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Elsevier

Academic Press

  • Genetics of Bone Biology and Skeletal Disease

    • 3rd Edition
    • Rajesh V. Thakker + 3 more
    • English
    Genetics of Bone Biology and Skeletal Disease, Third Edition is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid, and related disorders, and vitamin D and renal disorders.Sections cover bone biology and structure, joint and cartilage biology, principles of endocrine regulation, the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasia, rarer bone disorders, and much more.

  • Antimicrobial Therapeutics and Drug Discovery

    • 1st Edition
    • Chengyuan Liang + 1 more
    • English
    Antimicrobial Therapeutics and Drug Discovery is a comprehensive resource that provides an overview of antimicrobial drug discovery. It covers a wide spectrum of pathogenic organisms causing human infections, exploring alternative therapeutic strategies beyond traditional small molecule drugs. The contents in the book are structured into four parts, each focusing on a different aspect of antimicrobial drug discovery. From exploring viral and host targets, understanding antibiotic resistance mechanisms, to the potential of nanomedicine and computational approaches, the book offers a comprehensive view of the field. Employing a multidisciplinary approach, chapters discuss the importance of drug discovery for fungi, Mycobacteria, Mycoplasma, and parasites, and offers insights into innovative biomedical approaches and combination therapies. By bridging the gap between experimental research and practical application, Antimicrobial Therapeutics and Drug Discovery is a key reference for pharmacologists and pharmaceutical scientists working in academic and corporate research. Medicinal chemists and microbiologists will also benefit from the multidisciplinary coverage of the book.

  • Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy

    • 3rd Edition
    • Herbert B. Newton
    • English
    The Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy, Third Edition offers a unique cutting-edge collection of basic science and clinical information on brain tumor chemotherapy research. This book represents the most complete, single-volume resource available for information on the subject of brain tumor chemotherapy. Including a multidisciplinary approach, this volume combines recent advances in tumor therapy with molecular biology, molecular therapeutics, immunobiology, and immunotherapy approaches in one compilation. Chapters new to this volume include cutting-edge research on the molecular underpinnings of brain tumors such as glioblastoma and other gliomas, and the targeted molecular therapies to consider for treatment.

  • Fundamentals of Biologicals Regulation

    Vaccines and Biotechnology Medicines
    • 2nd Edition
    • Rebecca Sheets + 6 more
    • English
    This second edition of Fundamentals of Biologicals Regulation: Vaccines and Biotechnology Medicines serves as an introduction to the international regulatory arena in which biologicals are developed and offers an overview of the processes and insight into the scientific concepts underpinning global regulations. In this new edition the book provides more in-depth coverage of Quality by Design, Combination Products, Quality Target Product Profiles, Risk Management Plans and REMS, and switching from reliance on in vivo to in vitro analytical methods. This new edition also reflects the new developments and processes accelerated by the COVID-19 vaccine experience, including emergency use authorizations and conditional marking authorizations. New pedagogic elements and case studies have been added to improve learning outcomes for students. This book provides multiple levels of readership with guidance on basic concepts, a detailed look at regulatory challenges, and practical insight into how regulators consider regulatory science and regulatory process issues across various regions with emphasis on the European Medicines Agency and the U.S. Food and Drug Administration. Graduate students will benefit from the new pedagogic features. Regulatory professionals will have in Fundamentals of Biologicals Regulation: Vaccines and Biotechnology Medicines a complete guide to navigate through the approval process.

  • Retinoic Acids in Cancer Therapy

    Mechanisms of Sensitivity, Resistance, and Methods of Delivery
    • 1st Edition
    • Volume 23
    • Saeid Ghavami + 2 more
    • English
    Retinoic Acids in Cancer Therapy: Mechanisms of Sensitivity, Resistance, and Methods of Delivery provides an overview of how All-Trans Retinoic Acid (ATRA) kills cancer cells and how some cells survive treatment. Focusing on the cellular pathways and compartments involved in ATRA-mediated inhibition of proliferation, this book also discusses how aggressive tumors develop escape routes conferring retinoic acid resistance.Across 15 chapters, it describes the molecular structure and biological properties of ATRA, explains mechanisms of resistance, and defines ATRA’s efficacy in seven cancer types. It concludes with chapters on ATRA and cancer stem cell biology, strategies to improve treatment, future therapeutic perspectives, and delivery methods to reduce toxicity and enhance anticancer efficacy.Each chapter includes Learning Objectives and a “What We Learn” section, making the book highly accessible for undergraduate, graduate trainees, scientists, physicians, and biotech companies. Adding simple, attractive schemes and informative tables makes it ideal for all interested in the current status of Retinoic Acids in Cancer Therapy. This book serves as a valuable resource for health professionals, scientists, researchers, clinical practitioners, and all those seeking to broaden their knowledge and develop new drugs or therapeutic strategies to improve ATRA’s efficacy in the treatment of resistant cancers.

  • Laboratory Animal Medicine

    • 4th Edition
    • James G. Fox + 4 more
    • English
    **Selected for 2026 Doody's Core Titles in Veterinary Medicine**Laboratory Animal Medicine, Fourth Edition—a volume in the American College of Laboratory Animal Medicine (ACLAM) blue book series—is the authoritative reference on the biology, health, and care for species involved in research. Edited by recognized veterinary, operational, and research experts and endorsed as the official material for veterinary specialty certification by ACLAM, this work defines the standard for all aspects of humane laboratory animal care and science with animal models.This new edition contains significant changes in content and organization to reflect the evolution of the field. The animal welfare chapter has been moved to the beginning of the book to highlight this subject’s importance. Other chapters have either been consolidated to encourage the reader to recognize commonalities such as those between guinea pigs, gerbils and hamsters, or separated out in recognition of expansions in knowledge and cross-species complexity as illustrated by separate new and old world primate chapters. Advances in practice, technology, and knowledge are highlighted in the chapters on genetically modified organisms, with updates on new techniques in genetic engineering and consideration of non-rodent genetically modified models; microbiological monitoring, with an increased emphasis on environmental monitoring and sentinel free colony health monitoring methods; regulatory compliance, with a comprehensive chapter on birds; employee health and safety, with expanded consideration of compassion fatigue; and animal models in biomedical research, with increased emphasis on experimental design and rigor. New chapters on animal models for microbiome, infectious disease, and transplant research have been added to serve as a reference for the community.This book is an excellent reference for veterinarians and research scientists, as well as program directors and facility managers employed in a variety of academic and corporate settings. This edition continues the tradition of this text in setting standards for the research animal science community as well as expanding and updating relevant and essential topics for this specialty field.

  • Science, Culture, and Climate

    Navigating Change
    • 1st Edition
    • Thomas Rickenbach
    • English
    Science, Culture, and Climate: Navigating Change makes an engaging case that solutions to the climate crisis require a deep embrace of science, along with an understanding of social constructs and history. Initial chapters calibrate the reader’s understanding and significance of science, with following chapters focusing on how climate and life on Earth are deeply interconnected, the evolution of human society, and how our energy choices have triggered a climate crisis. Other sections explore how people process risk as they respond to challenges while reflecting on how major change was accomplished in America’s past.Concluding chapter highlights the moral imperatives that form the basis of trust to help pave the fraught road to lasting climate solutions, along with global approaches. This textbook is ideal for undergraduate students in environmental science and non-science majors studying climate change within history, anthropology, ethics, political science, engineering, psychology, and other disciplines. It is also useful for professionals in areas related to environment and sustainability, for advanced high school students, as well as for a general readership. Supplementary resource materials to accompany the book include narrated videos, in-class activities, and PowerPoint slides.

  • Clean Label Starch

    Processes, Properties and Functionality
    • 1st Edition
    • Parmjit Singh Panesar + 1 more
    • English
    Clean Label Starch: Processes, Properties and Functionality, a volume in the "Applications of Starches in Food and Packaging" series, provides the most up-to-date information on clean label starches, catering to a wide range of readers interested in starch modification and its applications in clean label food and packaging industries. Chapters cover hydro-thermal clean label starch, thermal and non-thermal physically modified starches, biotechnological approaches for clean label starch production, and its nanoencapsulation. Applications of clean label starch in the edible packaging industry, biodegradable packaging, and in bakery and confectionery are also included. The book discusses the challenges, and consumer acceptability, in addition to the quality attributes of clean label starch. Edited by an internationally diverse group of experts and leaders who possess extensive, up-to-date knowledge of native and modified starches and related technologies, this book is an excellent resource which highlights important global perspectives in the field.

  • Cutting Edge Advances in Transplantation

    • 1st Edition
    • Dai Dao Nghiem
    • English
    Cutting Edge Advances in Transplantation presents the current state of the science of transplantation. With a unique interdisciplinary approach, this reference collects contributions from selected transplant surgeons, scientists, and immunologists who have worked in the field for the last thirty years. Coverage includes transplantation tolerance, the molecular approach to transplant monitoring, sensitized transplant recipients, xenotransplantation, biologics, and regifted organs. This is the perfect reference for transplant surgeons and nephrologists that want to find new approaches and solutions to serve their patients. It is also ideal for transplantation researchers looking for the most up-to-date scientific information related to the field which can be built upon.

  • Artificial Intelligence in Precision Drug Design, Volume 2

    Advanced Applications
    • 1st Edition
    • Khalid Raza
    • English
    Artificial Intelligence in Precision Drug Design, Volume 2: Advanced Applications explores the transformative role of AI in modern drug discovery and development, presenting cutting-edge research and methodologies that integrate machine learning, network pharmacology, and computational modeling to accelerate therapeutic innovation. It covers a wide range of applications, including AI-driven drug repurposing, combination therapies, cancer immunotherapy, neuroscience, vaccine development, and molecular dynamics, but also delves into emerging technologies such as quantum computing, large language models, and graph neural networks. Designed for academics, this volume provides researchers, clinicians, and graduate students with a resource on the latest AI methodologies in precision medicine.Users will find this to be a great resource that supports evidence-based innovation, fosters interdisciplinary collaboration, and equips them with insights to advance personalized healthcare solutions.

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