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Academic Press

  • Genetics of Bone Biology and Skeletal Disease

    • 2nd Edition
    • Rajesh V. Thakker + 3 more
    • English
    Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets.

  • Weighted Residual Methods

    Principles, Modifications and Applications
    • 1st Edition
    • Mohammad Hatami
    • English
    Weighted Residual Methods: Principles, Modifications and Applications introduces a range of WRMs, providing examples that show how they can be used to solve complex engineering problems with greater accuracy and computational efficiency. Examples focus on non-linear problems, including the motion of a spherical particle, nanofluid flow and heat transfer, magnetohydrodynamic flow and heat transfer, and micropolar fluid flow and heat transfer. These are important factors in understanding processes, such as filtration, combustion, air and water pollution and micro contamination. In addition to the applications, the reader is provided with full derivations of equations and summaries of important field research.

  • Advances in Food Security and Sustainability

    • 1st Edition
    • Volume 2
    • English
    Advances in Food Security and Sustainability, Volume Two takes a scientific look at the challenges, constraints and solutions necessary to maintain a healthy and accessible food supply in different communities around the world. Topics covered in this new volume include the Management of major fungal diseases for sustainable oilseed rape crop production in the UK, Public Policy and the Construction of New Markets to Family Farms: Analyzing the Case of School Meals in São Paulo, Brazil, The environmental, social and market sustainability of sugar, and Sustainability performance of food chains: linking biodiversity and nutritional value in the Italian wheat to bread chain. This ongoing series addresses a wide range of issues on the principles and practices of food sustainability and security, exploring challenges related to protecting environmental resources while also meeting human nutritional requirements.

  • Environmental Issues Concerning Hydraulic Fracturing

    • 1st Edition
    • Volume 1
    • English
    Environmental Issues Concerning Hydraulic Fracturing, Volume One captures the state-of-the-art research currently used to evaluate the potential impact of unconventional gas and oil gas extraction processes. Topics in this comprehensive guide on the topic include chapters on The Human Health Implications of Unconventional Oil and Gas Development, The use of Noble Gas Analysis and other Forensic Techniques in Characterizing Contamination Pathways Associated with Oil and Gas Development, Well Integrity, Contamination Mechanisms and Groundwater Impacts Associated with Unconventional Oil and Gas Development, and Advances in Fracturing and Well Construction: Improving Efficiency and Reducing Risks. This serial explores a wide breadth of emerging and state-of-the-art technologies used to study the potential environmental impact and various processes in the massive industrial process of shale exploration and resource extraction.

  • Metagenomics

    Perspectives, Methods, and Applications
    • 1st Edition
    • Muniyandi Nagarajan
    • English
    Metagenomics: Perspectives, Methods, and Applications provides thorough coverage of the growing field of metagenomics. A diverse range of chapters from international experts offer an introduction to the field and examine methods for metagenomic analysis of microbiota, metagenomic computational tools, and recent metagenomic studies in various environments. The emphasis on application makes this text particularly useful for applied researchers, practitioners, clinicians and students seeking to employ metagenomic approaches to advance knowledge in the biomedical and life sciences. Case-study based application chapters examine topics ranging from viral metagenome profiling, metagenomics in oral disease and health, metagenomic insights into the human gut microbiome and metabolic syndromes, and more. Additionally, perspectives on future potential at the end of each chapter provoke new thought and motivations for continued study in this exciting and fruitful research area.

  • Principles of Electron Optics, Volume 1

    Basic Geometrical Optics
    • 2nd Edition
    • Peter W. Hawkes + 1 more
    • English
    Volume one of Principles of Electron Optics: Basic Geometrical Optics, Second Edition, explores the geometrical optics needed to analyze an extremely wide range of instruments: cathode-ray tubes; the family of electron microscopes, including the fixed-beam and scanning transmission instruments, the scanning electron microscope and the emission microscope; electron spectrometers and mass spectrograph; image converters; electron interferometers and diffraction devices; electron welding machines; and electron-beam lithography devices. The book provides a self-contained, detailed, modern account of electron optics for anyone involved with particle beams of modest current density in the energy range up to a few mega-electronvolts. You will find all the basic equations with their derivations, recent ideas concerning aberration studies, extensive discussion of the numerical methods needed to calculate the properties of specific systems and guidance to the literature of all the topics covered. A continuation of these topics can be found in volume two, Principles of Electron Optics: Applied Geometrical Optics. The book is intended for postgraduate students and teachers in physics and electron optics, as well as researchers and scientists in academia and industry working in the field of electron optics, electron and ion microscopy and nanolithography.

  • Tethered Space Robot

    Dynamics, Measurement, and Control
    • 1st Edition
    • Panfeng Huang + 3 more
    • English
    Tethered Space Robot: Dynamics, Measurement, and Control discusses a novel tethered space robot (TSR) system that contains the space platform, flexible tether and gripper. TSR can capture and remove non-cooperative targets such as space debris. It is the first time the concept has been described in a book, which describes the system and mission design of TSR and then introduces the latest research on pose measurement, dynamics and control. The book covers the TSR system, from principle to applications, including a complete implementing scheme. A useful reference for researchers, engineers and students interested in space robots, OOS and debris removal.

  • Immunology

    Volume 1: Immunotoxicology, Immunopathology, and Immunotherapy
    • 1st Edition
    • M. A. Hayat
    • English
    Immunology, Volume 1: Immunotoxicology, Immunopathology, and Immunotherapy discusses the investment of time, effort and finance that go into making progress in preventing and/or curing serious diseases by using standard treatments (chemotherapy, radiotherapy, surgery, and hormone therapy). The use of these treatments is accompanied by unavoidable, devastating side effects. At the cost of being repetitious, it has to be emphasized that an improved understanding of the immune system, avoidance of unhealthy habits (e.g., smoking, intake of alcohol, perpetual stress, and lack of exercise) and early detection (using biomarkers) are the only three friends we have to at least delay the onset of serious diseases.

  • GERD

    A New Understanding of Pathology, Pathophysiology, and Treatment
    • 1st Edition
    • Parakrama T. Chandrasoma
    • English
    GERD: A New Understanding of Pathology, Pathophysiology, and Treatment transforms the assessment of gastroesophageal reflux disease (GERD) from its present state, which is largely dependent on clinical definition and management, to a more objective scientific basis that depends on pathologic assessment. Sequential chapters in this single-author book describe the fetal development of the esophagus, the normal adult state, and the way exposure to gastric juice causes epithelial and lower esophageal sphincter damage at a cellular level. It allows recognition of the pathologic manifestations of lower esophageal sphincter damage and develops new histopathologic criteria for quantitating such damage. This understanding provides new pathologic criteria for definition and diagnosis of GERD from its earliest cellular stage. Algorithms based on measurement of sphincter damage can identify, even before the onset of clinical GERD, persons who will never develop GERD during life, those who develop GERD but remain with mild and easily controlled disease, and those who will progress to severe GERD with failure to control symptoms, Barrett esophagus and adenocarcinoma. Aggressive early intervention in the last group with the objective of preventing disease progression to its end points of uncontrolled symptoms and adenocarcinoma becomes feasible.

  • Laboratory Animals

    Regulations and Recommendations for the Care and Use of Animals in Research
    • 2nd Edition
    • Javier Guillen
    • English
    Laboratory Animals: Regulations and Recommendations for the Care and Use of Animals in Research, Second Edition, is the only publication to offer a global compilation of standards on the care, welfare and use of animals in research. The book provides updated information that will be of great interest to professionals across laboratory animal science and biomedical research. Users will find a broad picture of the regulations required in other areas of the world that will be essential to appropriately manage animal care and use programs.

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