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Economic Evaluation in Genomic Medicine
1st Edition - March 20, 2015
Authors: Vasilios Fragoulakis, Christina Mitropoulou, Marc Williams, George P. Patrinos
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 0 1 4 9 7 - 4
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 0 1 6 1 1 - 4
Economic Evaluation in Genomic Medicine introduces health economics and economic evaluation to genomic clinicians and researchers, while also introducing the topic to health… Read more
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Economic Evaluation in Genomic Medicine introduces health economics and economic evaluation to genomic clinicians and researchers, while also introducing the topic to health economists.
Each chapter includes an executive summary, questions, and case studies, along with supplementary online materials, including process guides, maps, flow charts, diagrams, and economic evaluation spreadsheets to enhance the learning process.
The text can easily be used as course material for related graduate and undergraduate courses, providing a succinct overview of the existing, state-of-the-art application of economic evaluation to genomic healthcare and precision medicine.
- Interrelates economic evaluation and genomic medicine
- Instructs healthcare professionals and bioscientists about economic evaluation in genomic medicine
- Teaches health economists about application of economic evaluation in genomic medicine
- Introduces health economics and economic evaluation to clinicians and researchers involved in genomics
- Includes process guides, maps, flow charts and diagrams
Bioscientists, geneticists, biotech industry professionals, undergraduate and graduate students in health economics and health sciences (namely medicine, pharmacy, and genetics), clinicians and health managers, public health officers, health policy makers, governmental organizations, health care professionals, hospital managers, healthcare policy makers
- Preface
- Chapter 1. Economic Evaluation in Health Care: Evidence-Based Medicine and Evidence-Based Health Economics
- The Scope of Economic Evaluation of Health Services: The Science of Economics
- Evidence-Based Medicine and Evidence-Based Health Economics
- The Necessity of Drafting Economic Evaluations
- References
- Chapter 2. Genomic Medicine Today: An Introduction for Health Economists
- Introduction
- Pharmacogenomics and Genomic Medicine
- Applications of Pharmacogenomics
- Facing the Current Challenges of Genomic Medicine
- Education of Health Professionals
- Demonstration of Clinical Utility
- Health Care Costs
- Insurance and Privacy Issues
- Conclusions and Future Perspectives
- References
- Chapter 3. Economic Evaluation and Genomic Medicine: What Can They Learn from Each Other?
- Introduction
- Genomics in Health Economics
- Triangulating Genomics with Health Technology Assessment and Health Economics
- Economic Evaluation in the Postgenomic Era
- References
- Chapter 4. Introduction to the Technical Issues of Economic Evaluation
- Introduction
- Unique Aspects and Differentiation of CEA from Alternative Approaches
- An Appropriate Measure for CEA
- CEA Decision Criteria
- The Concept of Extended Dominance
- Selection of Alternative Options During Economic Evaluation
- Valuing the Quality of Life–Cost–Utility Analysis
- A Conceptual Approach to QALY
- Assessing the Quality of an Economic Analysis
- Conclusions
- References
- Chapter 5. Advanced Methodological Aspects in the Economic Evaluation
- Introduction
- Model Types
- The Size of the ICER or the λ
- Estimates of Effectiveness
- Study Perspective and Cost Determination
- The Discount Rate
- Sensitivity Analysis
- The Value of Information and Bayesian Analysis
- Conclusions
- References
- Chapter 6. Economic Evaluation in the Genomic Era: Some Examples from the Field
- Introduction
- Using Pharmacogenomics to Prevent Adverse Events
- Balancing Adverse Events and Efficacy
- The Disease Makes a Difference
- Perspectives on Perspective
- Defining Performance Characteristics
- Cost-Effectiveness Analysis in Genomic Medicine and the Developing World
- Conclusions
- References
- Chapter 7. Special Requirements for Economic Evaluation and Health Technology Assessment in Genomic Medicine
- Introduction
- Analysis Costs
- Analysis Method
- Outcome of Analysis
- Analysis Effectiveness
- Conclusions
- References
- Chapter 8. A New Methodological Approach for Cost-Effectiveness Analysis in Genomic Medicine
- Introduction
- New Methodological Framework of the Decision-Making Process in Genomic Medicine
- Relaxation of Fixed λ
- A Simple Indicative Example
- An Application of the New Model in Genomic Medicine
- Implications
- Conclusions
- References
- Chapter 9. Conclusions and Future Perspectives
- Introduction
- Conclusions
- References
- Index
- No. of pages: 174
- Language: English
- Published: March 20, 2015
- Imprint: Academic Press
- Paperback ISBN: 9780128014974
- eBook ISBN: 9780128016114
VF
Vasilios Fragoulakis
Affiliations and expertise
University of Patras School of Health Sciences, Department of Pharmacy, Patras, Greece; National School of Public Health, Athens, GreeceCM
Christina Mitropoulou
Christina Mitropoulou is Managing Director and Principal Investigator at the Golden Helix Foundation (London, UK), a registered UK-Charity with Research and Educational activities in the field of Genomic and Personalized Medicine. Her research interests revolve around the health economic evaluation of genome-guided therapeutic interventions. Also, Christina Mitropoulou participates as Executive Committee member of the Ubiquitous Pharmacogenomics (U-PGx) project and coordinates the health economic evaluation of the PREPARE clinical study on pre-emptive Pharmacogenomics testing, involving approx. 8000 patients from 7 clinical sites and she is an active member of the Pharmacogenomics Access and Reimbursement Coalition.
Christina Mitropoulou has published several original articles on this topic in leading scientific journals and has edited two textbooks on economic evaluation in Genomic Medicine that are published by Elsevier/Academic Press.
Affiliations and expertise
Managing Director and Principal Investigator at the Golden Helix Foundation (London, UK), a registered UK-Charity with Research and Educational activities in the field of Genomic and Personalized MedicineMW
Marc Williams
Affiliations and expertise
Geisinger Health System, Danville, Pennsylvanian, USAGP
George P. Patrinos
Dr. Patrinos is internationally renowned for his involvement in the field of pharmacogenomics research. His research includes discovery work and addresses the issue of clinical implementation of pharmacogenomics in a holistic manner, including wet- and dry-lab, as well as public health genomics approaches. Dr. Patrinos has also a keen interest in the clinical implementation of genomic medicine in resource-limited environments.
Affiliations and expertise
Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece; Department of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates; Zayed Center of Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates