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Economic Evaluation in Genomic Medicine
- 1st Edition - March 20, 2015
- Authors: Vasilios Fragoulakis, Christina Mitropoulou, Marc Williams, George P. Patrinos
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 0 1 4 9 7 - 4
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 0 1 6 1 1 - 4
Economic Evaluation in Genomic Medicine introduces health economics and economic evaluation to genomic clinicians and researchers, while also introducing the topic to health ec… Read more
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Request a sales quoteEconomic Evaluation in Genomic Medicine introduces health economics and economic evaluation to genomic clinicians and researchers, while also introducing the topic to health economists.
Each chapter includes an executive summary, questions, and case studies, along with supplementary online materials, including process guides, maps, flow charts, diagrams, and economic evaluation spreadsheets to enhance the learning process.
The text can easily be used as course material for related graduate and undergraduate courses, providing a succinct overview of the existing, state-of-the-art application of economic evaluation to genomic healthcare and precision medicine.
- Interrelates economic evaluation and genomic medicine
- Instructs healthcare professionals and bioscientists about economic evaluation in genomic medicine
- Teaches health economists about application of economic evaluation in genomic medicine
- Introduces health economics and economic evaluation to clinicians and researchers involved in genomics
- Includes process guides, maps, flow charts and diagrams
Bioscientists, geneticists, biotech industry professionals, undergraduate and graduate students in health economics and health sciences (namely medicine, pharmacy, and genetics), clinicians and health managers, public health officers, health policy makers, governmental organizations, health care professionals, hospital managers, healthcare policy makers
- Preface
- Chapter 1. Economic Evaluation in Health Care: Evidence-Based Medicine and Evidence-Based Health Economics
- The Scope of Economic Evaluation of Health Services: The Science of Economics
- Evidence-Based Medicine and Evidence-Based Health Economics
- The Necessity of Drafting Economic Evaluations
- References
- Chapter 2. Genomic Medicine Today: An Introduction for Health Economists
- Introduction
- Pharmacogenomics and Genomic Medicine
- Applications of Pharmacogenomics
- Facing the Current Challenges of Genomic Medicine
- Education of Health Professionals
- Demonstration of Clinical Utility
- Health Care Costs
- Insurance and Privacy Issues
- Conclusions and Future Perspectives
- References
- Chapter 3. Economic Evaluation and Genomic Medicine: What Can They Learn from Each Other?
- Introduction
- Genomics in Health Economics
- Triangulating Genomics with Health Technology Assessment and Health Economics
- Economic Evaluation in the Postgenomic Era
- References
- Chapter 4. Introduction to the Technical Issues of Economic Evaluation
- Introduction
- Unique Aspects and Differentiation of CEA from Alternative Approaches
- An Appropriate Measure for CEA
- CEA Decision Criteria
- The Concept of Extended Dominance
- Selection of Alternative Options During Economic Evaluation
- Valuing the Quality of Life–Cost–Utility Analysis
- A Conceptual Approach to QALY
- Assessing the Quality of an Economic Analysis
- Conclusions
- References
- Chapter 5. Advanced Methodological Aspects in the Economic Evaluation
- Introduction
- Model Types
- The Size of the ICER or the λ
- Estimates of Effectiveness
- Study Perspective and Cost Determination
- The Discount Rate
- Sensitivity Analysis
- The Value of Information and Bayesian Analysis
- Conclusions
- References
- Chapter 6. Economic Evaluation in the Genomic Era: Some Examples from the Field
- Introduction
- Using Pharmacogenomics to Prevent Adverse Events
- Balancing Adverse Events and Efficacy
- The Disease Makes a Difference
- Perspectives on Perspective
- Defining Performance Characteristics
- Cost-Effectiveness Analysis in Genomic Medicine and the Developing World
- Conclusions
- References
- Chapter 7. Special Requirements for Economic Evaluation and Health Technology Assessment in Genomic Medicine
- Introduction
- Analysis Costs
- Analysis Method
- Outcome of Analysis
- Analysis Effectiveness
- Conclusions
- References
- Chapter 8. A New Methodological Approach for Cost-Effectiveness Analysis in Genomic Medicine
- Introduction
- New Methodological Framework of the Decision-Making Process in Genomic Medicine
- Relaxation of Fixed λ
- A Simple Indicative Example
- An Application of the New Model in Genomic Medicine
- Implications
- Conclusions
- References
- Chapter 9. Conclusions and Future Perspectives
- Introduction
- Conclusions
- References
- Index
- No. of pages: 174
- Language: English
- Edition: 1
- Published: March 20, 2015
- Imprint: Academic Press
- Paperback ISBN: 9780128014974
- eBook ISBN: 9780128016114
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Vasilios Fragoulakis
Affiliations and expertise
University of Patras School of Health Sciences, Department of Pharmacy, Patras, Greece; National School of Public Health, Athens, GreeceCM
Christina Mitropoulou
Christina Mitropoulou is Managing Director and Principal Investigator at the Golden Helix Foundation (London, UK), a registered UK-Charity with Research and Educational activities in the field of Genomic and Personalized Medicine. Her research interests revolve around the health economic evaluation of genome-guided therapeutic interventions. Also, Christina Mitropoulou participates as Executive Committee member of the Ubiquitous Pharmacogenomics (U-PGx) project and coordinates the health economic evaluation of the PREPARE clinical study on pre-emptive Pharmacogenomics testing, involving approx. 8000 patients from 7 clinical sites and she is an active member of the Pharmacogenomics Access and Reimbursement Coalition.
Christina Mitropoulou has published several original articles on this topic in leading scientific journals and has edited two textbooks on economic evaluation in Genomic Medicine that are published by Elsevier/Academic Press.
Affiliations and expertise
Managing Director and Principal Investigator at the Golden Helix Foundation (London, UK), a registered UK-Charity with Research and Educational activities in the field of Genomic and Personalized MedicineMW
Marc Williams
Affiliations and expertise
Geisinger Health System, Danville, Pennsylvanian, USAGP
George P. Patrinos
George P. Patrinos is a Professor of Pharmacogenomics and Pharmaceutical Biotechnology in the University of Patras (Greece), Department of Pharmacy, and Head of Division of Pharmacology and Biosciences of the same department and holds adjunct Full Professorships at Erasmus MC, Faculty of Medicine, and Health Sciences, Rotterdam (the Netherlands), and the United Arab Emirates University, College of Medicine, Department of Genetics and Genomics, Al-Ain (UAE). Also, from 2018 until the end of 2024, he was Chair of the Global Genomic Medicine Collaborative (G2MC). He served 12.5 years as a full member and Greece’s National representative in the CHMP Pharmacogenomics Working Party of the European Medicines Agency (EMA). George has more than 340 publications in peer-reviewed scientific journals, some of them in leading scientific journals, such as The Lancet, Nature Genetics, Nature Reviews Genetic, Nucleic Acids Research, Genes & Development. He has also coauthored and coedited more than 15 textbooks, among which the renowned textbook Molecular Diagnostics, published by Academic Press, now in its 3rd edition, while he is the editor of Translational and Applied Genomics book series, published by Elsevier. Furthermore, he serves as the Editor-In-Chief of the prestigious Pharmacogenomics Journal (TPJ), published by Nature Publishing Group, Associate Editor, and member of the editorial board of several scientific journals, and advisory and evaluation committees. Apart from that, George is the main coorganizer of the Golden Helix Conferences, an international meeting series on Pharmacogenomics and Genomic Medicine with more than 50 conferences organized in more than 25 countries worldwide.
Affiliations and expertise
Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece; Department of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates; Zayed Center of Health Sciences, United Arab Emirates University, Al-Ain, United Arab EmiratesRead Economic Evaluation in Genomic Medicine on ScienceDirect