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Elsevier

Academic Press

  • The ISPCAN International Handbook of Child Abuse and Neglect

    • 1st Edition
    • Kevin Lalor + 3 more
    • English
    The ISPCAN International Handbook of Child Abuse and Neglect offers a comprehensive examination of global knowledge on child maltreatment. In partnership with the International Society for the Prevention of Child Abuse and Neglect (ISPCAN), this handbook is designed for a diverse audience, including academics, researchers, policymakers, and health and social care professionals. It aims to cultivate a shared language and enhance understanding of the complexities surrounding child abuse and neglect, beginning with a global overview that explores the contextual and environmental factors influencing child maltreatment that is followed by discussions on various forms of abuse and supported by global case studies.Latter sections focus on the latest intervention and prevention strategies, critically evaluating their effectiveness across different settings. Concluding with insights into future directions, the book emphasizes emerging trends, innovative approaches, and the continual need for comprehensive research and policy development in this crucial field.

  • Drug Targeting Complexity

    Tissue-Specific Regulation and Molecular Paradigms in Cancer Therapy
    • 1st Edition
    • Lalit Kumar + 2 more
    • English
    Drug Targeting Complexity: Tissue-Specific Regulation and Molecular Paradigms in Cancer Therapy presents a rigorous examination of advanced strategies for the selective targeting of neoplastic cells and their distinct microenvironments. This comprehensive volume elucidates both tissue-specific and tumor-specific molecular targets, clarifying how these methodologies can significantly enhance therapeutic precision while mitigating off-target effects. The initial section of the text provides an in-depth analysis of tissue-specific regulatory targets across various organs, including the liver, lungs, brain, skin, and bones. It delineates the critical mediators and mechanisms that govern tumor immunity, thereby identifying novel therapeutic avenues.Each chapter meticulously evaluates key regulatory molecules such as TGF-β, CTLA-4, and IL-10, exploring their roles in tumorigenesis and the potential for targeted interventions across a spectrum of malignancies. Subsequent sections focus on tumor tissue-specific molecular targets, encompassing immunological checkpoints, growth factors, and signaling pathways pertinent to cancers of the liver, stomach, ovary, prostate, and colon. The text provides insights into the application of monoclonal antibodies and molecular inhibitors as strategies to impede cancer progression and address therapeutic resistance. Concluding chapters address emerging therapeutic paradigms, including precision medicine and nanotechnology.

  • The Economics of News Media

    • 1st Edition
    • Sangwoo Yang
    • English
    The Economics of News Media examines the economic underpinnings that shape news media, providing a comprehensive introduction to the field of news media economics that bridges the gap between economics, media studies, and journalism. Each chapter delves into critical topics, from the structure of news markets to the implications of media bias, competition, and evolving news landscapes in the digital age. By offering empirical studies and theoretical insights, this work not only addresses the needs of researchers and students, but also provides practical tools for professionals grappling with the economic dynamics of news media.This is an essential resource for anyone hoping to understand the economic complexities underpinning the news landscape. With clear explanations and rich, global examples, the book offers practical knowledge and approaches to navigate the multifaceted issues of misinformation, media power, and democratic accountability in today’s media environment.

  • Gene and Cell Therapies

    Principles of Pharmaceutical Development
    • 1st Edition
    • Chris Van Der Walle
    • English
    Interest in gene and cell therapies has increased dramatically following powerful demonstrations of their capability to treat rare genetic disorders, advanced cancers, and regenerate or repair tissues. Although these new, advanced medicines are continually being improved upon, their complex manufacture remains a key obstacle to increasing patient access. Gene and Cell Therapies: Principles of Pharmaceutical Development provides insight to the key principles of emerging scientific and technical strategies to overcome these obstacles. How the design of viral vectors, oncolytic viruses, ribonucleic acid cancer vaccines, autologous and allogeneic cell therapies, impacts their pharmaceutical development is outlined. The advances in molecular and cell biology that have led to efficacious and safe gene and cell therapies are related to the process and analytical developments that ensure their quality. The scope and style, along with included case studies, learning points and lecture slides, will allow the non-specialist to develop a foundational understanding, while the contemporary concepts discussed will urge further advancement of these exciting medicines.

  • The Immunology of Horses and Donkeys

    • 1st Edition
    • Ian R. Tizard
    • English
    The Immunology of Horses and Donkeys offers a comprehensive overview of the immune systems of equids, bridging a critical gap by combining current research with foundational concepts and emphasizing both mechanisms and practical applications. The book covers immune development, disease resistance, vaccination, and immune disorders, supporting improved health management in horses and donkeys. Organized logically, it begins with the evolutionary history and domestication of equids and then explores immune ontogeny, innate and adaptive responses, and lymphoid tissue structure. Chapters detail the major histocompatibility complex, cytokine signaling, antigen-presenting cells, and mucosal immunity.Additional sections address the microbiota, vaccine strategies, and immune responses to bacterial, viral, and parasitic infections, providing a holistic view of equine immune health. Users will find content that advances understanding in immunology, biomedical research, and veterinary medicine, supporting the development of better diagnostics, vaccines, and therapies. The book's clear, thorough approach benefits both scientific discovery and clinical application, ultimately improving equine health and informing broader mammalian immunology studies.

  • Lunar Exploration

    • 1st Edition
    • Volume 67
    • English
    Advances in Geophysics, Volume 67 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Sections in this new release include Introduction to the special issue, Electromagnetic induction in the Earth's mantle and oceans: Forward and inverse modeling, Marine controlled source and magnetotelluric methods, Probing the Lunar Interior with Electromagnetic Geophysical Methods, and Sensor development and applications in mineral exploration.

  • Effects of Climate Change in Movement Disorders

    • 1st Edition
    • Volume 11
    • English
    Effects of Climate Change in Movement Disorders, Volume 10 in the International Review of Movement Disorders series, highlights new advances in the field, with this updated volume presenting interesting chapters on a variety of timely topics, including Climate Change and the Global Burden of Parkinson’s Disease and Movement Disorders, Air Pollution and Neurotoxicity: The Role of Environmental Pollutants in Movement Disorders, Extreme Heat, Sleep Disruption, and the Glymphatic System: Implications for Parkinson’s Disease, Climate-Driven Changes in Vector-Borne Diseases and Neuroinfections: Risks for Movement Disorders, The Impact of Climate Change on Food Security and Nutritional Deficiencies in Movement Disorders, and much more.Other sections cover Invisible Invaders: The Emerging Threat of Microplastics to Brain Health and Movement Disorders, Socioeconomic and Healthcare Disparities in Climate-Related Vulnerability for Parkinson's Disease and Movement Disorders, The Role of Heat Stress, Oxidative Damage, and Neuroinflammation in Parkinson’s disease Pathophysiology, Climate-Linked Disruptions in Medication Availability and Treatment Strategies in movement disorders, and more.

  • An Introduction to Quantum Physics

    From Schrodinger's Equation to Quantum Computing
    • 1st Edition
    • Michael I. Bergman
    • English
    An Introduction to Quantum Physics: From Schrodinger's Equation to Quantum Computing focuses on the Schrodinger equation and its application to the hydrogen atom while also exploring other idealized but important quantum mechanical problems, such as the infinite square well and the harmonic oscillator to build students’ physical intuition. The text assumes only calculus-based introductory physics, but helps students understand the origin of the periodic table and the electronic structure of atoms in a deeper way. In addition, it enables users to make connections with concepts in linear algebra, a course that many students have recently taken or may be taking concurrently.For a student’s first exposure to quantum mechanics, the book offers a unique concentration on locality, entanglement, Bell’s theorem, and quantum gates. This valuable first edition delivers engaging explanations and illustrative examples for both classic problems solved by quantum mechanics and new ones that form the basis for quantum computing.

  • Advances in Virus Research

    • 1st Edition
    • Volume 125
    • English
    Advances in Virus Research, Volume 125 in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters surrounding online resource hubs for modeling viruses/databases to support virology communities

  • Mountain Diversity

    Dynamics of High‑Altitude Environments
    • 1st Edition
    • Robert Marchant
    • English
    Mountain Biodiversity: Pattern, Process and Challenges to our World's High-Altitude Areas explores the highly biodiverse, culturally rich, and often threatened mountain regions that comprise a quarter of the world's continental land surface. These complex areas play a fundamental role in shaping continental-scale climates and have long been recognized as globally important centers of biodiversity. Mountains cover only 25% of global continental land surface yet are home to more than 85% of the world’s amphibians, birds, and mammals, many of which are entirely restricted to mountains. Despite their importance as stores of biodiversity and drivers of global sustainability, high altitude areas are particularly vulnerable to climate change and human interventions.Writte... by a leading expert in tropical mountain ecology, this book explores the processes that define the world's high-altitude areas in an easily digestible manner. Early chapters characterize high-altitude areas according to topography, fire regime, and climate. Dr. Marchant collates palaeoecological, archaeological, and historical insights to synthesize the intersection between mountain societies, ecosystems, and climate. Middle chapters examine the relationship between mountain climates and insect, bird, and mammalian biodiversity. Final chapters describe the future of land use, climate, and biodiversity, and explore opportunities to combine insights from different disciplines to enable pathways for more sustainable futures in sustainable mountain development.High-alt... regions are not adequately protected, and many mountain ranges remain completely unprotected. The status of these important storehouses of biodiversity is under increasing threat via population growth, climatic extremes, and land use change. High-Altitude Biodiversity will present current biodiversity across the world's mountains and use this information to identify priorities for new ways to understand, value, protect, and conserve high altitude areas. By taking a novel interdisciplinary approach that combines temporally and spatially diverse datasets from high altitude areas around the world, this can be used to inform future development.

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