may well develop into a new major hydrocarbon province which will significantly contribute to Europe's energy needs in the next decades. This book presents papers from a conference held at Sebha University - on the eastern margins of the Murzug Basin - in September 1998.The book continues an ongoing series of presentations of the geology of Libya, but the 25 contributions herein mostly centre on the Murzuq Basin itself and on nearby areas. There are still many unresolved questions in terms of geological and hydrocarbon exploration in these difficult desert areas, but the papers herein will hopefully present a first comprehensive overview of an exciting frontier exploration region. About half of the papers are directly related to hydrocarbon exploration, and to source rock and reservoir development, but a wide variety of other features are also described, ranging from palaeontology and biostratigraphy to ore geology and water resources, covering the entire geological column from the Precambrian to the Holocene. The book concludes with a bibliography covering all geological aspects of this challenging but very promising frontier area.

  • Applied Polymer Science: 21st Century

    • 1st Edition
    • C. Craver + 1 more
    • English
    The 75th Anniversary Celebration of the Division of Polymeric Materials: Science and Engineering of the American Chemical Society, in 1999 sparked this third edition of Applied Polymer Science with emphasis on the developments of the last few years and a serious look at the challenges and expectations of the 21st Century.This book is divided into six sections, each with an Associate Editor responsible for the contents with the group of Associate Editors acting as a board to interweave and interconnect various topics and to insure complete coverage. These areas represent both traditional areas and emerging areas, but always with coverage that is timely. The areas and associated chapters represent vistas where PMSE and its members have made and are continuing to make vital contributions. The authors are leaders in their fields and have graciously donated their efforts to encourage the scientists of the next 75 years to further contribute to the well being of the society in which we all live.Synthesis, characterization, and application are three of the legs that hold up a steady table. The fourth is creativity. Each of the three strong legs are present in this book with creativity present as the authors were asked to look forward in predicting areas in need of work and potential applications. The book begins with an introductory history chapter introducing readers to PMSE. The second chapter introduces the very basic science, terms and concepts critical to polymer science and technology. Sections two, three and four focus on application areas emphasizing emerging trends and applications. Section five emphasizes the essential areas of characterization. Section six contains chapters focusing of the synthesis of the materials.

  • Histopathology of Preclinical Toxicity Studies

    Interpretation and Relevance in Drug Safety Evaluation
    • 2nd Edition
    • Peter Greaves
    • P. Greaves
    • English
    This book describes histopathological assessment of preclinical toxicology studies that are conducted to assess the safety of novel drugs. It discusses the implications of drug-induced changes that may be relevant to the critical early stages of the development of new therapeutic agents, notably prior to their first administration to humans and during early clinical trials. Covering virtually all aspects of drug-induced pathology in preclinical toxicity studies, the book is termed the 'gold standard' in the illustration of histopathology. This second revised edition continues to fill the gap for pathology literature relating to the development of new medicines and assessment of their safety based on preclinical studies. In addition to the updated references this edition contains many older references, some out of reach of modern computer based search tools.

  • Contemporary Ideas on Ship Stability

    • 1st Edition
    • D. Vassalos + 3 more
    • J. Otto de Kat + 2 more
    • English
    Widely publicised disasters serve as a reminder to the maritime profession of the eminent need for enhancing safety cost-effectively and as a strong indicator of the existing gaps in the stability safety of ships and ocean vehicles. The problem of ship stability is so complex that practically meaningful solutions are feasible only through close international collaboration and concerted efforts by the maritime community, deriving from sound scientific approaches. Responding to this and building on an established track record of co-operative research between UK and Japan, a Collaborative Research Project (CRP) was launched in 1995.This volume includes selected material from the first four workshops: 1st in University of Strathclyde, July 1995 organized by Professor Vassalos; 2nd in Osaka Japan, Osaka University, November 1996 organized by Professor Masami Hamamoto; 3rd in Crete Greece, Ship Design Laboratory of the National Technical University of Athens (NTUA-SDL), October 1997 organized by Professor Apostolos Papanikolaou; and 4th in Newfoundland Canada, Institute for Marine Dynamics, September 1998 organized by David Molyneux. It contains 46 papers that represent all currently available expertise on ship stability, spanning 17 countries from around the world. The framework adopted for grouping the papers aims to cover broad areas of ship stability in a way that it provides a template for future volumes.

  • Side Effects of Drugs Annual

    • 1st Edition
    • Volume 23
    • English
    The http://www.elsevier.... Effects of Drugs Annual offers clinicians in areas as widespread as dermatology, neuroscience, endocrinology and many other medical disciplines a reliable and critical overview of all that is known in the area of Adverse Drugs Reactions.An international team of specialists in the various areas have contributed to the current Annual. Particular attention is devoted to those publications providing essentially new information or throwing new light on problems already recognized. All that is truly new and informative (or points to what is misleading) is critically selected from the year's writing. Every four years the previous set of four Annuals is summarised and evaluated, leading to the publication of the update of the major reference work, http://www.elsevier.... Side Effects of Drugs. The /locate/isbn/0444500... updated Edition of Meyler's, published in December 2000, provides the reader with a summary of Side Effects of Drugs Annuals 20 - 23.

  • Elemental Speciation

    New Approches for Trace Element Analysis
    • 1st Edition
    • Volume 33
    • J.A. Caruso + 2 more
    • English
    This book provides a comprehensive discussion of the major aspects involved in elemental speciation. Sample preparation, separation techniques, instrumentation and quality assurance are all discussed. In addition, individual chapters are devoted to speciation of environmental samples and speciation of biological, clinical, and nutritional samples. Individual chapters are written by leaders in the field, and the book has been organized so that the reader may learn how to collect a sample and prepare it. Ways to separate and detect analytes of interest, and steps to take to ensure the validity of the measurements are also discussed. This book is unique in its comprehensive treatment of this subject.

  • Discrete Sample Introduction Techniques for Inductively Coupled Plasma Mass Spectrometry

    • 1st Edition
    • Volume 34
    • D. Beauchemin + 5 more
    • English
    The book starts with a detailed description of ICP-MS, including quadruple-based, sector-based and time-of-flight instruments. Instrumentation from existing manufacturers is described and compared to show their similarities and differences. Also, a review of the ICP-MS literature is carried out to outline both the strengths and limitations of the technique, whatever its brand, as well as what it can currently accomplish in terms of applications. Then, the book demonstrates how these limitations can be reduced and/or eliminated by combining various techniques with ICP-MS. Great detail is provided on each technique so that the reader can get a good understanding of it before carrying on to the instrumental requirements for its hyphenation to ICP-MS, and the resulting impact on the operation of the hyphenated instrument. Since this book is concerned with the ICP side only, which is fairly similar in all the instruments from the different manufacturers, the information should be useful to all ICP-MS users. The features and limitations of each technique are thoroughly discussed and illustrated with a review of the ICP-MS literature. Approaches which could be used but have not yet been tried with ICP-MS are also suggested. This is particularly true of flow injection techniques which are extremely flexible and have been used extensively in atomic spectroscopy and spectrophotometry. Many of the features of the technique have not yet been combined to ICP-MS, and one purpose of the book will be to point out potentially beneficial combinations.

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