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Elsevier

Academic Press

  • Molecular Insights into Proteinopathies

    Increased Scope from Neurodegeneration to other Pathologies of the Brain
    • 1st Edition
    • Eva Žerovnik + 1 more
    • English
    Molecular Insights into Proteinopathies: Increased Scope from Neurodegeneration to other Pathologies of the Brain investigates the molecular events that lead to various diseases. The book is divided into four parts, the first of which delves into protein aggregation across a range of diseases, including Alzheimer’s disease, Parkinson’s disease, schizophrenia, and neuropsychiatric diseases. It then moves on to discuss signaling pathways and biomarkers of disease, including oxidative stress, mitochondrial decline, and dysregulated molecular pathways. The third part explores small molecules as modulators of key processes in the pathogenesis of proteinopathies, including antioxidants, polyphenol compounds, metal chelators, and repurposed drugs that modulate proteinopathies.The final section considers biophysical methods, molecular dynamics, and machine learning approaches in the study of these aspects. The book provides a detailed overview of protein dysfunction and its implications for health and disease, aiding understanding of protein condensates and aggregates, protein misfolding, co-chaperoning and toxicity of pre-amyloid aggregates. By understanding the fundamental properties underlying these, the book paves the way for investigating how proteinopathies could be treated.

  • Semiconductors and Semimetals

    • 1st Edition
    • Volume 122
    • English
    Semiconductors and Semimetals series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Lights on for the Nervous System: Exploring the Effects of Photobiomodulation - Part A

    • 1st Edition
    • Volume 189
    • English
    Lights on for the Nervous System: Exploring the Effects of Photobiomodulation: Part A, Volume 187 in the International Review of Neurobiology series, highlights new advances in understanding how light interacts with the human body and brain. This comprehensive volume presents chapters written by an international board of authors, covering the history and theory of therapeutic light use, the underlying mechanisms of light–cell interactions, and the systemic effects of light exposure. It explores cognitive enhancement, sleep regulation, and microbiome modulation, as well as the potential of light-based interventions for neurodegenerative disorders, chronic pain, traumatic brain injury, depression, and retinal diseases.Specific sections cover History of Humans Using Light, Theory of Light: Why Should It Work, Mechanisms of Light, Systemic Effects of Light, Light Application and Dosage, How Does Light Affect Brain Activity, Light Talks: The Role of Biophoton in Cellular Communication, Biophotons: Communication with Light, Light Effects on Brain Activity: Simulations/Dynamic Function, Cognitive Enhancement through Transcranial Infrared Laser Stimulation: Insights from Research, Light Effects on the Microbiome, Lights On for Sleep, Exploring the Effect of Red and Near Infrared Light on Neurodegenerative Disease, Light Effects on Parkinson's Disease: Intracranial Application, Light Effects on Parkinson's Disease: Transcranial Application, and much more.

  • Comparative Fish Immunology

    • 1st Edition
    • Volume 42
    • English
    Comparative Fish Immunology, Volume 42 in the Fish Physiology series, presents chapters written by leading experts. Covering a broad range of topics, this edition explores the evolution and function of immune systems in fish, with particular attention to both innate and adaptive immune mechanisms across diverse aquatic species. Chapters examine adaptive immunity in jawless vertebrates and the unique VLR system, the role of antimicrobial peptides in teleost infections, and the use of zebrafish as a model for studying innate immune responses. Additional contributions explore pharyngeal mucosal lymphoid structures, the evolutionary origins of germinal centers in fish, and mechanisms of antigen presentation in teleosts.Other chapters address microbiota–host immune interactions, emerging insights into teleost neuroimmunology, and the modulation of immune function through behavioral fever. Together, these contributions provide a comprehensive overview of current discoveries and evolving perspectives in fish immunology, offering valuable insights for researchers, immunologists, and aquatic biologists interested in the physiology and immune biology of fishes.

  • Thiamine and Thiamine-Pyrophosphate (TPP) Riboswitches

    • 1st Edition
    • Volume 735
    • English
    This volume of "Methods in Enzymology" series is devoted to the cofactor thiamine, also known as vitamin B1, and its phosphorylated derivatives. The biosynthesis of thiamine is discussed in terms of key enzymes and their regulation, the evolution of metabolic pathways, and its importance in plant and yeast metabolism. The importance of quantifying and distinguishing between phosphorylated and unphosphorylated thiamine in animal and human tissues using chromatographic, enzymatic, and nanopore methods is also discussed. In addition to these methods, thiamine riboswitches are a major focus of this book, covering everything from their identification in plants and the elucidation of their structure to their application in detection.This book presents state-of-the-art methods and detailed protocols intended for all researchers interested in thiamine metabolism or its detection.

  • Cell Death Part E

    • 1st Edition
    • Volume 210
    • English
    Cell Death: Part E, Volume 210 presents the latest advances and comprehensive reviews in the rapidly evolving field of cell death. This volume explores the molecular mechanisms, regulatory pathways, and biological consequences of various forms of cell death—including apoptosis, necrosis, autophagy, and other non-canonical processes. Chapters in this new release include Flow cytometry analysis of mitochondrial apoptotic priming with BH3 profiling on senescent cells, Methods to study PIDDOsome and caspase 2 signaling, Isolation, characterization, and experimental applications of apoptotic bodies in vitro, Lipid ROS Measurement by Spectral Flow Cytometry based on the ratiometric dye BODIPYTM C11 581/591, and much more.Additional chapters cover CRISPR-Cas9 Screen to Identify Genes Regulating Cell Death, Flow cytometry-assisted discrimination of early apoptotic, late apoptotic and primary necrotic morphological markers in Saccharomyces cerevisiae, Cytofluorometric analysis of cell death in primary human neutrophils, Real-time tracking of cell death in human intestinal organoids: a quantitative imaging approach, and more.

  • Advanced and Integrative Therapeutic Strategies in Parkinson’s Disease Management

    • 1st Edition
    • Wael Mohamed
    • English
    Advanced and Integrative Therapeutic Strategies in Parkinson’s Disease Management offers a comprehensive exploration of the latest innovations and multidisciplinary approaches in Parkinson’s Disease treatment. The volume is organized into sections covering genetic therapies, gut microbiota, artificial intelligence, virtual reality, neuroprotective strategies, polypharmacy, and combination therapies. It addresses the integration of personalized medicine, neuroprotective diets, natural products, cognitive enhancers, and ethical considerations. Additional chapters introduce traditional medicine, music therapy, and the synergy between pharmacotherapy and complementary modalities. The book equips readers with the knowledge to implement innovative therapies, navigate complex ethical landscapes, and integrate multidisciplinary and complementary approaches.This reference is essential for those seeking to advance clinical practice and research in Parkinson’s Disease through the adoption of cutting-edge strategies.

  • Applied Charged Particle Optics: Part II

    • 1st Edition
    • Volume 239
    • English
    Advances in Imaging and Electron Physics, Volume 239 merges two long-running serials, Advances in Electronics and Electron Physics and Advances in Optical and Electron Microscopy.

  • Evolutionary Adaptations and Mosquito-Borne Viruses

    • 1st Edition
    • Volume 70
    • English
    Evolutionary Adaptations and Mosquito-Borne Viruses comprises comprehensive reviews of various topics in mosquito adaptations and mosquito-virus interactions, with insights into future research prospects. The topics covered in this volume include mechanisms of insecticide resistance, thermal and desiccation tolerance, insect-specific viruses and their interactions with pathogenic viruses, mosquito viral immunity, factors affecting vector competence, host preference, saliva and viral pathogenesis, microbiota and symbionts, gene drives and genetic modification of mosquitoes, and microRNA roles in mosquito-virus interactions.

  • Advances in Organometallic Chemistry

    • 1st Edition
    • Volume 85
    • English
    Advances in Organometallic Chemistry provides a comprehensive overview of recent developments and emerging trends in the field of organometallic chemistry. Covering a wide range of topics, the book explores the synthesis, structure, reactivity, and applications of organometallic compounds across various chemical disciplines. Chapters are authored by leading experts and highlight both fundamental research and innovative applications, including catalysis, materials science, bioorganometallic chemistry, and sustainable processes. This volume serves as an essential reference for researchers, graduate students, and professionals seeking up-to-date information on the dynamic and interdisciplinary field of organometallic chemistry.

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