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Elsevier

Academic Press

  • Epigenetic Mechanisms in Cancer

    • 1st Edition
    • Volume 3
    • Sabita Saldanha
    • English
    Epigenetic Mechanisms in Cancer provides a comprehensive analysis of epigenetic signatures that govern disease development, progression and metastasis. Epigenetic signatures dictating tumor etiologies present an opportunity for biomarker identification which has broad potential for improving diagnosis, prognosis, prediction, and risk assessment. This volumes offers a unique evaluation of signature differences in childhood, sex-specific and race-specific cancers, and in doing so broadly illuminates the scope of epigenetic biomarkers in clinical environments. Chapters detail the major epigenetic process in humans consisting of DNA methylation, histone modifications and microRNAs (miRNAs) involved in the initiation, progression and metastasis of tumors. Also delineated are recent technologies such as next generation sequencing that are used to identify epigenetic profiles (primarily methylation analysis) in samples (normal, benign and cancerous) and which are highly important to the analysis of epigenetic outcomes.

  • Submerged and Floating Photovoltaic Systems

    Modelling, Design and Case Studies
    • 1st Edition
    • Marco Rosa-Clot + 1 more
    • English
    Submerged and Floating Photovoltaic Systems: Modelling, Design and Case Studies investigates how the use of photovoltaic systems in and on the water can create a positive synergy by increasing the cost effectiveness of PV systems, satisfying the local energy demand and creating positive effects on water. Tina and Rosa-Clot combine their wealth of experience to present a theoretical, numerical, experimental and design-focused analysis of water-integrated PV systems. The book is dedicated to providing a very accessible and understandable analysis of the theoretical and modeling aspects of these PV systems. The authors explore and analyze many existing projects and case studies which provide the reader with an understanding of common design and installation problems, as well as a thorough economic study to help the reader justify the adoption of this very clean method of creating renewable energy.

  • Advances in Physical Organic Chemistry

    • 1st Edition
    • Volume 51
    • English
    Advances in Physical Organic Chemistry, Volume 51, the latest release in the series, is the definitive resource for authoritative reviews of work in physical organic chemistry. It provides a valuable source of information for not only physical organic chemists applying their expertise to both novel and traditional problems, but also for non-specialists across diverse areas who identify a physical organic component in their approach to research. Its hallmark is a quantitative, molecular level understanding of phenomena across a diverse range of disciplines.

  • Molecular Pathology

    The Molecular Basis of Human Disease
    • 2nd Edition
    • William B. Coleman + 1 more
    • English
    As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states.

  • Disaster Epidemiology

    Methods and Applications
    • 1st Edition
    • Jennifer Horney
    • English
    Disaster Epidemiology: Methods and Applications applies the core methods of epidemiological research and practice to the assessment of the short- and long-term health effects of disasters. The persistent movement of people and economic development to regions vulnerable to natural disasters, as well as new vulnerabilities related to environmental, technological, and terrorism incidents, means that in spite of large global efforts to reduce the impacts and costs of disasters, average annual expenditures to fund rebuilding from catastrophic losses is rising faster than either population or the gross world product. Improving the resilience of individuals and communities to these natural and technological disasters, climate change, and other natural and manmade stressors is one of the grand challenges of the 21st century. This book provides a guide to disaster epidemiology methods, supported with applications from practice. It helps researchers, public health practitioners, and governmental policy makers to better quantify the impacts of disaster on the health of individuals and communities to enhance resilience to future disasters. Disaster Epidemiology: Methods and Applications explains how public health surveillance, rapid assessments, and other epidemiologic studies can be conducted in the post-disaster setting to prevent injury, illness, or death; provide accurate and timely information for decisions makers; and improve prevention and mitigation strategies for future disasters. These methods can also be applied to the study of other types of public health emergencies, such as infectious outbreaks, emerging and re-emerging diseases, and refugee health. This book gives both the public health practitioner and researcher the tools they need to conduct epidemiological studies in a disaster setting and can be used as a reference or as part of a course.

  • Genetics of Bone Biology and Skeletal Disease

    • 2nd Edition
    • Rajesh V. Thakker + 3 more
    • English
    Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets.

  • Weighted Residual Methods

    Principles, Modifications and Applications
    • 1st Edition
    • Mohammad Hatami
    • English
    Weighted Residual Methods: Principles, Modifications and Applications introduces a range of WRMs, providing examples that show how they can be used to solve complex engineering problems with greater accuracy and computational efficiency. Examples focus on non-linear problems, including the motion of a spherical particle, nanofluid flow and heat transfer, magnetohydrodynamic flow and heat transfer, and micropolar fluid flow and heat transfer. These are important factors in understanding processes, such as filtration, combustion, air and water pollution and micro contamination. In addition to the applications, the reader is provided with full derivations of equations and summaries of important field research.

  • Environmental Issues Concerning Hydraulic Fracturing

    • 1st Edition
    • Volume 1
    • English
    Environmental Issues Concerning Hydraulic Fracturing, Volume One captures the state-of-the-art research currently used to evaluate the potential impact of unconventional gas and oil gas extraction processes. Topics in this comprehensive guide on the topic include chapters on The Human Health Implications of Unconventional Oil and Gas Development, The use of Noble Gas Analysis and other Forensic Techniques in Characterizing Contamination Pathways Associated with Oil and Gas Development, Well Integrity, Contamination Mechanisms and Groundwater Impacts Associated with Unconventional Oil and Gas Development, and Advances in Fracturing and Well Construction: Improving Efficiency and Reducing Risks. This serial explores a wide breadth of emerging and state-of-the-art technologies used to study the potential environmental impact and various processes in the massive industrial process of shale exploration and resource extraction.

  • Advances in Food Security and Sustainability

    • 1st Edition
    • Volume 2
    • English
    Advances in Food Security and Sustainability, Volume Two takes a scientific look at the challenges, constraints and solutions necessary to maintain a healthy and accessible food supply in different communities around the world. Topics covered in this new volume include the Management of major fungal diseases for sustainable oilseed rape crop production in the UK, Public Policy and the Construction of New Markets to Family Farms: Analyzing the Case of School Meals in São Paulo, Brazil, The environmental, social and market sustainability of sugar, and Sustainability performance of food chains: linking biodiversity and nutritional value in the Italian wheat to bread chain. This ongoing series addresses a wide range of issues on the principles and practices of food sustainability and security, exploring challenges related to protecting environmental resources while also meeting human nutritional requirements.

  • Principles of Electron Optics, Volume 1

    Basic Geometrical Optics
    • 2nd Edition
    • Peter W. Hawkes + 1 more
    • English
    Volume one of Principles of Electron Optics: Basic Geometrical Optics, Second Edition, explores the geometrical optics needed to analyze an extremely wide range of instruments: cathode-ray tubes; the family of electron microscopes, including the fixed-beam and scanning transmission instruments, the scanning electron microscope and the emission microscope; electron spectrometers and mass spectrograph; image converters; electron interferometers and diffraction devices; electron welding machines; and electron-beam lithography devices. The book provides a self-contained, detailed, modern account of electron optics for anyone involved with particle beams of modest current density in the energy range up to a few mega-electronvolts. You will find all the basic equations with their derivations, recent ideas concerning aberration studies, extensive discussion of the numerical methods needed to calculate the properties of specific systems and guidance to the literature of all the topics covered. A continuation of these topics can be found in volume two, Principles of Electron Optics: Applied Geometrical Optics. The book is intended for postgraduate students and teachers in physics and electron optics, as well as researchers and scientists in academia and industry working in the field of electron optics, electron and ion microscopy and nanolithography.

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