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  • Nitric Oxide (Donor/Induced) in Chemosensitization

    • 1st Edition
    • Volume 1
    • Benjamin Bonavida
    • English
    Nitric Oxide as a Chemosensitizing Agent, Volume One is the first book to describe several reviews by authoritative scientists and clinicians on novel findings in the reversal of drug resistant cancers by the combination treatment of Nitric Oxide and sub toxic concentrations of chemotherapeutic drugs that have been reported in both in vitro, in vivo and preclinical models. The book describes the various underlying chemical, molecular and genetic mechanisms by which NO and NO reactive species mediate the anti-cancer activity, thus reducing the threshold of drug resistance and enabling chemo therapeutic drugs to induce their cytotoxic activity and reversal of resistance. This book exposes scientists and clinicians to this highly beneficial topic for research investigations and pharmaceutical companies to new avenues for R&D. It is a valuable resource for cancer researchers, oncologists and members of several areas of the biomedical field who are interested in understanding how to use Nitric Oxide as a sensitizing agent for chemotherapy.

  • Cell Phone Location Evidence for Legal Professionals

    Understanding Cell Phone Location Evidence from the Warrant to the Courtroom
    • 1st Edition
    • Larry Daniel
    • English
    Cell Phone Location Evidence for Legal Professionals: Understanding Cell Phone Location Evidence from the Warrant to the Courtroom is a guide, in plain language, for digital forensics professionals, attorneys, law enforcement professionals and students interested in the sources, methods and evidence used to perform forensic data analysis of cell phones, call detail records, real time ping records and geo-location data obtained from cellular carriers and cell phones. Users will gain knowledge on how to identify evidence and how to properly address it for specific cases, including challenges to the methods of analysis and to the qualifications of persons who would testify about this evidence. This book is intended to provide digital forensics professionals, legal professionals and others with an interest in this field the information needed to understand what each type of evidence means, where it comes from, how it is analyzed and presented, and how it is used in various types of civil and criminal litigation. Relevant case law are included, or referred to, as appropriate throughout this book to give the reader an understanding of the legal history of this type of evidence and how it is being addressed by various state and federal courts.

  • Biomechanics of Living Organs

    Hyperelastic Constitutive Laws for Finite Element Modeling
    • 1st Edition
    • Yohan Payan + 1 more
    • English
    Biomechanics of Living Organs: Hyperelastic Constitutive Laws for Finite Element Modeling is the first book to cover finite element biomechanical modeling of each organ in the human body. This collection of chapters from the leaders in the field focuses on the constitutive laws for each organ. Each author introduces the state-of-the-art concerning constitutive laws and then illustrates the implementation of such laws with Finite Element Modeling of these organs. The focus of each chapter is on instruction, careful derivation and presentation of formulae, and methods. When modeling tissues, this book will help users determine modeling parameters and the variability for particular populations. Chapters highlight important experimental techniques needed to inform, motivate, and validate the choice of strain energy function or the constitutive model. Remodeling, growth, and damage are all covered, as is the relationship of constitutive relationships of organs to tissue and molecular scale properties (as net organ behavior depends fundamentally on its sub components). This book is intended for professionals, academics, and students in tissue and continuum biomechanics.

  • Topology Design Methods for Structural Optimization

    • 1st Edition
    • Osvaldo M. Querin + 4 more
    • English
    Topology Design Methods for Structural Optimization provides engineers with a basic set of design tools for the development of 2D and 3D structures subjected to single and multi-load cases and experiencing linear elastic conditions. Written by an expert team who has collaborated over the past decade to develop the methods presented, the book discusses essential theories with clear guidelines on how to use them. Case studies and worked industry examples are included throughout to illustrate practical applications of topology design tools to achieve innovative structural solutions. The text is intended for professionals who are interested in using the tools provided, but does not require in-depth theoretical knowledge. It is ideal for researchers who want to expand the methods presented to new applications, and includes a companion website with related tools to assist in further study.

  • Therapist's Guide to Clinical Intervention

    The 1-2-3's of Treatment Planning
    • 3rd Edition
    • Sharon L. Johnson
    • English
    Therapist’s Guide to Clinical Intervention, Third Edition, is an essential reference for providing clinical services and associated case formulations requiring formalized goals and objectives. It is ideal for use in assessment, treatment, consultation, completing insurance forms, and/or participating in managed care. This practical, hand-on book, outlines treatment goals and objectives for each type of psychopathology as defined by the diagnostic and statistical manual by the American Psychiatric Association. It additionally provides skill-building resources and samples of all major professional forms likely to be used in clinical treatment.The third edition conveniently maps individualized treatment plans utilizing evidence-based best practices and standards of care. Diagnostic information is presented by associated disorder or theme for easier access. New special assessments and skill-building entries are included. Also new are numerous website/URLs associated with research articles, and consumer resources have been provided to complement clinical information and patient education.

  • RNA Modification

    • 1st Edition
    • Volume 41
    • English
    RNA Modification, Volume 41 examines the powerful ability to regulate the function of RNA molecules or modify the message transmitted by RNA molecules. Chapters in this newly released volume include The Importance of Being Modified: Modifications Shape RNA Function through Chemistry, Structure and Dynamics, The evolution of multi-substrate specificity by RNA modification enzymes, TrmD: a methyl transferase for tRNA methylation with m1G37, Structures and activities of the Elongator complex and its co-factors, RNA pseudouridylation: Mechanism and Function, The activity of 5’3' exonucleases on hypo modified tRNA substrates and other structured RNAs, and the Synthesis, heterogeneity and function of post-transcriptional nucleotide modifications in eukaryotic ribosomal RNAs. This field has recently seen a very rapid progress in the understanding of the mechanism and enzymes involved in RNA modification. This volume presents some of the most recent advances in the identification and function of enzymes involved in modifying RNA molecules.

  • Kidney Transplantation, Bioengineering, and Regeneration

    Kidney Transplantation in the Regenerative Medicine Era
    • 1st Edition
    • Giuseppe Orlando + 2 more
    • English
    Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era investigates how the field of regenerative medicine is changing the traditional premises of solid organ transplantation, specifically within the field of kidney transplantation. In Section 1, chapters illustrate the state of the art in kidney transplantation as well as the research behind the bioengineering and regeneration of kidney organoids for therapeutic renal replacement. In Section II, chapters catalog the technologies that are being developed and the methods that are being implemented to bioengineer or regenerate kidneys in order to restore function, while critically highlighting those technological advances which hold the most promise. The book thus encompasses clinical renal transplantation, tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, as they are all applied to the kidney.

  • Toxicology: What Everyone Should Know

    • 1st Edition
    • Aalt Bast + 1 more
    • English
    Toxicology: What Everyone Should Know is an essential reference for anyone looking for an entry into this fascinating field of study. This innovative book describes important discoveries in toxicology through the ages, explores their historical and sociological impacts, and shows how they still influence recent, state-of-the-art developments. In addition, the book shows how these developments are extrapolated into public and political perceptions on risks and the regulatory consequences, emphasizing environmental issues, such as manmade and natural chemicals, their interaction and impact, nutrition, and drugs. Users will find a cutting-edge approach to nutritional and combinatorial toxicology, risk evaluation modeling and the benefits of chemicals exposure (nutrition versus man-made chemicals), environmental health, and legislative frameworks to control the public’s chemical exposure. This is an essential reference for those looking for an introduction to toxicology, its past, and exciting future.

  • Encapsulated Catalysts

    • 1st Edition
    • Samahe Sadjadi
    • English
    Encapsulated Catalysts provides valuable information for chemists, chemical engineers, and materials scientists in this promising area. The book describes many kinds of encapsulated catalysts and their applications in chemistry, including organic, inorganic, hybrid, and biological systems. Unlike other works, which discuss traditional supports, this useful resource uniquely focuses on extremely important topics, such as the encapsulation effects on reactivity and selectivity, the difficulty of their separation from reaction mixture, and/or their sensitivity to reaction conditions, and the limit of their industrial applications. In addition, the book covers the immobilization of homogenous catalysts on inorganic or organic supports and how it enables the separation of homogenous catalysts, as well as the protection or reuse of catalysts.

  • Smart Sensors Networks

    Communication Technologies and Intelligent Applications
    • 1st Edition
    • Fatos Xhafa + 2 more
    • English
    Smart Sensors Networks: Communication Technologies and Intelligent Applications explores the latest sensor and sensor networks techniques and applications, showing how networked wireless sensors are used to monitor and gather intelligence from our surrounding environment. It provides a systematic look at the unique characteristics of wireless sensor networks through their usage in a broad range of areas, including healthcare for the elderly, energy consumption, industrial automation, intelligent transportation systems, smart homes and cities, and more. The book shows how sensor-networks work and how they are applied to monitor our surrounding environment. It explores the most important aspects of modern sensors technologies, providing insights on the newest technologies and the systems needed to operate them. Readers will find the book to be an entry point for understanding the fundamental differences between the various sensor technologies and their use in for different scenarios. Indexing: The books of this series are submitted to EI-Compendex and SCOPUS

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