Receptor Chemistry Towards the Third Millennium

Pharmacological receptors: A century of discovery - and more (D.J. Triggle). Cholinergic receptors and neurodegenerative diseases (F. Gualtieri). Nicotinic systems in central nervous systems disease: Degenerative disorders and beyond (P. Newhouse). Central nicotinic receptor ligands and pharmacophores (R.A. Glennon). Structural aspects of high affinity ligands for the alpha4beta 2 neuronal nicotinic receptor (M.J. Dart). Recombinant human receptors and functional assays in the discovery of novel acetylcholine-gated ion channel (nAchR)Agonist (N.D.P. Cosford). Receptors in neurodegenerative diseases. Muscarinic cholinergic receptors (P. Angeli). Design and development of selective muscarinic agonists for the treatment of alzheimer's disease (W.S. Messer). Cl-1017 a functionally M1 selective muscarinic agonist: design synthesis and preclinical pharmacology (H. Tecle). Ligands for the common allosteric site of acetylcholine M2-receptors: development and application DEU (U. Holzgrabe). Receptors in cardiovascular disease: review and introduction (A. Leonardi). Adrenoceptor subclassification: an approach to improved cardiovascular therapeutics (J.P. Hieble). The alpha 1 a and alpha 1 b-adrenergic receptor subtypes: molecular mechanisms of receptor activity (S. Cotecchia). Alfa1-Adrenoreceptor antagonists bearing a quinazoline or a benzodioxane moiety (C. Melchiorre). Selection design and evaluation of new radioligands for pet studies of cardiac adrenoceptors (V.W. Pike). Enigmatic receptors (L. Brasili). Imidazoline receptors: A challenge (P. Bosquet). Sigma receptors: recent advances and new clinical potentials (W. Bowen). Excitatory amino acid receptors (G. Gaviraghi). Excitatory amino acid agonists and antagonists: Pharmacology and therapeutic applications (D. Trist). Metabotropic glutamate receptors: A structural view point (R. Pellicciari). Synthesis and pharmacological properties of novel glicine antagonists (D. Donati). Introduction to receptors in neurodegenerative diseases (W. Froestl). Neurotrophin receptor structure and interactions (M.V. Chao). The RET receptor tyrosine kinase: activation signalling and significance in neural development and GBR (I.J. Mason). The ciliary neurotrophic factor (CNTIF) and its receptor CNTIFR alpha (M. Sleeman ). Rediscovering good old friend IGF-1 in the new millennium (R. Quirion). Apoptosis induced by death receptors (P. Schneider). Hijacked receptors (D.J. Triggle). ICAM-1 receptors and cold viruses (J. Bella). Viral-encoded G-protein coupled receptors: new targets for drug research? (M.J. Smit). Chemokine receptors: interaction with HIV-1 and viral-encoded chemokines (S. Sozzani). General topics and perspectives (H. Timmerman). Pharmacological evidence of muscarinic receptor heterodimerization (R. Maggio). Constitutive activity of G protein coupled receptors and drug action (R. Leurs). New dimensions in G protein signalling: Gbeta5 and the RGS proteins (W.F. Simonds). Kappa opioid agonists as targets for pharmacotherapies in cocaine abuse (J.L. Neumeyer).