Imaging Blood-Brain Barrier Dysfunction in Brain Disorders
- 1st Edition - November 1, 2025
- Imprint: Academic Press
- Authors: Danny J.J. Wang, Xingfeng Shao
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 3 2 9 7 4 - 6
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 3 2 9 7 5 - 3
Imaging Blood-Brain Barrier Dysfunction in Brain Disorders delves into the intricate structure and function of the blood-brain barrier (BBB), examining its essential role in the pa… Read more
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Request a sales quoteImaging Blood-Brain Barrier Dysfunction in Brain Disorders delves into the intricate structure and function of the blood-brain barrier (BBB), examining its essential role in the pathogenesis of various brain disorders. The book offers a comprehensive overview of cutting-edge medical imaging technologies for visualizing BBB function, both in a healthy state and under diseased conditions. Readers will gain an in-depth understanding of how the BBB influences normal brain function, including aspects such as aging and sleep, and how its dysfunction is linked to serious neurological conditions.
Furthermore, the book explores BBB anomalies in brain disorders like stroke, traumatic brain injury, cerebral small vessel disease, Alzheimer's disease, and sleep apnea. It highlights modern medical imaging technologies, such as MRI, for observing BBB function in vivo. It emphasizes the importance of BBB imaging for monitoring and potentially curing brain disorders, and discusses its potential in the early detection of neurological disorders, allowing for timely and effective treatment strategies.
Furthermore, the book explores BBB anomalies in brain disorders like stroke, traumatic brain injury, cerebral small vessel disease, Alzheimer's disease, and sleep apnea. It highlights modern medical imaging technologies, such as MRI, for observing BBB function in vivo. It emphasizes the importance of BBB imaging for monitoring and potentially curing brain disorders, and discusses its potential in the early detection of neurological disorders, allowing for timely and effective treatment strategies.
- Explains the biology of BBB, its role in maintaining the normal brain function (e.g. aging and sleep), and its aberrations in brain disorders (e.g. stroke, cSVD, AD, TBI, sleep apnea)
- Shows how modern medical imaging technologies, in particular MRI, can visualize BBB function in both the healthy and diseased brain
- Includes multimedia contents, including videos and graphic illustrations to help readers understand the materials
MRI Technologists, biomedical engineers, neuroscientists, neuroimagers
1. Biology of BBB
1.1 Structure and function of BBB
1.2 BBB and glymphatic system
1.3 BBB variation with aging and circadian rhythm
2. Imaging of BBB function
2.1 Nuclear medicine approaches
2.2 MRI measurement of BBB permeability
2.3 MRI measurement of BBB water exchange
3. Imaging natural variation of BBB function
3.1 Imaging BBB function with aging and between genders
3.2 Imaging BBB function during sleep
4. Imaging BBB dysfunction in brain disorders
4.1 Dementia (AD, PD etc)
4.2 Stroke
4.3 Cerebral small vessel disease (cSVD)
4.4 Brain tumor
4.5 Psychiatric diseases (Schizophrenia, depression etc)
5. Imaging BBB for treating brain disorders
5.1 Therapeutic targets and drug delivery across the BBB
5.2 Transit BBB opening using focused ultrasound (FUS)
6. Looking into the future
6.1 Emerging technologies in BBB imaging (ultrahigh field)
6.2 Challenges and opportunities in BBB research
6.3 Ethical considerations and future directions in BBB studies
1.1 Structure and function of BBB
1.2 BBB and glymphatic system
1.3 BBB variation with aging and circadian rhythm
2. Imaging of BBB function
2.1 Nuclear medicine approaches
2.2 MRI measurement of BBB permeability
2.3 MRI measurement of BBB water exchange
3. Imaging natural variation of BBB function
3.1 Imaging BBB function with aging and between genders
3.2 Imaging BBB function during sleep
4. Imaging BBB dysfunction in brain disorders
4.1 Dementia (AD, PD etc)
4.2 Stroke
4.3 Cerebral small vessel disease (cSVD)
4.4 Brain tumor
4.5 Psychiatric diseases (Schizophrenia, depression etc)
5. Imaging BBB for treating brain disorders
5.1 Therapeutic targets and drug delivery across the BBB
5.2 Transit BBB opening using focused ultrasound (FUS)
6. Looking into the future
6.1 Emerging technologies in BBB imaging (ultrahigh field)
6.2 Challenges and opportunities in BBB research
6.3 Ethical considerations and future directions in BBB studies
- Edition: 1
- Published: November 1, 2025
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780443329746
- eBook ISBN: 9780443329753
DW
Danny J.J. Wang
Dr. Danny JJ Wang is Professor of Neurology and Radiology, Director of Imaging Technology Innovation at the Stevens Neuroimaging and Informatics institute, Keck School of Medicine at USC, as well as head of the Laboratory of Functional MRI technology (LOFT). During the past 25 years, his research has been focused on the technical development and clinical translations of novel functional and physiological MRI technologies. He is a recognized expert in perfusion and functional MRI and have extensive experience in clinical applications related to cerebrovascular disorders, dementia and neurodevelopment. He and Dr. Shao spearheaded non-contrast MRI mapping of BBB water exchange. To date, Dr. Wang has published over 230 peer reviewed papers and 25 review chapters with an h-index of 77 (total citations >22,000). Dr. Wang was elected Senior Fellow of the ISMRM in 2022.
Affiliations and expertise
Professor of Neurology and Radiology, Director of Imaging Technology Innovation, Stevens Neuroimaging and Informatics institute, Keck School of Medicine, USAXS
Xingfeng Shao
Dr. Xingfeng Shao is an Assistant Professor of Radiology at USC Stevens Neuroimaging and Informatics institute, Keck School of Medicine at USC. His research focuses on the development and applications of innovative MR image acquisition in normal and diseased populations, particularly in perfusion MRI, laminar ASL fMRI at ultra-high field and blood-brain barrier (BBB) function. Dr. Shao been actively participating international MRI societies and received prestigious awards such as the ISMRM I.I. Rabi Young Investigator finalist (2023), ISMRM W.S. Moore Young Investigator finalist (2018), ISMRM Junior Fellow, OCSMRM young investigator award and ISNVD young investigator award.
Affiliations and expertise
Assistant Professor of Radiology, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California (USC), USA