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    • Essential Pharmacokinetics

      • 1st Edition
      • March 25, 2015
      • Thorsteinn Loftsson
      • English
      • Paperback
        9 7 8 0 1 2 8 0 1 4 1 1 0
      • eBook
        9 7 8 0 1 2 8 0 1 4 9 1 2
      Essential Pharmacokinetics: A Primer for Pharmaceutical Scientists is an introduction to the concepts of pharmacokinetics intended for graduate students and new researchers working in the pharmaceutical sciences. This book describes the mathematics used in the mammillary model as well as the application of pharmacokinetics to pharmaceutical product development, and is useful as both a self-study and classroom resource. Content coverage includes detailed discussions of common models and important pharmacokinetic concepts such as biological half-life, clearance, excretion, multiple dosage regimens and more. Numerous equations, practical examples and figures are incorporated to clearly illustrate the theoretical background of pharmacokinetic behavior of drugs and excipients.

    • Protein and Peptide Nanoparticles for Drug Delivery

      • 1st Edition
      • Volume 98
      • March 25, 2015
      • English
      • Hardback
        9 7 8 0 1 2 8 0 2 8 2 8 5
      • eBook
        9 7 8 0 1 2 8 0 2 8 7 0 4
      Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.

    • Neural Surface Antigens

      • 1st Edition
      • March 23, 2015
      • Jan Pruszak
      • English
      • Hardback
        9 7 8 0 1 2 8 0 0 7 8 1 5
      • eBook
        9 7 8 0 1 2 8 0 1 1 2 6 3
      Neural Surface Antigens: From Basic Biology towards Biomedical Applications focuses on the functionalrole of surface molecules in neural development, stem cell research, and translational biomedical paradigms.With an emphasis on human and rodent model systems, this reference covers fundamentals of neural stemcell biology and flow cytometric methodology. Addressing cell biologists as well as clinicians working in theneurosciences, the book was conceived by an international panel of experts to cover a vast array of particularsurface antigen families and subtypes. It provides insight into the basic biology and functional mechanisms ofneural cell surface signaling molecules influencing mammalian development, regeneration, and treatments.

    • International Review of Cell and Molecular Biology

      • 1st Edition
      • Volume 316
      • March 23, 2015
      • Kwang W. Jeon
      • English
      • Hardback
        9 7 8 0 1 2 8 0 2 2 8 1 8
      • eBook
        9 7 8 0 1 2 8 0 2 4 7 9 9
      International Review of Cell and Molecular Biology presents comprehensive reviews and current advances in cell and molecular biology. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. The series has a world-wide readership, maintaining a high standard by publishing invited articles on important and timely topics authored by prominent cell and molecular biologists. Impact factor for 2013: 4.522.

    • Endocrine Disruption and Human Health

      • 1st Edition
      • March 21, 2015
      • Philippa D. Darbre
      • English
      • Hardback
        9 7 8 0 1 2 8 0 1 1 3 9 3
      • eBook
        9 7 8 0 1 2 8 0 1 1 2 0 1
      Endocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students.

    • Economic Evaluation in Genomic Medicine

      • 1st Edition
      • March 20, 2015
      • Vasilios Fragoulakis + 3 more
      • English
      • Paperback
        9 7 8 0 1 2 8 0 1 4 9 7 4
      • eBook
        9 7 8 0 1 2 8 0 1 6 1 1 4
      Economic Evaluation in Genomic Medicine introduces health economics and economic evaluation to genomic clinicians and researchers, while also introducing the topic to health economists. Each chapter includes an executive summary, questions, and case studies, along with supplementary online materials, including process guides, maps, flow charts, diagrams, and economic evaluation spreadsheets to enhance the learning process. The text can easily be used as course material for related graduate and undergraduate courses, providing a succinct overview of the existing, state-of-the-art application of economic evaluation to genomic healthcare and precision medicine.

    • Marine Mammals

      • 3rd Edition
      • March 20, 2015
      • Annalisa Berta + 2 more
      • English
      • Hardback
        9 7 8 0 1 2 3 9 7 0 0 2 2
      • eBook
        9 7 8 0 1 2 3 9 7 2 5 7 6
      Marine Mammals: Evolutionary Biology, Third Edition is a succinct, yet comprehensive text devoted to the systematics, evolution, morphology, ecology, physiology, and behavior of marine mammals. Earlier editions of this valuable work are considered required reading for all marine biologists concerned with marine mammals, and this text continues that tradition of excellence with updated citations and an expansion of nearly every chapter that includes full color photographs and distribution maps.

    • Advances in Planar Lipid Bilayers and Liposomes

      • 1st Edition
      • Volume 21
      • March 20, 2015
      • English
      • Hardback
        9 7 8 0 1 2 8 0 2 1 1 6 3
      • eBook
        9 7 8 0 1 2 8 0 2 2 0 1 6
      The Elsevier book-series "Advances in Planar Lipid Bilayers and Liposomes’ (APLBL) provides a global platform for a broad community of experimental and theoretical researchers studying cell membranes, lipid model membranes and lipid self-assemblies from the micro- to the nanoscale. Planar lipid bilayers are widely studied due to their ubiquity in nature and find their application in the formulation of biomimetic model membranes and in the design of artificial dispersion of liposomes. Moreover, lipids self-assemble into a wide range of other structures including micelles and the liquid crystalline hexagonal and cubic phases. Consensus has been reached that curved membrane phases do play an important role in nature as well, especially in dynamic processes such as vesicles fusion and cell communication. Self-assembled lipid structures have enormous potential as dynamic materials ranging from artificial lipid membranes to cell membranes, from biosensing to controlled drug delivery, from pharmaceutical formulations to novel food products to mention a few. An assortment of chapters in APLBL represents both an original research as well as comprehensives reviews written by world leading experts and young researchers.

    • Atomic and Molecular Photoabsorption

      • 1st Edition
      • March 18, 2015
      • Joseph Berkowitz
      • English
      • Hardback
        9 7 8 0 1 2 8 0 1 9 4 3 6
      • eBook
        9 7 8 0 1 2 8 0 1 9 5 8 0
      Atomic and Molecular Photoabsorption: Partial Cross Sections is a companion work to Joseph Berkowitz's earlier work, Atomic and Molecular Photoabsorption: Absolute Total Cross Sections, published with Academic Press in 2002. In this work Joseph Berkowitz selected the "best" absolute partial cross sections for the same species as included in the companion work. A contrast, however, is that photoabsorption measurements, being of order I/Io, do not require the most intense light sources, whereas acquiring data on the products of light interactions with gaseous matter (ions, electrons, various coincidence measurements) has benefited significantly with the arrival of second- and third-generation synchrotrons. The newer devices have also extended the energy range of the light sources to include the K-shells of the species discussed here. The newer light sources encouraged experimentalists to develop improved instrumentation. Thus, the determination of partial cross sections continues to be an active field, with more recent results in some cases superseding earlier ones. Where the accuracy of the absolute partial cross sections is deemed sufficient (less than five percent), numerical tables are included in this new work. In other cases, the available data are presented graphically.

    • TRP Channels as Therapeutic Targets

      • 1st Edition
      • March 14, 2015
      • Arpad Szallasi
      • English
      • Hardback
        9 7 8 0 1 2 4 2 0 0 2 4 1
      • eBook
        9 7 8 0 1 2 4 2 0 0 7 9 1
      TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use is authored by experts across academia and industry, providing readers with a complete picture of the therapeutic potential and challenges associated with using TRP channels as drug targets. This book offers a unique clinical approach by covering compounds that target TRP channels in pre-clinical and clinical phases, also offering a discussion of TRP channels as biomarkers. An entire section is devoted to the novel and innovative uses of these channels across a variety of diseases, offering strategies that can be used to overcome the adverse effects of first generation TRPV1 antagonists. Intended for all researchers and clinicians working toward the development of successful drugs targeting TRP channels, this book is an essential resource chocked full of the latest clinical data and findings.

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