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  • Functional Neural Transplantation II. Novel Cell Therapies for CNS Disorders

    • 1st Edition
    • Volume 127
    • S.B. Dunnett + 1 more
    • English
    The first edition of Functional Neural Transplantation, appearing in 1994, was commissioned to provide a systematic overview of the main areas of active research into the use of neural transplantation for functional repair at that time. There have though been major developments in the field over the last decade. First, whereas many of the model systems are the same, the sophistication of the research has developed dramatically. Secondly, there has been a major change in focus related to the nature of the optimal reparative process, moving away from a primary goal involving repair by replacement of lost cells, to strategies based on halting or reversing the disease process itself. Thirdly, the last decade has (not surprisingly) seen an expansion in the breadth of clinical applications for transplantation not only of primary embryonic neural tissues but also the initial applications of cells and cell lines.In order to address these recent developments as we enter the 21st century, 10 years after conception and 6 years after the publication of Functional Neural Transplantation, the Editors have now sought to co-ordinate and edit an updated version, Functional Neural Transplantation II.Functional Neural Transplantation II is not just a revised edition of the previous volume, but an entirely new and complementary second volume to update the field to 'state of the art' for the new millennium. For many major topic areas (such as functional repair in neurodegenerative disorders of the basal ganglia) there has been a continual flow of significant advances. Although these topics are covered in both volumes, the Editors have sought to avoid duplication by requiring that the present coverage emphasises the major developments over the last decade while relying on the first volume for the background overviews. Other topics though are entirely new in the present volume, such as novel applications of neural transplantation to other major clinical relevance such as retinal repair or alleviation of pain. A key departure of the present volume is the addition of several early chapters addressing the technical and developmental issues associated with identification of alternative sources of cells for transplantation - cell lines, immortalised cells, precursor/stem cells and xenotransplantation.

  • Inverse Problems in Engineering Mechanics II

    • 1st Edition
    • G.S. Dulikravich + 1 more
    • English
    Inverse Problems are found in many areas of engineering mechanics and there are many successful applications e.g. in non-destructive testing and characterization of material properties by ultrasonic or X-ray techniques, thermography, etc. Generally speaking, inverse problems are concerned with the determination of the input and the characteristics of a system, given certain aspects of its output. Mathematically, such problems are ill-posed and have to be overcome through development of new computational schemes, regularization techniques, objective functionals, and experimental procedures. Following the IUTAM Symposium on these topics, held in May 1992 in Tokyo, another in November 1994 in Paris, and also the more recent ISIP'98 in March 1998 in Nagano, it was concluded that it would be fruitful to gather regularly with researchers and engineers for an exchange of the newest research ideas. The most recent Symposium of this series "International Symposium on Inverse Problems in Engineering Mechanics (ISIP2000)" was held in March of 2000 in Nagano, Japan, where recent developments in inverse problems in engineering mechanics and related topics were discussed.The following general areas in inverse problems in engineering mechanics were the subjects of ISIP2000: mathematical and computational aspects of inverse problems, parameter or system identification, shape determination, sensitivity analysis, optimization, material property characterization, ultrasonic non-destructive testing, elastodynamic inverse problems, thermal inverse problems, and other engineering applications. The papers in these proceedings provide a state-of-the-art review of the research on inverse problems in engineering mechanics and it is hoped that some breakthrough in the research can be made and that technology transfer will be stimulated and accelerated due to their publication.

  • Cancer Metastasis: Experimental Approaches

    • 1st Edition
    • Volume 29
    • D. Rusciano + 1 more
    • D.R. Welch
    • English
    The book describes most of the methods that are currently used in metastasis research. Both in vivo and in vitro protocols are illustrated, so that the metastatic process can be either analysed as a whole, or single events addressed separately. Each method is described in the frame of the metastatic process, therefore its significance and its limitations in the context of metastasis are always taken into account. Whenever possible, several alternative procedures are reported per each experimental issue, so that the researcher can choose the one that better suits her/his needs and possibilities.During the past 30 years a big effort has been made to elucidate the molecular mechanisms of cancer metastatis, the leading cause of death for cancer patients. A considerable number of assays have been set up, that can be used to address specific questions concerning the single metastatic steps, or can be applied to develop and test drugs specifically interfering with selected events during the metastatic spread. This book contains an exhaustive description of most of the methods and their rationale, that are currently used in metastatic research, both to analyse metastasis in its entirety (in vivo models), or to dissect the single steps of the metastatic process (in vitro assays).

  • Experimental Design

    A Handbook and Dictionary for Medical and Behavioral Research
    • 1st Edition
    • Volume 14
    • J. Krauth
    • English
    Scientists planning experiments in medical and behavioral research will find this handbook and dictionary an invaluable desk reference tool. Also recommended as a textbook for students of Experimental Design or accompanying courses in Statistics. Principles of experimental design are introduced, techniques of experimental design are described, and advantages and disadvantages of often used designs are discussed.This two-part volume, a handbook of experimental design and a dictionary providing short explanations for many terms related to experimental design, contains information that will not quickly become outdated.

  • Lake Baikal

    A Mirror in Time and Space for Understanding Global Change Processes
    • 1st Edition
    • K. Minoura
    • English
    Lake Baikal is the oldest lake and largest freshwater reservoir in the world. As a result of its exceptionally long geological history, the lake has been a theatre of evolution and speciation of organisms, and it currently harbors more species than any other lake in the world. Based on its unique nature, Lake Baikal was recently designated a World Heritage site and is regarded as a hotspot for evolution, speciation, and biodiversity. With its tremendously peculiar biota, Lake Baikal is now awaiting modern analytical approaches to the profound problems of speciation and evolution. In late autumn 1998 a symposium was held in Japan with the theme "Lake Baikal: A mirror in time and space for understanding global change processes" to bring together scientists from different disciplines who are studying Lake Baikal. Three international scientific associations: The BICER (Baikal International Center for Ecological Research), BDP (Baikal Drilling Project), and DIWPA (Diversitas Western Pacific and Asia) were involved in the organisation.This book contains a selection of papers presented at this symposium. They are interdisciplinary in nature and bring together results from geology, paleontology, chemistry, biology, limnology and physics.

  • Muddy Coast Dynamics and Resource Management

    • 1st Edition
    • Volume 2
    • B.W. Flemming + 2 more
    • English
    Muddy coasts are land-sea transitional environments commonly found along low-energy shorelines which either receive large annual supplies of muddy sediments, or where unconsolidated muddy deposits are being eroded by wave action.In providing 21 case studies in different parts of the world this book provides an up-to-date review of the state of the art in muddy coast research. Issues dealing with hydrodynamics and suspended matter transport, erosion, deposition, and sediment budgets on tidal flats, primary production, nutrient fluxes and mineralization in lagoons are treated in a multi disciplinary manner. Most articles deal with issues which are of relevance with respect to global warming and future sea level rise.

  • Statistics for Petroleum Engineers and Geoscientists

    • 1st Edition
    • Volume 2
    • Jerry Jensen + 3 more
    • English
    Geostatistics is a common tool in reservoir characterization. Written from the basics of statistics, this book covers only those topics that are needed for the two goals of the text: to exhibit the diagnostic potential of statistics and to introduce the important features of statistical modelling. This revised edition contains expanded discussions of some materials, in particular conditional probabilities, Bayes Theorem, correlation, and Kriging. The coverage of estimation, variability, and modelling applications have been updated. Seventy examples illustrate concepts and show the role of geology for providing important information for data analysis and model building. Four reservoir case studies conclude the presentation, illustrating the application and importance of the earlier material. This book aims to help petroleum professionals develop more accurate models, leading to lower sampling costs. It is an ideal book for petroleum engineers, geoscientists, hydrologists, and faculty and students in these and related fields.

  • III-Nitride Semiconductors

    Electrical, Structural and Defects Properties
    • 1st Edition
    • M.O. Manasreh
    • English
    Research advances in III-nitride semiconductor materials and device have led to an exponential increase in activity directed towards electronic and optoelectronic applications. There is also great scientific interest in this class of materials because they appear to form the first semiconductor system in which extended defects do not severely affect the optical properties of devices. The volume consists of chapters written by a number of leading researchers in nitride materials and device technology with the emphasis on the dopants incorporations, impurities identifications, defects engineering, defects characterization, ion implantation, irradiation-induced defects, residual stress, structural defects and phonon confinement. This unique volume provides a comprehensive review and introduction of defects and structural properties of GaN and related compounds for newcomers to the field and stimulus to further advances for experienced researchers. Given the current level of interest and research activity directed towards nitride materials and devices, the publication of the volume is particularly timely. Early pioneering work by Pankove and co-workers in the 1970s yielded a metal-insulator-semi... GaN light-emitting diode (LED), but the difficulty of producing p-type GaN precluded much further effort. The current level of activity in nitride semiconductors was inspired largely by the results of Akasaki and co-workers and of Nakamura and co-workers in the late 1980s and early 1990s in the development of p-type doping in GaN and the demonstration of nitride-based LEDs at visible wavelengths. These advances were followed by the successful fabrication and commercialization of nitride blue laser diodes by Nakamura et al at Nichia. The chapters contained in this volume constitutes a mere sampling of the broad range of research on nitride semiconductor materials and defect issues currently being pursued in academic, government, and industrial laboratories worldwide.

  • Gallium Arsenide, Electronics Materials and Devices. A Strategic Study of Markets, Technologies and Companies Worldwide 1999-2004

    • 3rd Edition
    • R. Szweda
    • English
    The third edition of this highly respected market study provides a detailed insight into the global developments of the GaAs industry to 2004, and the implications for both suppliers and users of GaAs technology.The report has been completely revised and updated with a new chapter added on competitive technologies. The report also supplies market analysis by component type and application sectors.For a PDF version of the report please call Tina Enright on +44 (0) 1865 843008 for price details.

  • Fluorine Chemistry at the Millennium

    Fascinated by Fluorine
    • 1st Edition
    • R.E. Banks
    • English
    This volume brings together contributions by leading researchers covering a wide scope so characteristic of fluorine chemistry. It is a monograph of historical character comprising personalized accounts of progress and events in areas of particular interest.There is also much to interest and instruct chemists from other disciplines as a good proportion of the chapters contain a considerable amount of 'hard' referenced information relating to modern organic, organoelemental and inorganic chemistry. Historians of chemistry and technology will no doubt be tempted to dip into this book, and surely whoever addresses the task of commemorating Moissan's achievement at the 150-years stage will bless us all in some measure for its existence.

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