Holiday book sale: Save up to 30% on print and eBooks. No promo code needed.
Save up to 30% on print and eBooks.
Economic Evaluation in Genomic Medicine
1st Edition - March 20, 2015
Authors: Vasilios Fragoulakis, Christina Mitropoulou, Marc Williams, George P. Patrinos
Paperback ISBN:9780128014974
9 7 8 - 0 - 1 2 - 8 0 1 4 9 7 - 4
eBook ISBN:9780128016114
9 7 8 - 0 - 1 2 - 8 0 1 6 1 1 - 4
Economic Evaluation in Genomic Medicine introduces health economics and economic evaluation to genomic clinicians and researchers, while also introducing the topic to health… Read more
Purchase options
LIMITED OFFER
Save 50% on book bundles
Immediately download your ebook while waiting for your print delivery. No promo code is needed.
Economic Evaluation in Genomic Medicine introduces health economics and economic evaluation to genomic clinicians and researchers, while also introducing the topic to health economists.
Each chapter includes an executive summary, questions, and case studies, along with supplementary online materials, including process guides, maps, flow charts, diagrams, and economic evaluation spreadsheets to enhance the learning process.
The text can easily be used as course material for related graduate and undergraduate courses, providing a succinct overview of the existing, state-of-the-art application of economic evaluation to genomic healthcare and precision medicine.
Interrelates economic evaluation and genomic medicine
Instructs healthcare professionals and bioscientists about economic evaluation in genomic medicine
Teaches health economists about application of economic evaluation in genomic medicine
Introduces health economics and economic evaluation to clinicians and researchers involved in genomics
Includes process guides, maps, flow charts and diagrams
Bioscientists, geneticists, biotech industry professionals, undergraduate and graduate students in health economics and health sciences (namely medicine, pharmacy, and genetics), clinicians and health managers, public health officers, health policy makers, governmental organizations, health care professionals, hospital managers, healthcare policy makers
Preface
Chapter 1. Economic Evaluation in Health Care: Evidence-Based Medicine and Evidence-Based Health Economics
The Scope of Economic Evaluation of Health Services: The Science of Economics
Evidence-Based Medicine and Evidence-Based Health Economics
The Necessity of Drafting Economic Evaluations
References
Chapter 2. Genomic Medicine Today: An Introduction for Health Economists
Introduction
Pharmacogenomics and Genomic Medicine
Applications of Pharmacogenomics
Facing the Current Challenges of Genomic Medicine
Education of Health Professionals
Demonstration of Clinical Utility
Health Care Costs
Insurance and Privacy Issues
Conclusions and Future Perspectives
References
Chapter 3. Economic Evaluation and Genomic Medicine: What Can They Learn from Each Other?
Introduction
Genomics in Health Economics
Triangulating Genomics with Health Technology Assessment and Health Economics
Economic Evaluation in the Postgenomic Era
References
Chapter 4. Introduction to the Technical Issues of Economic Evaluation
Introduction
Unique Aspects and Differentiation of CEA from Alternative Approaches
An Appropriate Measure for CEA
CEA Decision Criteria
The Concept of Extended Dominance
Selection of Alternative Options During Economic Evaluation
Valuing the Quality of Life–Cost–Utility Analysis
A Conceptual Approach to QALY
Assessing the Quality of an Economic Analysis
Conclusions
References
Chapter 5. Advanced Methodological Aspects in the Economic Evaluation
Introduction
Model Types
The Size of the ICER or the λ
Estimates of Effectiveness
Study Perspective and Cost Determination
The Discount Rate
Sensitivity Analysis
The Value of Information and Bayesian Analysis
Conclusions
References
Chapter 6. Economic Evaluation in the Genomic Era: Some Examples from the Field
Introduction
Using Pharmacogenomics to Prevent Adverse Events
Balancing Adverse Events and Efficacy
The Disease Makes a Difference
Perspectives on Perspective
Defining Performance Characteristics
Cost-Effectiveness Analysis in Genomic Medicine and the Developing World
Conclusions
References
Chapter 7. Special Requirements for Economic Evaluation and Health Technology Assessment in Genomic Medicine
Introduction
Analysis Costs
Analysis Method
Outcome of Analysis
Analysis Effectiveness
Conclusions
References
Chapter 8. A New Methodological Approach for Cost-Effectiveness Analysis in Genomic Medicine
Introduction
New Methodological Framework of the Decision-Making Process in Genomic Medicine
Relaxation of Fixed λ
A Simple Indicative Example
An Application of the New Model in Genomic Medicine
Implications
Conclusions
References
Chapter 9. Conclusions and Future Perspectives
Introduction
Conclusions
References
Index
No. of pages: 174
Language: English
Published: March 20, 2015
Imprint: Academic Press
Paperback ISBN: 9780128014974
eBook ISBN: 9780128016114
VF
Vasilios Fragoulakis
Affiliations and expertise
University of Patras School of Health Sciences, Department of Pharmacy, Patras, Greece; National School of Public Health, Athens, Greece
CM
Christina Mitropoulou
Christina Mitropoulou is Managing Director and Principal Investigator at the Golden Helix Foundation (London, UK), a registered UK-Charity with Research and Educational activities in the field of Genomic and Personalized Medicine. Her research interests revolve around the health economic evaluation of genome-guided therapeutic interventions. Also, Christina Mitropoulou participates as Executive Committee member of the Ubiquitous Pharmacogenomics (U-PGx) project and coordinates the health economic evaluation of the PREPARE clinical study on pre-emptive Pharmacogenomics testing, involving approx. 8000 patients from 7 clinical sites and she is an active member of the Pharmacogenomics Access and Reimbursement Coalition.
Christina Mitropoulou has published several original articles on this topic in leading scientific journals and has edited two textbooks on economic evaluation in Genomic Medicine that are published by Elsevier/Academic Press.
Affiliations and expertise
Managing Director and Principal Investigator at the Golden Helix Foundation (London, UK), a registered UK-Charity with Research and Educational activities in the field of Genomic and Personalized Medicine
MW
Marc Williams
Affiliations and expertise
Geisinger Health System, Danville, Pennsylvanian, USA
GP
George P. Patrinos
Dr. Patrinos is internationally renowned for his involvement in the field of pharmacogenomics research. His research includes discovery work and addresses the issue of clinical implementation of pharmacogenomics in a holistic manner, including wet- and dry-lab, as well as public health genomics approaches. Dr. Patrinos has also a keen interest in the clinical implementation of genomic medicine in resource-limited environments.
Affiliations and expertise
Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece; Department of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates; Zayed Center of Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates