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    • Histone Modifications in Therapy

      • 1st Edition
      • Volume 20
      • August 21, 2020
      • Pedro Castelo-Branco + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 8 1 6 4 2 2 8
      • eBook
        9 7 8 0 1 2 8 1 6 7 4 0 3
      Histone Modifications in Therapy provides an in-depth analysis of the role of histone mechanisms in major diseases and the promise of targeting histone modifications for disease prevention and treatment. Here, researchers, clinicians and students will discover a thorough, evidence-based discussion of the biology of histones, the diseases engaged by aberrant histone modifications, and pathways with therapeutic potential. Expert chapter addresses the role of histone modifications across a variety of disorders, including cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, autoimmune and inflammatory disorders, among others. In relation to these disease types, histone modifications are discussed, both as mechanisms of prevention and possible treatment. A concluding chapter brings together future perspectives for targeting histone modifications in therapy and next steps in research.

    • Odorant Binding and Chemosensory Proteins

      • 1st Edition
      • Volume 642
      • August 20, 2020
      • English
      • Hardback
        9 7 8 0 1 2 8 2 1 1 5 7 1
      • eBook
        9 7 8 0 1 2 8 2 1 1 5 8 8
      This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field.

    • Emerging Technologies for Heart Diseases

      • 1st Edition
      • August 19, 2020
      • Udi Nussinovitch
      • English
      • Hardback
        9 7 8 0 1 2 8 1 3 7 0 4 8
      • eBook
        9 7 8 0 1 2 8 1 3 7 0 5 5
      The increasing pace of advances in cardiology throughout the last few decades has fundamentally altered the natural course of heart patients. In the last few years, available therapies have been revolutionized completely by new transcatheter therapeutic approaches, novel ventricular assist devices, and new drugs. Also, molecular biology and genetics have a rapidly growing impact on cardiovascular diseases, enabling the field of regenerative medicine to become increasingly closer to routine clinical implementation. Emerging Technologies for Heart Diseases was conceived to cover the recent extensive literature on current and novel therapeutic options for cardiac patients. The first volume is dedicated to heart failure and valvular disorders, and the second covers myocardial ischemia and arrhythmias. The clinical topic is addressed in several chapters divided according to the therapeutic approach (mechanical or electrical device-based, or cell and gene-based). Each of the 46 chapters focuses on clinically available solutions, new therapies currently under evaluation in clinical trials, promising preclinical technologies, and emerging concepts and innovations that have not yet been tested in a preclinical model. Also, the book discusses future challenges and opportunities for clinical implementation. Lessons learned from abandoned experimental practices are also covered, giving the readers the widest possible perspective of current therapeutic dilemmas. Overall, this textbook was designed for physicians who want to stay up-to-date with current therapies and those of the future, for biomedical companies, and for those who wish to broaden their knowledge of new cardiovascular therapeutic options.

    • Emerging Technologies for Heart Diseases

      • 1st Edition
      • August 19, 2020
      • Udi Nussinovitch
      • English
      • Hardback
        9 7 8 0 1 2 8 1 3 7 0 6 2
      • eBook
        9 7 8 0 1 2 8 1 3 7 0 7 9
      The increasing pace of advances in cardiology throughout the last few decades has fundamentally altered the natural course of heart patients. In the last few years, available therapies have been revolutionized completely by new transcatheter therapeutic approaches, novel ventricular assist devices, and new drugs. Also, molecular biology and genetics have a rapidly growing impact on cardiovascular diseases, enabling the field of regenerative medicine to become increasingly closer to routine clinical implementation. Emerging Technologies for Heart Diseases was conceived to cover the recent extensive literature on current and novel therapeutic options for cardiac patients. The first volume is dedicated to heart failure and valvular disorders, and the second covers myocardial ischemia and arrhythmias. The clinical topic is addressed in several chapters divided according to the therapeutic approach (mechanical or electrical device-based, or cell and gene-based). Each of the 46 chapters focuses on clinically available solutions, new therapies currently under evaluation in clinical trials, promising preclinical technologies, and emerging concepts and innovations that have not yet been tested in a preclinical model. Also, the book discusses future challenges and opportunities for clinical implementation. Lessons learned from abandoned experimental practices are also covered, giving the readers the widest possible perspective of current therapeutic dilemmas. Overall, this textbook was designed for physicians who want to stay up-to-date with current therapies and those of the future, for biomedical companies, and for those who wish to broaden their knowledge of new cardiovascular therapeutic options.

    • RNA-Based Regulation in Human Health and Disease

      • 1st Edition
      • August 19, 2020
      • English
      • Paperback
        9 7 8 0 1 2 8 1 7 1 9 3 6
      • eBook
        9 7 8 0 1 2 8 1 7 1 9 4 3
      RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics.

    • Soft Numerical Computing in Uncertain Dynamic Systems

      • 1st Edition
      • August 19, 2020
      • Tofigh Allahviranloo + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 8 2 2 8 5 5 5
      • eBook
        9 7 8 0 1 2 8 2 2 9 9 4 1
      Soft Numerical Computing in Uncertain Dynamic Systems is intended for system specialists interested in dynamic systems that operate at different time scales. The book discusses several types of errors and their propagation, covering numerical methods—including convergence and consistence properties and characteristics—and proving of related theorems within the setting of soft computing. Several types of uncertainty representation like interval, fuzzy, type 2 fuzzy, granular, and combined uncertain sets are discussed in detail. The book can be used by engineering students in control and finite element fields, as well as all engineering, applied mathematics, economics, and computer science students. One of the important topics in applied science is dynamic systems and their applications. The authors develop these models and deliver solutions with the aid of numerical methods. Since they are inherently uncertain, soft computations are of high relevance here. This is the reason behind investigating soft numerical computing in dynamic systems. If these systems are involved with complex-uncertain data, they will be more practical and important. Real-life problems work with this type of data and most of them cannot be solved exactly and easily—sometimes they are impossible to solve. Clearly, all the numerical methods need to consider error of approximation. Other important applied topics involving uncertain dynamic systems include image processing and pattern recognition, which can benefit from uncertain dynamic systems as well. In fact, the main objective is to determine the coefficients of a matrix that acts as the frame in the image. One of the effective methods exhibiting high accuracy is to use finite differences to fill the cells of the matrix.

    • Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B

      • 1st Edition
      • Volume 174
      • August 19, 2020
      • English
      • Hardback
        9 7 8 0 1 2 8 2 2 6 1 5 5
      • eBook
        9 7 8 0 1 2 8 2 2 6 0 4 9
      Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B, represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain.

    • The Future of Pharmaceutical Product Development and Research

      • 1st Edition
      • August 19, 2020
      • English
      • Hardback
        9 7 8 0 1 2 8 1 4 4 5 5 8
      • eBook
        9 7 8 0 1 2 8 1 4 4 5 6 5
      The Future of Pharmaceutical Product Development and Research examines the latest developments in the pharmaceutical sciences, also highlighting key developments, research and future opportunities. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of the product development phase of drug discovery and drug development. Each chapter covers fundamental principles, advanced methodologies and technologies employed by pharmaceutical scientists, researchers and the pharmaceutical industry. The book focuses on excipients, radiopharmaceuticals... and how manufacturing should be conducted in an environment that follows Good Manufacturing Practice (GMP) guidelines. Researchers and students will find this book to be a comprehensive resource for those working in, and studying, pharmaceuticals, cosmetics, biotechnology, foods and related industries.

    • Fundamentals of Heat and Fluid Flow in High Temperature Fuel Cells

      • 1st Edition
      • August 18, 2020
      • Majid Ghassemi + 2 more
      • English
      • Paperback
        9 7 8 0 1 2 8 1 5 7 5 3 4
      • eBook
        9 7 8 0 1 2 8 1 5 7 5 4 1
      Fundamentals of Heat and Fluid Flow in High Temperature Fuel Cells introduces key-concepts relating to heat, fluid and mass transfer as applied to high temperature fuel cells. The book briefly covers different type of fuel cells and discusses solid oxide fuel cells in detail, presenting related mass, momentum, energy and species equation. It then examines real case studies of hydrogen- and methane-fed SOFC, as well as combined heat and power and hybrid energy systems. This comprehensive reference is a useful resource for those working in high temperature fuel cell modeling and development, including energy researchers, engineers and graduate students.

    • Swarm Intelligence for Resource Management in Internet of Things

      • 1st Edition
      • August 18, 2020
      • Aboul Ella Hassanien + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 8 1 8 2 8 7 1
      • eBook
        9 7 8 0 1 2 8 1 8 2 8 8 8
      Internet of Things (IoT) is a new platform of various physical objects or “things” equipped with sensors, electronics, smart devices, software, and network connections. IoT represents a new revolution of the Internet network which is driven by the recent advances of technologies such as sensor networks (wearable and implantable), mobile devices, networking, and cloud computing technologies. IoT permits these the smart devices to collect, store and analyze the collected data with limited storage and processing capacities. Swarm Intelligence for Resource Management in the Internet of Things presents a new approach in Artificial Intelligence that can be used for resources management in IoT, which is considered a critical issue for this network. The authors demonstrate these resource management applications using swarm intelligence techniques. Currently, IoT can be used in many important applications which include healthcare, smart cities, smart homes, smart hospitals, environment monitoring, and video surveillance. IoT devices cannot perform complex on-site data processing due to their limited battery and processing. However, the major processing unit of an application can be transmitted to other nodes, which are more powerful in terms of storage and processing. By applying swarm intelligence algorithms for IoT devices, we can provide major advantages for energy saving in IoT devices. Swarm Intelligence for Resource Management in the Internet of Things shows the reader how to overcome the problems and challenges of creating and implementing swarm intelligence algorithms for each application

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