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The Living Laboratory for Precision Medicine
Solutions for Clinical Implementation
- 1st Edition - March 1, 2025
- Editors: Dame Anna Dominiczak, Sandosh Padmanabhan, Carol Clugston
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 5 3 1 1 - 5
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 5 3 1 2 - 2
The Living Laboratory for Precision Medicine: Solutions for Clinical Implementation provides a comprehensive resource on precision medicine through a convergence of innovatio… Read more
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Request a sales quoteThe Living Laboratory for Precision Medicine: Solutions for Clinical Implementation provides a comprehensive resource on precision medicine through a convergence of innovation and solutions across multiple domains, including large population cohorts, artificial intelligence, genomics, phenomics, clinical trials, health economics and regulation exemplified by the living lab concept. This book is the first to look at precision medicine through the lens of last-mile solutions which make it broad in scope, practically relevant, and cutting-edge. The book explores the use of precision medicine to stimulate regional economic growth through a healthier population, savings on healthcare, and using innovation as a driver of economic development. The term precision medicine has been popularized by clinical, scientific, political, financial and technological interests as the biggest innovation to revolutionize healthcare. While over the past decade a few precision medicine-based solutions have come to fruition, the transformative leap in healthcare delivery and population benefit is yet to be realized. Current focus on precision medicine primarily focuses on patient stratification which constrains it to either a single disease area, a few sub-disciplines, or using a limited set of genomic technologies. While useful, experience over the last few years indicates precision medicine needs to be considered as a complex process with multiple feedback loops requiring significant interdisciplinary collaboration and innovation.
- Written by international experts providing a global perspective of innovative and cutting-edge advances that are in both early-development or advanced conceptual stages
- Includes real-life case studies that provide practical advice for clinical applications
- Presents the living lab concept as a last mile solution for precision medicine
readers with background in clinical sciences, basic science, health policy, public health, healthcare regulation, computer science, artificial intelligence and data science
1. Transforming healthcare through precision medicine
2. The Living Laboratory for precision medicine - solutions for the last-mile of implementation of precision medicine
3. Living Lab and diagnostics
4. Living Lab Case Studies
5. Oncology – Pancreatic Cancer
6. Oncology – Cancer 2
7. AI - Imaging
8. AI – Respiratory disease
9. Polypharmacy
10. Startups
11. Health Economics
12. Ethical, Legal and Social Implications
2. The Living Laboratory for precision medicine - solutions for the last-mile of implementation of precision medicine
3. Living Lab and diagnostics
4. Living Lab Case Studies
5. Oncology – Pancreatic Cancer
6. Oncology – Cancer 2
7. AI - Imaging
8. AI – Respiratory disease
9. Polypharmacy
10. Startups
11. Health Economics
12. Ethical, Legal and Social Implications
- No. of pages: 350
- Language: English
- Edition: 1
- Published: March 1, 2025
- Imprint: Academic Press
- Paperback ISBN: 9780323953115
- eBook ISBN: 9780323953122
DD
Dame Anna Dominiczak
Professor Dame Anna Dominiczak DBE, MD, FRCP, FAHA, FRSE, FMedSci
Chief Scientist (Health) for the Scottish Government and Regius Professor of Medicine at the University of Glasgow.
With major research interests in hypertension, cardiovascular genomics, and precision medicine.
Professor Dominiczak is a world-leading cardiovascular scientist and clinical academic. She has published extensively in top peer-reviewed journals (over 550 publications, a h-index of 123 according to Web of Science). Between 2010 and 2020 she was Vice-Principal and Head of the College of Medical, Veterinary and Life Sciences at the University of Glasgow. She was the driving force behind the fundraising, development and delivery of the University’s clinical academic campus at the Queen Elizabeth University Hospital, where she led a triple helix partnership between academia, the NHS, and industry to accelerate innovation, maximize patient benefits and economic growth.
Dame Anna is a member of several editorial boards and, from 2012 - 2022, was Editor-in-Chief of Hypertension, journal of the American Heart Association. Currently, she is Editor-in Chief of Precision Medicine, a new Prism journal of the Cambridge Press.
In March 2020, Anna led the establishment of Lighthouse Laboratory in Glasgow to provide rapid Covid–19 diagnostics, and then was asked to become Director of Laboratories at the UK Department of Health and Social Care to lead all 10 Lighthouse Laboratories across the UK, the role she fulfilled until 2022.
In July 2022 Professor Dominiczak was appointed as Chief Scientist (Health) for the Scottish Government, where she leads and coordinates health research and innovation, working in partnership with the NHS, academia and industry to develop rapid translation and adoption of transformative innovations for the Scottish NHS.
Affiliations and expertise
Regius Professor of Medicine, University of Glasgow; Honorary Consultant Physician and Endocrinologist at NHS Greater Glasgow and Clyde; and Health Innovation Champion for the Medical Research Council, UKSP
Sandosh Padmanabhan
Dr. Sandosh Padmanabhan MD, PhD, FRCP, FAHA, FBHS, FBPhS is a Professor and Physician at the Institute of Cardiovascular and Medical Sciences, University of Glasgow. Dr. Padmanabhan completed his MBBS and MD at JIPMER, Pondicherry, India and was awarded the Gold Medal for MD General Medicine in 1995. His PhD thesis (1999-2003) on G-protein signaling in hypertension was awarded the Bellahouston Medal by the University of Glasgow in 2004, and he received the Austin Doyle Award from the International Society of Hypertension in 2004. Dr. Padmanabhan’s pharmacogenetic genome-wide linkage study led to a BHF Intermediate Fellowship (2006-2009), and he also led a genome wide association analysis of hypertension between 2008 and 2010, resulting in the discovery of a new gene and pathway for hypertension. Dr. Padmanabhan was a visiting fellow to the Broad Institute of Harvard and MIT (2010-2012). Currently, he is a Fellow of the Royal College of Physicians, the British Hypertension Society, and the American Heart Association. His active research areas span the genetics of cardiovascular traits, pharmacogenomics and stratified medicine, and hypertension epidemiology.
Affiliations and expertise
Professor of Cardiovascular Genomics and Therapeutics, BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, UKCC
Carol Clugston
Dr Clugston is Dean of Corporate Engagement & Innovation and Chief Operating Officer of the College of Medical, Veterinary and Life Sciences. As Dean she leads the College's Innovation, Engagement and Enterprise Strategy. She is Director and SRO of the ‘Living Laboratory for Precision Medicine’. The Living Laboratory is rapidly developing a life sciences industry ecosystem around the Queen Elizabeth University Hospital. The Living Laboratory has increased cross-sector collaboration and is turning research into treatments and innovations that benefit patients whilst making savings for the NHS locally and across Scotland. Dr Clugston was awarded the Lord Provost's Award from the City of Glasgow in 2017, in the category of health. She was also the 2018 recipient of the 30% Club Scholarship to the London Business School’s Senior Executive Program. Dr Clugston is a Trustee of Glasgow Science Centre, and Board member of Precision Medicine Scotland.
Affiliations and expertise
Dean of Corporate Engagement and Innovation and Chief Operating Officer of the College of Medical, Veterinary and Life Sciences; Trustee of Glasgow Science Centre, and Board member of Precision Medicine Scotland, UK