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Elsevier

Academic Press

  • Regulatory Affairs in the Pharmaceutical Industry

    • 1st Edition
    • Javed Ali + 1 more
    • English
    Regulatory Affairs in the Pharmaceutical Industry is a comprehensive reference that compiles all the information available pertaining to regulatory procedures currently followed by the pharmaceutical industry. Designed to impart advanced knowledge and skills required to learn the various concepts of regulatory affairs, the content covers new drugs, generic drugs and their development, regulatory filings in different countries, different phases of clinical trials, and the submission of regulatory documents like IND (Investigational New Drug), NDA (New Drug Application) and ANDA (Abbreviated New Drug Application). Chapters cover documentation in the pharmaceutical industry, generic drug development, code of Federal Regulation (CFR), the ANDA regulatory approval process, the process and documentation for US registration of foreign drugs, the regulation of combination products and medical devices, the CTD and ECTD formats, and much more.

  • State of the Art on Grammatical Inference Using Evolutionary Method

    • 1st Edition
    • Hari Mohan Pandey
    • English
    State of the Art on Grammatical Inference Using Evolutionary Method presents an approach for grammatical inference (GI) using evolutionary algorithms. Grammatical inference deals with the standard learning procedure to acquire grammars based on evidence about the language. It has been extensively studied due to its high importance in various fields of engineering and science. The book's prime purpose is to enhance the current state-of-the-art of grammatical inference methods and present new evolutionary algorithms-based approaches for context free grammar induction. The book's focus lies in the development of robust genetic algorithms for context free grammar induction. The new algorithms discussed in this book incorporate Boolean-based operators during offspring generation within the execution of the genetic algorithm. Hence, the user has no limitation on utilizing the evolutionary methods for grammatical inference.

  • Mental Health in a Digital World

    • 1st Edition
    • Dan J. Stein + 2 more
    • English
    Mental Health in a Digital World addresses mental health assessments and interventions using digital technology, including mobile phones, wearable devices and related technologies. Sections discuss mental health data collection and analysis for purposes of assessment and treatment, including the use of electronic medical records and information technologies to improve services and research, the use of digital technologies to enhance communication, psychoeducation, screening for mental disorders, the problematic use of the internet, including internet gambling and gaming, cybersex and cyberchondria, and internet interventions, ranging from online psychotherapy to mobile phone apps and virtual reality adjuncts to psychotherapy.

  • Calcareous Nannofossil Biostratigraphy

    • 1st Edition
    • Volume 6
    • Michael Montenari
    • English
    Stratigraphy & Timescales, Volume Six in the Advances in Sequence Stratigraphy series covers research in stratigraphic disciplines, including the most recent developments in the geosciences. This fully commissioned review publication aims to foster and convey progress in stratigraphy with its inclusion of a variety of topics, including Carbon isotope stratigraphy - principles and applications, Interpreting Phanerozoic δ13C patterns as periodic glacio-eustatic sequences, Stable carbon isotopes in archaeological plant remains, Review of the Upper Ediacaran-Lower Cambrian Detrital Series in Central and North Iberia: NE Africa as possible Source Area, Calibrating δ13C and δ18O chemostratigraphic correlations across Cambrian strata of SW, and much more.

  • Emerging Plant Growth Regulators in Agriculture

    Roles in Stress Tolerance
    • 1st Edition
    • M. Naeem + 1 more
    • English
    Emerging Plant Growth Regulators in Agriculture: Roles in Stress Tolerance presents current PGR discoveries and advances for agricultural applications, providing a comprehensive reference for those seeking to apply these tools for improved plant health and crop yield. As demand for agricultural crops and improved nutritional requirement continue to escalate in response to increasing population, plant researchers have focused on identifying scientific approaches to minimize the negative impacts of climate change on agriculture crops. Among the various applied approaches, the application of plant growth regulators (PGRs) have gained significant attention for their ability to enhance stress tolerance mechanisms. This book was developed to provide foundational and emerging information to advance the discovery of novel, cost-competitive, specific and effective PGRs for applications in agriculture.

  • Current Research in Neuroadaptive Technology

    • 1st Edition
    • Stephen H. Fairclough + 1 more
    • English
    Current Research in Neuroadaptive Technology provides readers with insight into the state-of-the-art field of neuroadaptive technology. The book covers the breadth and depth of current research in this field, covering a range of application domains in sufficient technical detail. The multidisciplinary character of this field means that the publication of key research is often fragmented across specialist journals. Here, the editors have consolidated current research, carefully selecting key topics that are clustered around the concept of neuroadaptive technology. In summary, the book meets the needs of readers by consolidating multidisciplinary research around a nascent technological concept. The topic of neuroadaptive technology is novel and contemporary and editors Dr. Stephen H. Fairclough and Dr. Thorsten O. Zander have captured issues related to this emerging technology at the point of inception. It is a key reference for biomedical engineers and researchers in neural engineering, biomedical engineering, computer science, and mathematics.

  • The DNA Replication-Repair Interface

    • 1st Edition
    • Volume 661
    • English
    Replication-Coupled Repair, Volume 661 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including the Repair of replication-born DNA breaks by sister chromatid recombination, High resolution and high throughput DNA cyclization measurements to interrogate DNA bendability, A programmable detection method for genomic signatures: from disease diagnosis to genome editing, Characterization of the telomerase modulating activities of yeast DNA helicases, Eukaryotic DNA replication with purified budding yeast proteins, Single molecule studies of yeast Rad51 paralogs, Light activation and deactivation of Cas9 for DNA repair studies, and more. Other chapters explore MIDAS: Direct sequencing to map mitotic DNA synthesis and common fragile sites at high precision, Studying the DNA damage response in embryonic systems, GLASS-ChIP to map Mre11 cleavage sites in the human genome, New chemical biology approaches to trap reaction intermediates in living cells, Single-molecule imaging approaches for monitoring replication fork conflicts at genomic DNA G4 structures and R-loops in human cells, Monitoring the replication of structured DNA through heritable epigenetic change, Visualizing replication fork encounters with DNA interstrand crosslinks, and much more.

  • Epigenetics in Precision Medicine

    • 1st Edition
    • Volume 30
    • Jose Luis Garcia-Gimenez
    • English
    In recent years, knowledge of epigenetic mechanisms underlying disease onset and progression has proven crucial for the development of novel early diagnosis and prognosis biomarkers for patient stratification and precision medicine. Epigenetics in Precision Medicine, a new volume in the Translational Epigenetics series, provides a thorough discussion and overview of current developments in clinical epigenetics with special emphasis on epigenetic biomarkers that can be used for clinical diagnosis, prognosis, patient stratification, and treatment monitoring. Disease types discussed include cancer, metabolic disorders, neurodegenerative diseases, bone disease, and immune-related disorders. The book examines the challenges of advancing epigenetics research and translating findings to the clinic and drug discovery in each of these areas, as well as current solutions; chapter authors discuss how to leverage epigenomic technologies, applications, and tools, such as next-generation sequencing, to discover new epigenetic biomarkers in disease and drug studies. Epigenetics in Precision Medicine focuses on complex epigenetic mechanisms in several pathologies, and explores how epigenetics can power the advance of precision medicine, not only by improving in vitro diagnostic and prognostic tools, but by providing new therapeutic approaches to treat human disease.

  • Integrated Population Models

    Theory and Ecological Applications with R and JAGS
    • 1st Edition
    • Michael Schaub + 1 more
    • English
    Integrated Population Models: Theory and Ecological Applications with R and JAGS is the first book on integrated population models, which constitute a powerful framework for combining multiple data sets from the population and the individual levels to estimate demographic parameters, and population size and trends. These models identify drivers of population dynamics and forecast the composition and trajectory of a population. Written by two population ecologists with expertise on integrated population modeling, this book provides a comprehensive synthesis of the relevant theory of integrated population models with an extensive overview of　practical applications, using Bayesian methods by means of case studies. The book contains fully-documented, complete code for fitting all models in the free software, R and JAGS. It also includes all required code for pre- and post-model-fitting analysis. Integrated Population Models is an invaluable reference for researchers and practitioners involved in population analysis, and for graduate-level students in ecology, conservation biology, wildlife management, and related fields.　The text is ideal for self-study and advanced graduate-level courses.

  • Current Progress in iPSC Disease Modeling

    • 1st Edition
    • Alexander Birbrair
    • English
    Current Progress in iPSC Disease Modeling, Volume Fourteen in the Advances in Stem Cell Biology series, is a timely and expansive collection of information and new discoveries in the field. This new volume addresses advances in research on how induced pluripotent stem cells are used for the creation of new tissues and organs. The creation of iPSC technology allowed the development of disease-specific human pluripotent stem cells. These cells allow researchers to study questions once impossible for some human diseases. This volume addresses iPSCs for vascular tissue engineering, bioprinting, derived lung organoids for pulmonary disorders, skeletal muscle engineering, human kidney organoids, and more. It is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation, and is contributed by world-renowned authors in the field.

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